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Recent Advances in the Treatment of Colorectal Cancer
by Hideyuki Ishida Keiji KodaThis book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment. Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. <P><P>Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.
Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology
by Seth Kwabena Amponsah Yashwant V. PathakThis book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies.The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges
Recent Advances in Transthyretin Evolution, Structure and Biological Functions
by Vivian Cody Samantha J. RichardsonThere is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies. The evolution of transthyretin has been extensively investigated - from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships. This monograph will bring the reader up to date on the latest developments and discoveries.
Recent Advances of Sarcopenia and Frailty in CKD
by Akihiko Kato Eiichiro Kanda Yoshihiko KannoThis book highlights recent advances in our understanding of sarcopenia and frailty in CKD. The prevalence of sarcopenia and frailty increases substantially as CKD progresses, and experimental studies have demonstrated the pivotal role of accumulated uremic toxin in the development of muscle wasting. Further, sarcopenia and frailty are associated with falls, bone fractures, cognitive impairment, and poor survival prognoses, especially in elderly CKD patients. The syndromes are also related to the risk of end-stage kidney disease. This book provides readers with a deeper understanding of the prevention and management of sarcopenia and frailty in CKD patients to improve their renal and overall health, and suggests directions for future basic and clinical research.
Recent Advances of the Fragment Molecular Orbital Method: Enhanced Performance and Applicability
by Yuji Mochizuki Shigenori Tanaka Kaori FukuzawaThis book covers recent advances of the fragment molecular orbital (FMO) method, consisting of 5 parts and a total of 30 chapters written by FMO experts. The FMO method is a promising way to calculate large-scale molecular systems such as proteins in a quantum mechanical framework. The highly efficient parallelism deserves being considered the principal advantage of FMO calculations. Additionally, the FMO method can be employed as an analysis tool by using the inter-fragment (pairwise) interaction energies, among others, and this feature has been utilized well in biophysical and pharmaceutical chemistry. In recent years, the methodological developments of FMO have been remarkable, and both reliability and applicability have been enhanced, in particular, for non-bio problems. The current trend of the parallel computing facility is of the many-core type, and adaptation to modern computer environments has been explored as well. In this book, a historical review of FMO and comparison to other methods are provided in Part I (two chapters) and major FMO programs (GAMESS-US, ABINIT-MP, PAICS and OpenFMO) are described in Part II (four chapters). dedicated to pharmaceutical activities (twelve chapters). A variety of new applications with methodological breakthroughs are introduced in Part IV (six chapters). Finally, computer and information science-oriented topics including massively parallel computation and machine learning are addressed in Part V (six chapters). Many color figures and illustrations are included. Readers can refer to this book in its entirety as a practical textbook of the FMO method or read only the chapters of greatest interest to them.
Recent Advances on the Modular Organization of the Cortex
by Manuel F. Casanova Ioan OprisThe way you perceive the world, plan, make decisions and communicate your thoughts and feelings depends on the function and hierarchical arrangement of cortical modules. The ability to both provide adaptive responses to our ever-changing environment and to pursue a useful role in society is the most important problem faced by present day neuroscientists. In essence, the workings of cortical modules define the nature of our soul, making each of us who we are. This book provides a breath-taking view of different perspectives by world renowned authorities as to the workings of these cortical modules both in the normal state and in mental disorders.
Recent Concepts in Minimal Access Surgery: Volume 1
by Deborshi Sharma Priya HazrahThe book covers the recent developments in various aspects of minimal access surgery (laparoscopic and robotic surgery), which is fairly a new branch of surgery that has advanced tremendously in last few years. This is the first volume of the set of books on recent concepts in minimal access surgery. It provides step-by-step descriptions accompanied by numerous helpful photographs and anatomical drawings. It also includes the controversies and gives a cumulative opinion on the recent changes developing in minimal access surgery (MAS). It includes system wise topics and separate chapters on the different topics within the system with the meta-analysis of recent topic or their controversies.The book is useful for practitioners and young faculties as well as residents, trainees and fellows of surgery and minimal access surgery.
Recent Contributions to Bioinformatics and Biomedical Sciences and Engineering (Lecture Notes in Networks and Systems #658)
by Sotir Sotirov Tania Pencheva Janusz Kacprzyk Krassimir T. Atanassov Evdokia Sotirova Simeon RibaginThis book presents a collection of high-quality research papers, presented at the Second International Symposium on Bioinformatics and Biomedicine (BioInfoMed’2022). It offers a comprehensive look into some of the fastest growing fields of science, such as biomedicine, bioinformatics, artificial intelligence, and mathematical modeling. The different chapters of the work include both practical solutions and strictly scientific considerations expanding knowledge about the future bioinformatics and biomedical engineering challenges. We believe that the presented works will have a great impact not only on the development and the application of new methods for modeling, decision making and data mining in healthcare and biomedicine, but also it will provide a source of inspiration for researchers who can implement the proposed methods into their practice and scientific studies.
Recent Developments in Fungal Diseases of Laboratory Animals (Fungal Biology)
by Arti Gupta Nagendra Pratap SinghFungal growths affect both human and animal well-being. Many natural pathogens of laboratory animals alter host physiology, rendering the host unsuitable for experimental uses. While the number and prevalence of few pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using laboratory animals in biomedical experimentation should be aware of the profound effects that many of these agents can have on research. What does the future hold regarding the natural pathogens of laboratory animals? The selection of an animal model must carefully address issues of the type of human disease to mimic, the parameters to follow, and the collection of the appropriate data to answer those questions being asked. Overall, animal models of fungal infection will continue to deepen our understanding of how these infections occur. This book provides a valuable source of information to biological and biomedical scientists and to clinical and doctoral researchers working in the area of fungal infections and diseases of laboratory animal species.
Recent Developments in Mathematical, Statistical and Computational Sciences: The V AMMCS International Conference, Waterloo, Canada, August 18–23, 2019 (Springer Proceedings in Mathematics & Statistics #343)
by D. Marc Kilgour Herb Kunze Roman Makarov Roderick Melnik Xu WangThis book constitutes an up-to-date account of principles, methods, and tools for mathematical and statistical modelling in a wide range of research fields, including medicine, health sciences, biology, environmental science, engineering, physics, chemistry, computation, finance, economics, and social sciences. It presents original solutions to real-world problems, emphasizes the coordinated development of theories and applications, and promotes interdisciplinary collaboration among mathematicians, statisticians, and researchers in other disciplines.Based on a highly successful meeting, the International Conference on Applied Mathematics, Modeling and Computational Science, AMMCS 2019, held from August 18 to 23, 2019, on the main campus of Wilfrid Laurier University, Waterloo, Canada, the contributions are the results of submissions from the conference participants. They provide readers with a broader view of the methods, ideas and tools used in mathematical, statistical and computational sciences.
Recent Developments in Microbiology, Biotechnology and Pharmaceutical Sciences
by B. Sundaravadivazhagan Sekar Mohan Balakrishnaraja RengarajuThe Conference brought together innovative academics and industrial experts in the field of Medical, Biological and Pharmaceutical Sciences to a common forum. The primary goal of the conference was to promote research and developmental activities in Medical, Biological and Pharmaceutical Sciences. Another goal was to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world.
Recent Developments in Modeling and Applications in Statistics
by Maria da Graça Temido Paulo Eduardo Oliveira Carla Henriques Maurizio VichiStatistics has been a main tool in almost every field of activity and an essential part of applied scientific work, supporting conclusions and offering insights into new uses for established methodologies, thus making it a valuable resource in looking for faceless facts. Model construction describing populations or phenomena subject to randomness use a wide range of methods. Data collection provides the basis for modelling and assumption verification. Modelling must be conducted using suitable techniques that give researchers the means to search for hidden facts or behaviours. This may be addressed by fitting pre-defined shapes and distributions to the data or by allowing the data to reveal its intrinsic properties by using nonparametric methods. This volume contains a selection of contributions presented at the XVIII Annual Congress of the Portuguese Statistical Society.
Recent Developments in Multivariate and Random Matrix Analysis: Festschrift in Honour of Dietrich von Rosen
by Thomas Holgersson Martin SingullThis volume is a tribute to Professor Dietrich von Rosen on the occasion of his 65th birthday. It contains a collection of twenty original papers. The contents of the papers evolve around multivariate analysis and random matrices with topics such as high-dimensional analysis, goodness-of-fit measures, variable selection and information criteria, inference of covariance structures, the Wishart distribution and growth curve models.
Recent Developments in the Regulation of Kinins
by Jagdish N. SharmaThis volume presents key topics of current interest with regard to several pathophysiological conditions including (a) the basic and clinical aspects of bradykinin receptor antagonists, (b) the kallikrein-kinin pathways in hypertension and diabetes, (c) tissue kallikrein-kinin therapy for hypertension and organ damage, (d) the renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension, (e) the kallikrein-kinin system in diabetes retinopathy, and (f) genetic manipulation and genetic variation of the kallikrein-kinin system and their impacts on cardiovascular and renal disease. Written by internationally reputed scientists, the book provides an essential overview of the latest developments in the field of kinin research, making it a valuable asset for endocrinologists, nephrologists, cardiologists, pharmacologists, physiologists, ophthalmologists and rheumatologists. Furthermore, it is also intended for postgraduate students in the fields of medicine, pharmacy, physiology and pharmacology, and those working at research organizations.
Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology
by Irving SunshinePapers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr
Recent Fertility Trends in Sub-Saharan Africa: Workshop Summary
by Engineering Medicine National Academies of SciencesFertility rates and population growth influence economic development. The marked declines in fertility seen in some developing nations have been accompanied by slowing population growth, which in turn provided a window of opportunity for rapid economic growth. For many sub-Saharan African nations, this window has not yet opened because fertility rates have not declined as rapidly there as elsewhere. Fertility rates in many sub-Saharan African countries are high: the total rate for the region is estimated to be 5.1 births per woman, and rates that had begun to decline in many countries in the region have stalled. High rates of fertility in these countries are likely to contribute to continued rapid population growth: the United Nations projects that the region's population will increase by 1.2 billion by 2050, the highest growth among the regions for which there are projections. In June 2015, the Committee on Population organized a workshop to explore fertility trends and the factors that have influenced them. The workshop committee was asked to explore history and trends related to fertility, proximate determinants and other influences, the status and impact of family planning programs, and prospects for further reducing fertility rates. This study will help donors, researchers, and policy makers better understand the factors that may explain the slow pace of fertility decline in this region, and develop methods to improve family planning in sub-Saharan Africa.
Recent Health Policy Innovations in Social Security (International Social Security Ser. #Vol. 5)
by Aviva Ron Xenia Scheil-AdlungThe debate about health care reform has gone on for many years. The debate has generated often innovative ideas for reform that transcend national boundaries. For example, proposals have been made for an extension of health insurance with a framework of social protection; progressive development of funding methods; controls on expenditure; bringing benefits into line with what is actually needed; and the application of technological advances.The book concentrates on health insurance policy innovations in selected countries in Africa, the Americas, Asia, and Europe. In addition this book addresses recent institutional economic findings with regard to application of information technology in health insurance systems. Topics discussed include: new approaches in extending coverage in a health insurance system, confronting resource scarcity: innovative strategies, refining benefits to meet current needs, new institutional and administrative frameworks, and transformation through information technology systems. Many of the innovations presented here have already been integrated into existing reforms and the authors refer to concrete developments in individual countries and regions. This book presents those important innovations to social health insurance systems in industrialized and developing countries that have been brought forward in recent years and, as far as possible, already evaluated. In doing so, the intention is to show developments that are valid for more than one country and could have long term impact on health insurance systems. This book is intended to promote deeper exchanges of experience between differing regions, countries, and health insurance systems. In this way it will stimulate ideas for politicians and practitioners, scientists and other experts.
Recent Innovations in Surgical Procedures of Pancreatic Neoplasms
by Juan Bellido Luque Angel Nogales MuñozOur understanding of pancreatic tumors is changing thanks to recent advances in the field. New diagnostic techniques and imaging tests have improved the early diagnosis of these lesions, and as a result, the growing number of R0 surgical resections has meant a better prognosis for patients. Further, minimally invasive laparoscopic approaches have increased postoperative comfort.Presenting the latest research in the field, this book will appeal to clinicians in a wide range of medical specialities, including gastroenterologists, general physicians, and abdominal and biliopancreatic surgeons.
Recent Progress in Alzheimer's and Parkinson's Diseases
by Israel Hanin Ramon Cacabelos Abraham FisherThis book brings together the proceedings of Alzheimer's and Parkinson's Diseases: New Perspectives, the Sixth International Conference on Alzheimer's Disease and Parkinson's Disease, held recently in Seville, Spain, and discusses the latest developments in the basic science and therapy of Alzheimer's and Parkinson's diseases by leading specialists
Recent Progress in Brain and Cognitive Engineering
by Seong-Whan Lee Heinrich H. Bülthoff Klaus-Robert MüllerFor 'Recent Progress in Brain and Cognitive Engineering' Brain and Cognitive Engineering is a converging study field to derive a better understanding of cognitive information processing in the human brain, to develop "human-like" and neuromorphic artificial intelligent systems and to help predict and analyze brain-related diseases. The key concept of Brain and Cognitive Engineering is to understand the Brain, to interface the Brain, and to engineer the Brain. It could help us to understand the structure and the key principles of high-order information processing on how the brain works, to develop interface technologies between a brain and external devices and to develop artificial systems that can ultimately mimic human brain functions. The convergence of behavioral, neuroscience and engineering research could lead us to advance health informatics and personal learning, to enhance virtual reality and healthcare systems, and to "reverse engineer" some brain functions and build cognitive robots. In this book, four different recent research directions are presented: Non-invasive Brain-Computer Interfaces, Cognitive- and Neural-rehabilitation Engineering, Big Data Neurocomputing, Early Diagnosis and Prediction of Neural Diseases. We cover numerous topics ranging from smart vehicles and online EEG analysis, neuroimaging for Brain-Computer Interfaces, memory implantation and rehabilitation, big data computing in cultural aspects and cybernetics to brain disorder detection. Hopefully this will provide a valuable reference for researchers in medicine, biomedical engineering, in industry and academia for their further investigations and be inspiring to those who seek the foundations to improve techniques and understanding of the Brain and Cognitive Engineering research field.
Recent Progress in Microbiology VIII: Symposia Held at the VIII International Congress for Microbiology Montreal, 1962
by N. E. GibbonsThis important volume presents the symposia and panel discussions held at the VIII International Congress for Microbiology, Montreal, 1962. The topics reported on include: Structure and Function ("Membrane Permeation"; "Properties of Isolated Cellular Particles"); Agricultural Microbiology ("Insect Microbiology"; Psychrophilic Microorganisms"; "Enzymes in Soils"; "Effect of Chemical and Biological Control Measures on Soil Micro-organisms"); Industrial Microbiology ("Genetics Applied to Industrial Microbiology"; "Microbial Production of Amino Acids"; "Evolutionary Operation and Horizons in Industrial Microbiology"); Virology ("Mechanisms of Immunity in Infectious Diseases"; "Interference and Interferon"; "Demonstrations of Viruses in Neoplasia"); Medical and Veterinary Microbiology ("Pleuropneumonia-like Organisms as Agents of Human and Animal Diseases"; "The Virulence of Staphylococci"); general subjects ("Microbial Classification"; "Influence of the Environment on the Epidemiology of Mycoses"). The contributors are experts from nineteen countries and all continents except Africa. The volume provides an up-to-date account of international developments in microbiology.
Recent Progress in Nanobiotechnology: Modern Techniques in Biomedical Applications (Interdisciplinary Biotechnological Advances)
by P. M. Visakh Oguz BayraktarThis book describes recent important advancements in nanobiotechnology for biomedical applications as well as explaining fundamentals and examining potential applications in biomedical settings. Nanobiotechnology is the study of applications of nanotechnologies in biological or biomedical settings. It is an interdisciplinary field of growing importance whose subcategories encompass chemical engineering, molecular biophysics, and cellular mechanics or tissue engineering. This book is structured in a way to summarize the latest process in nanobiotechnology at the molecular, cellular, tissue, and organ levels. The principles of the underlying science are presented, and widely accepted applications in the field and newly designed techniques are extensively described. Fresh insights are provided into the convergence of science and technology. This book is an ideal guide to the field that will be of value especially for researchers from interdisciplinary fields and higher level graduate students with extraordinary inspirations and research training.
Recent Progress in the Management of Cerebrovascular Diseases: Treatment strategies, techniques and complication avoidance
by Yoko Kato Xiaohua Zhang Jiong Dai Ahmed AnsariThis book has included 19 recent topics about the treatment of cerebrovascular diseases from basics to surgical (include microneurosurgical, endovascular, endoscopic and Stereotactic radiosurgical techniques) aspects in the management of cerebrovascular diseases. With illustrative cases, the treatment strategies, techniques and complication avoidance have been covered extensively in the chapters to guide the readers on when and what to expect the worst in surgeries. The neurosurgical aspect in the present scenario of COVID is also included. This book will assist the junior neurosurgeons and junior neurological physicians in endeavoring to learn the core concepts and common problems of cerebrovascular surgery. This is a worthwhile addition in this ever growing field of cerebrovascular surgery.
Recent Strategies in High Risk Surgery
by Joel Faintuch Salomao FaintuchMajor surgical societies have been publishing perioperative recommendations for over half a century, based on committees conducting reviews of the literature. Surgical books fundamentally target the intraoperative period when anesthesia is going on. Fatalities are often embedded in a larger context of systemic failures, in which initial problems are sidestepped or mishandled till they become overwhelming and irreversible. There must be a guiding principle and a truly integrated approach for each condition and treatment, of course based on the strongest available evidence. This unique book provides the reader standardized instructions and recommendations on the management of all high-risk surgical candidates in different specialties and contexts, encompassing a continuum of care, and not just in selected phases or groups.Written by worldwide experts, it is divided in 11 sections and 41 chapters which discuss: Preoperative evaluation, Lifestyle interventions, Surgical specialties, Protocols of special relevance, Fluids, electrolytes and shock, Perioperative surgical challenges, Bedside and adjunct procedures, Wound care, Innovative Approaches (including artificial intelligence and machine learning), End of life care and other ethical challenges. It also includes an additional section with supplementary material.Residents, fellows, practitioners in training and seasoned professionals seeking society recertification, primarily in surgery, anesthesiology, intensive care medicine, internal medicine, emergency services, trauma, vascular surgery, nursing, and physical therapy will find this book valuable. Professionals in the industry (especially those related to surgery, critical care monitoring devices, imaging diagnosis and interventional radiology), policy makers and government agencies will also benefit from this work.
Recent Studies on Risk Analysis and Statistical Modeling (Contributions to Statistics)
by Teresa A. Oliveira Christos P. Kitsos Amílcar Oliveira Luís GriloThis book provides an overview of the latest developments in the field of risk analysis (RA). Statistical methodologies have long-since been employed as crucial decision support tools in RA. Thus, in the context of this new century, characterized by a variety of daily risks - from security to health risks - the importance of exploring theoretical and applied issues connecting RA and statistical modeling (SM) is self-evident. In addition to discussing the latest methodological advances in these areas, the book explores applications in a broad range of settings, such as medicine, biology, insurance, pharmacology and agriculture, while also fostering applications in newly emerging areas. This book is intended for graduate students as well as quantitative researchers in the area of RA.