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Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine (Gene and Cell Therapy)
by Anthony Atala Sean V. MurphyMiniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.
Regenerative Medicine Using Pregnancy-Specific Biological Substances
by Niranjan Bhattacharya Phillip StubblefieldThe proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.
Regenerative Pharmacology
by George J. Christ Karl-Erik AnderssonRegenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i. e. , nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research.
Regenerative Rehabilitation: From Basic Science to the Clinic (Physiology in Health and Disease)
by Sarah M. Greising Jarrod A. CallThis contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.
Regenerative Strategies for the Treatment of Knee Joint Disabilities
by Joaquim Miguel Oliveira Rui Luís ReisThis book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.
Regenerative Therapies in Ischemic Stroke Recovery
by Syed Shadab RazaThis book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.
Regenerative Therapy Using Blood-Derived Stem Cells
by David S. Allan Dirk StrunkBlood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders. The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine.
Régime à jeun : manger au bon moment : découvrez comment le jeûne intermittent peut
by Chace KirkDécouvrez comment manger au bon moment peut changer radicalement l'apparence de votre corps en seulement 4 semaines aujourd'hui ! Le jeûne devient peu à peu un sujet courant. Ceci est principalement dû aux preuves étayées par la recherche qui ont été publiées par de nombreuses publications réputées énumérant les divers avantages du jeûne tels que l'amélioration de la santé du cerveau, l'augmentation de la production de l'hormone de croissance humaine, un système immunitaire plus fort, la santé cardiaque et la perte de poids. -d'où son attrait pour les personnes soucieuses de leur santé en tant que catalyseur de leurs objectifs de santé. Adopter le jeûne comme choix de vie vous empêchera de manger pendant quelques heures à quelques jours. La première chose que vous devez faire est d'établir votre routine de jeûne. Par exemple, vous pouvez choisir de sauter le petit-déjeuner et de faire du déjeuner votre premier repas de la journée. Allez-y avec cohérence. Aussi, vous pouvez décider d'espacer vos repas sur quelques heures ; de sorte que lorsque les heures fixées se sont écoulées, vous atteigniez votre fenêtre de repas, puis repreniez le jeûne. Le vrai défi est de rester engagé. Vous constaterez qu'il sera difficile de briser le cycle alimentaire auquel votre corps était habitué, mais lorsque vous persévérez ; votre corps s'adaptera bien sûr à votre nouvelle habitude. Si vous décidez de passer des jours sans nourriture, les résultats seront très prononcés, mais n'oubliez pas d'hydrater constamment votre corps pour éliminer les toxines. Dans ce livre, vous apprendrez : ✓ Introduction au jeûne ✓ Qu'est-ce que la fenêtre de repas ? ✓ Jeûne ciblé pour votre type de corps ✓ Pourquoi vous perdrez du poids en jeûnant ✓ Dernières recherches et études sur le jeûne ✓ Traiter le jeûne comme un choix de style de vie ✓ L'obésité
'Regimental Practice' by John Buchanan, M.D.: An Eighteenth-Century Medical Diary and Manual
by Paul KoppermanIn 1746, Dr John Buchanan, recently retired as a medical officer in the British Army, produced a manuscript entitled, 'Regimental Practice, or a Short History of Diseases common to His Majesties own Royal Regiment of Horse Guards when abroad (Commonly called the Blews).' Revised in several stages almost until the time of Buchanan's death in 1767, this work was for the most part based on the author's observations while surgeon to a cavalry regiment serving in Flanders 1742-45, during the War of the Austrian Succession. It is a work of immense value to the understanding of eighteenth-century interpretation and treatment of diseases, but as yet has never been published. Presented here is an annotated modern edition of the text, with an introductory section setting the work in the context of Buchanan's life and career, and within the broader framework of eighteenth-century medical practice. Buchanan's practice of medicine generally represented the mainstream of professional practice as regarded both his understanding of disease and his treatment of it. Across the decades of the eighteenth century there were discoveries and fashions that impacted both the theory and the practice of medicine. Various writers of that age, as well as a number of historians since, have conveyed the sense that practice was chaotic. On the contrary, what this book argues is that methods used to treat diseases were fairly standard. Therefore, by reading Buchanan's manuscript one sees not only how he treated more than three dozen diseases, as well as various wounds and injuries, but also how these conditions were often treated in this period.
Régimes Alimentaires qui Guérissent: Comment guérir les maladies et les affections pour être en meilleure santé
by Doug Fredrick- Vous voulez perdre du poids et à reduire la graisse corporelle? - Vous cherchez à être plus sain, plus fort et à avoir plus d'énergie? Aimeriez-vous pouvoir aider à éliminer la maladie, l'inconfort, l'inflammation, la douleur et la dépression? Pendant longtemps, les régimes cétogènes ont été utilisés pour traiter un certain nombre de maladies et faciliter la perte de poids! L'utilisation de techniques de régime céto aidera ėvalement à dėfendre contre les maladies chroniques et l'inflammation, aidera à votre système immunitaire, aux niveaux d'énérgie, à la concentration, au bonheur général et bien plus encore! Présentation des secrets que les professionnels de la guérison naturelle utilisent pour se sentir en meilleure santé que jamais! Avec des décennies de stratégies testées, cet ebook vous montrera le moyen le plus rapide et le plus efficace d'utiliser la guérison naturelle de votre corps pour votre bien-être! Vous apprendrez comment augmenter votre bien-être en quelques semaines seulement. À part cela, vous améliorerez littéralement chaque aspect de votre vie. Vous voulez savoir comment les individus font face aux maladies chroniques et aux maux? Vous aussi, vous pouvez apprendre les secrets pour y parvenir, vous permettant d'être plus heureux et en meilleure santé. Ce guide vous enseigne des techniques ėprouvées sans utiliser de suppléments ou de cours coûteux. Ce qui est inclu: -Régime cétogène. -Perte de poids. -Battre la dépression. -Etre plus heureux. -Battre la maladie chronique. -Avoir plus d'énergie. -Mieux dormir. -Surmonter les maux. -Nutrition. -Ce que vous devriez savoir. + BEAUCOUP PLUS! Si vous voulez être en meilleure santé, guérir des maux ou améliorer votre concentration et votre bien-être, ce guidee est fait pour vous.
Regional Anesthesia in Trauma
by Jeff GadsdenThe management of pain from acute injuries is a priority in trauma care. Regional analgesic techniques are very effective at treating acute pain and are gaining in popularity as recognition of their beneficial effects on morbidity increases. Regional Anesthesia in Trauma employs multiple narrative problem-solving case scenarios that explore the use of regional anesthesia in: * Blunt chest trauma, amputations, upper and lower extremity fractures and spinal injury * Burn injury * Patients with pre-existing nerve injury and other co-morbidities * Patients at risk for compartment syndrome * Pregnant, obese, elderly and pediatric patients * Local anesthetic systemic toxicity With a focus on ultrasound-guided techniques, the reader is guided through the technical aspects of performing regional anesthesia as well as the medical and surgical considerations that influence the choice of analgesic therapy. Regional Anesthesia in Trauma is invaluable for practitioners and trainees in anesthesiology, emergency medicine and trauma surgery.
Regional Fisheries Oceanography of the California Current System: The CalCOFI Program
by Sam McClatchieThe California Current System is one of the best studied ocean regions of the world, and the level of oceanographic information available is perhaps only surpassed by the northeast and northwest Atlantic. The current literature (later than 1993) offers no comprehensive, integrated review of the regional fisheries oceanography of the California Current System. This volume summarizes information of more than 60-year California Cooperative Oceanic Fisheries Investigation (CalCOFI). While providing a large bibliography, the intent was to extract themes relevant to current research rather than to prepare a compendious review of the literature. The work presents a useful review and reference point for multidisciplinary fisheries scientists and biological oceanographers new to working in the California Current System, and to specialists wishing to access information outside their core areas of expertise. In addition, the first editioin published in 2014 aimed to deliver an up to date reference to the current state of knowledge of fisheries oceanography in the California Current System. The second edition adds some new sections, and data visualizations. The most important new material is included in the perspectives on CalCOFI chapter. New vignettes have been added for Reuben Lasker, Ed Brinton, Abraham Fleminger, Elizabeth Venrick, and Andrew Leising. The vignette for Noelle Bowlin has been updated to reflect her position as the current NOAA lead for the CalCOFI program, and a vignette has also been added for Sam McClatchie.
Regional Mortality Differences in Germany
by Eva U.B. KibeleRegional mortality differences are one dimension of health inequalities, but its trends and determinants in Germany are widely unknown. This book examines and illustrates patterns of regional mortality in Germany--with focus on small-area differentials--and their changes over time. It identifies explanatory factors at individual and regional level. Mortality differences between eastern and western Germany exist, but small-area mortality differentials are often greater. Though the main spatial mortality patterns remain, this study provides evidence that some distinct changes in the small-area mortality patterns in Germany--especially among women--occurred within a short period of time. Mortality inequalities at younger ages and in behavior-related causes as well as differences in socioeconomic conditions contribute strongly to regional mortality differences in Germany. The book shows that the complex interplay between individual- and regional-level mortality risk factors requires a multidimensional approach to reduce regional mortality inequalities.
Regional Nerve Blocks in Anesthesia and Pain Therapy
by Danilo Jankovic Philip PengIn recent years the field of regional anesthesia, in particular peripheral and neuraxial nerve blocks, has seen an unprecedented renaissance following the introduction of ultrasound-guided regional anesthesia. This comprehensive, richly illustrated book discusses traditional techniques as well as ultrasound-guided methods for nerve blocks and includes detailed yet easy-to-follow descriptions of regional anesthesia procedures. The description of each block is broken down into the following sections: definition; anatomy; indications; contraindications; technique; drug choice and dosage; side effects; potential complications and how to avoid them; and medico-legal documentation. A checklist record for each technique and a wealth of detailed anatomical drawings and illustrations offer additional value. Regional Nerve Blocks in Anesthesia and Pain Medicine provides essential guidelines for the application of regional anesthesia in clinical practice and is intended for anesthesiologists and all specialties engaged in the field of pain therapy such as pain specialists, surgeons, orthopedists, neurosurgeons, neurologists, general practitioners, and nurse anesthetists.
Regional Nerve Blocks in Anesthesia and Pain Therapy: Imaging-guided and Traditional Techniques
by Danilo Jankovic Philip PengThis comprehensive atlas, which includes a wealth of illustrations and anatomic pictures created by the editors, covers a broad range of both regional anesthesia and pain intervention techniques, including neuromodulation. The book is unique in that it covers ultrasound and fluoroscopic-guided techniques, as well as traditional landmark-guided techniques. The authors and editors are internationally renowned experts, and share extensive theoretic and practical insights into regional anesthesia, pain therapy and anatomic sciences for everyday practice.The book addresses the application of ultrasound and fluoroscopic guidance for pain interventions and provides detailed coverage of ultrasound-guided and landmark-guided regional anesthesia. The book represents a detailed guide to the application of regional anesthesia and pain medicine; furthermore, examples of medico-legal documentation are also included in this edition. The 5th edition of Regional Nerve Blocks in Anesthesia and Pain Medicine is practically oriented and provides essential guidelines for the clinical application of regional anesthesia. It is intended for anesthesiologists and all professionals engaged in the field of pain therapy such as pain specialists, surgeons, orthopedists, neurosurgeons, neurologists, general practitioners, and nurse anesthetists.
Regionalized Management of Medicine (Translational Bioinformatics #17)
by Hui Shen Yiming Zeng Li Li Xiangdong WangThe Book mainly focuses on various aspects of regionalized management of medicine, related with updates of new biotechnology, application of therapeutic strategy, and understanding of disease-associated molecular mechanisms. The book also discusses how medical informatics, systems analysis, database sharing, and artificial intelligent can be applied for improving the quality of hospital managements, disease therapies, regional collaborations, and medical services. This book serves as a professional reference book to clinicians and experts who are interested in medical informatics and artificial intelligence for diseases therapies and therapeutic strategy, better systems analysis and database sharing, and more efficient regional collaborations and medical services.
Regionalizing Emergency Care: Workshop Summary
by Institute of Medicine of the National AcademiesDuring medical emergencies, hospital staff and emergency medical services (EMS) providers, can face barriers in delivering the fastest and best possible care. Overcrowded emergency rooms cannot care for patients as quickly as necessary, and some may divert ambulances and turn away new patients outright. In many states, ambulance staff lacks the means to determine which hospitals can provide the best care to a patient. Given this absence of knowledge, they bring patients to the closest hospital. In addition, because emergency service providers from different companies compete with each other for patients, and emergency care legislation varies from state to state, it is difficult to establish the necessary local, interstate, and national communication and collaboration to create a more efficient system. In 2006, the IOM recommended that the federal government implement a regionalized emergency care system to improve cooperation and overcome these challenges. In a regionalized system, local hospitals and EMS providers would coordinate their efforts so that patients would be brought to hospitals based on the hospitals' capacity and expertise to best meet patients' needs. In September 2009, three years after making these recommendations, the IOM held a workshop sponsored by the federal Emergency Care Coordination Center to assess the nation's progress toward regionalizing emergency care. The workshop brought together policymakers and stakeholders, including nurses, EMS personnel, hospital administrators, and others involved in emergency care. Participants identified successes and shortcomings in previous regionalization efforts; examined the many factors involved in successfully implementing regionalization; and discussed future challenges to regionalizing emergency care. This document summarizes the workshop.
Registered Health Information Technician (RHIT) Exam Preparation Sixth Edition
by Darcy Carter Patricia ShawConfidently prepare for the RHIT exam with Registered Health Information Technician (RHIT) Exam Preparation. The exam experience is simulated in this textbook with 850 multiple choice questions, including two complete practice exams based on the RHIT competency statements. Whether you're still learning or ready to test your skills immediately, RHIT Exam Preparation will help prepare you for exam day.
Registered Health Technician (RHIT) Exam Preparation, Fifth Edition
by Darcy Carter Patricia ShawThis book contains 550 multiple choice practice questions and two complete practice exams of 150 questions each that are organized by the RHIT domains.
Registerial Expertise in Traditional Chinese Medical Translation (Routledge Studies in Language, Health and Culture)
by null Yan YueYue’s book explores the nature of translation using traditional Chinese medicine (TCM) and the TCM classic Huangdi Neijing and its various translations. Yue examines in great detail and depth the important factors that cause the differences in the translators’ treatment of language indeterminacies. Apart from having multi-faceted and fine-grained linguistic analysis, this book also serves as a good model of methodology, in terms of corpus building, contrastive analysis, exemplification, and glossing following systemic functional linguistics (SFL) convention. This book is an argument for greater emphasis on the linguistic notion of register in translator’s expertise, specifically in the way that professional experience and training – with their registerial demands – may be the key to semantic decisions forced on a translator by the inevitable vagaries and indeterminacies of establishing a working “equivalence” across languages and cultures and deep time. It probes the issue in an extreme case: the debate over who is the “ideal” translator in Chinese medicine translation through various case studies. The result suggests it is possible to demonstrate, empirically, that clinical experience in translators is likely to have consistent, or even measurable, consequences.This book will be of interest to three different fields: translators in training, applicable systemic functional linguistics, and traditional Chinese medicine communication.
The Registrar's Wedding Wish
by Lucy ClarkA knight in Geelong GeneralAnnie Beresford is a talented surgeon and trainee consultant. But her wish is for marriage and children before it's too late. She knows she's vulnerable, and that falling for Hayden Robinson, her new boss, is a bad idea. But this man might just be the one!Hayden rescues her more than once, and his desire for her is clear, but after one failed marriage he'd rather focus on saving lives. So Annie must help her reluctant knight because she comes to realize they can't be happy without each other--even if he won't believe her yet!
Registreren aan stem, spraak en taal: Deel 9 - Handboek Stem-, Spraak- en Taalpathologie
by R. Bastiaanse J. Borsel P.H.O. Dejonckere K. Jansonius-Schultheiss Sj. Meulen B.J.E. Mondelaers H.F.M. PetersHet Handboek Stem-Spraak-Taalpathologie verscheen tussen 1997 en 2007 gefaseerd in losse afleveringen. Daarin werd alle kennis op het gebied van de stem-, spraak- en taalpathologie vanuit verschillende disciplines samengebracht. Het Handboek is bestemd voor iedereen die klinisch-praktisch of meer theoretisch is geïnteresseerd, of vanuit een ander vakgebied hiermee in aanraking komt. Voor logopedisten, artsen, linguïsten, spraak- en taalpathologen, audiologen, pedagogen en psychologen in Nederland en België is het Handboek een onmisbare vraagbaak.Deel 9 gaat over het meten van stem, spraak en taal, waarbij een onderscheid wordt gemaakt tussen (objectieve) instrumentele metingen en (subjectieve) perceptuele metingen.
Regression: Models, Methods and Applications
by Brian Marx Ludwig Fahrmeir Stefan Lang Thomas KneibThe aim of this book is an applied and unified introduction into parametric, non- and semiparametric regression that closes the gap between theory and application. The most important models and methods in regression are presented on a solid formal basis, and their appropriate application is shown through many real data examples and case studies. Availability of (user-friendly) software has been a major criterion for the methods selected and presented. Thus, the book primarily targets an audience that includes students, teachers and practitioners in social, economic, and life sciences, as well as students and teachers in statistics programs, and mathematicians and computer scientists with interests in statistical modeling and data analysis. It is written on an intermediate mathematical level and assumes only knowledge of basic probability, calculus, and statistics. The most important definitions and statements are concisely summarized in boxes. Two appendices describe required matrix algebra, as well as elements of probability calculus and statistical inference.
Regression Analysis in Medical Research: for Starters and 2nd Levelers
by Ton J. Cleophas Aeilko H. ZwindermanRegression analysis of cause effect relationships is increasingly the core of medical and health research. This work is a 2nd edition of a 2017 pretty complete textbook and tutorial for students as well as recollection / update bench and help desk for professionals. It came to the authors' attention, that information of history, background, and purposes, of the regression methods addressed were scanty. Lacking information about all of that has now been entirely covered. The editorial art work of the first edition, however pretty, was less appreciated by some readerships, than were the original output sheets from the statistical programs as used. Therefore, the editorial art work has now been systematically replaced with original statistical software tables and graphs for the benefit of an improved usage and understanding of the methods. In the past few years, professionals have been flooded with big data. The Covid-19 pandemic gave cause for statistical software companies to foster novel analytic programs better accounting outliers and skewness. Novel fields of regression analysis adequate for such data, like sparse canonical regressions and quantile regressions, have been included.
Regression Analysis of Survival Data in Cancer Chemotherapy (Statistics: A Series of Textbooks and Monographs)
by Walter H. Carter Jr. Galen L. Wampler Doanld M. StableinThis book presents ideas and procedures for regression analysis of survival data in cancer chemotherapy based on regression-based approaches for improvements in the quality of care through the effective location of optimal treatment levels. It is useful for cancer chemotherapists.