- Table View
- List View
Resistance Behavior to National eHealth Implementation Programs
by Philipp KlöckerThis monograph discusses challenges faced during the implementation of national eHealth programs. In particular, it analyzes the causes of stakeholders' reluctance to adopt these technologies by drawing on user resistance theory and context specific variables. Taking the example of the introduction of the electronic health card (Elektronische Gesundheitskarte - eGK) technology in Germany, the book presents insights into why these programs are often lengthy, costly and have previously been met with fierce resistance from key stakeholders. It also presents a quantitative and qualitative study of individual physicians' resistance behavior towards these new eHealth technologies.
Resistance of Cancer Cells to CTL-Mediated Immunotherapy
by Benjamin Bonavida Salem ChouaibThis comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.
Resistance of Targeted Therapies Excluding Antibodies for Lymphomas
by Andrés J. FerreriIn the last decade, the literature on molecular mechanisms and activated pathways in the different lymphoma categories increased exponentially, which was followed by a more diffuse and successful use of targeted therapies. In this book, expert authors revisit the most relevant aspects of these therapies, with special emphasis on molecular mechanisms and clinical effects of resistance. The knowledge of the underlying mechanisms involved in tumor resistance to target therapies is of paramount importance because they will result in a better selection of patients with sensitive disease and the establishment of suitable combinations of drugs that target different molecules and could overcome the established resistance.
The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment
by Forum on Emerging InfectionsThe resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. "The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.
Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways (Resistance to Targeted Anti-Cancer Therapeutics #15)
by Yosef Yarden Moshe ElkabetsThis volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.
Resistance to Aromatase Inhibitors in Breast Cancer
by Alexey LarionovAromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.
Resistance to COVID-19 Vaccination: Drivers, Impact on Human Wellbeing, and Policy Implications (Human Well-Being Research and Policy Making)
by Stephanie Rossouw Talita GreylingThis book presents advanced methodologies for analyzing attitudes towards the COVID-19 vaccine across 10 countries spanning both the Northern and Southern hemispheres, employing cutting-edge Big Data and Fourth Industrial Revolution (4IR) techniques. Serving as an important resource for policymakers, it addresses attitudes towards and causes of growing vaccine hesitancy —a pressing concern identified by the World Health Organization as a top 10 global health threat. Moreover, the book sheds light on key factors associated with positive vaccine attitudes, aiming to bolster vaccine uptake rates. The authors explore the role of happiness in shaping health-related decision-making, offering actionable policy recommendations for governments. By sharing best-case practices, they equip policymakers and health officials worldwide with the necessary strategies to address future pandemics effectively.
Resistance to Ibritumomab in Lymphoma (Resistance to Targeted Anti-Cancer Therapeutics #18)
by Makoto Hosono Jean-François ChatalThis volume, in discussing resistance to ibritumomab, will focus on the mechanism, hematological aspects, radiological and nuclear medicine aspects, and medical physics that deal with radiation dosimetry, and will outline future prospects for overcoming resistance and enhancing efficacy of ibritumomab.
Resistance to Immunotherapeutic Antibodies in Cancer: Strategies to Overcome Resistance
by Benjamin BonavidaThe traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.
Resistance to Immunotoxins in Cancer Therapy
by Rama Shanker Verma Benjamin BonavidaThis book will be a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.
Resistance to Molecular Therapies for Hepatocellular Carcinoma
by Augusto VillanuevaThis volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
Resistance to Photodynamic Therapy in Cancer
by Valentina Rapozzi Giulio JoriThis volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
Resistance to Proteasome Inhibitors in Cancer
by Q. Ping DouThe book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e. g. , ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.
Resistance to Targeted ABC Transporters in Cancer
by Thomas EfferthThis critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.
Resistance to Targeted Therapies Against Adult Brain Cancers
by Amanda TivnanThis volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Resistance to Targeted Therapies in Lymphomas (Resistance to Targeted Anti-Cancer Therapeutics #21)
by Ana C. Xavier Mitchell S. CairoOver the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.
Resistance to Targeted Therapies in Multiple Myeloma (Resistance to Targeted Anti-Cancer Therapeutics #22)
by Silvia Cw Ling Steven TrieuMultiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
Resistance Training for the Prevention and Treatment of Chronic Disease
by Joseph T. Ciccolo William J. KraemerCurrent evidence supports the use of resistance training as an independent method to prevent, treat, and potentially reverse the impact of numerous chronic diseases. With physical inactivity one of the top risk factors for global mortality, a variety of worldwide initiatives have been launched, and resistance training is promoted by numerous organisations. An evidence-based guide, this book presents an in-depth analysis of the independent and positive effects of resistance training on the prevention, management, and treatment of many chronic conditions. Written by some of the world's leading exercise physiologists and resistance training experts, the chapters provide detailed descriptions of the benefits of resistance training for specific clinical populations, including guidelines on how to construct a tailored resistance training prescription. Chapters cover resistance training to treat cardiovascular disease, metabolic diseases, cancer, orthopedic diseases, neuromuscular disorders, and more.
Resistance Training Methods: From Theory to Practice (Lecture Notes in Bioengineering)
by Alejandro Muñoz-López Redha Taiar Borja SañudoThis book reviews the main principles of resistance training, from basics to modern insights. It includes practical ways to develop most of the strength training methods, including monitoring and testing procedures. It merges practical tips with knowledge about the scientific background concerning program and periodization. It describes procedures for special populations, such as elderly or women.Gathering contributions by authoritative researchers and professors in the fields of sport science and biomechanics, this book provides an integrated view of strength training programming, and describes the most important biological factors associated with this type of training. The evidence-based and detailed description of each single mechanism to be trained to enhance performance is covered in depth. Thanks to its strong academic background, an being self-contained, this book offers a valuable reference guide for advanced undergraduate and graduate students in sports science, as well as an inspiring guide for sport and health researchers and professional trainers alike.
Resistant
by Michael PalmerThey fight without conscience or remorse. Their only job is to kill. They are the most ruthless enemy we have ever faced. And they are one millionth our size. When Dr. Lou Welcome fills in last minute for his boss at a national conference in Atlanta he brings along his best friend, Cap Duncan. But an accident turns tragic when Cap injures his leg while running. Surgeons manage to save the leg, but the open wound is the perfect breeding ground for a deadly microbial invader committed to eating Cap alive from the inside out. Meanwhile, hundreds of miles away, a teenaged girl is fighting for her life against the same bacteria. The germ is resistant toany known antibiotic and the government scientist tasked with finding a cure has been kidnapped. Turning to the Centers for Disease Control for help, Lou Welcome uncovers a link to a shadowy group known as One Hundred Neighbors that has infiltrated our society and is using our health institutions as hostages. Like the deadly germs they can unleash, One Hundred Neighbors will stop at nothing to further their agenda. From the hospital corridors where anything you touch can mean your end, to the top corridors of power in this race against time, Lou must stop an epidemic, save his best friend, and face even his own most terrifying demons. From the New York Times bestselling author comes another heart stopping thriller that will make you look at the world around you in a new and frightening way.
Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment
by Giuseppe ManciaA growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors. This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.
Resistant Hypertension
by Massimo SalvettiThis book is designed to assist physicians in the everyday management of hypertensive patients, with a particular focus on difficult-to-treat and resistant hypertension. The selected clinical cases are representative of the patients who are seen in the real world, rather than rare clinical cases, and provide examples of management according to current international guidelines. The scenarios considered include not only cases in which arterial hypertension is truly resistant but also instances of pseudo-resistant hypertension, including cases in which resistance is related to comorbidities, concomitant treatments, or the use of drugs. The ultimate objective is to provide paradigmatic examples of evidence-based approaches to difficult-to-treat patients that will help physicians to select the most appropriate diagnostic tools and evidence-based treatment strategy for each individual patient. "
Resistant Hypertension in Chronic Kidney Disease
by Adrian Covic Mehmet Kanbay Edgar V. LermaThis comprehensive volume provides a detailed review on the general work up of chronic kidney disease-associated resistant hypertension. This title is separated into four parts; the first of which provides definitions, epidemiology, characteristics, risk stratification and outcomes of resistant and apparent treatment resistant hypertension. The next two sections explore pathophysiology and diagnosis, treatment in the light of new guidelines, as well as procedures and devices for neural modulation. Part four discusses public health approaches to resistant hypertension, educational programs, and resistant hypertension for general practitioners. Resistant Hypertension in CKD brings up-to-date information to nephrologists, internists, cardiologists and a wide array of other clinicians and health professionals taking care of chronic kidney disease patients.
Resisting Her Army Doc Rival
by Sue MacKayTwo military doctors face past trauma and guilt in order to heal their broken hearts—and move into the future together . . . Flirting with danger! Infuriating, irresistible army doc Sam Lowe is the last person Madison Hunter wants to work with. He challenges her, and soon the only thing hotter than their rivalry is their growing chemistry! But Maddy hides scars that tell a heartbreaking story, and Sam has his own emotional wounds. He’s determined to take his heart with him when he leaves the army base, yet as he starts to see beneath Maddy’s tough exterior, it becomes more and more clear that his heart belongs with her . . .
Resisting Her Rebel Doc
by Joanna NeilWorking beneath her bad-boy first love yields trouble for a beautiful doctor in this contemporary romance.Pediatrician Caitlin Braemar has moved back home to Buckinghamshire for a fresh start! She never expected to find her first love, Brodie Driscoll—who’s still drop-dead gorgeous—living next door . . . or that he’d be her new boss!In the past, Brodie always lived up to his bad-boy reputation, but as they work to save the little lives in their care, Caitlin starts to see Brodie in a whole new light!And it’s becoming clear that she might just be the woman to tame him . . .