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Recombinant Antibodies For Immunotherapy
by Melvyn LittleRecombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, "arming" mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.
Recombinant Antibodies for Infectious Diseases (Advances In Experimental Medicine And Biology #1053)
by Theam Soon LimThere are many principles and applications of recombinant antibodies for infectious diseases. The preferred technology associated to recombinant antibody generation is mainly phage display. The adaptation of antibodies for infectious diseases is an area lacking information as most literature is focused on oncology or autoimmunity. This project highlights the power and potential of antibody phage display for infectious diseases. In addition to that, supplementary information regarding technologies associated to antibody generation and engineering in the context of infectious disease will also help to provide greater insight to the potential of recombinant antibodies for infectious diseases.
Recombinant DNA Products: Insulin, Interferon and Growth Hormone
by Arthur P. BollonThis book reviews advances made in recombinant DNA technology as it relates to the techniques employed, and the production and testing of potentially important products such as human interferon, insulin, and growth hormone.
Recombinant Gene Expression
by Argelia LorenceStudies related to recombinant gene expression have brought new advance such as the emergence of the "omics" technologies. While Escherichia coli, Sacharomyces cerevisiae and insect cells continue to be the dominant production platforms of recombinant proteins. In Recombinant Gene Expression: Review and Protocols, Third Edition, expert researchers in the field detail many of the methods now commonly used to study recombinant gene expression. These include methods and techniques for bacteria, lower eukaryotes, fungi, plants and plant cells, and animals and animal cells. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Recombinant Gene Expression: Review and Protocols, Third Edition seeks to aid scientists in the further study of this crucially important research into recombinant gene expression.
Recombinant Poxviruses
by Matthew M. Binns Geoffrey L. SmithRecombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines.Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Recombinant Protein Production in Yeast
by Roslyn M. BillIn the last few years, significant advances have been made in understanding how a yeast cell responds to the stress of producing a recombinant protein, and how this information can be used to engineer improved host strains. The molecular biology of the expression vector, through the choice of promoter, tag and codon optimization of the target gene, is also a key determinant of a high-yielding protein production experiment. Recombinant Protein Production in Yeast: Methods and Protocols examines the process of preparation of expression vectors, transformation to generate high-yielding clones, optimization of experimental conditions to maximize yields, scale-up to bioreactor formats and disruption of yeast cells to enable the isolation of the recombinant protein prior to purification. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Recombinant Protein Production in Yeast: Methods and Protocols, seeks to aid scientists in adopting yeast as a protein production host.
Recombinant Virus Vaccines
by Maureen C. Ferran Gary R. SkuseThis volume provides readers with methods and protocols for understanding the development of recombinant viruses and their use as vaccines platforms. Recombinant Virus Vaccines: Methods and Protocols details the use of recombinant vaccines that are employed to either produce immunogens in vitro or elicit antibody production in vivo. The chapters in this book are divided into four parts: Part I explores double-stranded DNA viruses; Part II discusses negative sense single-stranded RNA viruses; Part III talks about positive sense single-stranded RNA viruses; and Part IV describes bacteriophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Recombinant Virus Vaccines: Methods and Protocols is a valuable resource for scientists and clinicians who are interested in learning about and adopting methods for use in basic and biomedical research directed toward generating and developing recombinant viral vaccines.
Recommended Dietary Allowances (10th edition)
by Subcommittee on the Tenth Edition of the RDAs National Research CouncilSince its introduction in 1943, "Recommended Dietary Allowances" has become the accepted source of nutrient allowances for healthy people. These Recommended Dietary Allowances (RDAs) are used throughout the food and health fields. Additionally, RDAs serve as the basis for the U.S. Recommended Daily Allowances, the Food and Drug Administration's standards for nutrition labeling of foods. The "10th Edition" includes research results and expert interpretations from years of progress in nutrition research since the previous edition and provides not only RDAs but also "Estimated Safe and Adequate Daily Dietary Intakes" - provisional values for nutrients where data were insufficient to set an RDA. Organized by nutrient for ready reference, the volume reviews the function of each nutrient in the human body, sources of supply, effects of deficiencies and excessive intakes, relevant study results, and more. The volume concludes with the invaluable "Summary Table of Recommended Dietary Allowances," a convenient and practical summary of the recommendations.
Recommended Standards for Delivering High-Quality Care to Veterans with Invisible Wounds
by Carrie M. Farmer Sierra Smucker Natalie Ernecoff Hamad Al-IbrahimThe authors identified ten standards for the delivery of high-quality care for veterans with posttraumatic stress disorder, depression, substance use disorders, and mild traumatic brain injury. They also provide considerations for implementing and disseminating these standards as a first step to improve access to high-quality care for veterans with invisible wounds.
Recommender Systems for Medicine and Music (Studies in Computational Intelligence #946)
by Zbigniew W. Ras Alicja Wieczorkowska Shusaku TsumotoMusic recommendation systems are becoming more and more popular. The increasing amount of personal data left by users on social media contributes to more accurate inference of the user’s musical preferences and the same to quality of personalized systems. Health recommendation systems have become indispensable tools in decision making processes in the healthcare sector. Their main objective is to ensure the availability of valuable information at the right time by ensuring information quality, trustworthiness, authentication, and privacy concerns. Medical doctors deal with various kinds of diseases in which the music therapy helps to improve symptoms. Listening to music may improve heart rate, respiratory rate, and blood pressure in people with heart disease. Sound healing therapy uses aspects of music to improve physical and emotional health and well-being. The book presents a variety of approaches useful to create recommendation systems in healthcare, music, and in music therapy.
Reconcilable Differences
by Neil Jacobson Andrew ChristensenEvery couple has arguments, but what happens when recurring battles begin to feel like full-scale war? Do you retreat in hurt and angry silence, hoping that a spouse who "just doesn't get it" will eventually see things your way? Spend the time between skirmishes gathering evidence that you're right? Demand some immediate changes--or else? Whether due to innate personality traits or emotional vulnerabilities, there are some aspects of our behavior that are difficult to alter. But these differences do not have to get in the way of healthy, happy, and long-lasting romance. This practical guide offers new solutions for couples frustrated by continual attempts to make each other change. Aided by thought-provoking exercises and lots of real-life examples, readers will learn why they keep having the same fights again and again; how to keep small incompatibilities from causing big problems; and how true acceptance can restore health to their relationships.
Reconcilable Differences, Second Edition
by Neil S. Jacobson Andrew Christensen Brian D. DossEvery couple has disagreements, but what happens when recurring conflicts start to pull your relationship apart? Do you lie awake hoping that your spouse will eventually see things your way, or rehashing the evidence that you're right? Demand some immediate changes--or else? This popular, science-based guide offers powerful solutions for couples frustrated by continual attempts to make each other change. True acceptance may seem difficult to accomplish, but the clear-cut steps and thought-provoking exercises in this book can make it a reality. You'll learn why you keep having the same fights again and again; how to keep small incompatibilities from causing big problems; what communication strategies really work to resolve conflicts; and how to problem-solve and make positive changes--together. Updated throughout with new research, practical tools, and examples, the second edition features a new chapter on mindfulness. Mental health professionals: learn about using this self-help guide as an adjunct to therapy at the authors' website (http://ibct.psych.ucla.edu).
Reconcilable Differences, Second Edition
by Neil S. Jacobson Andrew Christensen Brian D. DossEvery couple has disagreements, but what happens when recurring conflicts start to pull your relationship apart? Do you lie awake hoping that your spouse will eventually see things your way, or rehashing the evidence that you're right? Demand some immediate changes--or else? This popular, science-based guide offers powerful solutions for couples frustrated by continual attempts to make each other change. True acceptance may seem difficult to accomplish, but the clear-cut steps and thought-provoking exercises in this book can make it a reality. You'll learn why you keep having the same fights again and again; how to keep small incompatibilities from causing big problems; what communication strategies really work to resolve conflicts; and how to problem-solve and make positive changes--together. Updated throughout with new research, practical tools, and examples, the second edition features a new chapter on mindfulness. Mental health professionals: learn about using this self-help guide as an adjunct to therapy at the authors' website (http://ibct.psych.ucla.edu).
Reconfigured: A Memoir
by Barbara Wolf TeraoWhen Barbara Terao moves into a new home in Washington, two thousand miles from her husband in Illinois, she doesn&’t know when—or if—she&’ll ever live with him again. Her diagnosis of breast cancer three months later changes both of them in ways they never imagined. In the ensuing months, Barbara&’s husband and adult children show up to help her through a year of difficult treatments and surgery, and Barbara, in her Whidbey Island cottage, learns to listen to her heart and intuition. Nurtured by Douglas fir forests, the Salish Sea, and her community, she changes her life from the inside out. Her journey, she realizes, wasn&’t about leaving her husband so much as finding herself. Reconfigured in body, mind, and spirit, Barbara finally has words for what she wants to say—and the strength to be a survivor.
Reconfiguring Global Health Innovation (Routledge International Studies In Health Economics Ser. #7)
by Padmashree Gehl SampathReconfiguring Global Health Innovation presents the findings of multi-year research, contrasting experiences of different latecomer countries in building health innovation systems to cater to local needs. It analyses the emerging industrial structures in health innovation as more and more latecomer countries are foraying into what is a highly difficult and technologically intensive sector, with the aim of finding ways and means to balance these promising developments with public health needs worldwide. The bookpresents empirical findings from six countries across Asia and Africa on health innovation, namely, India, Bangladesh, Vietnam, Kenya, Tanzania and Nigeria. The book concludes that the growth of knowledge and the accumulation of capabilities influence the ability of a country to generate wealth.
Reconfiguring Reproduction: Feminist Health Perspectives on Assisted Reproductive Technologies
by Edited by Sarojini N. Vrinda MarwahThough commonplace today as a technological quick fix for infertility, assisted reproduction is a complex phenomenon, located at the intersection of patriarchy, medicalization and commerce. These technologies create both challenges and opportunities, and response to them have sought to balance questions of ethics, rights and politics. The essays in this volume map the journey of ARTs in different countries, examining the global industry and the challenges it poses in the context of markets and look at regulatory frameworks in diverse settings. Together they bring a feminist lens to the examination of the now-established ART industry. Sama's longstanding work provides a special focus on India: the spread and features of the industry, the gendered nature of the burden and treatment of infertility, the destabilization of the family as we know it, and feminist debates around surrogacy that re-assess ideas of agency and commodification.
Reconsidering Dementia Narratives: Empathy, Identity and Care (Routledge Advances in the Medical Humanities)
by Rebecca BitencReconsidering Dementia Narratives explores the role of narrative in developing new ways of understanding, interacting with, and caring for people with dementia. It asks how the stories we tell about dementia – in fiction, life writing and film – both reflect and shape the way we think about this important condition. Highlighting the need to attend to embodied and relational aspects of identity in dementia, the study further outlines ways in which narratives may contribute to dementia care, while disputing the idea that the modes of empathy fostered by narrative necessarily bring about more humane care practices. This cross-medial analysis represents an interdisciplinary approach to dementia narratives which range across auto/biography, graphic narrative, novel, film, documentary and collaborative storytelling practices. The book aims to clarify the limits and affordances of narrative, and narrative studies, in relation to an ethically driven medical humanities agenda through the use of case studies. Answering the key question of whether dementia narratives align with or run counter to the dominant discourse of dementia as ‘loss of self’, this innovative book will be of interest to anyone interested in dementia studies, ageing studies, narrative studies in health care, and critical medical humanities.
Reconsidering Law and Policy Debates
by John G. CulhaneThis book offers fresh approaches to a variety of social and political issues that have become highly polarized and resistant to compromise by examining them through a population-based public health perspective. The topics included are some of the most contentious: abortion and reproductive rights; end-of-life issues, including the right to die and the treatment of pain; the connection between racism and poor health outcomes for African-Americans; the right of same-sex couples to marry; the toll of gun violence and how to reduce it; domestic violence and how the criminal justice model fails to deal with it effectively; and how tort compensation and punitive damages can further public health goals. People at every point along the political spectrum will find the book enlightening and informative. Written by eight authors, all of whom have cross-disciplinary expertise, this book shifts the focus away from the point of view of rights, politics, or morality and examines the effect of laws and policies from the perspective of public health and welfare.
Reconstructing Bodies: Biomedicine, Health, and Nation-Building in South Korea Since 1945
by John P. DimoiaSouth Korea represents one of the world's most enthusiastic markets for plastic surgery. The growth of this market is particularly fascinating as access to medical care and surgery arose only recently with economic growth since the 1980s. Reconstructing Bodies traces the development of a medical infrastructure in the Republic of Korea (ROK) from 1945 to the present, arguing that the plastic surgery craze and the related development of biotech ambitions is deeply rooted in historical experience. Tracking the ROK's transition and independence from Japan, John P. DiMoia explains how the South Korean government mobilized biomedical resources and technologies to consolidate its desired image of a modern and progressive nation. Offering in-depth accounts of illustrative transformations, DiMoia narrates South Korean biomedical practice, including Seoul National University Hospital's emergence as an international biomedical site, state-directed family planning and anti-parasite campaigns, and the emerging market for aesthetic and plastic surgery, reflecting how South Koreans have appropriated medicine and surgery for themselves as individuals, increasingly prioritizing private forms of health care.
Reconstructing Medical Practice: Engagement, Professionalism and Critical Relationships in Health Care
by Christine JormReconstructing Medical Practice examines how doctors see health care and their place in it, why they remain in medicine and why they are limited in their ability to lead change in the current system. Doctors are beset by doubts and feel rejected by systems where they should be leaders - some see their role as 'flog[ging] a derelict system to get the last breath of workability out ... for their patients'. Others simply turn away. Rigorous studies carried out at large public teaching hospitals in Australia found that doctors were reluctant to increase safety in the wider health system, despite making every effort for their 'own' patients. Doctors' self-esteem was found to be delicate due to the uncertain nature of their work; colleagues provide the support doctors need to deliver good care. However, these essential relationships and their cherished connections with patients have disadvantages: reducing doctors' ability to admit to error. On top of this, senior doctors predict a future bereft of professional values - one where medicine is 'just a job'. While the loss of professional identity introduces new risks for patients and doctors, the repercussions of the more self-serving attitudes of younger doctors are unknown. Reconstructing Medical Practice concludes that regulation, despite its recent proliferation, is a clumsy and limited approach to ensuring good care. It presents original and much-needed ideas for ways to rebuild the critical relationship between doctors and the system. By better valuing communicative interactions and workplace relationships, safe and satisfying medical practice can be reconstructed.
Reconstructing Obesity
by Jessica A. Hardin Megan B. McculloughIn the crowded and busy arena of obesity and fat studies, there is a lack of attention to the lived experiences of people, how and why they eat what they do, and how people in cross-cultural settings understand risk, health, and bodies. This volume addresses the lacuna by drawing on ethnographic methods and analytical emic explorations in order to consider the impact of cultural difference, embodiment, and local knowledge on understanding obesity. It is through this reconstruction of how obesity and fatness are studied and understood that a new discussion will be introduced and a new set of analytical explorations about obesity research and the effectiveness of obesity interventions will be established.
Reconstructing Research Integrity: Beyond Denial
by Barbara RedmanThis book exposes significant threats to research integrity and identifies policies and practices that can reverse these trends. It is focused on human research and US policy. Recent assessments have shown inadequacies in institutions, policies, and practices that seriously compromise ethics. The presumed self-regulatory nature of the scientific endeavor has been exposed to have allowed unabated areas of poor-quality science, an incomplete and inaccessible scientific record, conflicts of interest, differing notions of accountability, virtually no evidence base to direct research integrity policy, and a growing sense of alienation, moral injury and even revolt among scientists. Reconstructing Research Integrity aims to capture ways of vigorously moving toward scientific and ethical rigor, including self-correction and emerging or already-successful initiatives. The book begins with analysis of the full system of institutions, policies, and practices involved in production, dissemination, and application of research, including an examination of the blind spots in research ethics ideology, policy, and practice. The book then identifies policies and practices that can reverse harmful ethical trends, such as strengthening Responsible Conduct of Research (RCR) training and improving self-regulation in the scientific community. Finally, the book discusses the constant evolution of research ethics and integrity, which is illustrated by emerging research fields like gene editing and data science. This book will be of interest to all research administrators in academic, commercial and government positions; to policy advisors at the National Science Foundation and at the National Academies of Science, Engineering, and Medicine; to graduate students in research ethics; to advanced bioethics education programs across the globe; and to researchers and consultants in ELSI (ethical, legal, and social implications) programs.
Reconstructing Womanhood, Reconstructing Feminism: Writings on Black Women
by Delia Jarrett-MacauleyReconstructing Womanhood, Reconstructing Feminism is the first British feminist anthology to examine concepts of womanhood and feminism within the context of `race' and ethnicity. Challenging contemporary feminist theory, the book highlights ways in which constructions of womanhood have traditionally excluded black women's experience, and proposes a reconsideration of terms such as `feminist'. The research subjects and methods of many of the contributors have been shaped by the specifics of the Black British experience and context. The collection brings together various ideas about `difference' and identity. It covers a wide range of social and cultural issues including the position of black women in the church, lesbian identity in film, contemporary African feminism, and British immigration law.
Reconstruction of Upper Cervical Spine and Craniovertebral Junction
by Ondrej Choutka Petr SuchomelAn illustrative manual for general spine surgeons, this text atlas covers all currently available techniques of upper cervical spine and craniovertebral junction reconstruction. All the surgical risks and benefits are discussed and compared with the outcome of more than 300 surgeries of this region. The surgical procedures are demonstrated step-by-step in instructive drawings and illustrations describing the approach, technique of implant introduction and spine reconstruction. A special focus is on realtime and virtual navigation techniques as well as potential complications and their avoidance.
Reconstruction, Segmentation, and Analysis of Medical Images
by Maria A. Zuluaga Kanwal Bhatia Bernhard Kainz Mehdi H. Moghari Danielle F. PaceThis book constitutes the refereed proceedings of two workshops held at the 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016, in Athens, Greece, in October 2016: the First International Workshop on Reconstruction and Analysis of Moving Body Organs, RAMBO 2016, and the First International Workshop on Whole-Heart and Great Vessel Segmentation from 3D Cardiovascular MRI in Congenital Heart Disease, HVSMR 2016. The 17 revised regular papers presented in this book were carefully reviewed and selected from a total of 21 submissions. The papers cover following topics: Registration; Reconstruction; Deep learning for heart segmentation; Discrete optimization and probabilistic intensity modeling; Atlas-based strategies; Random forests.