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Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery: A Practical Guide for Pharmaceutical Scientists
by Emile P. ChenDevelop drugs with a greater understanding of their bodily impact Pharmaceutical scientists in the fields of pharmacokinetics and pharmacodynamics study how drugs behave in the body and how they reach their site of action to exert their intended pharmacological activities. Drug discovery stands to benefit enormously from the timely application of pharmacokinetics and pharmacodynamics in order to make informed decisions and solve practical problems. Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery bridge between scientific concepts and practical industrial practice by bringing these principles to bear on every stage of the drug discovery process. Beginning with target identification and moving through each subsequent decision point including high throughput screening, hit-to-lead, lead optimization and candidate selection. The book offers a comprehensive guide to minimizing attrition, reducing costs, and more. The result is an invaluable tool in developing smarter and more effective drug discovery processes. Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery readers will also find: A work designed to make scientific principles accessible to pharmaceutical scientists in diverse areas, not just pharmacokinetists or DMPK scientists Industrial examples, both positive and negative, showing pharmacokinetic and pharmacodynamic principles at work Interactive exercises at the end of each section to encourage holistic and integrated thinking Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery is ideal for any researchers or professionals involved in drug discovery and development, including medicinal chemists, biopharmaceutics scientists, clinicians, project leaders, and many others.
Putting Systems and Complexity Sciences Into Practice: Sharing The Experience
by Joachim P. SturmbergThis idea-packed resource takes systems and complexity sciences out of blue-sky territory and into the concrete world of contemporary healthcare practice. Beginning with a new reframing of health and illness, its chapters redesign traditional disease-centered models of care into modern, health-centered—and patient-centered—health service systems. The approaches shown here combine innovation and common sense to recognize and attend to patients’ needs across areas including health education and training, information accessibility, health service organization and delivery, and disease in individual context. The variety of solutions applied to this wide spectrum of issues shows the suitability of systems, complexity, and adaptive thinking to the ongoing objectives of making health services more responsive, effective, and equitable. Highlights of the coverage: Healthy smoker: an oxymoron? Maybe, but it is more complicated than thatTransforming monitoring and improving care with variability-derived clinical decision supportLinking Gulf War illness to genome instability, somatic evolution, and complex adaptive systemsComplexity of knowledge in primary care: understanding the discipline’s requisite knowledge: a bibliometric studyNew ways of knowing and researching: integrating complexity into a translational health sciences programUnderstanding the emergency department ecosystem using agent-based modelling Putting Systems and Complexity Sciences into Practice is an inspiring idea book that sill interest health policymakers, health financiers, organizational leaders, healthcare administrators, clinicians, researchers, students, and interested lay readers.
Putting Your Patients on the Pump
by Gary Scheiner Nicholas B. Argento Susan L. Barlow Karen M. BoldermanIn a clear and concise style, the extensively revised Putting Your Patients on the Pump offers physicians, nurse practitioners, physician assistants, clinicians, and educators experience and practical guidance on how to help patients successfully manage their diabetes using an insulin pump. Ten chapters provide an in-depth description of insulin pump therapy advantages and disadvantages, pump and infusion set options and selection, pump candidate basics, getting the patient ready, pump start-up, pump therapy management, other considerations (e.g., dining out, alcohol, exercise and physical activity, intimacy, managing sick days, stress, travel, weight change, menses and menopause, pregnancy, pediatrics, and older patients), resources, tips from pump experts, and insulin pumps of the future.Filled with checklists and step-by-step instructions, Putting Your Patients on the Pump is the ideal resource for health care professionals with expertise in diabetes care who wish to successfully start and maintain diabetes patients on insulin pump therapy.
Pvp: A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone)
by Wolfgang SchwarzPolyvinylpyrrolidone is widely used in medicine, pharmaceuticals, cosmetics, foods, printing inks, textiles, and many more diverse applications. This book describes the 50 years of research, published and unpublished, on the absorption, distribution, storage, and excretion of PVP. The toxicology of PVP is critically evaluated. The author's involvement in the recent reevaluation of PVP by the Joint Expert Committee on Food Additives of the World Health Organization (WHO) and the Food and Agriculture Organization (FOA) led them to undertake this comprehensive review of all the information on the subject. This book will be invaluable for anyone who is involved with polyvinylpyrrolidone. Included is a broad review of the toxicological studies performed on PVP, including acute, subchronic, chronic, reproductive, mutagenicity, and carcinogenicity studies. There is also an appendix listing the key studies, with references, on the absorption, renal elimination, distribution, acute toxicity, subchronic toxicity, chronic toxicity, teratogenicity, mutagenicity, and carcinogenicity of PVP.
Pyrosequencing Protocols
by Sharon MarshThis book presents detailed protocols for the multidisciplinary application of Pyrosequencing® technology, all written by world-renowned experts. This comprehensive volume enables quick reference by collecting the primary applications for Pyrosequencing®, and supplementing each protocol with troubleshooting tips specific to that method. This volume both highlights the versatility of and provides detailed protocols for the application of Pyrosequencing®.
Pyrrhic Progress: The History of Antibiotics in Anglo-American Food Production (Critical Issues in Health and Medicine)
by Claas KirchhellePyrrhic Progress analyses over half a century of antibiotic use, regulation, and resistance in US and British food production. Mass-introduced after 1945, antibiotics helped revolutionize post-war agriculture. Food producers used antibiotics to prevent and treat disease, protect plants, preserve food, and promote animals’ growth. Many soon became dependent on routine antibiotic use to sustain and increase production. The resulting growth of antibiotic infrastructures came at a price. Critics blamed antibiotics for leaving dangerous residues in food, enabling bad animal welfare, and selecting for antimicrobial resistance (AMR) in bacteria, which could no longer be treated with antibiotics. Pyrrhic Progress reconstructs the complicated negotiations that accompanied this process of risk prioritization between consumers, farmers, and regulators on both sides of the Atlantic. Unsurprisingly, solutions differed: while Europeans implemented precautionary antibiotic restrictions to curb AMR, consumer concerns and cost-benefit assessments made US regulators focus on curbing drug residues in food. The result was a growing divergence of antibiotic stewardship and a rise of AMR. Kirchhelle’s comprehensive analysis of evolving non-human antibiotic use and the historical complexities of antibiotic stewardship provides important insights for current debates on the global burden of AMR.
Pyruvate Carboxylase
by KeechThis book is a welcome source of information on this enzyme which is vitally important to many forms of life. Each chapter or section of each volume is not written primarily for those specializing in that narrow area, but rather to provide a coherent and integrated summary of that aspect got those working on other, quite different facets of the same enzyme.
Python Machine Learning Cookbook: Over 100 recipes to progress from smart data analytics to deep learning using real-world datasets, 2nd Edition
by Prateek Joshi Giuseppe CiaburroDiscover powerful ways to effectively solve real-world machine learning problems using key libraries including scikit-learn, TensorFlow, and PyTorch Key Features Learn and implement machine learning algorithms in a variety of real-life scenarios Cover a range of tasks catering to supervised, unsupervised and reinforcement learning techniques Find easy-to-follow code solutions for tackling common and not-so-common challenges Book Description This eagerly anticipated second edition of the popular Python Machine Learning Cookbook will enable you to adopt a fresh approach to dealing with real-world machine learning and deep learning tasks. With the help of over 100 recipes, you will learn to build powerful machine learning applications using modern libraries from the Python ecosystem. The book will also guide you on how to implement various machine learning algorithms for classification, clustering, and recommendation engines, using a recipe-based approach. With emphasis on practical solutions, dedicated sections in the book will help you to apply supervised and unsupervised learning techniques to real-world problems. Toward the concluding chapters, you will get to grips with recipes that teach you advanced techniques including reinforcement learning, deep neural networks, and automated machine learning. By the end of this book, you will be equipped with the skills you need to apply machine learning techniques and leverage the full capabilities of the Python ecosystem through real-world examples. What you will learn Use predictive modeling and apply it to real-world problems Explore data visualization techniques to interact with your data Learn how to build a recommendation engine Understand how to interact with text data and build models to analyze it Work with speech data and recognize spoken words using Hidden Markov Models Get well versed with reinforcement learning, automated ML, and transfer learning Work with image data and build systems for image recognition and biometric face recognition Use deep neural networks to build an optical character recognition system Who this book is for This book is for data scientists, machine learning developers, deep learning enthusiasts and Python programmers who want to solve real-world challenges using machine-learning techniques and algorithms. If you are facing challenges at work and want ready-to-use code solutions to cover key tasks in machine learning and the deep learning domain, then this book is what you need. Familiarity with Python programming and machine learning concepts will be useful.
Python Parallel Programming Cookbook: Over 70 recipes to solve challenges in multithreading and distributed system with Python 3, 2nd Edition
by Giancarlo ZacconeImplement effective programming techniques in Python to build scalable software that saves time and memory Key Features Design distributed computing systems and massive computational tasks coherently Learn practical recipes with concise explanations that address development pain points encountered while coding parallel programs Understand how to host your parallelized applications on the cloud Book Description Nowadays, it has become extremely important for programmers to understand the link between the software and the parallel nature of their hardware so that their programs run efficiently on computer architectures. Applications based on parallel programming are fast, robust, and easily scalable. This updated edition features cutting-edge techniques for building effective concurrent applications in Python 3.7. The book introduces parallel programming architectures and covers the fundamental recipes for thread-based and process-based parallelism. You'll learn about mutex, semaphores, locks, queues exploiting the threading, and multiprocessing modules, all of which are basic tools to build parallel applications. Recipes on MPI programming will help you to synchronize processes using the fundamental message passing techniques with mpi4py. Furthermore, you'll get to grips with asynchronous programming and how to use the power of the GPU with PyCUDA and PyOpenCL frameworks. Finally, you'll explore how to design distributed computing systems with Celery and architect Python apps on the cloud using PythonAnywhere, Docker, and serverless applications. By the end of this book, you will be confident in building concurrent and high-performing applications in Python. What you will learn Synchronize multiple threads and processes to manage parallel tasks Use message passing techniques to establish communication between processes to build parallel applications Program your own GPU cards to address complex problems Manage computing entities to execute distributed computational task Write efficient programs by adopting the event-driven programming model Explore cloud technology with Django and Google App Engine Apply parallel programming techniques that can lead to performance improvements Who this book is for The Python Parallel Programming Cookbook is for software developers who are well-versed with Python and want to use parallel programming techniques to write powerful and efficient code. This book will help you master the basics and the advanced of parallel computing.
A Q&A Approach to Organic Chemistry
by Michael B. SmithA Q&A Approach to Organic Chemistry is a book of leading questions that begins with atomic orbitals and bonding. All critical topics are covered, including bonding, nomenclature, stereochemistry, conformations, acids and bases, oxidations, reductions, substitution, elimination, acyl addition, acyl substitution, enolate anion reactions, the Diels–Alder reaction and sigmatropic rearrangements, aromatic chemistry, spectroscopy, amino acids and proteins, and carbohydrates and nucleosides. All major reactions are covered. Each chapter includes end-of-chapter homework questions with the answer keys in an Appendix at the end of the book. This book is envisioned to be a supplementary guide to be used with virtually any available undergraduate organic chemistry textbook. This book allows for a "self-guided" approach that is useful as one studies for a coursework exam or as one reviews organic chemistry for postgraduate exams. Key Features: Allows a "self-guided tour" of organic chemistry Discusses all important areas and fundamental reactions of organic chemistry Classroom tested Useful as a study guide that will supplement most organic chemistry textbooks Assists one in study for coursework exams or allows one to review organic chemistry for postgraduate exams Includes 21 chapters of leading questions that covers all major topics and major reactions of organic chemistry
Q Fever
by Svetoslav P. MartinovInformation on the changing epidemiology and expanding nosological range of Q fever in humans has gained much attention in the past decade. Q fever is a zoonotic disease caused by the highly infectious pathogen Coxiella burnetii and has global distribution with important health, social and economic implications. A number of other properties and characteristics of the causative agent and disease, define Q fever as a lasting and difficult veterinary and epidemiological problem, namely: the adaptability of C. burnetii and its high resistance in the external environment; the possibility of the existence of the agent in three- and two-member parasitic systems; the availability of natural and agricultural foci of infection; peculiarities of pathogenesis in humans and animals, and the mechanisms of excretion of the pathogen into the environment; and the high susceptibility of non-immune populations of animals and people. Given that C. burnetii is included in the arsenal of bacteriological weapons as agent with potential bioterrorist threat must be borne in mind the strategic importance of this microorganismThis book summarizes and analyzes the scientific facts and developments about Q Fever researched worldwide and performed by the author to propose a system for monitoring, control and prevention covering the main necessary actions, measures and activities in the fight against this fever. There is an uneven level of knowledge of Q fever in animals and humans in various countries on the planet, while the assessment of the relevance of the problem is often ambiguous and unrealistic in terms of veterinary, medical and social and economic aspects, which can result in an incomplete diagnosis, inaccurate information about the spread of disease and lack of purposeful struggle. The scientific topics discussed include: Biological, morphological and immunological properties of Coxiella burnetiiDiagnosis, clinical forms and manifestations, pathologic changesEpidemiology of Q fever in animals and humansPrevention and Control
Q Fever, Volume I: The Disease
by Thomas J. MarrieThis fascinating book describes the history, and epidemiology in both man and animals, and clinical features of this zoonosis. It reveals detailed information pertaining to the basic science aspects of the interaction of Coxiella burnetii, the etiologic agent of Q (Query) fever, with the host and the immune response of the host to this unique pathogen. This one-of-a-kind work uses the rules of epidemiological evidence to determine whether or not Coxiella burnetii is a perinatal pathogen for man. This interesting, easy-to-understand text concludes with chapters dealing with the antibiotic susceptibility of Coxiella burnetii and the studies that resulted in a vaccine that now can be used to prevent this infection. This volume is an absolute must for all microbiologists, respirologists, infectious disease physicians and veterinarians.
Qigong for Multiple Sclerosis: Finding Your Feet Again
by Nigel MillsThis book has been written to help people with Multiple Sclerosis (MS) improve their physical and psychological functioning using the Chinese system of movement and meditation known as Qigong, closely related to Tai Chi. Qigong focuses on the important basic principles of balance, body alignment and energy flow without the need to learn the complex patterns of Tai Chi. People with MS often experience impaired balance, difficulties in walking, tremor, low energy levels, and anxiety. Qigong can be used to improve their day-to-day wellbeing. The program described in this book was developed in a hospital setting and rigorously evaluated, and is cited by the National Institute of Clinical Excellence. Most of the participants reported specific improvements on many dimensions. The author provides a step-by-step guide, with photographs and clear text, to show how people with MS can improve their health and quality of life using Qigong. Many of the exercises can be done either seated or standing, and are suitable for anyone, regardless of their level of ability. He explains how to use Qigong to improve balance and walking, and promote healthy breathing and relaxation. He also explores the role of stress in triggering relapses in MS, and an approach designed to help people with MS overcome previous traumatic events, manage stress, and reduce the likelihood of further relapses is included. This practical book will help people with MS to find achievable ways to improve their lives. It will also be of great interest to carers, teachers of Tai Chi or Qigong, physiotherapists, occupational therapists, nurses and complementary therapists.
Qigong for Wellbeing in Dementia and Aging
by Stephen Rath The Natural Healing Research Foundation Laurha FrankfortQigong is the centuries-old practice of moving vital energy (Qi) through the channels of the body, known as meridians, to promote vitality and health. Stephen Rath details current research and Traditional Chinese Medicine theory to show how Qigong practice can support cognitive functioning, as well as emotional and physical wellbeing, in people with dementia. Qigong for Wellbeing in Dementia and Aging presents a set of accessible Qigong exercises and breathing techniques adapted specifically for older people who may be frail or have limited mobility, which address specific symptoms associated with dementia. These include exercises for the hands and feet, exercises for releasing emotions through the Five Animal Sounds, seated exercises, and facial exercises. The exercises, contributed by the Natural Healing Research Foundation from their Senior Exercise Class in Hawaii, are presented with clear explanatory illustrations. The final part of the book describes the Chinese understanding of nutrition as an essential underpinning of good health into old age, and provides health-giving food and drink recipes for people with dementia based on these principles. There is also a helpful chapter on practicing Qigong to protect against caregiver burnout. This will be an invaluable book for care professionals, nurses, activity coordinators, and physical therapists, as well as people with dementia and their families.
Qt5 C++ GUI Programming Cookbook: Practical recipes for building cross-platform GUI applications, widgets, and animations with Qt 5
by Lee Zhi Eng<p>Use Qt 5 to design and build functional, appealing, and user-friendly graphical user interfaces (GUIs) for your applications. <p>Key Features: <p> <li>Learn to use Qt 5 to design and customize the look and feel of your application <li>Improve the visual quality of an application by using graphics rendering and animation <li>Understand the balance of presentation and web content that will make an application appealing yet functional</li> <p> <p>Book Description: <p>With the growing need to develop GUIs for multiple targets and multiple screens, improving the visual quality of your application becomes important so that it stands out from your competitors. With its cross-platform ability and the latest UI paradigms, Qt makes it possible to build intuitive, interactive, and user-friendly user interfaces for your applications. <p>Qt5 C++ GUI Programming Cookbook, Second Edition teaches you how to develop functional and appealing user interfaces using the latest version of QT5 and C++.This book will help you learn a variety of topics such as GUI customization and animation, graphics rendering, implementing Google Maps, and more. You will also be taken through advanced concepts like asynchronous programming, event handling using signals and slots, network programming, various aspects of optimizing your application. <p>By the end of the book, you will be confident to design and customize GUI applications that meet your clients' expectations and have an understanding of best practice solutions for common problems. <p>What you will learn: <p> <li>Animate GUI elements using Qt5's built-in animation system <li>Draw shapes and 2D images using Qt5's powerful rendering system <li>Implement an industry-standard OpenGL library in your project <li>Build a mobile app that supports touch events and exports it onto devices <li>Parse and extract data from an XML file and present it on your GUI <li>Interact with web content by calling JavaScript functions from C++ <li>Access MySQL and SQLite databases to retrieve data and display it on your GUI</li> <p> <p>Who this book is for: This intermediate-level book is designed for those who want to develop software using Qt 5. If you want to improve the visual quality and content presentation of your software application, this book is for you. Prior experience of C++ programming is required.</p>
The Quack Doctor: Historical Remedies For All Your Ills
by Caroline RanceFrom the harangues of charlatans to the sophisticated advertising of the Victorian era, quackery sports a colourful history. Featuring entertaining advertisements from the nineteenth and early twentieth centuries, this book investigates the inventive ways in which quack remedies were promoted – and suggests that the people who bought them should not be written off as gullible after all. There’s the Methodist minister and his museum of intestinal worms, the obesity cure that turned fat into sweat, and the device that brought the fresh air of Italy into British homes. The story of quack advertising is bawdy, gruesome, funny and sometimes moving – and in this book it takes to the stage to promote itself as a fascinating part of the history of medicine.
Quackery: A Brief History of the Worst Ways to Cure Everything
by Lydia Kang Nate PedersenWhat won’t we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine—yes, that strychnine, the one used in rat poison—was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices. Ranging from the merely weird to the outright dangerous, here are dozens of outlandish, morbidly hilarious “treatments”—conceived by doctors and scientists, by spiritualists and snake oil salesmen (yes, they literally tried to sell snake oil)—that were predicated on a range of cluelessness, trial and error, and straight-up scams. With vintage illustrations, photographs, and advertisements throughout, Quackery seamlessly combines macabre humor with science and storytelling to reveal an important and disturbing side of the ever-evolving field of medicine.
Quadruplex Nucleic Acids
by David Graves Jonathan B. ChairesGaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.
Qualität, Effizienz und Patientenwohl im Krankenhaus: DIN trifft LEAN – Konzepte mit Synergiepotenzialen
by Kirstin BörchersEine medizinische Versorgung, die sich am Wohle des Menschen orientiert, verknüpft mit einer Kultur des Gelingens - hierin liegt die Zukunft. Gerade die COVID-19-Pandemie hat gezeigt, wie wichtig Qualität und Effizienz im Sinne des Patientenwohls im Krankenhaus sind. Qualitätsmanagement und Lean Management können voneinander profitieren und beide haben das Potenzial, gemeinsam ein erfolgreiches integriertes Managementsystem zu bilden. Sowohl DIN als auch LEAN fokussieren in ihrer Entwicklung den prozessorientierten Ansatz für mehr Qualität, die Notwendigkeit der kontinuierlichen Verbesserung sowie ein effizientes Arbeiten.Dieses Buch gibt zahlreiche Impulse zur erfolgreichen Zusammenarbeit im Sinne „DIN trifft LEAN“. Nach einer Einführung in die zugrunde liegenden Theorien schließen sich zwei Kapitel zur Lean-Philosophie und DIN EN ISO 9000-Qualitäts-Philosophie im Krankenhaus an. Dass es sich bei den beiden Philosophien um „universelle Einstellungen“ handelt, wird an den gezeigten Beispielen „Polwettlauf Südpol“ und „Bergrettung“ deutlich. Sie sind zugleich Lehrstücke in Führung und Lean Leadership. Die 25 etablierten und erfolgreichen Arbeitsweisen zur Bewertung und Verbesserung von Qualität, Effizienz und Patientenwohl im Krankenhaus mit anschaulichen Beispielen im Kapitel „Best Practice“ können sofort umgesetzt werden.
Qualität in der Medizin quantifizieren?: Eine Begriffsklärung in der Pay-for-Performance-Diskussion (essentials)
by Thomas Friedrich WeigelIn dem vorliegenden Buch wird die Messung der Ergebnisqualität durch Qualitätsindikatoren rekonstruiert und anhand von Beispielen, vor allem aus dem Bereich der Chirurgie, näher betrachtet. Bei dem Konzept der qualitätsorientierten Vergütung (pay for performance) werden Klinikabteilungen insgesamt beurteilt. Dabei werden komplexe Behandlungsabläufe mit Hilfe von einigen Parametern (Qualitätsindikatoren) zusammenfassend als Ergebnisqualität beurteilt und bewertet. Der Autor Thomas Friedrich Weigel diskutiert die Grundlagen der quantitativen Beurteilungen und leistet damit einen wichtigen Beitrag zu der Debatte über die Qualitätsmessung im Medizinsystem.
Qualitative and Mixed Methods in Public Health
by Deborah K. PadgettPublic health research methods for the 21st centuryDesigned to meet the needs of public health students, practitioners, and researchers, this exciting and contemporary new text from the author of Qualitative Methods in Social Work Research, Second Edition offers a firm grounding in qualitative and mixed methods, including their social science roots and public health applications. It uniquely addresses two profound changes taking place in public health in the 21st century: the explosion of interest in global public health, and the growing reliance on community-engaged research methods. The author brings public health to life through the use of real-world case studies drawn from the author′s funded research projects in breast cancer screening as well as homelessness and mental illness.
Qualitative Metasynthesis: A Research Method for Medicine and Health Sciences
by Kirsti MalterudQualitative Metasynthesis presents a research method developed for upcycling and synthesis of qualitative primary studies, aimed at researchers within medicine and health sciences.This book demonstrates how and why qualitative metasynthesis can be a method for reuse and expansion of medical knowledge. It presents the principles of metasynthesis as a qualitative research method, so that the reader can assess whether this is a research strategy that fits the aim of their study. The author offers practical advice for conducting research using this methodology. The presentation is illustrated by a study carried out by the author and collaborators, reflecting on real-life challenges and solutions as an example of meta-ethnography, one of the most frequently used strategies for qualitative metasynthesis. The author also looks at systematic reviews, a methodology developed within in the tradition of evidence-based medicine, discussing strengths, weaknesses and pitfalls of this methodology. Rooted in the interpretative paradigm, qualitative metasynthesis challenges several of the principles from the evidence-based medicine tradition, offering reflections on challenges when epistemologically very different methodologies intersect.This book should be considered essential reading for anyone carrying out qualitative research within the fields of medicine, health and social care.
Qualitative Methods and Health Policy Research (Social Problems And Social Issues Ser.)
by Elizabeth MurphyQualitative researchers have traditionally been cautious about claiming that their work was scientific. The "right-on" schools have exaggerated this caution into an outright rejection of science as a model for their work. Science is, for them, outmoded; "an archaic form of consciousness surviving for a while yet in a degraded form" (Tyler 1986:200). Scientists' assertions that they are in pursuit of truth simply camouflage their own lust for power. There is no essential difference between truth and propaganda.The authors acknowledge that the boundary between science and propaganda has often been breached and some distrust of scientific claims may be healthy. They also question the claim that science creates disinterested and objective knowledge of an observer-independent world without concluding that science is impossible. The skeptics' reservations about qualitative research are based on the deep-rooted assumption among natural scientists, and some social scientists, that there is a world "out there," prior to, and independent of, their observations. This world can be known objectively in the sense that all observers will, if identically placed, see it in exactly the same way. If a suitable language were available, they would also all produce identical descriptions. From these observations they can work out the laws governing the world's operations. The authors try to resolve these contrary claims by asserting that science is a procedural commitment. It consists of openness to refutation, a conscientious and systematic search for contradictory evidence, and a readiness to subject one's preconceptions to critical examination. The devotion to truth as a regulative ideal is an essential difference between science and propaganda. This work is a unique and innovative defense of scientific method.
Qualitative Methods for Health Research (Introducing Qualitative Methods series)
by Judith Green Nicki Thorogood G.J. Melendez-TorresWhether you are looking to interpret and evaluate existing health research, or conduct your own, this book discusses every step of the research process, from theory and ethics to data collection, analysis and dissemination. Clear, engaging and drawing on diverse examples from various health disciplines – from public health and nursing to occupational health and nutrition – this fifth edition: Offers detailed guidance on synthesising and integrating evidence, with a new chapter on systematic reviews. Fully embeds material on the effective use of digital and social media research in health across all chapters. Showcases what health research looks like in practice, with 28 case studies from across the globe. Ideal for undergraduates, postgraduates and beginner researchers in health and related fields, this book is a vital resource for building your confidence in understanding and doing qualitative research.
Qualitative Methods for Health Research (Introducing Qualitative Methods series)
by Judith Green Nicki Thorogood G.J. Melendez-TorresWhether you are looking to interpret and evaluate existing health research, or conduct your own, this book discusses every step of the research process, from theory and ethics to data collection, analysis and dissemination. Clear, engaging and drawing on diverse examples from various health disciplines – from public health and nursing to occupational health and nutrition – this fifth edition: Offers detailed guidance on synthesising and integrating evidence, with a new chapter on systematic reviews. Fully embeds material on the effective use of digital and social media research in health across all chapters. Showcases what health research looks like in practice, with 28 case studies from across the globe. Ideal for undergraduates, postgraduates and beginner researchers in health and related fields, this book is a vital resource for building your confidence in understanding and doing qualitative research.