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Renal Cell Carcinoma
by Mototsugu OyaRenal Cell Carcinoma: Molecular Features and Treatment Updates provide a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. The United States Food and Drug Administration has approved four tyrosine-kinase inhibitors (TKIs), including sorafenib, sunitinib, pazopanib and axitinib and two mTOR inhibitors, including everolimus and temsirolimus. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.
Renal Cell Carcinoma
by Brian I. Rini Robert A. Figlin W. Kimryn RathmellThis book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma.
Renal Denervation: Treatment and Device-Based Neuromodulation
by Richard R. Heuser Markus P. Schlaich Dagmara Hering Stefan C. BertogThis extensively revised edition examines renal pathophysiology and the rationale for renal denervation for the management of hypertension, as well as possible long-term benefits and risks of this therapy. Renal denervation is a minimally invasive, endovascular catheter-based procedure that makes use of radiofrequency ablation to treat resistant hypertension, with studies showing a high degree of effectiveness. The devices involved in the continued evolution of this therapy are discussed and the book incorporates analyses of the development of the technique while evaluating its cost effectiveness and future applications. Renal Denervation: A New Approach to Treatment of Resistant Hypertension describes the technique in detail, its advances and its pitfalls. While it has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension, hypertension remains the leading cause of cardiovascular morbidity and mortality thus strengthening arguments to consider a wider range of potential solutions to manage these patients.
Renal Denervation
by Richard R. Heuser Markus Schlaich Horst SievertHypertension remains the leading cause of cardiovascular morbidity and mortality in spite of current medical therapies. It has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension. Renal denervation (RDN) is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation aimed at treating resistant hypertension. Early studies show a high degree of effectiveness in renal denervation to treat hypertension. This book examines renal pathophysiology and the rationale for renal denervation, as well as possible long term benefits and risks of this new therapy. The myriad of devices involved in the evolution of this therapy are discussed and the book concludes with analyses of the cost effectiveness and future applications.
Renal Diet Cookbook for Caregivers: Recipes, Tips, and Meal Plans to Manage Kidney Disease Together
by Emily Campbell RD, CDE, MScFNRecipes to help you manage chronic kidney disease for your loved one When your loved one has chronic kidney disease (CKD), adopting a renal health-focused diet with them can help you both live life to the fullest. Featuring 75 flavor-packed renal diet recipes, each one optimized for the various stages of CKD, this cookbook sets the two of you up for long-term success. What sets this renal diet cookbook apart: Caregiver guidance—Learn about the five stages of CKD, the dos and don'ts of a proper diet, and ways that you, as a caregiver, can advocate for your loved one. Introductory plans—Get started with sample menus that guide the two of you through every meal for an entire week. Key nutrition facts—Each recipe includes detailed serving size and nutrition info, ensuring you serve up properly balanced plates. Ensure you are taking care of your loved one with this standout kidney disease diet cookbook.
Renal Disease
by Michael S. GoligorskyLeading experts distill their extensive experience into user-friendly methods for the study of fluid-electrolyte homeostasis and kidney function in health and disease. Described in step-by-step detail, the techniques move from the molecular level to the whole organism, from simple models to integrative physiology. Here the researcher will find established disease models, methods for optimizing renal disease research, as well as much help in choosing imaging techniques for studies of the kidney's structure and function in health, disease, and during embryonic development. Subjects covered include molecular diagnostics, strategies for studying the molecular mechanisms of kidney disease, technical means to assess the functional correlates of disease, and the planning of clinical trials.
Renal Disease in Pregnancy (Royal College Of Obstetricians And Gynaecologists Study Group)
by Catherine Nelson-Piercy Kate Bramham Matt HallWith higher risks to mother and baby in pregnant women with renal disease, critical decision-making is key. <P><P>Giving practical guidance for antenatal, post-partum and maternity unit challenges, this book supports good practice and evidence-based management. <P>The book includes evidence on antenatal and post-partum care; management of acute kidney injury in the delivery suite; and care guidelines for acute, chronic, and previously undiagnosed kidney diseases. The book also covers acute kidney injury, transplant, dialysis, pre-conception counselling, and medications. Previously published by RCOG, this revised edition includes: • Updated expert consensus statements • Complete revision, with a new chapter on contraception • Updates in management of acute kidney injury, hypertension, dialysis and pregnancy, renal transplantation and pre-eclampsia. Structured to help clinicians make decisions, this book is for use by obstetricians, renal physicians, maternal medicine clinicians, midwives, urologists and specialist nurses.<P> With updated expert consensus guidelines from obstetrics and nephrology, the book provides reliable and up-to date guidance for the care of pregnant women with kidney disease.<P> Covers all aspects of pregnancy, from antenatal to post-partum care as well as delivery suite management, for those caring for women with acute, chronic, and previously undiagnosed kidney diseases.<P> Revised to include a new chapter on contraception, and updates in the management of hypertension, dialysis and pregnancy, renal transplantation and pre-eclampsia.
The Renal Drug Handbook: The Ultimate Prescribing Guide for Renal Practitioners, 5th Edition
by Caroline Ashley Aileen DunleavyThis invaluable guide, endorsed by the UKMi and reflecting the extensive experience of the UK Renal Pharmacy Group, features drug monographs guiding physicians in how to prescribe, prepare, and administer drugs to patients with different levels of kidney function and when undergoing renal replacement therapy. It has been fully updated for this fifth edition to include up to 100 additional drugs, while maintaining the clear structure and format that is easy to use and simple to follow in the busy clinical setting. It continues to offer support and guidance to health care professionals enabling them to prescribe medications to their renal patients appropriately and safely.
Renal Fibrosis: Mechanisms and Therapies (Advances in Experimental Medicine and Biology #1165)
by Bi-Cheng Liu Hui-Yao Lan Lin-Li LvThis book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
Renal Mass Biopsy: Indications, Risks, Technical Aspects and Future Trends
by Raymond J. Leveillee Merce JordaThis text presents a comprehensive and state-of-the-art approach to renal mass biopsy, and reviews current techniques for obtaining samples, proper tissues processing, indications for biopsy, and treatment outcomes. Sections address preliminary issues faced by urologists, pathologists, interventional radiologists, oncologists, and nephrologists who may be initially reconsidering the role for RMB including clinical decision making, financial considerations, misconceptions, sampling errors, and understanding limitations. Basic techniques and set-up, navigational tools, and tips and tricks to maximize sampling and avoid complications is also included. Sections also address patient selection, pre-biopsy considerations, technical aspects of the most common techniques and equipment, and image guidance systems. Pathological considerations include role of fine needle aspirations, touch preparation, core biopsies, immunohistochemistry, and classification schemata. The text concludes with chapters on future directions and improvements in diagnostic imaging, future developments in optical biopsies (confocal microscopy), and ancillary studies on renal masses. Written by experts in the field of urology and pathology, Renal Mass Biopsy is your go to resource for techniques and outcomes for the treatment of renal masses.
Renal Medicine and Clinical Pharmacy (Advanced Clinical Pharmacy - Research, Development and Practical Applications #1)
by Rhiannon BraundThis first volume of an exciting new book series offers a comprehensive and logically organized introduction to clinical pharmacy as applied to renal medicine. The volume opens with a review of renal pharmacokinetics: absorption; distribution; metabolism; and elimination, as well as drug dosing in renal impairment, and important knowledge specific to aging and renal impairment. Acute kidney injury receives extensive attention, including pre-renal, intra-renal, and post-renal injuries. The book also outlines the role of clinical pharmacy in chronic kidney disease and end stage renal failure. Additional chapters provide detailed information on the methods and pharmacokinetics of renal dialysis, and the epidemiology and management of drug-induced nephrotoxicity. The Advanced Clinical Pharmacy series provides a review of core pharmaceutical concepts, a foundation for optimizing pharmacotherapy, and an introduction to advanced clinical practice. The editors and contributors are international experts who distill the core knowledge of each specialty. The books offer real-world insights to benefit both new practitioners, and experienced pharmacists exploring new areas of clinical pharmacy
Renal Neoplasms
by Tatjana Antic Jerome B. TaxyRenal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.
Renal Nursing: A Guide to Practice
by Bobbee TerrillThis book explores the emotional problems patients relatives close friends and professionals experience and the support they need when someone is dying. It focuses on the skills required to support the patient and to provide pre- and post-bereavement counselling for relatives. Clear and easy to read the book is based on the author's previous work but now includes valuable new insights from her recent research in this field and is illustrated with examples from her practical and international experience. It emphasises practical communication skills that can be applied in everyday working practice. It encourages readers to reflect on their own practice strengths and weaknesses and their contribution to the multi-professional team. Questions and exercises at the end of each chapter encourage reflection discussion and learning. This is a book that all health professionals will find of great benefit especially those working in palliative and terminal care hospices and nursing homes. It is of particular use to members of nursing teams. It will also be of interest to patients and relatives who are close to a dying person.
Renal Nursing: Care and Management of People with Kidney Disease
by Nicola ThomasNow in its fifth edition, Renal Nursing continues to be the essential evidence-based guide to nephrology and kidney care for nurses and allied health care professionals. This comprehensive text examines the stages of chronic kidney disease, pre-dialysis care, acute kidney injury, renal replacement therapy, renal nutrition, renal care in children and young people and more. Offers thorough coverage of all major aspects of kidney care Includes updated content on current practice, changes in policies, care and management, with the latest research evidence and current NICE guidance on renal replacement therapy Has an innovative chapter on patient and public involvement in kidney care Renal Nursing is an indispensable resource for nurses working in nephrology, dialysis and transplantation, nurses in post-registration renal courses, student nurses in renal wards, specialist renal dietitians, pharmacists and other allied health professionals in related fields.
Renal Nursing
by Nicola ThomasRenal Nursing is a comprehensive evidence-based guide to nursing in the field of nephrology and kidney care. This fully updated fourth edition discusses the stages of chronic kidney disease, prevention and early management, pre-dialysis care, haemodialysis and peritoneal dialysis, transplantation, investigations and nutrition. It also includes key information on renal care in infancy, childhood and early adolescence. The underlying anatomy, physiology and psychology of kidney disease are reviewed in depth, along with the skills and knowledge required to provide support, treatment and high-quality care. Special features: Fully grounded in the NHS National Service Framework for renal services New chapter on patient involvement in renal care Content and references fully updated to reflect changes in policies, evidence, care and management Begins with the basics and covers all the vital material required by anyone working in renal care Renal Nursing is an ideal reference text for nurses undertaking post-registration renal courses, student nurses undertaking a placement in a renal ward, specialist renal dietitians, pharmacists and other professions allied to medicine.
Renal Nursing: Care and Management of People with Kidney Disease
by Nicola Thomas Helen NobleRENAL NURSING Now in its Sixth Edition, Renal Nursing continues to be the essential evidence-based guide to the care of people with kidney disease, updated to reflect the latest changes in practice, policy, care, and management. This text is a valuable resource, covering all the essential topics for this specialty in one place so that readers do not have to dig through a multitude of articles and research in various places. The text is written by leading experts in their field, using clear and simple language that is easy to follow and supplemented with full-colour illustrations to aid understanding. Readers of Renal Nursing will find: The latest research evidence and current NICE guidance on chronic kidney disease and renal replacement therapy Anatomy, physiology and investigations in kidney care, as well as chapters on emotional wellbeing and patient/carer involvement Acute kidney injury, chronic kidney disease, advanced kidney care, haemodialysis, peritoneal dialysis, and transplantation Non-dialytic options and the role of palliative care, children and young people in kidney care, and renal nutrition Offering thorough coverage of all major aspects of kidney care, Renal Nursing is an ideal reference text for nurses undertaking post-registration renal courses, student nurses undertaking a placement in a kidney ward, specialist renal dietitians, pharmacists, and other healthcare professions.
Renal Pathophysiology: The Essentials
by Helmut Rennke Bradley M. DenkerUp-to-date, easy-to-read, and rich with dynamic visual aids and engaging learning resources, Renal Pathophysiology: The Essentials, 6th Edition, helps you develop a confident understanding of the complex mechanisms that cause kidney dysfunction and disease. This case-based approach grounds renal disease in realistic scenarios that open each chapter and are accompanied by learning objectives and integrated open-ended questions to reinforce your mastery of the material and challenge you to apply what you’ve learned. Updated with the latest clinical advances and research as well as new cases, questions, and online tools, this 6th Edition makes difficult concepts approachable and helps you establish a foundation for success in clinical practice.
Renal Pathophysiology: The Essentials
by Helmut G. Rennke Bradley M. DenkerPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Renal pathophysiology can be a difficult subject even for the most advanced medical students. This Fifth Edition of Renal Pathophysiology: The Essentials provides an easy-to-read, case-based approach to learning the mechanisms of renal disease. Each chapter focuses on a mechanism of kidney disease and includes an opening case, learning objectives, integrated open-ended questions, and chapter-ending summaries. This new edition has been updated with the latest clinical advances and research on renal disease and is supported with many full-color illustrations and photomicrographs, suggested readings, and online review questions to reinforce learning.
Renal Pharmacotherapy
by Tyree H. Kiser Dimitriy A. Levin Larry K Golightly Isaac Teitelbaum Nancy M. Stolpman Michael A. Jones Gerard R. Barber Katherine S. LundinAs the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes. This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.
Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidneys
by Tyree H. Kiser Isaac Teitelbaum Nancy M. Stolpman Gerard R. Barber Larry K. Golightly Bonita A. SimendingerTo promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function. Failure to enjoin appropriate dosage adjustments in patients with abnormal or rapidly changing kidney function continues to lead to reports of drug toxicity involving a broad array of renally eliminated medications.This updated edition captures nearly 200 new drugs that have been approved by the FDA since the initial publication of Renal Pharmacotherapy. It also covers new evidence that has emerged regarding the need to adjust dosage of certain older medications that are eliminated by the kidneys. Additionally, it presents new data that are being continuously derived in the areas of patient-specific dose individualization for drugs of all types.Comprehensive, convenient, and evidence-based, this reference closes several identified knowledge gaps and will continue to be the leading collection of dosage recommendations for patients with compromised kidney function.
Renal Physiology and Hydrosaline Metabolism
by Pedro A. Gallardo Carlos P. VioThis volume discusses renal function and the mechanisms by which the kidney regulates the composition and volume of the extracellular fluid. It also highlights the role of the kidney in the development and progression of arterial hypertension. Most textbooks of renal physiology are based in mammalians physiology and mostly human physiology of the kidney, but the authors considered that this book should also include other species to include the broad spectrum of students and researchers in the life and biomedical sciences. In this sense, we included chapters such as comparative osmoregulation in non-mammalian vertebrates and we emphasize that in vertebrates like fish, reptiles, amphibians and birds, the kidneys and extrarenal organs are vital to maintain fluid homeostasis. The purpose of the book is to provide a concise frame of knowledge in a clear and direct language, of the renal function to medical and biological sciences students. In the context of normal renal function, we provide pathophysiological basis for chronic renal diseases and hypertension with the participation of renal vasoactive hormones. This book is used as textbook in several physiology courses for medical, nursing and biological sciences students at the Pontifical Catholic University of Chile, Finis Terrae University, Universidad San Sebastian as well as other universities.
The Renal System (Peate's Body Systems)
by Ian PeatePEATE’S BODY SYSTEMS THE RENAL SYSTEM A CONCISE, ILLUSTRATED, AND ACCESSIBLE GUIDE TO THE RENAL SYSTEM Each of the twelve volumes in Peate’s Body Systems series is rooted in the belief that a deep and thorough understanding of the human body is essential for providing the highest standard of care. Offering clear, accessible and up-to-date information on different body systems, this series bridges the gap between complex scientific concepts and practical, everyday applications in health and care settings. This series makes for an invaluable resource for those committed to understanding the intricacies of human biology, physiology and the various systems that sustain life. The Renal System is the perfect companion for students and newly registered practitioners across nursing and allied health fields with an interest in renal care, providing a comprehensive yet easy-to-digest guide for both academic and clinical application. Equips healthcare students and practitioners with the necessary information to provide safe and competent care Features colourful illustrations to aid comprehension, clarify complicated concepts, and render content more engaging and accessible Empowers readers to adapt to a rapidly evolving healthcare landscape, preparing them for the future of healthcare delivery Contains information necessary for effective patient care of those with chronic and acute kidney disease, urinary tract infection, and other renal diseases and conditions
The Renal System at a Glance
by Christopher O'CallaghanThe Renal System at a Glance is a highly illustrated and practical guide to the structure and function of the kidney, renal, and urinary system. It also covers related disorders and abnormalities and their treatment. Fully updated to reflect the many exciting new developments in the understanding of nephrology, this new edition has been restructured to better integrate basic science and clinical examples to the medical school curricula. New chapters on glomerular filtration and global kidney medicine are included, while the latest guidance and approaches to acute kidney injury, chronic kidney diseases, and renal replacement therapy have also been incorporated. The Renal System at a Glance: Offers clear explanations on tricky topics such as electrolytes, fluid balance and acid-base handling Features new sections on glomerular filtration, and a new chapter on the global differences in kidney problems Includes cross-referencing between basic science and related clinical content Focuses on clinical disorders and investigations - ideal for those embarking on medicine rotations Illustrates each topic in a double page spread, complete with charts, graphs, and photographs This new edition is the perfect guide for medical students, junior doctors, and allied health professionals, including specialist nurses, who wish to learn, or refresh their knowledge, on the kidney and renal system in health and disease.
Renal Tubular Acidosis in Children: New Insights in Diagnosis and Treatment
by Ricardo MuñozThis book is a compilation of scientific knowledge regarding the clinical entity known as “Renal Tubular Acidosis in Children” (RTA). It contains the information needed to comprehend the intricate mechanisms of acid-base metabolism, electrolyte imbalance, and complications related to renal tubular acidosis in the pediatric age group, since the acid-base physiology and the clinical disorders associated with it in children are quite different from the adult counterpart. The chapters, written by authors, experts in the field, describe systemic and renal physiology, electrolyte alterations, as well as the pathogenesis and chromosomal mutations leading to the development of RTA. The reader will find the latest information on diagnostic tools and learn how to approach diagnosis, avoiding improper treatment, rickets, nephrocalcinosis, and renal failure. In addition, new insights on classification, the clinical presentation of each type of RTA, molecular biology, and transmembrane protein transporters are covered. This work is primarily directed at pediatric nephrologists and pediatricians. Nevertheless, general practitioners, medical students, residents and fellows at different medical training programs, and other health care professionals of nutrition, growth and development, gastroenterology and endocrinology may surely benefit from it.
Renal Tumors of Childhood
by Kathy Pritchard-Jones Jeffrey S. DomeThis book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.