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The Biology of Gastric Cancers
by James Fox Timothy Wang Andy GiraudThe purpose of this work is to provide a general and comprehensive reference work on the biology of gastric cancers for those researchers working in this area. This monograph will be written by a panel of experts in each area and represent the latest work in a series of different areas of gastric cancer research.
The Biology of Glial Cells: Recent Advances
by Prakash Narain Tandon Ishan Patro Pankaj Seth Nisha PatroThis book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease.
The Biology of Happiness
by Bjørn GrindeThe briefs presents a model for happiness based on current knowledge in evolutionary biology and neurobiology. Briefly, the primary purpose of nervous systems is to direct an animal toward behaviour relevant for survival and procreation. In primitive animals actions are based on reflexes, while in humans the modules directing behaviour engage positive and negative affect (good and bad feelings), and they are swayed by cognitive processes. The reason why evolution opted for this strategy was the improved flexibility in response - i.e., we learn from previous experiences. The human capacity for happiness is an accidental consequence. An array of brain modules has evolved to care for various pursuits, but recent studies suggest that they converge on shared neural circuits designed to generate positive and negative mood. Happiness can be construed as the net output of the relevant modules. The briefs suggests a strategy for how to avoid having negative feelings (such as anxiety, depression and chronic pain) dominate the mind, and how to exercise positive feelings. In short, the book offers both a deeper understanding of what happiness is about, and a framework for improving well-being. An array of brain modules has evolved to care for various pursuits, but recent studies suggest that they converge on shared neural circuits designed to generate positive and negative mood. Happiness can be construed as the net output of the relevant modules. The book suggests a strategy for how to avoid having negative feelings (such as anxiety, depression and chronic pain) dominate the mind, and how to exercise positive feelings. In short, the book offers both a deeper understanding of what happiness is about, and a framework for improving well-being.
The Biology of Marijuana: From Gene to Behavior
by Emmanuel S. OnaiviMarijuana is the prototypical cannabinoid, and is one of the most widely used drugs in the world. Interestingly, cannabinoids are molecules found naturally in the human body and brain as well as in cannabis.This book provides an extensive reference on the biology of marijuana and the role of molecular techniques in elucidating neuropharmaco
The Biology of Multiple Sclerosis
by Gregory J. Atkins Sandra Amor Jean M. Fletcher Kingston H.G. MillsMultiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.
The Biology of Oligodendrocytes
by Patricia J. Armati Emily K. MatheyTraditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
The Biology of Parasites
by Craig Roberts Robert Poulin Richard Lucius Brigitte Loos-Frank Richard P. Lane Richard K. GrencisThis heavily illustrated text teaches parasitology from a biological perspective. It combines classical descriptive biology of parasites with modern cell and molecular biology approaches, and also addresses parasite evolution and ecology. Parasites found in mammals, non-mammalian vertebrates, and invertebrates are systematically treated, incorporating the latest knowledge about their cell and molecular biology. In doing so, it greatly extends classical parasitology textbooks and prepares the reader for a career in basic and applied parasitology.
The Biology of Senescence: A Translational Approach (Practical Issues in Geriatrics)
by Bernard SwynghedauwThis book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.
The Biology of Subcellular Nitric Oxide
by Tamás RőszerThis book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.
The Biology of mRNA: Structure and Function (Advances in Experimental Medicine and Biology #1203)
by Marlene Oeffinger Daniel ZenklusenThe book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.
The Biology of the First 1,000 Days (Oxidative Stress and Disease)
by Tim Green Klaus Kraemer Crystal Karakochuk Kyly WhitfieldThe first 1,000 days, from conception to two years of age, is a critical period of growth and development. Exposures to dietary, environmental, hormonal, and other stressors during this window have been associated with an increased risk of poor health outcomes, some of which are irreversible. The book addresses this crucial interval of early life across biological disciplines, linking concepts related to all biological fields to outcomes during the first 1,000 days (e.g. fetal growth and pregnancy outcomes) and beyond (e.g. gut microbiome and cardiovascular disease later in life). The strength of this book lies in its cross-disciplinary nature.
The Biomechanics of Impact Injury
by Albert I. KingThis text acquaints the reader on the biomechanics of injury to the human body caused by impact and the use of computer models to simulate impact events. It provides a basic understanding of the biomechanics of the injuries resulting from the impact to the head, neck, chest, abdomen, spine, pelvis and the lower extremities, including the foot and ankle. Other topics include side impact, car-pedestrian impact, effectiveness of automotive restraint systems and sports-related injuries. Featuring problems and PowerPoint slides for lectures, the volume is ideal for students in graduate programs in biomechanics, as well as practicing engineers, and researchers in the life sciences concerned with orthopedics.
The Biomedical Empire: Lessons Learned from the COVID-19 Pandemic
by Barbara Katz RothmanWe are all citizens of the Biomedical Empire, though few of us know it, and even fewer understand the extent of its power. In this book, Barbara Katz Rothman clarifies that critiques of biopower and the "medical industrial complex" have not gone far enough, and asserts that the medical industry is nothing short of an imperial power. Factors as fundamental as one's citizenship and sex identity—drivers of our access to basic goods and services—rely on approval and legitimation by biomedicine. Moreover, a vast and powerful global market has risen up around the empire, making it one of the largest economic forces in the world. Katz Rothman shows that biomedicine has the key elements of an imperial power: economic leverage, the faith of its citizens, and governmental rule. She investigates the Western colonial underpinnings of the empire and its rapid intrusion into everyday life, focusing on the realms of birth and death. This provides her with a powerful vantage point from which to critically examine the current moment, when the COVID-19 pandemic has exposed the power structures of the empire in unprecedented ways while sparking the most visible resistance it has ever seen.
The Biomedical Sciences in Society: An Interdisciplinary Analysis
by Iain CrinsonThis textbook provides a comprehensive introduction to the interdisciplinary field of the Social Studies of Science and Technology (SSST). Over the past two decades, the biomedical sciences have transformed our understanding of the relationship between the social and natural worlds, while its ‘promissory visions’ are seen to offer extraordinary opportunities for economic and social development. But alongside these scientific innovations have emerged new, and frequently unanticipated social, political, bioethical, and legal dilemmas and challenges. This cutting-edge text explores ‘post-genomic’ developments in the field of pharmacogenomics and the prospects for a new ‘precision’ or personalised medicine; the potential of environmental epigenetics to reconfigure the boundaries of the social and natural worlds; the emergence of an array of ‘neuro-disciplines’, seeking to identify the neural basis of a whole range of social and economic behaviours; and the challenges of constructing a coherent and robust governance framework for the conduct of biomedical science research and innovation, responsive to the social and health needs of the whole population.
The Biomedical Writer: What You Need to Succeed in Academic Medicine
by Yellowlees Douglas Maria B. GrantCo-authored by a leading ophthalmology researcher and a professor with 15 years of experience teaching writing in the biomedical sciences, The Biomedical Writer addresses ways to use psychology and neuroscience to equip researchers and clinicians with an understanding of how effects like priming, primacy, recency, framing, and apparent paradoxes can make or break your articles and grant proposals. The Biomedical Writer covers everything from making sentences readable, effective, and memorable to working with collaborators under unforgiving deadlines. Going far beyond the basic structure and content of manuscripts and proposals, this guide to writing in biomedicine also focuses on topics that include handling negative results and the most important and neglected step in submitting manuscripts to journals. Addresses the micro components of writing in biomedicine, and how to write by anticipating how readers process information.<P> Written by two researchers with complementary backgrounds and wide working knowledge of an array of fields in the biomedical sciences. <P> Guides researchers in every field in biomedicine on to how to write persuasively and effectively.
The Biopsychosocial Formulation Manual: A Guide for Mental Health Professionals
by William H. Campbell Robert M. RohrbaughBased on George Engel’s model, The Biopsychosocial Formulation Manual presents ways to help psychiatry residents and students effectively gather and organize patient data to arrive at a complete mental health history in a limited timeframe. While most current models only take one factor into account, Campbell and Rohrbaugh emphasize and analyze three essential components (biological, social, and psychological). The process of identifying pertinent data for each component of the biopsychosocial formulation is explicated in detail. A separate section outlines how to use the biopsychosocial formulation to generate treatment recommendations. This volume includes a complete package for practicing the biopsychosocial method; this easy-to-use guide includes a data record sheet and downloadable resources to facilitate organization and assessment, appealing to both the psychiatric professional and the trainee.
The Biopsychosocial Model of Health and Disease: New Philosophical and Scientific Developments
by Grant Gillett Derek BoltonThis open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.
The Biostatistics of Aging
by Bruce Levin Gilberto LevyA practical and clarifying approach to aging and aging-related diseasesProviding a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion--with consequential biomedical and public health relevance--of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population.With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features:Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme valuesA comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populationsThe development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiologyAn explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principlesThe amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical softwareTechnical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseasesThe Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.
The Bipolar Disorder Survival Guide, Second Edition
by David J. MiklowitzGetting an accurate diagnosis is the first step toward reclaiming your life from bipolar disorder. But if you or someone you love is struggling with the frantic highs and crushing lows of this illness, there are still many hurdles to surmount at home, at work, and in daily life. You need current information and practical problem-solving advice you can count on. You've come to the right place. * How can you distinguish between early warning signs of bipolar mood swings and normal ups and downs? * What medications are available, and what are their side effects? * What should you do when you find yourself escalating into mania or descending into depression? * How can you tell your coworkers about your illness without endangering your career? * If you have a family member with bipolar disorder, how can you provide constructive help and support? Trusted authority Dr. David J. Miklowitz offers straight talk, true stories, and proven strategies that can help you achieve greater balance and free yourself from out-of-control moods. The updated second edition of this bestselling guide has the latest facts on medications and therapy, an expanded discussion of parenting issues for bipolar adults, and a new chapter, "For Women Only."
The Bipolar Disorder Survival Guide, Third Edition: What You and Your Family Need to Know
by David J. MiklowitzBipolar disorder is a lifelong challenge--but it doesn't have to rule your life. Find the science-based information you need in the revised third edition of this indispensable guide. Trusted authority Dr. David J. Miklowitz shares proven strategies for managing your illness or supporting a loved one with the disorder. Learn specific steps to cope with mood episodes, reduce recurrences, avoid misdiagnosis, get the most out of treatment, resolve family conflicts, and make lifestyle changes to stay well. Updated throughout, the third edition has a new chapter on kids and teens; the latest facts on medications and therapy, including important advances in personalized care; and expanded coverage of the bipolar II subtype. It features boxes on complementary and alternative treatments and provides downloadable practical tools.
The Bipolar Disorder Workbook: Powerful Tools and Practical Resources for Bipolar II and Cyclothymia
by Peter Forster MD Gina Gregory LCSWBuild real-world skills for managing the day-to-day symptoms of bipolar II and cyclothymia through the practical strategies and exercises in The Bipolar Disorder Workbook. Finding stability and fulfillment while living with bipolar disorder or cyclothymia can be challenging. But with the right tools it's possible to overcome the symptoms associated with these diagnoses. In The Bipolar Disorder Workbook, clinical psychiatrist Dr. Peter Forster and clinical social worker Gina Gregory help you explore how symptoms like hypomania and depression show up in your daily life, and guide you to develop real-world skills for facing these everyday challenges. The Bipolar Disorder Workbook presents therapeutic ideas, tools, and techniques that draw from Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT). Divided into 3 easy-to-follow parts, The Bipolar Disorder Workbook will help you identify the patterns of your symptoms, increase the stability of your mood, and successfully manage your bipolar disorder or cyclothymia. Based on the most up-to-date research on bipolar disorder and cyclothymia, The Bipolar Disorder Workbook offers: Compassionate, knowledgeable guidance for understanding bipolar disorder and cyclothymia, including the mood states that define them and an overview of different approaches to treatment. Practical checklists, self-assessments, writing exercises and other workbook features for managing the highs and lows, recognizing the warning signs of a mood shift, and minimizing the negative impact of bipolar disorder and cyclothymia on your life. Thoughtful suggestions for talking with friends and family and creating a support system through a variety of channels such as a treatment team, community resources, and loved ones. "Whole-Health Strategies" for enhancing the connection between your physical health and mood stability. Though it can take time, deciding to transform one's life is a brave and courageous thing to do. Here, in The Bipolar Disorder Workbook, you'll find the supportive, straightforward guidance you need to find relief from the symptoms of bipolar disorder or cyclothymia, and begin creating the kind of life you want and deserve.
The Birth of Grapevine Health: A Doctor's Journey to Build Trust and Restore Humanity in Medicine
by Lisa K. FitzpatrickThe COVID-19 pandemic has taught the world many things, but one of the most crucial is the need to communicate tailored health information through trusted messengers effectively. The Birth of Grapevine Health chronicles the experiences of one physician, Dr. Lisa Fitzpatrick, a CDC-trained medical epidemiologist on a mission to deliver trusted health information to the Black community through Grapevine Health, a community and health outreach organization she started with the aim to improve patient engagement and health literacy in underserved communities through the digital delivery of tailored health messages. Fitzpatrick reveals why she began building an organization that, in 2020, appeared tailored for the COVID-19 pandemic long before that crisis unfolded across the globe. Frustrated by the lack of progress in addressing health inequity, Dr. Lisa moved into an under-resourced community to become proximal enough to better understand health inequity and the structural and policy changes needed to address it. She weaves her professional experiences with storytelling and lessons learned into a call to action for healthcare leaders, decisionmakers, and funders to move beyond data collection and shift toward action to focus on health prevention, move our health support further upstream and, ultimately, improve health outcomes for underserved communities. The Birth of Grapevine Health is part memoir, part health equity playbook, and offers a roadmap to actions needed to achieve health equity. At a time when health equity conversations seem ubiquitous, what sets The Birth of Grapevine Health apart is its embrace and integration of community voice. This book delivers deep insights and, at times, uncomfortable advice through the eyes of Black and brown patients and their communities about what it will take to achieve health equity.
The Birth of Homeopathy out of the Spirit of Romanticism
by Alice KuzniarHomeopathy was founded in 1796 by the German physician Samuel Hahnemann who ardently proposed that "like cures like," counter to the conventional treatment of prescribing drugs that have the opposite effect to symptoms. Alice A. Kuzniar critically examines the alternative medical practice of homeopathy within the Romantic culture in which it arose. In The Birth of Homeopathy out of the Spirit of Romanticism, Kuzniar argues that Hahnemann was a product of his time rather than an iconoclast and visionary. It is the first book in English to examine Hahnemann’s unpublished writings, including case journals and self-testings, and links to his contemporaries such as Goethe and Alexander von Humboldt. Kuzniar’s engaging writing style seamlessly weaves together medical, philosophical, semiotic, and literary concerns and reveals homeopathy as a phenomenon of its time. The Birth of Homeopathy out of the Spirit of Romanticism sheds light on issues that continue to dominate the controversy surrounding homeopathy to this very day.
The Birth of a Genetics Policy: Social Issues of Newborn Screening
by Joëlle VaillyTesting for genetic diseases or traits is a rapidly developing practice, the most widely used form of testing currently in use being newborn screening. Based on a five-year research project and winner of the Prix ’Le Monde’ for academic research in France, The Birth of a Genetics Policy analyses the three dimensions - scientific, political and moral - of the social issues raised by a policy of screening for the genetic disease of cystic fibrosis amongst babies. Drawing on extensive interview material and observational research, it explores the conditions under which a screening policy is decided upon and implemented, the types of political logic underlying it, and the effects it has on norms and values. Revealing the ties that exist between forms of biomedical knowledge and political techniques, whilst showing how the notion of biomedical abnormality is being extended, this book sheds light on judgements surrounding the idea of the ’quality (of) life’. A rigorous examination of the discourses and practices of medical genetics in the early twenty-first century, The Birth of a Genetics Policy will appeal to sociologists and anthropologists with interests in medicine and the body, evidence-based care and questions of biopolitics and governmentality.
The Bitterest Pills
by Joanna MoncrieffA challenging reappraisal of the history of antipsychotics, revealing how they were transformed from neurological poisons into magical cures, their benefits exaggerated and their toxic effects minimized or ignored.