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Quantitative Methods in Health Care Management
by Yasar A. OzcanThoroughly revised and updated for Excel®, this second edition of Quantitative Methods in Health Care Management offers a comprehensive introduction to quantitative methods and techniques for the student or new administrator. Its broad range of practical methods and analysis spans operational, tactical, and strategic decisions. Users will find techniques for forecasting, decision-making, facility location, facility layout, reengineering, staffing, scheduling, productivity, resource allocation, supply chain and inventory management, quality control, project management, queuing models for capacity, and simulation. The book's step-by-step approach, use of Excel, and downloadable Excel templates make the text highly practical.Praise for the Second Edition "The second edition of Dr. Ozcan's textbook is comprehensive and well-written with useful illustrative examples that give students and health care professionals a perfect toolkit for quantitative decision making in health care on the road for the twenty-first century. The text helps to explain the complex health care management problems and offer support for decision makers in this field."-Marion Rauner, associate professor, School of Business, Economics, and Statistics, University of Vienna. "Quantitative Methods in Health Care Administration, Second Edition covers a broad set of necessary and important topics. It is a valuable text that is easy to teach and learn from."-David Belson, professor, Department of Industrial Engineering, Viterbi School of Engineering, University of Southern California.
Quantitative Methods in Pharmaceutical Research and Development: Concepts and Applications
by Olga V. Marchenko Natallia V. KatenkaThis contributed volume presents an overview of concepts, methods, and applications used in several quantitative areas of drug research, development, and marketing. Chapters bring together the theories and applications of various disciplines, allowing readers to learn more about quantitative fields, and to better recognize the differences between them. Because it provides a thorough overview, this will serve as a self-contained resource for readers interested in the pharmaceutical industry, and the quantitative methods that serve as its foundation. Specific disciplines covered include:BiostatisticsPharmacometricsGenomicsBioinformaticsPharmacoepidemiologyCommercial analyticsOperational analyticsQuantitative Methods in Pharmaceutical Research and Development is ideal for undergraduate students interested in learning about real-world applications of quantitative methods, and the potential career options open to them. It will also be of interest to experts working in these areas.
Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues
by Luis Olivares-Quiroz Osbaldo Resendis-AntonioThis book presents cutting-edge research on the use of physical and mathematical formalisms to model and quantitatively analyze biological phenomena ranging from microscopic to macroscopic systems. The systems discussed in this compilation cover protein folding pathways, gene regulation in prostate cancer, quorum sensing in bacteria to mathematical and physical descriptions to analyze anomalous diffusion in patchy environments and the physical mechanisms that drive active motion in large sets of particles, both fundamental descriptions that can be applied to different phenomena in biology. All chapters are written by well-known experts on their respective research fields with a vast amount of scientific discussion and references in order the interested reader can pursue a further reading. Given these features, we consider Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues as an excellent and up-to-date resource and reference for advanced undergraduate students, graduate students and junior researchers interested in the latest developments at the intersection of physics, mathematics, molecular biology, and computational sciences. Such research field, without hesitation, is one of the most interesting, challenging and active of this century and the next.
Quantitative Models in Life Science Business: From Value Creation to Business Processes (SpringerBriefs in Economics)
by Jung Kyu Canci Philipp Mekler Gang MuThis open access book explores the field of life science business from a multidisciplinary perspective. Applying statistical, mathematical, game-theoretic, and data science tools to pharmaceutical and biotechnology business endeavors, the book describes value creation, value maintenance, and value realization in the life sciences as a sequence of processes using the quantitative language of applied mathematics. Written by experts from a variety of fields, the contributions illustrate the shift from a deterministic to a stochastic view of the processes involved, offering a new perspective on life sciences economics. The book covers topics such as valuing and managing intellectual property in life science, licensing in the pharmaceutical business, outsourcing pharmaceutical R&D, and stochastic modelling of a pharmaceutical supply chain. The book will appeal to scholars of economics and the life sciences, as well as to professionals in chemical and pharmaceutical industries.
Quantitative MRI in Cancer (Imaging in Medical Diagnosis and Therapy)
by Thomas E. Yankeelov David R. Pickens Ronald R. PricePropelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications.The introductory part of the book c
Quantitative MRI of the Brain: Principles of Physical Measurement, Second edition (Series in Medical Physics and Biomedical Engineering)
by Mara Cercignani Nicholas G. Dowell Paul S. ToftsBuilding on the success of the first edition of this book, the winner of the 2004 British Medical Association Radiology Medical Book Competition, Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel, non-invasive information monitors how tissue changes with disease and responds to treatment. The book opens with a detailed exposition of the principles of good practice in quantification, including fundamental concepts, quality assurance, MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density, T1, T2, T2*, diffusion, advanced diffusion, magnetisation transfer, CEST, 1H and multi-nuclear spectroscopy, DCE-MRI, quantitative fMRI, arterial spin-labelling and image analysis, and finally a chapter on the future of quantification. The physical principles behind each quantity are stated, followed by its biological significance. Practical techniques for measurement are given, along with pitfalls and examples of clinical applications. This second edition of this indispensable 'how to' manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain, most techniques are applicable to characterising tissue in the whole body. This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease, its progression, and its response to treatment. Features: The first edition was awarded the book prize for Radiology by the British Medical Association in 2004 Written by an authority in the field: Professor Tofts has an international reputation for quantification in MRI Gives specific ‘how to’ information for implementation of MRI measurement sequence techniques
Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
by Honghui Zhou Diane R. MouldThorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.
Quantitative Physiology: Systems Approach
by Shangbin Chen Alexey ZaikinStephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states.Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology.This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics.Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
Quantitative Process Control Theory (ISSN)
by Weidong ZhangQuantitative Process Control Theory explains how to solve industrial system problems using a novel control system design theory. This easy-to-use theory does not require designers to choose a weighting function and enables the controllers to be designed or tuned for quantitative engineering performance indices such as overshoot.In each chapter, a s
Quantitative Proteomics by Mass Spectrometry
by Salvatore SechiThis volume is a compendium of cutting-edge protocols for quantitative proteomics, and presents the most significant methods used in the field today. The focus on mass spectrometry (MS) is integral. Attention is given to state-of-the-art techniques for the characterization of the phosphoproteome and tandem MS for detection of inborn errors of metabolism. This volume is an indispensable resource in the search for novel biomarkers.
Quantitative Real-Time PCR: Methods and Protocols (Methods in Molecular Biology #2065)
by Roberto Biassoni Alessandro RasoThis book expands upon the useful first edition by exploring classic Quantitative Polymerase Chain Reaction (qPCR) techniques as well as a number of recently developed applications. With the changes in instrumentation due to technological advances and the development of new reagents to fulfill ethical and legal issues, the qPCR field is now an up-to-date technology that indeed is widely used in research and clinical diagnostics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Revised and authoritative, Quantitative Real-Time PCR: Methods and Protocols, Second Edition is an ideal guide to this expanding and vital field of study.
Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens
by Romualdo BenigniApplied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals. This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on
Quantitative Thin-Layer Chromatography
by Bernd Spangenberg Colin F. Poole Christel WeinsThin-layer chromatography (TLC) is widely used particularly for pharmaceutical and food analysis. While there are a number of books on the qualitative identification of chemical substances by TLC, the unique focus here is on quantitative analysis. The authors describe all steps of the analytical procedure, beginning with the basics and equipment for quantitative TLC followed by sample pretreatment and sample application, development and staining, scanning, and finally statistical and chemometric data evaluation and validation. An important feature is the coverage of effect-directed biological detection methods. Chapters are organized in a modular fashion facilitating the easy location of information about individual procedural steps.
Quantitative Trait Loci
by Angela Cox Nicola J. CampIn Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Quantitative Trait Loci (QTL)
by Scott A. RifkinOver the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.
Quantitative Ultrasound and Photoacoustic Imaging for the Assessment of Vascular Parameters
by Kristen M. MeiburgerThis book describes the development of quantitative techniques for ultrasound and photoacoustic imaging in the assessment of architectural and vascular parameters. It presents morphological vascular research based on the development of quantitative imaging techniques for the use of clinical B-mode ultrasound images, and preclinical architectural vascular investigations on quantitative imaging techniques for ultrasounds and photoacoustics. The book is divided into two main parts, the first of which focuses on the development and validation of quantitative techniques for the assessment of vascular morphological parameters that can be extracted from B-mode ultrasound longitudinal images of the common carotid artery. In turn, the second part highlights quantitative imaging techniques for assessing the architectural parameters of vasculature that can be extracted from 3D volumes, using both contrast-enhanced ultrasound (CEUS) imaging and photoacoustic imaging without the addition of any contrast agent. Sharing and summarizing the outcomes of this important research, the book will be of interest to a broad range of researchers and practitioners in the fields of medical imaging and biomedical engineering.
Quantitative Ultrasound in Soft Tissues
by Jonathan Mamou Michael L. OelzeDue to parallel advances in signal processing and computer hardware in the last 15 years, quantitative ultrasound techniques have reached maturity, allowing for the construction of quantitative maps or images of soft tissues. This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: - Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc. ; - Envelope statistics analysis as a means of quantifying and imaging tissue properties; - Ultrasound elastography for quantifying elastic properties of tissues (several clinical ultrasound scanners now display elastography images); - Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution (desktop size scanners are now available); and - Ultrasound computer tomography for breast cancer imaging (new ultrasound tomography systems have been developed and are currently under evaluation clinically).
Quantitative Ultrasound in Soft Tissues (Advances in Experimental Medicine and Biology #1403)
by Jonathan Mamou Michael L. OelzeQuantitative ultrasound (QUS) continues to mature as a research field and is primed to make a swift transition to routine preclinical and clinical applications. This book will serve two main purposes: Advanced education in QUS by providing a complete and thorough review of all theoretical, physical, and engineering aspects of QUS.Review of recent development of QUS by lead contributors in the research field. This 2nd edition will focus on 6 modern research topics related to quantitative ultrasound of soft tissues: Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.Attenuation estimation for tissue characterization and improving spectral based methodsEnvelope statistics analysis as a means of quantifying and imaging tissue properties.Ultrasound computed tomography for preclinical and clinical imaging.Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution.Phantoms for quantitative ultrasound.
Quantitative Understanding of Biosystems: An Introduction to Biophysics, Second Edition (Foundations of Biochemistry and Biophysics)
by Thomas M. Nordlund Peter M. HoffmannPraise for the prior edition "The author has done a magnificent job… this book is highly recommended for introducing biophysics to the motivated and curious undergraduate student."―Contemporary Physics "a terrific text … will enable students to understand the significance of biological parameters through quantitative examples―a modern way of learning biophysics." ―American Journal of Physics "A superb pedagogical textbook… Full-color illustrations aid students in their understanding" ―Midwest Book Review This new edition provides a complete update to the most accessible yet thorough introduction to the physical and quantitative aspects of biological systems and processes involving macromolecules, subcellular structures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and computational tools. The authors have also incorporated additions to the multimedia component of video clips and animations, as well as interactive diagrams and graphs. Key Features: Illustrates biological examples with estimates and calculations of biophysical parameters. Features two brand-new chapters on experimental methods, a general overview and focused introduction to atomic force microscopy. Includes new coverage of important topics such as measures of DNA twist, images of nanoparticle assembly, and novel optical and electron nanoscopy. Provides a guide to investigating current expert biophysical research. Enhanced self-study problems and an updated glossary of terms.
Quantum Adaptivity in Biology: From Genetics to Cognition
by Masanari Asano Andrei Khrennikov Masanori Ohya Yoshiharu Tanaka Ichiro YamatoThis book examines information processing performed by bio-systems at all scales: from genomes, cells and proteins to cognitive and even social systems. It introduces a theoretical/conceptual principle based on quantum information and non-Kolmogorov probability theory to explain information processing phenomena in biology as a whole. The book begins with an introduction followed by two chapters devoted to fundamentals, one covering classical and quantum probability, which also contains a brief introduction to quantum formalism, and another on an information approach to molecular biology, genetics and epigenetics. It then goes on to examine adaptive dynamics, including applications to biology, and non-Kolmogorov probability theory. Next, the book discusses the possibility to apply the quantum formalism to model biological evolution, especially at the cellular level: genetic and epigenetic evolutions. It also presents a model of the epigenetic cellular evolution based on the mathematical formalism of open quantum systems. The last two chapters of the book explore foundational problems of quantum mechanics and demonstrate the power of usage of positive operator valued measures (POVMs) in biological science. This book will appeal to a diverse group of readers including experts in biology, cognitive science, decision making, sociology, psychology, and physics; mathematicians working on problems of quantum probability and information and researchers in quantum foundations.
Quantum and Blockchain-based Next Generation Sustainable Computing (Contributions to Environmental Sciences & Innovative Business Technology)
by Adarsh Kumar Cathryn Peoples Srikanth Pulipeti Nagaraju MysoreQuantum and Blockchain technology innovations have recently gained a lot of attention and have been integrated with other contemporary technologies for numerous applications. As a result, these applications achieve sustainability, robustness, scalability, security, accountability, and efficiency. Thus, this book covers the principles, terminologies, methods, protocols, and sustainability of quantum and blockchain technology. Furthermore, it provides insights into numerous challenges associated with other domains of computer science. In addition, the book provides various opportunities to integrate the quantum and blockchain technology-based sustainable solutions that incorporate low-cost, quality of services, secure and faster delivery of services for future demands in the fields such as cryptography, artificial intelligence (AI), machine learning (ML), deep learning (DL), computer vision, healthcare, autonomous vehicles, transportation, information, and communication theory. The information in this book is extremely useful for readers and practitioners in different fields including chemistry, mechanical and automotive engineering, healthcare, computer science, data science, and business analysis specialists in combining both basic and advanced level principles.
Quantum Biology of the Eye: Understanding the Essentials
by Kambiz Thomas MoazedAs we enter the quantum era, new research on applying the rules of quantum physics to biology, which was previously considered impossible, has revolutionized our understanding and our concept of molecular and atomic particles behavior and their interactions. This book is the first comprehensive review of the quantum biology of the visual system. Chapters discuss the relevance of quantum physics to the biological systems, especially in the visual system. The main purpose of this book is to simplify quantum biology concepts relevant to physiology of human eye and to help the reader understand the essentials of this new emerging, complex and anti-intuitive field of science. It offers a contemporary view of the emerging interplay between the biochemistry, physiology, molecular biology, and molecular and atomic particle quantum characteristics such as vibration, spin etc.Quantum Biology of the Eye is an essential resource for Ophthalmologists, physicians, residents, fellows, all fields of visual science and medical students in ophthalmology, and other converging fields of science such as visual optics biochemists, psychology etc.
Quantum Change
by Janet C'Debaca William MillerMost of us walk through each day expecting few surprises. If we want to better ourselves or our lives, we map out a path of gradual change, perhaps in counseling or psychotherapy. Psychologists William Miller and Janet C'de Baca were longtime scholars and teachers of traditional approaches to self-improvement when they became intrigued by a different sort of change that was sometimes experienced by people they encountered something often described as "a bolt from the blue" or "seeing the light." And when they placed a request in a local newspaper for people's stories of unexpected personal transformation, the deluge of responses was astounding. These compelling stories of epiphanies and sudden insights inspired Miller and C'de Baca to examine the experience of "quantum change" through the lens of scientific psychology. Where does quantum change come from? Why do some of us experience it, and what kind of people do we become as a result? The answers that this book arrives at yield remarkable insights into how human beings achieve lasting change--sometimes even in spite of ourselves.
Quantum DNA Healing: Consciousness Techniques for Altering Your Genetic Destiny
by Althea S. HawkHow consciousness and quantum energies affect your genetic expression and the development of disease and chronic health conditions• Draws on cellular medicine, genetics, quantum physics, and consciousness studies to define the real underlying mechanisms of disease and how they can be addressed • Explains how consciousness influences quantum DNA to erase the genetic imprint of illness, allowing your body to remember how to function efficiently and effectively• Shares the author’s discoveries that enabled her to successfully heal the cellular dysfunction at the root cause of her cancer, tumors, chronic inflammation, and toxicity• Explores consciousness tools to re-encode DNA and includes detailed scripts for techniques that readers can apply to their own healing journeysDrawing on new advancements in quantum physics, cellular medicine, genetics, and consciousness studies, as well as her own journey of self-healing from a number of challenging health conditions, Althea S. Hawk reveals how you can consciously influence your DNA and re-encode it to improve your health and alter your genetic destiny.Sharing the discoveries that enabled her to successfully heal from her cancer, tumors, toxicity, and inflammatory-related conditions, the author explains how genes are not solely responsible for creating disease. She shows how human physiology interacts with the quantum energies of our external and personal environments and how the resulting information triggers the development and persistence of disease and chronic conditions. We each inherit susceptibilities, but it is our unique experience of these environmental factors, as well as our beliefs, thoughts, and emotions, that alter the way our genes are expressed. Detailing how our DNA is both quantum-energetic and biological-chemical, Hawk explains how your environment and your consciousness influence your quantum DNA, which in turn interacts with your biological DNA. By working directly with energetic information that affects how your quantum and biological DNA communicate, you can alter the expression of your genes by re-encoding the gene sequences on your physical DNA, erasing the imprint of illness and enabling your body to remember how to function properly.Hawk explores consciousness tools and mind-body techniques to re-encode your DNA, such as sound and breathing work, DNA marker removal, recalibration of Akashic information, and cellular communication exercises that readers can apply to their own healing journeys.
Quantum Dots
by Marcel Bruchez Charles Z. HotzQuantum Dots captures many diverse applications enabling utility in biological detection. Organized into five parts, the first two parts cover the use of QDs in imaging fixed and living cells (and tissues). Protocols are included for using QDs in routine as well as enabling applications. Part 3 shows early efforts aimed at using QDs in live animals. The final two parts demonstrate the versatility of QD technology in existing assay technology.