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Recent Advances in Pharmaceutical Innovation and Research
by Prati Pal SinghThis book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.
Recent Advances in Phototrophic Prokaryotes
by Patrick C. HallenbeckThis volume is based on ISPP2009, and presents selected invited works, reviews and research articles, covering the spectrum of the diverse subject matter covered by this symposium series. Here the authors have greatly expanded on what was presented in Montreal to ensure complete coverage of each topic, covering the gamut from ecology, physiology, proteins and genomics, signal transduction, to applied aspects. Not only are these articles timely, presenting up-to-date published and unpublished results, but, since they are extensively referenced, should serve as valuable source material for some time to come.
Recent Advances in Prolactin Research
by Maria DiakonovaRecent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
Recent Advances in Redox Active Plant and Microbial Products
by Claus Jacob Gilbert Kirsch Alan Slusarenko Paul G. Winyard Torsten BurkholzNature endows us with a treasure chest of Green Gold full of amazing 'redox-active' substances which interfere with numerous biological processes in our own body, in animals, bacteria, fungi and plants. Whilst such natural products are all around and also in us, we still do not fully understand how these compounds actually work. This book attempts to resolve some of the mysteries and riddles associated with such products. Written by more than thirty international experts from academia and industry, it places a focus on modern developments in this field and considers such natural products from various angles, from their isolation and characterization all along to product development and commercialization. Throughout, the reader will be confronted with modern approaches which enable the efficient identification and isolation of new natural products, help to elucidate their mode(s) of action and permit practical uses in Medicine, Cosmetics, Agriculture, Industry and as functional foods.
Recent Advances in Research on Impulsivity and Impulsive Behaviors (Current Topics in Behavioral Neurosciences #47)
by Harriet De Wit J. David JentschThis volume provides an empirical and conceptual overview of advances in our understanding of impulsivity and impulsive behaviors. Prominent scientists review the range of behavioral phenomena referred to as ‘impulsive’, as well as the defining features and psychological, neurocognitive and behavioral processes that underlie of the manifestation of impulsive behaviors, focussing on progress made and the questions remaining to be answered.
Recent Advances in Stem Cells
by Essam M. AbdelalimThis volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer's Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.
Recent Advances in Surgery 31
by Irving Taylor Colin JohnsonRecent Advances in Surgery 31 is the latest volume in the successful and well-established Recent Advances series. This title is updated annually, covering the latest trends within surgery and reflecting any changes to the professional examinations for surgeons. Suitable for experienced medical professionals, as well as students and candidates of the MRCS/AFRCS, this edition reviews the latest trends within surgery and forms a useful update of general surgery for candidates of the Intercollegiate examination.Over 30 contributors, who are recognized experts in their particular field, provide in-depth reviews of important topics relevant to the management of all surgical patients and advancing areas in surgical subspecialties.
Recent Advances in Technologies for Inclusive Well-Being: Virtual Patients, Gamification and Simulation (Intelligent Systems Reference Library #196)
by Anthony Lewis Brooks Sheryl Brahman Bill Kapralos Amy Nakajima Jane Tyerman Lakhmi C. JainIn a time of ongoing pandemic when well-being is a priority this volume presents latest works across disciplines associated to Virtual Patients, Gamification and Simulation. Chapters herein present international perspectives with authors from around the globe contributing to this impactful third edition to the series following a 2014 Springer book on Technologies for Inclusive Well-Being and a 2017 Springer book Recent Advances in Technologies for Inclusive Well-Being. Digital technologies are pervasive in life and the contributions herein focus on specific attributes and situations, especially in training and treatment programmes spanning across ranges of diagnosis, conditions, ages, and targeted impacts. This volume purposefully does not cover all (even if that was possible) aspects on how virtual interactive space can align to statial computing, which in turn can align with related embodied entities (whatever the terms used e.g. Virtual, Augmented, Extended, Mixed Realities) along with AI, Deep Learning etc. It also doesn’t cover what some may refer to as ‘trendy terms’ such as 360 degree, video, WebXR, cryptocurrency, blockchain, virtual goods, AR museums, travel and teleportation…however, what is covered in this book, and the prior volumes it builds upon (as above), is a sharing and questioning of advancing technologies for inclusive well-being through research and practices from an avant-garde perspective.
Recent Advances in the 3D Physiological Human
by Nadia Magnenat-Thalmann Jian J. Zhang David Dagan FengResearch into the 3D Physiological Human is a very active field focusing on the creation of patient-specific computer models for personalised healthcare. Reporting on how these models can simulate and provide a better understanding of human physiology and pathology, this book also looks at how the evolution and the improvement of technological devices such as scanners, medical instruments, and computer power have helped in our understanding of the human body and its functionalities. The book contains contributions from leading researchers from a variety of disciplines (including computer graphics, biomechanics, knowledge representation, human-machine interfaces etc) associated with medical imaging, simulation, computer-assisted surgery and 3D semantics. Divided into three parts: anatomical and physiological modelling, physically-based simulation, and medical analysis and knowledge management, this book provides a clear picture of the most recent advances in this increasingly important area.
Recent Advances in the Science of Cannabis
by Robert M. Strongin, Jiries Meehan-Atrash, and Monica VialpandoRecent Advances in the Science of Cannabis describes progress in a variety of significant areas of cannabis science. This unique book covers topics in cultivation and secondary metabolites, aroma and chemotypes, cannabinoid structures, physiology and pharmacology, as well as the development of unique topical products. State-of-the-art analytical methods and instrumentation are covered, including current developments in mass spectrometry and chromatography, as well as microbial testing. Given the popularity of smoking and vaporizing cannabis, the chemistry of vaping cannabinoid and terpene concentrates is also presented, along with emerging regulatory issues. Key Features: A guide to emerging modern cannabis technology in a dynamic regulatory climate and appealing to both novices and specialists. Building upon pioneering studies of terpene and cannabinoid chemistry, this distinctive volume describes current best practices, technological breakthroughs and historical context. Written by researchers in industry and academia, a greater understanding of the risks of exposure to emissions from vaping or dabbing cannabis concentrates is provided here. A selection of the book content reviewing Thermal Degradation of Cannabinoids and Cannabis Terpenes has been included in “Hot 2021” RSC Advances.
Recent Advances in the Treatment of Colorectal Cancer
by Hideyuki Ishida Keiji KodaThis book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment. Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. <P><P>Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.
Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology
by Seth Kwabena Amponsah Yashwant V. PathakThis book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies.The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges
Recent Advances in Transthyretin Evolution, Structure and Biological Functions
by Vivian Cody Samantha J. RichardsonThere is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies. The evolution of transthyretin has been extensively investigated - from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships. This monograph will bring the reader up to date on the latest developments and discoveries.
Recent Advances of Sarcopenia and Frailty in CKD
by Akihiko Kato Eiichiro Kanda Yoshihiko KannoThis book highlights recent advances in our understanding of sarcopenia and frailty in CKD. The prevalence of sarcopenia and frailty increases substantially as CKD progresses, and experimental studies have demonstrated the pivotal role of accumulated uremic toxin in the development of muscle wasting. Further, sarcopenia and frailty are associated with falls, bone fractures, cognitive impairment, and poor survival prognoses, especially in elderly CKD patients. The syndromes are also related to the risk of end-stage kidney disease. This book provides readers with a deeper understanding of the prevention and management of sarcopenia and frailty in CKD patients to improve their renal and overall health, and suggests directions for future basic and clinical research.
Recent Advances of the Fragment Molecular Orbital Method: Enhanced Performance and Applicability
by Yuji Mochizuki Shigenori Tanaka Kaori FukuzawaThis book covers recent advances of the fragment molecular orbital (FMO) method, consisting of 5 parts and a total of 30 chapters written by FMO experts. The FMO method is a promising way to calculate large-scale molecular systems such as proteins in a quantum mechanical framework. The highly efficient parallelism deserves being considered the principal advantage of FMO calculations. Additionally, the FMO method can be employed as an analysis tool by using the inter-fragment (pairwise) interaction energies, among others, and this feature has been utilized well in biophysical and pharmaceutical chemistry. In recent years, the methodological developments of FMO have been remarkable, and both reliability and applicability have been enhanced, in particular, for non-bio problems. The current trend of the parallel computing facility is of the many-core type, and adaptation to modern computer environments has been explored as well. In this book, a historical review of FMO and comparison to other methods are provided in Part I (two chapters) and major FMO programs (GAMESS-US, ABINIT-MP, PAICS and OpenFMO) are described in Part II (four chapters). dedicated to pharmaceutical activities (twelve chapters). A variety of new applications with methodological breakthroughs are introduced in Part IV (six chapters). Finally, computer and information science-oriented topics including massively parallel computation and machine learning are addressed in Part V (six chapters). Many color figures and illustrations are included. Readers can refer to this book in its entirety as a practical textbook of the FMO method or read only the chapters of greatest interest to them.
Recent Advances on the Modular Organization of the Cortex
by Manuel F. Casanova Ioan OprisThe way you perceive the world, plan, make decisions and communicate your thoughts and feelings depends on the function and hierarchical arrangement of cortical modules. The ability to both provide adaptive responses to our ever-changing environment and to pursue a useful role in society is the most important problem faced by present day neuroscientists. In essence, the workings of cortical modules define the nature of our soul, making each of us who we are. This book provides a breath-taking view of different perspectives by world renowned authorities as to the workings of these cortical modules both in the normal state and in mental disorders.
Recent Concepts in Minimal Access Surgery: Volume 1
by Deborshi Sharma Priya HazrahThe book covers the recent developments in various aspects of minimal access surgery (laparoscopic and robotic surgery), which is fairly a new branch of surgery that has advanced tremendously in last few years. This is the first volume of the set of books on recent concepts in minimal access surgery. It provides step-by-step descriptions accompanied by numerous helpful photographs and anatomical drawings. It also includes the controversies and gives a cumulative opinion on the recent changes developing in minimal access surgery (MAS). It includes system wise topics and separate chapters on the different topics within the system with the meta-analysis of recent topic or their controversies.The book is useful for practitioners and young faculties as well as residents, trainees and fellows of surgery and minimal access surgery.
Recent Contributions to Bioinformatics and Biomedical Sciences and Engineering (Lecture Notes in Networks and Systems #658)
by Sotir Sotirov Tania Pencheva Janusz Kacprzyk Krassimir T. Atanassov Evdokia Sotirova Simeon RibaginThis book presents a collection of high-quality research papers, presented at the Second International Symposium on Bioinformatics and Biomedicine (BioInfoMed’2022). It offers a comprehensive look into some of the fastest growing fields of science, such as biomedicine, bioinformatics, artificial intelligence, and mathematical modeling. The different chapters of the work include both practical solutions and strictly scientific considerations expanding knowledge about the future bioinformatics and biomedical engineering challenges. We believe that the presented works will have a great impact not only on the development and the application of new methods for modeling, decision making and data mining in healthcare and biomedicine, but also it will provide a source of inspiration for researchers who can implement the proposed methods into their practice and scientific studies.
Recent Developments in Fungal Diseases of Laboratory Animals (Fungal Biology)
by Arti Gupta Nagendra Pratap SinghFungal growths affect both human and animal well-being. Many natural pathogens of laboratory animals alter host physiology, rendering the host unsuitable for experimental uses. While the number and prevalence of few pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using laboratory animals in biomedical experimentation should be aware of the profound effects that many of these agents can have on research. What does the future hold regarding the natural pathogens of laboratory animals? The selection of an animal model must carefully address issues of the type of human disease to mimic, the parameters to follow, and the collection of the appropriate data to answer those questions being asked. Overall, animal models of fungal infection will continue to deepen our understanding of how these infections occur. This book provides a valuable source of information to biological and biomedical scientists and to clinical and doctoral researchers working in the area of fungal infections and diseases of laboratory animal species.
Recent Developments in Mathematical, Statistical and Computational Sciences: The V AMMCS International Conference, Waterloo, Canada, August 18–23, 2019 (Springer Proceedings in Mathematics & Statistics #343)
by D. Marc Kilgour Herb Kunze Roman Makarov Roderick Melnik Xu WangThis book constitutes an up-to-date account of principles, methods, and tools for mathematical and statistical modelling in a wide range of research fields, including medicine, health sciences, biology, environmental science, engineering, physics, chemistry, computation, finance, economics, and social sciences. It presents original solutions to real-world problems, emphasizes the coordinated development of theories and applications, and promotes interdisciplinary collaboration among mathematicians, statisticians, and researchers in other disciplines.Based on a highly successful meeting, the International Conference on Applied Mathematics, Modeling and Computational Science, AMMCS 2019, held from August 18 to 23, 2019, on the main campus of Wilfrid Laurier University, Waterloo, Canada, the contributions are the results of submissions from the conference participants. They provide readers with a broader view of the methods, ideas and tools used in mathematical, statistical and computational sciences.
Recent Developments in Microbiology, Biotechnology and Pharmaceutical Sciences
by B. Sundaravadivazhagan Sekar Mohan Balakrishnaraja RengarajuThe Conference brought together innovative academics and industrial experts in the field of Medical, Biological and Pharmaceutical Sciences to a common forum. The primary goal of the conference was to promote research and developmental activities in Medical, Biological and Pharmaceutical Sciences. Another goal was to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world.
Recent Developments in Modeling and Applications in Statistics
by Maria da Graça Temido Paulo Eduardo Oliveira Carla Henriques Maurizio VichiStatistics has been a main tool in almost every field of activity and an essential part of applied scientific work, supporting conclusions and offering insights into new uses for established methodologies, thus making it a valuable resource in looking for faceless facts. Model construction describing populations or phenomena subject to randomness use a wide range of methods. Data collection provides the basis for modelling and assumption verification. Modelling must be conducted using suitable techniques that give researchers the means to search for hidden facts or behaviours. This may be addressed by fitting pre-defined shapes and distributions to the data or by allowing the data to reveal its intrinsic properties by using nonparametric methods. This volume contains a selection of contributions presented at the XVIII Annual Congress of the Portuguese Statistical Society.
Recent Developments in Multivariate and Random Matrix Analysis: Festschrift in Honour of Dietrich von Rosen
by Thomas Holgersson Martin SingullThis volume is a tribute to Professor Dietrich von Rosen on the occasion of his 65th birthday. It contains a collection of twenty original papers. The contents of the papers evolve around multivariate analysis and random matrices with topics such as high-dimensional analysis, goodness-of-fit measures, variable selection and information criteria, inference of covariance structures, the Wishart distribution and growth curve models.
Recent Developments in the Regulation of Kinins
by Jagdish N. SharmaThis volume presents key topics of current interest with regard to several pathophysiological conditions including (a) the basic and clinical aspects of bradykinin receptor antagonists, (b) the kallikrein-kinin pathways in hypertension and diabetes, (c) tissue kallikrein-kinin therapy for hypertension and organ damage, (d) the renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension, (e) the kallikrein-kinin system in diabetes retinopathy, and (f) genetic manipulation and genetic variation of the kallikrein-kinin system and their impacts on cardiovascular and renal disease. Written by internationally reputed scientists, the book provides an essential overview of the latest developments in the field of kinin research, making it a valuable asset for endocrinologists, nephrologists, cardiologists, pharmacologists, physiologists, ophthalmologists and rheumatologists. Furthermore, it is also intended for postgraduate students in the fields of medicine, pharmacy, physiology and pharmacology, and those working at research organizations.
Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology
by Irving SunshinePapers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr