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Rhinosporidiosis
by Nitin M. Nagarkar Rupa MehtaThis textbook covers all aspects of rhinosporidiosis known till date and puts forward the various aspects of the disease on which further research can be carried out. Detailed descriptions of varied presentations of rhinosporidiosis managed at our institute is provided, accompanied by numerous clinical and intraoperative photographs. This book will serve as a comprehensive source of information related to all aspects of rhinoporidiosis. Experts from multiple specialties have contributed about aspects pertaining to their specialties.
Rhinovirus: Methods and Protocols (Methods in Molecular Biology #2903)
by Umadevi SajjanThis volume details methods to detect Rhinovirus (RV) in clinical samples, propagation and purification of virus, in vivo and in vitro model systems, and the newer molecular tools that are useful for the studying the RV infection and pathogenesis. Chapters guide readers through a greater of understanding of RV pathogenesis in COPD, childhood asthma development and protective innate immunity. However, there is much to learn about RV infection in order to develop therapies to treat asthma and COPD exacerbations, prevent development of asthma and treat common colds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Rhinovirus: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Rhinoviruses
by David A. Jans Reena GhildyalRhinoviruses: Methods and Protocols highlights the numerous molecular, cellular and in vivo tools now available to conduct human rhinovirus (HRV) research in an effort to increase understanding of the clinical disease caused by HRVs as well as the functions of its individual proteins and its replication. Human rhinoviruses are the major cause of common colds as well as being more recently recognized as the major viral cause of asthma and chronic obstructive pulmonary disease (COPD) exacerbations. The huge advancements in technical applications of biophysics and improvements in high-end imaging techniques have also had implications for HRV research among other infectious diseases. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Rhinoviruses: Methods and Protocols seeks to serve both professionals and novices with the latest technical advances in HRV research to ultimately enable the development of therapeutic approaches to combat HRV, and most importantly, its pathogenic effects in asthma exacerbation.
RHIT Exam Secrets Study Guide
by Mometrix Exam Secrets Test Prep Team***Includes Practice Test Questions*** RHIT Exam Secrets helps you ace the Registered Health Information Technician Exam without weeks and months of endless studying.
Rhizosphere Biology: Interactions Between Microbes and Plants (Rhizosphere Biology)
by Anil K. Sharma Vadakattu V. S. R. GuptaThis book presents a detailed discussion on the direct interactions of plants and microorganisms in the rhizosphere environment. It includes fifteen chapters, each focusing on a specific component of plant-microbe interactions, such as the influence of plants on the root microbiome, and the downstream effects of rhizosphere microbial dynamics on carbon and nutrient fluxes in the surroundings. As such, the book helps readers gain a better understanding of diversity above the ground, and its effect on the microbiome and its functionality.
The Rho GTPases in Cancer
by Kenneth Van GolenThe Rho GTPases were first discovered due to their homology to Ras GTPase. Approximately 30% of human cancers harbor an activating mutation to Ras, and Ras mutations promote cell growth and survival. Due to their homology to Ras, great enthusiasm has ensued over the discovery of the Rho GTPases. It was thought that activating mutations, similar to what is seen in Ras, would be found in the Rho proteins and would account for a proportion of human cancers that did not harbor Ras mutations. After an intense survey of multiple human cancer specimens, no evidence of activating mutations were found. Instead, overexpression of Rho proteins and aberrant activation were found to be common. Aberrant activation of Rho GTPase is found to be caused by alterations in the activity of upstream Rho-regulatory proteins. Since their discovery, 22 human Rho proteins have been identified and several have been shown to be involved in cancer progression. In contrast to Ras and its closely related members, Rho proteins act as dynamic switches to alter the actin cytoskeleton. Because of this, these proteins regulate nearly all aspects of cell physiology including growth, polarity and migration. Thus, they are very important molecules in cancer biology and constitute potential and desirable therapeutic targets. The roles and importance of the Rho GTPases in cancer is just really becoming to be appreciated and the amount of new information gathered over the past 5 years has been staggering. However, there currently is no comprehensive source of information for Rho biology. Therefore, this volume could be very timely and of great interest.
Rhodopsin
by Beata JastrzebskaThis volume explores the technological improvements in protein engineering, expression, purification, and crystallization of several rhodopsin photoactive intermediates, thus increasing our understanding of rhodopsin activation. The first chapters of the book focus on methods developed to study fundamentals of rhodopsin structure and function, starting with improved purification protocols of native and mutated rhodopsin, followed by methods used for rhodopsin reconstitution into lipid bilayers stabilizing rhodopsin function properties, and finally describing recently developed methods to study structural dynamics of rhodopsin activation and its mechanistic properties. Subsequently, chapters underline various techniques that have been developed to visualize the rhodopsin dimer and to study its functional significance. The next few chapters highlight cutting-edge imaging techniques of photoreceptors, rhodopsin trafficking, and its diffusion within signaling membranes. Finally the book concludes with recent developments that could be potentially beneficial in patient treatments, and treatment strategies for retinal degenerative diseases. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Timely and practical, Rhodopsin: Methods and Protocols reaches out to researchers and health practitioners, and provides timely protocol useful for studying structural and functional properties of rhodopsin.
Rhoton Cranial Anatomy and Surgical Approaches
by Albert L. Rhoton Jr. Congress of Neurological SurgeonsRhoton Cranial Anatomy and Surgical Approaches is the masterwork of the legendary neurosurgeon Albert L. Rhoton, Jr.—a distillation of 40 years of work to, in the author’s words, make the “delicate, fateful, and awesome” procedures of neurosurgery more “gentle, accurate, and safe.” This definitive text on the microsurgical anatomy of the brain remains an essential tool for the education and enrichment of neurosurgeons at any level of experience. The hardbound collection of this complete classic work contains more than 2,000 high-quality images.
Rhythms in Healthcare (Studies in Rhythm Engineering)
by M. Shamim Kaiser Mufti Mahmud Shamim Al MamunThis book provides an insightful review and methodological contribution about future healthcare system. It also provides a space for creating and designing techniques for effective sensing, processing, and analysis of patient health situations based on bio-signal processing. Additionally, it discusses novel methods and algorithms which are needed to overcome limitations in current rhythmic bio-signals models. It also discusses solutions and systems needed to efficiently evaluate and process real-time data. The book is useful for wide range of users, including students, research scientists, teachers, and practitioners working in the field of heath informatics, neuroscience, biomedical engineering, and medical image processing and diagnosis.
Rhythms of Broken Hearts: History, Manifestations, and Treatment of Heart Rhythm Disorders and Heart Disease
by J. Anthony GomesThis book provides an overview of the history, manifestations, and treatment of heart disease and heart rhythm disorders. In addition, it covers the effects on the lives of patients, coping mechanisms, and relationships with doctors, family, religion, and death. The book uniquely intersects the fields of medicine, literature, science, and art. Chapters begin by familiarizing the reader with the historical aspects of manifestations and treatment – discussing both scientific and psychological aspects of the disease. Chapters also discuss the evolution of several treatment modalities. Every chapter of the book contains interesting and evocative patient stories and their treatment.Rhythms of Broken Hearts will be of interest to a wide spectrum of health care practitioners as well as to patients and related family members with interest in understanding their symptoms and disease entity. _____________________________________________________________________In Rhythm of Broken Hearts, Dr. Gomes distills a multifaceted perspective with a unique story that knits history, physiology, emotion, and wisdom.Jonathan L. Halperin, M.D.If you ever have a broken heart -- romantic or medical -- you will be totally absorbed in this dazzling multicultural read. Grace SchulmanDr. Gomes’s affinity and empathy for his patients and their stories narrated in this book, make universal the experiences of illness that we all must navigate at some point in our lives.Jeremy N. Ruskin, MD
Rib Fracture Management: A Practical Manual
by John Mayberry Marc De MoyaIn recent years the approach towards rib fractures has evolved. Abandoned in the past, due to inadequate instrumentation and lack of evidence, rib fixation has recently re-emerged as a treatment option for trauma patients. There have been a number of advances over the last 25 years that now allow surgeons to internally fix rib fractures that otherwise may have not had other options. However, as a result there has been a rapid increase in literature and many institutions interested in initiating rib fixation programs. Due to a variety of practitioners involved namely, trauma surgeons, orthopedic surgeons, and thoracic surgeons there has been no comprehensive guide to patient selection, technique, and post-operative care. The purpose of this text is to fill the educational gap for those trauma, orthopedic, and thoracic surgeons interested in learning the cutting edge evidence-based approaches to treatment of rib fractures. This topic has caught the interest of many and has been a recurrent theme at surgical meetings over the last two years. Although there has been ever increasing levels of interest and experience nationally there are many questions which remain.This text will provide not only the theoretical background for improving outcomes in those with rib fractures but also serve as a practical guide to those interested in starting new programs. The text will include tips and tricks that can be used in the OR or at the bedside to improve patient care. Therefore, the focus will be on a comprehensive review but also including tips and tricks from the most experienced surgeons around the country who are performing internal fixation for rib fractures.
Ribosome Biogenesis: Methods and Protocols (Methods in Molecular Biology #2533)
by Karl-Dieter EntianThis Open Access volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50 years ribosomes are a major research topic. Our knowledge about ribosome biogenesis and function such as transcription, mRNA modification, and translation was the sine qua non for developing the powerful RNA-based vaccines against RNA-viruses causing the world-threatening Covid-19 pandemia. The chapters in this book are organized into six parts. Part One discusses a comparative survey about the unity and diversity of ribosome biogenesis in pro- and eukaryotic cells. Part Two deals with the genomic organization of eukaryotic rDNA and the role of RNA polymerase I in ribosomal RNA transcription. Part Three explores in vitro methods to study RNA polymerase I structure and its function, and Part Four analyzes the nucleo-cytoplasmic transport of assembled ribosomes and RNP complexes. Part Five covers modifications that increase the complexity of rRNAs, and Part Six provides readers with a review of eukaryotic translation and - for the first time - describes a new method to analyze translation in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Ribosome Biogenesis: Methods and Protocols is a valuable resource for scientists and researchers interested in learning more about the increasing importance of in vitro RNA-technologies.
Riboswitches
by Alexander SerganovThe revolutionary discoveries of RNA interference and bacterial regulatory RNAs led to further breakthroughs such as the identification of riboswitches and related RNA sensors, mRNA regions capable of alternating their conformations in response to the presence of cellular metabolites and other physical or chemical cues. In Riboswitches: Methods and Protocols, expert researchers provide comprehensive and up-to-date coverage of various methods used to study riboswitches and other RNAs involved in gene expression control. Examining biochemical and modern biophysical techniques, the volume focuses on mRNAs responding to small organic molecules but expands the definition of a riboswitch to incorporate classes of RNA that undergo conformational transitions in response to other stimuli in order to control the expression of genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Riboswitches: Methods and Protocols promises to inspire both novices and experts working in a wide range of contemporary biological areas who wish to further develop their RNA methodology.
Ribozymes: Methods and Protocols (Methods in Molecular Biology #2167)
by Robert J. Scarborough Anne GatignolThis volume provides protocols designed to study the function and the structure of diverse ribozymes. Chapters guide readers through different techniques to identify and characterize new ribozymes and methods to use ribozymes to alter the function of CRISPR-based guide RNAs, AgoshRNAs and aptamers or to study RNA capping and long non-coding RNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Ribozymes: Methods and Protocols aims to help in accelerating ribozyme research and inspiring others to develop new methods to study ribozyme structure and function.
Rice By-products: Phytochemicals and Food Products Application
by Bee Ling Tan Mohd Esa NorhaizanRice is a vitally important staple food for almost half of the world’s population. As the global population increases, the demands for rice are expected to remain high. Since the rice industry will remain sustainable for a long time, the production of rice by-products will remain high. Substantial evidence suggests that rice by-products such as rice husk, rice straw, broken rice, rice germ, rice bran, and brewers’ rice may possess beneficial effects against oxidative stress and metabolic disorders. These beneficial effects have been linked to the phytochemicals present in rice by-products such as vitamin E, dietary fiber, γ-oryzanol, γ-aminobutyric acid (GABA), and phytosterols. Despite this evidence, the literature pertaining to rice by-products and its derived components has not well been compiled. To this end, Rice By-products: Phytochemicals and Food Products Application provides full coverage of issues pertaining to rice by-products, namely rice demands and rice by-products production, phytonutrients and antioxidant properties of rice by-products, potential health benefits, application in food products, and future prospects. By summarizing all the information in a lucid and comprehensive manner, authors provide a cohesive representation of the literature on the molecular mechanisms involved in the pharmacological effects of the bioactive components that present in rice by-products, as well as plausible means for the prevention of metabolic disorders for readers and allied stakeholders.
Ricebean: Exploiting the Nutritional Potential of an Underutilized Legume
by Rajan KatochThis book presents valuable research and advances in technologies related to ricebean cultivation production and utilization. Focusing on ricebean as a possible solution to the problems of nutritional insecurity and growing populations in developing countries, it provides comprehensive insights into its nutritional significance as an alternative food legume and discusses its utilization to prevent potential food calamities. This book is a valuable resource for food scientists and technologists, agricultural scientists, nutritionists and researchers.
The Richard and Hinda Rosenthal Lecture 2011: New Frontiers in Patient Safety
by The National Academy of SciencesMore than 10 years ago, the IOM released its landmark report on patient safety, To Err is Human: Building a Safer Health System. The 2011 Rosenthal Lecture featured the Honorable Kathleen G. Sebelius, Secretary of the U. S. Department of Health and Human Services, who presented the new steps that HHS is taking to improve patient safety. A panel of leaders in patient safety followed to discuss patient safety progress and opportunities.
The Richard & Hinda Rosenthal Symposium 2014: A Problem Without Borders
by Institute of MedicineThe Institute of Medicine launched an innovative outreach program in 1988. Through the generosity of the Rosenthal Family Foundation (formerly the Richard and Hinda Rosenthal Foundation), a discussion series was created to bring greater attention to some of the significant health policy issues facing our nation today. Each year a major health topic is addressed through remarks and conversation between experts in the field. The IOM later publishes the proceedings from this event for the benefit of a wider audience. This volume summarizes remarks by and an engaging discussion with Dr. Rima Khabbaz, Dr. Stuart Levy, Dr. Margaret (Peg) Riley, and Dr. Brad Spellberg on "Antimicrobial Resistance: A Problem Without Borders. " The Centers for Disease Control and Prevention identified antimicrobial resistance as one of five urgent health threats facing the United States this year. Antimicrobial resistance is a global health security threat that will demand collaboration from many stakeholders around the world. This report highlights the crosscutting character of antimicrobial resistance and the needs for many disciplines to be brought together to be able to deal with it more effectively.
Richtlijnen behandeling van voeten: Van personen met diabetes mellitus en van personen met een reumatische aandoening
by ProvoetMensen die lijden aan diabetes mellitus of reumatische aandoeningen hebben regelmatig last van hun voeten. De behandeling van en begeleiding bij voetproblemen wordt voor die patiënten (deels) toevertrouwd aan een medisch pedicure. Om de kennis en vaardigheden van deze zorgprofessionals up-to-date te houden, heeft brancheorganisatie ProVoet de laatste inzichten en adviezen over de behandeling van deze aandoeningen vastgelegd in deze richtlijnen.Deze richtlijnen zijn voornamelijk gebaseerd op bewijs uit wetenschappelijke publicaties, aangevuld met de ervaringen van de werkgroepleden die de richtlijnen hebben opgesteld. Daardoor is het een praktische leidraad geworden met uitvoerbare adviezen. Het gebruiksgemak wordt bovendien vergroot door de consistente indeling: diabetes mellitus en reumatische aandoeningen zijn opgesplitst in twee delen, die elk dezelfde indeling hebben. Elk deel begint met een vakinhoudelijke inleiding en bevat verder hoofdstukken over behandeling, over specialistische technieken en over preventie, educatie, emotionele aspecten en organisatie van de (na)zorg. Het boek is voorzien van een uitgebreide literatuurlijst.Bent u lid van ProVoet? Dan krijgt u korting op deze titel. Ga voor meer informatie naar www.provoet.nl.
Richtlijnen behandeling van voeten: Van personen met diabetes mellitus en van personen met een reumatische aandoening
by ProVoetMensen die lijden aan diabetes mellitus of reumatische aandoeningen hebben regelmatig last van hun voeten. De behandeling van en begeleiding bij voetproblemen wordt voor die patiënten (deels) toevertrouwd aan een medisch pedicure. Om de kennis en vaardigheden van deze zorgprofessionals up-to-date te houden, heeft brancheorganisatie ProVoet de laatste inzichten en adviezen over de behandeling van deze aandoeningen vastgelegd in deze richtlijnen.Deze richtlijnen zijn voornamelijk gebaseerd op bewijs uit wetenschappelijke publicaties, aangevuld met de ervaringen van de werkgroepleden die de richtlijnen hebben opgesteld. Daardoor is het een praktische leidraad geworden met uitvoerbare adviezen. Het gebruiksgemak wordt bovendien vergroot door de consistente indeling: diabetes mellitus en reumatische aandoeningen zijn opgesplitst in twee delen, die elk dezelfde indeling hebben. Elk deel begint met een vakinhoudelijke inleiding en bevat verder hoofdstukken over behandeling, over specialistische technieken en over preventie, educatie, emotionele aspecten en organisatie van de (na)zorg. Het boek is voorzien van een uitgebreide literatuurlijst.Bent u lid van ProVoet? Dan krijgt u 40%korting op deze titel. Ga voor meer informatie naar www.provoet.nl.
Ricin and Shiga Toxins
by Nicholas MantisIn May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventatives or therapeutics for ricin toxin. Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat. It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. The chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years.
Rickettsial Diseases (Infectious Disease and Therapy)
by Didier Raoult Philippe ParolaThe only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho
Rickettsiales
by Sunil ThomasInsect-transmitted rickettsiales diseases are significant sources of morbidity and mortality all over the world. Their incidence has been increasing in recent years in large part due to climate change and the movement of animals carrying the insect vectors. Currently there are no effective vaccines against diseases caused by members of the order Rickettsiales. Rickettsiales diseases are often misdiagnosed; this book is intended to serve as a tool for their understanding and diagnosis. Rickettsiales covers the seven main genera: Anaplasma, Ehrlichia, Midichloria, Neorickettsia, Orientia, Rickettsia and Wolbachia. Discussion of each genus includes immunology and molecular biology of host-pathogen interactions, epidemiology and diagnosis, and vaccination strategies and therapies.
Rickham's Neonatal Surgery
by John M. Hutson Risto J. Rintala Paul D. Losty Alan W. Flake Naomi LwaiThis book provides a detailed guide to neonatal surgery and its related disciplines including: fetal medicine, fetal surgery, radiology, newborn anaesthesia, intensive care, neonatal medicine, medical genetics, pathology, cardiac surgery, and urology. The book aims to cover all the latest advances in newborn surgery, with contributions from the basic sciences and laboratory research to reflect the steady progress in our current working knowledge and understanding of many neonatal surgical disorders. As huge advances have been made in neonatal surgery in the past decades, ethical issues, long term outcomes, and quality of life are also emphasised. This book is an authoritative reference for surgical residents in training, consultant surgeons, general surgeons with an interest in paediatric surgery, neonatologists, paediatricians, intensive care specialists, and nursing staff.