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Rawsome!
by Brigitte MarsA raw foods diet advocates exactly that: raw foods. No cooking, no grilling, no steaming, no application of heat of any kind. Why? Because eating food closest to its natural state engenders a tremendous exchange of energy between food and body. The result, over time, is a feeling of buoyant, radiant health. Tackling head-on the skepticism likely to greet proponents of what the world sees as a "fad" diet, renowned nutritionist and long-time raw-foods adherent Brigitte Mars presents historical data, case studies, and scientific evidence confirming the efficacy of raw foods diets. In addition, Mars points out the environmental benefits of the raw foods diet, making a case for eating raw foods as a means of reducing waste, making the most of agricultural practice, and reducing the human footprint on the earth. Whether the reader wants to jump right into an all-raw diet or just wants to introduce more raw foods into the diet, Mars offers gentle encouragement and practical instruction. Readers will find advice on planning a balanced diet to meet their nutritional needs, combining foods for best effect, preserving raw foods, equipping the raw kitchen, sprouting, juicing, and every other technique that makes the raw foods diet simple, delicious, and healthful. In-depth profiles describe the nutritional and health benefits of hundreds of fruits, vegetables, nuts, and seasonings. Perhaps most important, Mars provides more than 200 kitchen-tested, real-people-approved raw foods recipes. Under Mars's instruction, readers will enjoy making everything from juices and shakes to salads, soups, dressings, yogurts, crackers, spreads, dips, vegetable burgers, curries, vegetable pastas, wraps, and more.
Raynaud’s Phenomenon: From Pathogenesis to Management
by Fredrick M. Wigley Ariane L. Herrick Nicholas A. FlavahanThis book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud’s phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud’s is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud’s phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch. This fully updated second edition comprehensively discusses various causes of Raynaud’s phenomenon including childhood Raynaud’s phenomenon, Raynaud’s phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud’s phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud’s phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud’s phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors’ expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud’s phenomenon and the vascular disease of secondary Raynaud’s phenomenon. Engaging readers with case vignettes and a plethora of visual aids, Raynaud’s Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers.
Razoxane and Dexrazoxane - Two Multifunctional Agents
by Walter Rhomberg Kurt HellmannRazoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer´s disease could be stabilized by one or both these drugs.
The RCEM Lecture Notes: Emergency Medicine (Lecture Notes)
by Catherine Williams Amy NicksonThe RCEM Lecture Notes: Emergency Medicine 5th Edition Comprehensive introduction to the core specialty area of emergency medicine Presented in a user-friendly format, combining flowcharts and high-quality illustrations together for an easy-to-read experience, this fifth edition of The RCEM Lecture Notes: Emergency Medicine has been thoroughly revised to reflect recent advances in the field of emergency medicine and to give readers a comprehensive and highly accessible overview of the field. The RCEM Lecture Notes: Emergency Medicine, Fifth Edition presents important ‘need to know’ information for all those involved in treating patients in an emergency setting. The text serves as an excellent starting point to support initial teaching on the subject and reference or revision at the end of a module, rotation, or final exams. Contributions made by a variety of healthcare professionals with significant firsthand experience in the field, The RCEM Lecture Notes: Emergency Medicine contains information on: Major trauma and injuries. Burns, contamination, irradiation, and poisoning. Acute medical, surgical and obstetric conditions relevant to emergency medicine. Paediatric emergency medicine. Mental health and medicolegal aspects of emergency medicine. For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email This new edition is also available as an e-book. For more details, please see http://www.wiley.com/buy/9781119325819 All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more.
RCGP AKT: Research, Epidemiology and Statistics
by Julian Hick Ralph EmmersonThis book has been specifically designed to help GP trainees pass the compulsory AKT examination. Each topic has been skilfully refined to correlate directly with primary care and the RCGP curriculum, revealing how and why critical appraisal and evidence based medicine are essential for good medical practice throughout a career as an independent, k
RCSI Handbook of Clinical Surgery for Finals
by Arnold Hill Gozie OffiahDeveloped over previous editions by the Royal College of Surgeons in Ireland to support students attending the three RCSI universities, this convenient handbook provides pragmatic guidance to the principles and practice of surgery that students can expect to encounter during undergraduate studies. Spanning the full range of surgical specialties, information is presented in a convenient and clinically relevant format that takes the students through the patient journey from presenting symptoms and aetiology to investigations, management and follow-up. The text, written as easy-to-read and easy-to-remember bullet lists, is supplemented throughout by tables, management algorithms and colour illustrations. Key Features: • Concise – specifically for the undergraduate medical student by a highly experienced team of surgical educators • Accessible – bullet text ideal for rapid reference • Flexible – for use when on the ward and during finals revision • Complete - print book supplemented by video clips, online question and answer material and an image library for the full learning and revision package Thoroughly updated, this fifth edition has enhanced pedagogy and, for the first time, is accompanied by video clips and questions for self-testing. Covering the core surgical knowledge needed to become a safe and competent doctor, the book will be an invaluable companion for clinical placements and during the critical run-up to final examinations.
RCSI Handbook of Clinical Surgery for Finals
Developed over three editions by the Royal College of Surgeons of Ireland to support students attending the three RCSI universities, this convenient handbook provides pragmatic guidance to the principles and practice of surgery that students can expect to encounter during undergraduate and early postgraduate studies. Spanning the full range of surgical specialties, information is presented in a convenient and clinically-relevant format that takes the students through the patient journey from presenting symptoms and etiology to investigations, management and follow up. The text, written as easy-to-read and easy-to-remember bullet lists, is supplemented throughout by tables, management algorithms and colour illustrations. Thoroughly updated, this fourth edition is available to customers outside the RCSI universities for the first time. Covering the core surgical knowledge needed to become a safe and competent doctor, the book will be an invaluable companion for clinical placements and during the critical run-up to final examinations.
(Re)designing the Continuum of Care for Older Adults: The Future of Long-Term Care Settings
by Farhana Ferdous Emily RobertsThis book broadens the visioning on new care environments that are designed to be inclusive, progressive, and convergent with the needs of an aging population. The contents cover a range of long-term care (LTC) settings in a single collection to address the needs of a wide audience.Due to the recent COVID-19 pandemic, rethinking the spatial design of care facilities in order to prepare for future respiratory and contagious pathogens is one of the prime concerns across the globe, along with social connectedness and autonomy in care settings. This book contributes to the next generation of knowledge and understanding of the growing field of the design of technology, programs, and environments for LTC that are more effective in infection prevention and control as well as social connectedness. To address these issues, the chapters are organized in four sections: Part I: Home- and community-based care; Part II: Facility-based care; Part III: Memory care and end-of-life care; and Part IV: Evidence-based applied projects and next steps. (Re)designing the Continuum of Care for Older Adults: The Future of Long-Term Care Settings is an essential resource for researchers, practitioners, educators, policymakers, and students associated with LTC home and healthcare settings. With diverse topics in theory, substantive issues, and methods, the contributions from notable researchers and scholars cover a range of innovative programming, environments, and technologies which can impact the changing needs and support for older adults and their families across the continuum of care.
Re-engineering Affordable Care Policy in China: Is Marketization a Solution? (Routledge Contemporary China Series)
by Peter Nan-shong LeePresenting a comprehensive examination of China’s medical care system, this book tackles issues of policymaking, organization, management and financing in the context of the provision of affordable care in China. Making use of extensive field investigations, interviews and a thorough analysis of documents, this book examines the re-structuring of the medical care system, spanning more than three and half decades from 1979 to the present day. Assessing the difficulties of regulatory control in the health care sector, it also explores theoretical alternatives, including post-Weberian constructs of uncertainty and control, as well as franchise and asymmetric information in market transactions. Ultimately, it argues that patient medical care has become less and less affordable amid shrinking government subsidies, breakdowns of public insurances and increases in user charges, especially between the mid-1990s and mid-2000s. Whilst the government took decades to re-organize the public hospital system and rebuild public insurances, it faced a dilemma of enforcing both low-cost medical care and maintaining revenue flow to public hospitals through marketization. Re-engineering Affordable Care Policy in China provides extensive discussion of the policymaking process as well as detailed analysis of policy contents. As such, it will be invaluable to students and scholars of Chinese social policy and public administration, as well as Chinese Studies more generally.
Re-imagining Educational Futures in Developing Countries: Lessons from Global Health Crises
by Emmanuel Mogaji Felix Maringe Robert Ebo Hinson Varsha JainThis book explores the challenges and precarity of higher education post-pandemic, explicitly focusing on higher education in emerging countries. Looking beyond the pandemic, the editors and contributors provide a holistic view of the residual legacies of global health crises like COVID-19 in developing countries. The book calls for the need to reimagine, reevaluate and reposition the higher education system: exploring the challenges experienced by students, staff, administrators and other stakeholders. Bringing forth insights from researchers, practitioners and senior leadership, the book shares theoretical and practical insights on dealing with the aftermath of a pandemic and what can be learned for the future. It will be of interest and value to researchers, practitioners and leaders who wish to understand a develop new approaches for their teaching and management post-pandemic.
Re-imagining Mothering and Career: Insights from a Time of Crisis
by Jenna A. LoGiudice;Evelyn Bilias Lolis;Kathryn E. PhillipsThe COVID-19 pandemic disrupted the global world but impacted women with children and careers disproportionately. The social, familial, and professional strains of this crisis birthed with it the opportunity to reflect on the values, expectations, lifestyle, and priorities that have defined motherhood. This book uplifts the shared consciousness of motherhood; the common veil that transcends time, region, and boundary. Part contemporary anthology, part historical narrative, and fully nestled in the tenets of psychological science, this book spotlights the awakenings of 33 mothers of varied ages, ethnicities, family compositions, and professional backgrounds in the United States as they renegotiated motherhood and career. Each reflection offers a window into the heart of a career mother, capturing the kaleidoscope of her struggles, vulnerabilities, and hopes, while empowering her insights. The reflections are bound together by themes that cut across lived maternal experiences, bringing to light a powerful creed for a life re-imagined– one that propels mothers forward in all of their roles.
Re-inventing Drug Development
by Jeffrey S. HandenThe biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This
Re/Invention: Methods of Social Fiction (Qualitative Methods "How-To" Guides)
by Patricia LeavyFrom Patricia Leavy, a leader in arts-based research, this is the first comprehensive guide to what social fiction is and how to write it. In an engaging, personal tone, Leavy explores the unique contribution that creative writing--such as novels, series, and short stories--can make to addressing qualitative research questions. In-depth discussions of narrative models (such as the three-act structure) and elements (such as plot, metaphor, dialogue) are accompanied by excerpts from Leavy's published fiction, reflections on the writing process, and technical suggestions. The book offers evaluation criteria for social fiction as well as practical publishing advice. Instructive features include "tip bubbles" with additional writing hints, end-of-chapter "Skill-Building" and "Rethink Your Research" exercises, and an appendix with suggested readings.
Re-irradiation: New Frontiers
by Carsten Nieder Johannes LangendijkNew developments such as refined combined modality approaches and significant technical advances in radiation treatment planning and delivery are facilitating the re-irradiation of previously exposed volumes. As a consequence, both palliative and curative approaches can be pursued at various disease sites. Re-irradiation: New Frontiers is the first book to provide a comprehensive overview on current re-irradiation strategies. Re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance are all discussed in detail. In addition, disease-specific chapters document recent clinical results and future research directions. Professionals involved in radiation treatment planning and multimodal oncology treatment will find this book to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Re-Irradiation: New Frontiers
by Carsten Nieder Johannes LangendijkThis book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Re-Visioning Psychiatry
by Kirmayer, Laurence J. and Lemelson, Robert and Cummings, Constance A. Laurence J. Kirmayer Robert Lemelson Constance A. CummingsRe-Visioning Psychiatry explores new theories and models from cultural psychiatry and psychology, philosophy, neuroscience and anthropology that clarify how mental health problems emerge in specific contexts and points toward future integration of these perspectives. Taken together, the contributions point to the need for fundamental shifts in psychiatric theory and practice: • Restoring phenomenology to its rightful place in research and practice • Advancing the social and cultural neuroscience of brain-person-environment systems over time and across social contexts • Understanding how self-awareness, interpersonal interactions, and larger social processes give rise to vicious circles that constitute mental health problems • Locating efforts to help and heal within the local and global social, economic, and political contexts that influence how we frame problems and imagine solutions. In advancing ecosystemic models of mental disorders, contributors challenge reductionistic models and culture-bound perspectives and highlight possibilities for a more transdisciplinary, integrated approach to research, mental health policy, and clinical practice.
Re-Write: A Trauma Workbook of Creative Writing and Recovery in Our New Normal
by Duygu Balan Yener BalanAttachment theory-based treatments including depth psychology, somatic psychology, holistic therapy, and Eye Movement Desensitization and Reprocessing (EMDR) are becoming even more popular and desired by clinicians, health systems, and the patients they care for. Up until recently, cognitive behavioral therapy and medication management were the mainstays for trauma-informed care, although we are witnessing a demand for a more somatic, holistic, and, therefore, deeper level of treatment to target attachment injury and change/re-write the trauma narrative. This book provides the response and tools to meet this current need. Due to the pandemic, lockdowns, and significant changes in our stability, the economy, sense of belonging, and community, there is a heightened level of triggering which has resulted in multifactorial trauma responses. The devastating traumatic impact spans nations, ages, and socioeconomic statuses. Unfortunately, domestic violence, child abuse, substance use, medical trauma, self-injury, suicide, and violence turned outwards have all increased significantly in the past two years. This workbook focuses on the healing journey of the trauma survivor, utilizing easy-to-use methodologies for long-lasting effects. It includes various exercises, writing prompts, coping mechanisms, and soothing techniques with the intention of allowing the person to create an individualized experience. This empowers the person to go in the order they choose, experiment with different techniques from different modalities, and find the ones that meet their needs the best. The authors also address generational trauma, societal trauma, and trauma at the family and individual levels, and their work can be used in conjunction with a clinical treatment plan or by the end user. Re-Write: A Trauma Workbook of Creative Writing and Recovery in Our New Normal employs practical strategies using evidence-based methodologies with psychological theory within a human-centered design framework.
Reach for the Stars! The Complete Guide to Successful Nursing Assistant Care
by Diana L. DuganA student-friendly text, Reach for the Stars! The Complete Guide to Successful Nursing Assistant Care reflects Diana Dugan's 15 years of experience teaching nursing assistants in community colleges, proprietary schools, and long-term care facilities. This comprehensive textbook to train nursing assistants teaches all state, federal, and safety requirements. It is beautifully illustrated and clearly photographed with color tabs for easy location of material. This book emphasizes safety, privacy, and respect before and after providing care. Organized around learning objectives, it contains creative methods to teach care and related observations, ways to promote independence, essential information on preventing abuse and neglect, and chapter-ending material which develops critical thinking, encourages research, and organizes study tasks as well as tests the chapter.
Reaching Down the Rabbit Hole: A Renowned Neurologist Explains the Mystery and Drama of Brain Disease
by Allan H. Ropper Brian David BurrellA Harvard neurologist’s “gripping” account of his day-to-day work that “rarely falls into jargon and always keeps the narrative lively and engaging” (Kirkus Reviews, starred review).Tell the doctor where it hurts—it sounds simple enough, unless the problem affects the very organ that produces awareness and generates speech. What is it like to try to heal the body when the mind is under attack? In this book, Dr. Allan H. Ropper and Brian David Burrell take us behind the scenes at Harvard Medical School’s neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions. Like Alice in Wonderland, Dr. Ropper inhabits a world where absurdities abound:• A figure skater whose body has become a ticking time bomb• A salesman who drives around and around a traffic rotary, unable to get off• A college quarterback who can’t stop calling the same play• A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive• A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth livingHow does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarefied world where lives and minds hang in the balance.“Entertaining . . . Like an episode of the popular television series House, the book presents mysterious medical cases . . . In the hands of a lesser writer, this book might have been nothing more than a collection of colorful tales about the many ways a human brain can break down. But Dr. Ropper and Mr. Burrell manage to tell a more profound story about the value of men over machines.” —The New York Times Book Review“A captivating stroll through the concepts and realities of neurological science.” —Publishers Weekly“A must-read . . . each chapter reads like a detective story . . . This is medical writing at its best; in the tradition of Rouche, Lewis Thomas, and Oliver Sacks.” —V. S. Ramachandran, New York Times–bestselling author of The Tell-Tale Brain
Reaching Down the Rabbit Hole: A Renowned Neurologist Explains the Mystery and Drama of Brain Disease
by Allan H. Ropper Brian David BurrellDr. Allan Ropper and Brian Burrell take the reader behind the scenes at Harvard Medical School's neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions: - A figure skater whose body has become a ticking time-bomb - A salesman who drives around and around a traffic rotary, unable to get off - A college quarterback who can't stop calling the same play - A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive - A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth living. How does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarefied world where lives and minds hang in the balance.
Reaching Excellence in Healthcare Management (ACHE Management)
by John GriffithReaching Excellence in Healthcare Management is the 2012 American College of Healthcare Executive's James A. Hamilton Book of the Year Award winner. Learn what Baldrige winners and other outstanding healthcare organizations do and how they do it. Reaching Excellence in Healthcare Management is a handy guide for healthcare managers, nurse leaders, physician executives, and department heads. Quality is high at excellent healthcare organizations. Employees love where they work. Patients consistently check the top box on satisfaction surveys. Profits are increasing even as costs are going down. Sound impossible? It’s not. The short, focused chapters of Reaching Excellence provide a checklist for high performance. The book describes what each part of the organization must do, how to measure success, and how to continually improve performance. Learn how high-performing organizations answer these questions and many more: How does a healthcare organization (HCO) start its cultural transformation? How does an HCO ensure accurate diagnosis? How does an HCO recruit physicians? What builds medical staff loyalty? How does an HCO start the move toward excellent nursing? Where do we get the money for knowledge management? What’s the new model in human resources management? What’s the role of incentive compensation? How do excellent HCOs surpass Ritz-Carlton in service? How can an HCO control overhead costs? How are capital investment requests prepared and reviewed? Can multihospital systems contribute to marketing and strategy? This book is based on the award-winning text The Well-Managed Healthcare Organization, written by the same authors.
Reaching Out in Family Therapy
by Nancy Hafer Bry Nancy Boyd-FranklinThis volume provides the skills practitioners need to conduct family therapy sessions in the home, school, and community. The authors demonstrate how meetings outside of the traditional office setting can enable therapists to intervene actively in the various systems that affect clients' lives. This multisystems approach can be particularly useful when working with poor and ethnic minority families, whose support networks may include extended family, school personnel, and members of the "church family." Practitioners learn how to utilize out-of-office sessions to meet the people who are influential in clients' lives; observe the life realities of children, adolescents, and parents; and identify resources that can be mobilized to produce change. Detailed strategies are presented to help families navigate the overlapping demands of multiple agencies and institutions and to manage and prevent such problems as substance abuse, school drop-out, and child abuse. Throughout, therapeutic and ethical guidelines are illustrated by extensive clinical case material. The book is ideal for those already doing home-based work, as well as those who would like to incorporate it into their practice.
Reactive Attachment Disorder
by Daniel F. ShreeveA child's close bond with mother, father, or guardian usually provides a foundation for trust in all future attachments. Children deprived of early and healthy dependency--who do not form normal attachment with their caregivers--may later suffer from Reactive Attachment Disorder (RAD). This childhood disorder is characterized by a general failure in social relationships resulting from pathogenic care. Although first included in the third edition of the Diagnostic and Statistical Manual (DSM-III) in 1980, RAD is one of the more uncommon and understudied forms of psychopathology. Reactive Attachment Disorder: A Case-Based Approach adds to a now growing research base, providing scholars and clinicians with a well-rounded analysis of RAD and suggested treatments. The case-based approach used in this Brief follows the representative case of "Jorge," presented as unfolding over time and structured to illustrate challenges of diagnosis, to show examples of co-morbidity, and to provoke reflection on what questions may arise during treatment. Readers are asked to appraise the overlap with other clinical syndromes, the forms of psychotherapy which may apply, and the potential role of psychiatric medications as part of a comprehensive treatment plan.
Reactive Drug Metabolites
by Deepak Dalvie Douglas A. Smith R. Scott Obach Raimund Mannhold Gerd Folkers Hugo KubinyiClosing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictiveand by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustratingthe power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Reactive Oxygen Metabolites: Chemistry and Medical Consequences
by Manfred K. EberhardtIn recent years, the field of radical chemistry has undergone explosive growth. Although its roots lie in organic chemistry, the implications of its findings are having enormous impact in a broad range of disciplines, and we now have evidence for radical involvement in over 100 diseases. As important as this is, however, the subject of radicals and