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Reviews on New Drug Targets in Age-Related Disorders (Advances in Experimental Medicine and Biology #1260)
by Paul C. GuestAging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.
A Revised Consent Model for the Transplantation of Face and Upper Limbs: Covenant Consent (International Library of Ethics, Law, and the New Medicine #73)
by James L. BenedictThis book supports the emerging field of vascularized composite allotransplantation (VCA) for face and upper-limb transplants by providing a revised, ethically appropriate consent model which takes into account what is actually required of facial and upper extremity transplant recipients. In place of consent as permission-giving, waiver, or autonomous authorization (the standard approaches), this book imagines consent as an ongoing mutual commitment, i. e. as covenant consent. The covenant consent model highlights the need for a durable personal relationship between the patient/subject and the care provider/researcher. Such a relationship is crucial given the recovery period of 5 years or more for VCA recipients. The case for covenant consent is made by first examining the field of vascularized composite allotransplantation, the history and present understandings of consent in health care, and the history and use of the covenant concept from its origins through its applications to health care ethics today. This book explains how standard approaches to consent are inadequate in light of the particular features of facial and upper limb transplantation. In contrast, use of the covenant concept creates a consent model that is more appropriate ethically for these very complex surgeries and long-term recoveries.
Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept
by Panos Macheras Athanasios A. TsekourasThis book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.
Revision ACL Reconstruction: Indications and Technique
by Robert G. MarxAlthough anterior cruciate ligament (ACL) reconstruction has a success rate of 80-90%, a substantial number of patients are still left with unsatisfactory results. Revision ACL Reconstruction: Indications and Technique is a practical guide to the surgical techniques involved in the repair of failed or compromised ACL reconstructions. Concise chapters by a leading group of international orthopedic surgeons detail the basics of diagnosing a failed ACL reconstruction, imaging and preoperative planning for ACL revision surgery, and common causes of ACL reconstruction failures.
Revision Anterior Cruciate Ligament Reconstruction: A Case-Based Approach
by Michael J. Alaia Kristofer J. JonesAnterior cruciate ligament reconstruction is one of the most common procedures performed in sports medicine centers. However, these procedures can carry a long-term failure rate as high as 5-15%%, and when these procedures fail, revision is significantly more complex. Considerable factors need to be assessed in patients that are indicated for surgery, as revisions carry a higher failure rate and potentially less optimal outcomes and return to sport and activity. These factors include, but are not limited to, the status of the meniscus, overall alignment, graft options, placement of prior implants or tunnels, collateral ligament quality, and whether or not the revision must be staged into two procedures. This text provides a comprehensive, case-based presentation of the most efficient and practical treatment algorithms for patients in need of revision ACL repair and reconstruction. Opening chapters discuss the initial patient work-up, radiography, surgical indications, graft options, and pre-operative considerations and preparations. The main portion of the book then describes both common factors leading to revision surgery as well as the surgical techniques themselves, illustrated via plentiful operative photos and vivid clinical case material. The management of osteolysis, ligamentous laxity, extra-articular tenodesis, plane correction, and meniscus deficiency, among others, are discussed in detail. Special populations, such as the pediatric patient, the elite athlete and the female athlete, are discussed as well. Shedding light on this challenging surgical repair, Revision Anterior Cruciate Ligament Reconstruction is the go-to resource for sports medicine and orthopedic surgeons, knee specialists and residents and fellows in these areas.
Revision Guide for MRCPsych Paper A
by Elizabeth Templeton Richard William Kerslake Lisanne StockThis text covers the key information necessary to pass Paper A of the postgraduate examination to become a member of the Royal College of Psychiatrists (MRCPsych). It emphasises memory aids in the forms of diagrams or tables, a novel presentation of these materials, providing a quick and portable source for pre-exam revision and visual memory aids and prompts.
Revision in Sciences Basic to Ophthalmology (Medical Finals Revision Series)
by Raman Malhotra David EastyThis is a self-assessment book for candidates for postgraduate examinations in ophthalmology, principally the FRCOphth Part I. It covers all of the sciences fundamental to ophthalmology: anatomy (60 questions), physiology (93 questions), pharmacology (36), pathology (33) and microbiology (42). Questions are grouped according to specialty area, followed by true/false answers that are all supported with concise explanations. The book can therefore be used for learning as well as practice.The book's most innovative feature is the set of 21 structed essay plans, covering the major topics of concern in this field. It is notoriously difficult to provide model answers to essay questiosn, but here the authors have developed a new, highly visual approach with the consistent use of icons, to provide an at-a-glance understanding.
Revision MCQs and EMIs for the MRCPsych: Practice questions and mock exams for the written papers
by Basant K Puri Roger Ho Ian TreasdenThis new revision guide with over 1500 questions, reasoned answers and links to explanatory text gives a comprehensive range of multiple choice questions (MCQs) and extended matching items (EMIs). Complete with sample papers, this book provides everything you need for the written parts of the MRCPsych and comparable hi
Revision Notes for MRCPsych Paper 1
by Jawad SarahCompletely up-to-date with the current MRCPsych Paper 1 examination, this list-based revision guide provides comprehensive coverage of the syllabus. It offers a focused set of essential notes that create a solid knowledge base for the candidate, rather than relying only on MCQs and EMIs for self-testing. Individual chapters are dedicated to each of the main topics within the curriculum and the succinct, bullet-point format aids recall and offers a realistic and user-friendly method for retaining knowledge. Key points are presented in manageable portions fostering confidence and encouraging further investigation. Written by a current trainee, Revision Notes for MRCPsych Paper 1 provides the most closely linked and relevant guide for candidates. It is also a highly useful reference for all Royal College candidates and medical and nursing students wanting an accessible introduction to psychiatry.
Revision Notes for the DRCOG: A Textbook of Women's Health, Second Edition
by Jamila Groves Deena El-ShirbinyFirst published as Mastering the DRCOG, this highly acclaimed revision text has been completely updated and revised to follow the syllabus of the DRCOG examination. This book:Provides relevant content arranged in seven chapters, following the DRCOG curriculumDelivers useful information such as references to guidelines and researchPresents content r
Revision Notes in Psychiatry
by Basant Puri Annie Hall Roger HoRevision Notes in Psychiatry, Third Edition continues to provide a clear and contemporary summary of clinical psychiatry and the scientific fundamentals of the discipline. It is an essential study aid for all those preparing for postgraduate examinations in psychiatry and a superb reference for practising psychiatrists.Structured to follow the enti
Revision Questions for Paediatrics: EMQs with Answers Explained
by Olamide OrekunrinThis revision tool helps readers strengthen their existing knowledge of childhood disorders through Extended Matching Questions (EMQs) on topics frequently asked in Paediatrics examinations, ranging from neonatology to emergency medicine and public health. Detailed answers in each section build comprehension and knowledge. Many medical schools now examine undergraduates using EMQs, but they also feature highly in postgraduate examinations. This revision aid will therefore also be useful to those preparing for postgraduate examinations such as the Diploma of Child Health (DCH) and Membership of the Royal College of Paediatrics and Child Health (MRCPCH), as well as foundation doctors on their first paediatric rotations and all those wishing to consolidate their knowledge and understanding of Paediatrics.
Revision Shoulder Arthroplasty
by Francesco Franceschi George S. Athwal Alexandre Lädermann Edoardo Giovannetti de SanctisFilling an unmet need this book covers all relevant aspects of Revision Shoulder Arthroplasty. Edited by internationally renowned experts in the field it offers the reader solid theoretical and practical knowledge to address this complex surgical procedure.The chapters are grouped into seven sections each addressing a macro-topic: arthroplasty failure, pre-operative planning and operative techniques, the failed glenoid and humerus, infections, instability and soft tissue management, and surgical outcomes. This book offers a timely and up-to-date resource for shoulder surgeons wishing to deepen their knowledge of this complex and challenging procedure.
Revision Spine Surgery: Pearls and Pitfalls
by Alexander R. Vaccaro Gregory D. Schroeder Ali A. BaajRevision spine surgery requires a unique skill set different from performing a primary operation. Understanding when a simple revision is sufficient, when a more complex approach is needed, or when a non-surgical option should be considered is critical to good patient care and outcomes. In this first book to focus exclusively on the complex topic o
Revision Surgery of the Foot and Ankle: Surgical Strategies and Techniques
by Mark J. Berkowitz Michael P. Clare Paul T. Fortin Lew C. Schon Roy W. SandersThis unique text utilizes a bulleted, case-based approach to present a variety of surgical strategies and techniques for tackling the many challenges posed by revision foot and ankle surgery.The book is organized thematically into sections on the forefoot, trauma, sports injuries, and arthritis and reconstruction, with each chapter including key takeaway points, discussions of evaluation, surgical planning, and the cases themselves. Specific revision topics presented include first MTP joint fusion, failed bunion and hammertoe, failed Lisfranc and fifth metatarsal fracture, failed flatfoot and subtalar fusion, and nonunion of ankle fusion and failed total ankle replacement, among others. The challenge of revision foot and ankle surgery is that there are countless ways for a surgery to fail. Therefore, presenting as many different scenarios as possible and techniques to address them is the main advantage of the book. Practical and user-friendly, Revision Surgery of the Foot and Ankle will prove indispensable to both the young and veteran orthopedic surgeon preparing for these challenging surgical interventions.
Revision Total Hip Arthroplasty
by James V. Bono Eric L. SmithRevision total hip arthroplasty (THA) helps solve the reconstructive challenges facing surgeons today. This comprehensive text encompasses the necessary background and foundation for the reader to better understand the principles of revision THA, highlighting the preferred techniques and solutions of regional centers across the US that are known for excellence in revision THA. Across eleven thematic sections, this book presents modern techniques to solve common problems, with an emphasis on intra-operative and clinical photos. The opening section discusses general considerations and principles of revision THA, including the global burden, soft tissue balancing and biomechanics, and biomaterials. The next few sections cover evaluation, pre-operative planning and surgical exposures, then dive into acetabular, femoral and trochanteric reconstruction techniques. An entire section is dedicated to author-preferred techniques for managing instability, aseptic loosening, periprosthetic infection and fracture, corrosion, implant failure and more. The final sections discuss methods to minimize complications, unique considerations and special considerations for revision THA, from abductor tears to the role of physical therapy. This well-illustrated, state-of-the-art-text will prepare orthopedic surgeons of every level to solve unique and common etiologies of failed THA, making this a practical guide for every revision surgeon.
Revision Total Hip Arthroplasty: Approaches to THA Failure
by Yixin ZhouCompared with primary total hip arthroplasty, revision total hip arthroplasty is challenging due to more complicated pre-operative planning, longer operating time, more blood loss, more uncertainties during operation, and uncertainties in clinical outcome. This book presents up-to-date information on revision total hip arthroplasty covering different failures for primary total hip arthroplasty. Each chapter starts with the principles of diagnosis and treatment of specific THA failure mechanism, and then several typical cases. Each case includes history report, physical examination, laboratory test, radiology, failure mechanism, reconstruction strategy, operation record, post-operative follow-up, tips & tricks, and pitfalls. Written by experts with wealthy of clinical experience, it will be useful reference for arthroplasty surgeons, attending orthopedic surgeons, residents, attendants, and researchers and engineers from orthopedic industry.
Revision Total Joint Arthroplasty
by E. Carlos Rodríguez-MerchánThis comprehensive book is devoted to revision total joint arthroplasty and provides state-of-the-art guidance in a field where level-I evidence is difficult to produce.In the book’s respective sections, each of which focuses on a specific joint – the knee, hip, shoulder, elbow, or ankle – readers will learn how to manage these complex surgical techniques. Each section thoroughly describes the epidemiology, causes and surgical techniques, as well as clinical results and complications. Filling an important gap in a rapidly evolving field, this book will appeal to all healthcare workers involved in the care of affected patients, including orthopedic surgeons and fellows, rehabilitation specialists, pain physicians, podiatrists and nurses.
Revision Total Knee Arthroplasty
by James V. Bono Richard D. ScottEdited by two leading authorities in the field, this volume is a technique-oriented 'how-to' guide to an increasingly performed procedure, corrective surgery for the failed total knee arthroplasty. This book offers an in-depth, comprehensive approach for orthopedic surgeons, sports medicine specialists, and residents to revision total knee arthroplasty and its complications. More than 350 illustrations 60 in full color complement detailed descriptions of surgical procedures. This book offers clinical pearls on topics such as diagnosis and evaluation, pre-op planning and component selection, surgical approach, revision technique, post-op complications, and salvage all covered by top experts in the field. "
Revision Total Knee Arthroplasty
by James V. Bono Richard D. ScottNow in a fully revised and updated third edition, this comprehensive text covers all aspects of revision total knee arthroplasty (TKA), complete with step-by-step descriptions of surgical techniques. Sensibly divided into four thematic sections, part I discusses evaluation and diagnosis of the failed TKA, including imaging, updates on implant bearings, and rationale for reoperation. General principles of revision surgery are presented in part II, addressing skin and extensile exposure, component removal, allografts, metaphyseal sleeves and cones, femoral and tibial alignment, and restoration of stability. Part III presents the many special considerations that come into play with revision TKA, including periprosthetic fracture, infection, stiffness and other post-operative complications and complexities. The role of arthrodesis and the economics of revision TKA are also elucidated. A final, brand new section describes cutting edge topics for TKA in the near future, such as patient specific 3D implants, the use of robotics, and sensor and digital technology. Utilizing the most current evidence and generously illustrated, orthopedic surgeons, sports medicine specialists, residents and fellows alike will find Revision Total Knee Arthroplasty, Third Edition a thorough and informative resource when treating the patient following knee replacement surgery.
Revision Total Knee Arthroplasty: A Practical Guide
by Hosam E. Matar Benjamin V. Bloch Hugh U. Cameron Peter J. JamesThis book is a practically applicable guide to the use of revision total knee arthroplasty. Demand for primary total knee arthroplasty (TKA) continues to rise, with some estimates predicting this to be as high as 400% than it currently is, and this will inevitably lead to increased demand for revision surgery. Furthermore, this is a sub-specialist area of arthroplasty that is complex and challenging with high failure rates, meaning that there is a real need to improve the outcomes of these procedures. Within this book, the chapters focus on a particular subject area focusing on how to successfully perform a procedure in a step-by-step manner in a variety of scenarios from condylar revisions to salvage cases. Topics covered include how to use surgical techniques in instances of periprosthetic distal femur fractures and manage infections where bone loss has been significant. Long-term outcome data is also presented to enable the reader to develop a deep understanding of where a particular strategy might be most effective. Revision Total Knee Arthroplasty: A Practical Guide concisely details how to use the techniques covered in all aspects of revision knee surgery, making it an indispensable resource for all those involved in the care of these patients or who use these techniques in their day-to-day clinical practice.
Revisional and Reconstructive Surgery of the Foot and Ankle
by Thomas Zgonis Thomas S. RoukisComprehensive and highly illustrated, Revisional and Reconstructive Surgery of the Foot and Ankle is a problem-based guide for both orthopaedic and podiatric foot and ankle surgeons who perform revision surgeries for complications resulting from foot and ankle procedures. Edited by Dr. Thomas Zgonis, author of the well-regarded Surgical Reconstruction of the Diabetic Foot and Ankle, along with co-editor Dr. Thomas S. Roukis, this up-to-date reference provides authoritative, easy-to-follow guidance from recognized experts in the field.
Revisional Foregut Surgery
by Frank J. Borao Steven J. Binenbaum Gurdeep S. MatharooThis book is divided into 3 parts, each containing chapters that cover commonly encountered clinical scenarios of reoperative surgery. These parts include revisional bariatric surgery, reoperation for complications of bariatric surgery, and revisional anti-reflux and gastric procedures. The information covered discusses existing literature and best-practices in patient care, with a focus on operative technique, pitfalls, and post-operative complications. The aim of this book is to provide the reader with information on how to successfully manage a patient requiring reoperation. Chapters also highlight the difference in patient outcomes when the procedures are completed in a minimally invasive approach rather than an open approach.Revisional Foregut Surgery serves as a valuable resource for medical students, surgical residents, fellows, and attending surgeons seeking advice and guidance on reoperative upper gastrointestinal surgery and their related complications.
Revisionsendoprothetik Knie (Operationstechniken Orthopädie Unfallchirurgie)
by Markus Tingart Jörg Eschweiler Björn RathDieses Buch gibt einen Überblick über die Hauptversagensgründe von Knieprothesen und bietet in prägnanten Texten und Grafiken einen Leitfaden zur Indikationsstellung und zur operativen Durchführung von Revisionseingriffen am Kniegelenk. Der Schwerpunkt liegt dabei auf der Praxis: Schritt für Schritt wird das How to do beschrieben. Darüber hinaus vermitteln die Autoren zahlreiche Tipps und Tricks, die für einen erfolgreichen Operationsverlauf essentiell sind. Neben den brillanten Grafiken und Fotos illustriert und erläutert ein 10-minütiges Video alle entscheidenden Schritte am Beispiel eines exemplarischen Revisionseingriffes. So ist die Umsetzung der Theorie in die Praxis auf kurzem Weg möglich.
Revisiting Barrett’s Esophagus
by Giuseppe GalloroThis book focuses on Barrett’s Esophagus (BE), a clinical condition that must be evaluated in all patients affected by chronic GERD, and with an important link to esophageal cancer. Divided into four sections (morphological background, epidemiology and natural history, diagnosis, and treatments), this handy volume provides the latest indications regarding endoscopic approaches (first level and advanced endoscopy), pathological studies (pathology and molecular biology), and state-of-the-art therapeutic options (medical, endoscopic, and surgical) for BE. As such, it offers a valuable reference guide for all professionals involved in the management of BE (gastroenterologists, endoscopists, pathologists and surgeons), offering them a comprehensive overview and deeper understanding of this seemingly superficial disease.