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The Cell as a Machine (Cambridge Texts in Biomedical Engineering)
by Michael Sheetz Hanry YuThis unique introductory text explains cell functions using the engineering principles of robust devices. Adopting a process-based approach to understanding cell and tissue biology, it describes the molecular and mechanical features that enable the cell to be robust in operating its various components, and explores the ways in which molecular modules respond to environmental signals to execute complex functions. The design and operation of a variety of complex functions are covered, including engineering lipid bilayers to provide fluid boundaries and mechanical controls, adjusting cell shape and forces with dynamic filament networks, and DNA packaging for information retrieval and propagation. Numerous problems, case studies and application examples help readers connect theory with practice, and solutions for instructors and videos of lectures accompany the book online. Assuming only basic mathematical knowledge, this is an invaluable resource for graduate and senior undergraduate students taking single-semester courses in cell mechanics, biophysics and cell biology.
The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future
by Joshua Z. RappoportYour body has trillions of cells, and each one has the complexity and dynamism of a city. Your life, your thoughts, your diseases, and your health are all the function of cells. But what do you really know about what goes on inside you? The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant. The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world. Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover: A deeper understanding of how cells work and the basic nature of life on earth. Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research. The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells. The ability to make better decisions about health and to debunk the misinformation that comes in daily via media. Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.
The Cellular Basis of Central Nervous System HIV-1 Infection and the AIDS Dementia Complex
by Richard W Price John J SidtisIn this exciting symposium, the editor brings to print important new information on AIDS and how HIV affects the brain. Each chapter focuses on one or more of the cell types that reside in or traffic through the central nervous system (CNS). Each of these cells is important to considerations of the pathogenesis of the CNS. Neurologists, AIDS physicians, and other professionals caring for AIDS patients will find that this “cell-based” view provides a unique perspective and that it will guide and stimulate future investigation of this clinically important and pathogenetically intriguing disorder. The editor also introduces some general considerations for therapeutic intervention of AIDS dementia complex (ADC).The contributors to The Cellular Basis of Central Nervous System HIV-1 Infection and the AIDS Dementia Complex deal with the cells and mechanisms involved in HIV-1 brain infection and the resultant ADC. Each author was asked to review the involvement of their assigned cells in CNS HIV-1 infection and how these cells might be involved in the pathology and process of brain injury associated with ADC. Readers will be enlightened on the functional roles of various cells and how these cells and mechanisms might fit into the broader picture of ADC pathogenesis.
The Centrosome and its Functions and Dysfunctions (Advances in Anatomy, Embryology and Cell Biology #235)
by Heide SchattenThe book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
The Cerebellum: Learning Movement, Language, and Social Skills
by Dianne M. BroussardThe Cerebellum provides a concise, accessible overview of modern data on physiology and function of the cerebellum as it relates to learning, plasticity, and neurodegenerative diseases. Encompassing anatomy and physiology, theoretical work, cellular mechanisms, clinical research, and disorders, the book covers learning and plasticity while introducing the anatomy of the cerebellum. Known and proposed "functions of the cerebellum" are addressed on clinical, physiological, cellular, and computational levels, providing academics, researchers, medical students, and graduate students with an invaluable reference.
The Certification of Insanity: Local Origins and Imperial Consequences (Mental Health in Historical Perspective)
by Filippo Maria SposiniThis book represents the first systematic study of the certification of lunacy in the British Empire. Considering a variety of legal, archival, and published sources, it traces the origins and dissemination of a peculiar method for determining mental unsoundness defined as the ‘Victorian system’. Shaped by the dynamics surrounding the clandestine committal of wealthy Londoners in private madhouses, this system featured three distinctive tenets: standardized forms, independent medical examinations, and written facts of insanity. Despite their complexity, Victorian certificates achieved a remarkable success. Not only did they survive in the UK for more than a century, but they also served as a model for the development of mental health laws around the world. By the start of the Second World War, more than seventy colonial and non-colonial jurisdictions adopted the Victorian formula for making lunacy official with some countries still relying on it to this very day. Using case studies from Europe, the Americas, and the Pacific, this book charts the temporal and geographical trajectory of an imperial technology used to determine a person’s destiny. Shifting the focus from metropolitan policies to colonial dynamics, and from macro developments to micro histories, it explores the perspectives of families, doctors, and public officials as they began to deal with the delicate business of certification. This book will be of interest to scholars working on mental health policy, the history of medicine, disability studies, and the British Empire.
The Challenge of CMC Regulatory Compliance for Biopharmaceuticals
by John GeigertThis book highlights the challenges facing quality assurance/quality control (QA/QC) in today's biopharmaceutical environment and presents the strategic importance and value generated by QA/QC for their involvement in control of manufacturing. It will put into perspective the need for a graded approach to QA/QC from early clinical trials through market approval. Since the first edition published in 2004, there have been more than 50 new regulatory guidances released by the Food and Drug Administration (FDA), European Medicines Agency (EMA) and ICH that affect the CMC regulatory compliance of biopharmaceuticals; also the application of biosimilars has been developed in Europe and is under development in the USA. The revised update will be broadened to include not only biopharmaceuticals (biotech drugs) but also other biologics (vaccines, cell therapy, plasma-derived proteins, etc.)
The Challenge of CMC Regulatory Compliance for Biopharmaceuticals
by John GeigertBiopharmaceuticals (i.e., biological medicines sourced from genetically-engineered living systems) for treatment of human diseases have become a significant percentage of the pharmaceutical industry. And not just the recombinant DNA-derived proteins and monoclonal antibodies (both from the innovators and biosimilars); but now, an increasing awareness of the importance of gene therapy and genetically engineered cellular medicinal products. These biopharmaceuticals are being developed by many companies whose Chemistry, Manufacturing & Control (CMC) teams have varying degrees of familiarity or experience with the CMC strategy and regulatory compliance requirements for these challenging products. Companies clearly plan out the strategy for their clinical study plans, but frequently, the development of a strategy for CMC is an afterthought. Coupled with the complexity of the biopharmaceutical manufacturing processes and products, and this can be a recipe for disaster. The third edition of this book provides insights and practical guidance for the CMC teams to develop an acceptable cost-effective, risk-based CMC regulatory compliance strategy for all biopharmaceuticals (recombinant proteins, monoclonal antibodies, genetically engineered viruses and genetically engineered human cells) from early clinical stage development through market approval. The third edition of this book provides added coverage for the biosimilars, antibody drug conjugates (ADCs), bispecific antibodies, genetically engineered viruses, and genetically engineered cells. This third edition of the book also addresses the heightened pressure on CMC regulatory compliance timelines due to the introduction of expedited clinical pathways moving the clinical development closer to a seamless phase process (e.g., FDA Breakthrough Therapy designation, CBER Regenerative Medicine Advanced Therapy (RMAT) designation, EMA Priority Medicines (PRIME) designation). The Challenge of CMC Regulatory Compliance for Biopharmaceuticals is essential, practical information for all pharmaceutical development scientists, Manufacturing and Quality Unit staff, Regulatory Affairs personnel, and senior management involved in the manufacture of biopharmaceuticals.
The Challenge of CMC Regulatory Compliance for Biopharmaceuticals
by John GeigertEach year for the past three years, there have been about 50 new molecular medicines approved by the United States Food & Drug Administration (FDA), of which approximately 25% were new biopharmaceuticals. Over 200 recombinant proteins, monoclonal antibodies, antibody drug conjugates, fusion proteins, and Fab fragments are now in the marketplace in both the United States of America (USA) and European Union (EU). There are also now over 60 biosimilars available for all major classes of recombinant proteins and monoclonal antibodies. In addition, gene therapies using genetically engineered viruses and genetically engineered cells are now in the marketplace, and continually growing. This degree of change is reflected in the over 400 CMC regulatory compliance references listed in this book that were either issued or updated since the release of the third edition. Deficiencies in biopharmaceutical CMC regulatory compliance rarely result in termination of a product, but in can readily cause months if not years of delay in initiating clinical trials, or advancing clinical development stages, or even market approval. In summary, this book:Updates real-world CMC deficiency examples with current examples;Addresses current FDA and EMA requirements and expectations for CMC regulatory compliance;Now includes CMC regulatory compliance for the new gene-based biopharmaceuticals.
The Challenge of Chance: A Multidisciplinary Approach from Science and the Humanities (The Frontiers Collection)
by Klaas Landsman Ellen WoldeThis book presents a multidisciplinary perspective on chance, with contributions from distinguished researchers in the areas of biology, cognitive neuroscience, economics, genetics, general history, law, linguistics, logic, mathematical physics, statistics, theology and philosophy. The individual chapters are bound together by a general introduction followed by an opening chapter that surveys 2500 years of linguistic, philosophical, and scientific reflections on chance, coincidence, fortune, randomness, luck and related concepts. A main conclusion that can be drawn is that, even after all this time, we still cannot be sure whether chance is a truly fundamental and irreducible phenomenon, in that certain events are simply uncaused and could have been otherwise, or whether it is always simply a reflection of our ignorance. Other challenges that emerge from this book include a better understanding of the contextuality and perspectival character of chance (including its scale-dependence), and the curious fact that, throughout history (including contemporary science), chance has been used both as an explanation and as a hallmark of the absence of explanation. As such, this book challenges the reader to think about chance in a new way and to come to grips with this endlessly fascinating phenomenon.
The Challenge of Highly Pathogenic Microorganisms
by Arie Ordentlich Baruch Velan Avigdor ShaffermanThis book addresses the unique features of four microorganisms that constitute the top bioterror threat agents: Bacillus anthracis; Yersinia pestis, Francisella tularensis and Orthopoxviruses. Side-by-side updated information about their pathogenisis, virulence and epidemiology is provided in a single volume, allowing for evaluation of common features as well as common strategies for defense. Classical microbiological as well as genomic, proteomic & transcriptomic approaches towards development of strategies of novel prophylactic and post-exposure treatment and related aspects of diagnostics and bioforensics are covered. Written by top scientists, this book will be of major interest to all researchers interested in the intricate biology of highly pathogenic microorganisms, to scientists and clinicians interested in microbial pathogenesis and prevention, and to a wide range of professionals dealing with the various aspects of bio-defense.
The Challenge of Regulating Managed Care
by John E. Billi Gail Bopp AgrawalRepresentatives of industry, government, caregivers, and consumers join scholars and policy analysts in comparing market forces to regulation as potential means for righting what is wrong with managed care. The contributors that John E. Billi and Gail B. Agrawal have gathered here quickly move the healthcare debate beyond the classroom, think tank, and statehouse to the boardroom and examining room. Some argue strongly that the solution is to be found in the democratic process and government intervention, while others maintain that only market forces in a competitive environment can respond quickly to the needs of consumers and purchasers alike. The contributors' diverse opinions about the oversight of managed care reflect an enduring divide, one that will affect how society ultimately resolves questions about the inevitable tradeoffs among health-care quality, cost, and access in an environment of limited resources. The Challenge of Regulating Managed Care will appeal to policymakers, those in the medical field, and all readers interested in the American experience with managed care.
The Challenge to Change: Reforming Health Care on the Front Line in the United States and the United Kingdom
by Rebecca Kolins GivanThere is constant pressure on hospitals to improve health care delivery and increase cost effectiveness. New initiatives are the order of the day in the dramatically different health care systems of the United States and Great Britain. Often, as we know all too well, these efforts are not successful. In The Challenge to Change, Rebecca Kolins Givan analyzes the successes and failures of efforts to improve hospitals and explains what factors make it likely that the implementation of reforms will be rewarded by positive transformation in a particular institution's day-to-day operation. Givan's in-depth qualitative case studies of both top-down initiatives and changes first suggested by staff on the front lines of care point clearly to the importance of all hospital workers in effecting change and even influencing national policy.Givan illuminates the critical role of workers, managers, and unions in enabling or constraining changes in policies and procedures and ensuring their implementation. Givan spotlights an Anglo-American model of hospital care and work organization, even while these countries retain their differences in access and payment. Entrenched professional roles, hierarchical workplace organization, and the sometimes-detached view of policymakers all shape the prospects for change in hospitals. Givan provides important examples of how the dedication and imagination of the people who work in hospitals can make all the difference when it comes to providing quality health care even in a challenging economic environment.
The Challenged Resident: Moral Distress, Moral Disengagement, and Ethical Climate in U.S. Medical Residencies
by Aloysius OchasiThe purpose of this timely and stimulating book is to examine the causes and impacts of moral distress among US medical residents. Based on a comprehensive study conducted by the author, the work not only delves into the causes of moral distress among medical residents but also explores how this distress can lead to moral disengagement, potentially resulting in suboptimal clinical care and adverse patient outcomes. The book begins with an overview of existing scholarship on moral distress experienced by practitioners within the medical establishment and its negative psychological impacts. Chapter two discusses how moral distress can lead to moral disengagement and its subsequent effects on patient care. In chapter three, the author explores residents’ perceptions of the role of the "ethical climate" in contributing to moral distress. Chapter four outlines the impetus behind the study and details its methodology. Chapter five reviews the study’s findings, focusing on the relationship between moral distress and moral disengagement, including the influence of the ethical climate within medical institutions. Chapter six summarizes the quantitative and qualitative findings of the study. Chapter seven addresses how these issues were managed during the recent COVID-19 pandemic, when medical personnel were often stressed, overworked, and apprehensive about contracting the virus themselves. Finally, in chapter eight, the author suggests strategies for preventing moral distress and disengagement and provides recommendations for medical residents on managing the inherent stresses of medical training. The Challenged Resident offers a unique and insightful contribution to the clinical literature on ethics and medical residency, enabling clinicians, trainees, administrators, policymakers, and other stakeholders to better understand the pressures and stressors faced by medical residents and to consider strategies and policies that address moral distress, promote resident self-care, foster a more supportive and ethical training environment, and reduce moral disengagement.
The Challenges of Creating a Global Health Resource Tracking System
by Elisa Eiseman Donna FossumThe RAND Corporation conducted interviews, consulted with experts, and carried out detailed analyses of existing tracking systems that focus on health resources flowing to and within developing countries, the objective being to determine how to provide a truly global health resource tracking system that will provide comprehensive, accurate, up-to-date data for policymakers and other users and will address the current systems' limitations.
The Challenges of MRI: Techniques and Quantitative Methods for Health
by Olivier Beuf Hélène RatineyAfter a review of the essential concepts of magnetic resonance imaging (MRI), The Challenges of MRI presents the recent techniques and methods of MRI and resulting medical applications. These techniques provide access to information that goes well beyond anatomy, with functional, hemodynamic, structural, biomechanical and biochemical information. MRI allows us to probe living organisms in a multitude of ways, guaranteeing the potential for continuous development involving several disciplines: physics, electronics, life sciences, signal processing and medicine. This collective work is made up of chapters written and designed by experts from the French community. They have endeavored to describe the techniques by recalling the underlying physics and detailing the modeling, methods and strategies for acquiring or extracting information. This book is aimed at master’s students and PhD students, as well as lecturers and researchers in medical imaging and radiology.
The Challenges of Mental Health Caregiving
by Ronda C. Talley Gregory L. Fricchione Benjamin G. DrussCaring for the ill, disabled, very old, or very young requires a labor-intensive commitment that is not only essential to the well-being of individuals and to society as a whole, but also fraught with physical, financial, and psychological risks. And despite the critical nature of their job, caregivers rarely have avenues of support. The Challenges of Mental Health Caregiving addresses the complexities of the situation with uncommon depth and breadth. Suited to researchers, scientist-practitioners and clinicians, and students seeking a rounded understanding of the field, it examines how caregiving affects the lives, work, and mental health of family and professional caregivers. Chapters explore developmental, cultural, and spiritual contexts of care, addressing ongoing concerns about care in relation to larger health systems and emphasizing the need for care to be viewed as a community, rather than an individual or family experience. Further, the book's conclusion strongly advocates for more effective and efficient uses for available funds and resources while offering workable proposals for service improvements at the policy level. Key areas of coverage: The impact of caregiving on physical and mental health. Integrating mental health and primary care. The promotion of positive mental health outcomes in children and youth. Mid-life concerns and caregiver experience. Loss, grief, bereavement and the implications for mental health caregiving. Policy issues in caregiving and mental health. The Challenges of Mental Health Caregiving is a clear-sighted reference for researchers, clinicians and scientist-practitioners, and graduate students in the caregiving fields, including clinical psychology, social work, public health/medicine, geriatrics/gerontology, public policy, and educational policy.
The Challenges of Nursing Stroke Management in Rehabilitation Centres
by Bianca Buijck Gerard RibbersThis volume provides integral knowledge of all aspects of stroke care and rehabilitation after stroke, and is therefore highly relevant for nurses who work in rehabilitation centers. It outlines the several phases after stroke, for example the type of care patients may receive in the chronically phase at home. Nurses will obtain knowledge about treatment, importance of observation and caring with a special focus on communication problems, swallowing problems, activities of daily living, urinary and defecation problems, shoulder and hand issues. Thanks to photographs, nurses will learn to transfer patients in the adequate positions. Several chapters provide nurses with examples of effective and efficient collaboration with multidisciplinary professionals, informal caregivers and patients themselves. There is also an emphasis on behavior and cognitive functioning. And lastly, in the final chapters authors highlight the organization of rehabilitation and integrated care issues. Nurses play a very important role in rehabilitation, education, counseling, prevention, and caring for patients with cerebrovascular accident (CVA). In caring for stroke patients, nurses need specific competences and abilities that go beyond the general neurologic knowledge and experience. Nurses need to collaborate in an efficient and effective manner with multidisciplinary team members in their organization and across organizations. This book discusses medical aspects and specific symptoms of a stroke, as well as the limitations that patients experience, and which interventions are indicated for recovery.
The Challenges of On-Call Neurosurgery (Elements in Emergency Neurosurgery)
by Marco Lee Abteen Mostofi Nihal GurusingheOn-call neurosurgery concerns practice related to urgent and emergency neurosurgical care including outside of 'normal' working hours. Being on-call involves many competing responsibilities and is regarded as one of the most demanding aspects of a neurosurgical career. The on-call work pattern has evolved over the past decade due to changes in demographics, technology and working practices, each of which have brought new and emerging challenges. These challenges aside, the on-call provides a unique and rewarding environment to make a meaningful difference to patients and to learn the science and art of neurosurgery. Success in on-call work requires not only good technical knowledge and application but also a wide variety of non-technical skills. These skills will help deal with some of the difficult situations neurosurgeons in training face when on-call to make the experience more manageable and educational.
The Changing Face of Disease: Implications for Society (Society For The Study Of Human Biology Ser.)
by Nick Mascie-Taylor Jean Peters Stephen T. McGarveyDisease is an ever-present threat faced by all human societies. Today, this concept has become an influential area of study known as the global burden of disease, which encompasses contemporary health concerns such as the economic costs of disease, the societal impact of illness in developing nations, and infectious diseases resulting from lifestyl
The Changing Face of Medical Education (Radcliffe Ser.)
by Cavenagh Leinster PenelopeThe past 50 years - and even the past 20 years - have seen almost revolutionary change in medical education, which has emerged as a distinct discipline during that time. The curriculum to be covered, the most effective learning and teaching methods, and what kind of professional (and indeed person) medical education is intended to produce, how success can best be assessed and - not least - the make-up of students and teachers themselves have all changed enormously. This unique text draws together a wide variety of perspectives and focuses in particular on the experiences of one of the U.K.'s newer medical schools. It examines the key changes that have shaped the field, its practitioners and its students, presenting unique perspectives on both its history and on the current state of the art. This book is rewarding and informative reading for educationalists, academics, sociologists and researchers in medical history and education. 'The education of our healthcare professionals is one of the most important challenges for higher education. In setting up the new medical school at UEA we recognised this challenge and set out to develop a method of teaching and learning that put the student and their learning needs at the centre of the curriculum. The results of this and some of the developments that have emerged from those early days are outlined in this book.' - from the Foreword by Shirley Pearce
The Changing Face of Medicine: Women Doctors and the Evolution of Health Care in America
by Ann K. Boulis Jerry A. JacobsBoulis and Jacobs (sociology, U. of Pennsylvania) analyze from a sociological perspective the increase over recent decades of women who study and practice medicine in the US. They discuss specific issues that arise when female physicians meet the American health care system. Topics covered include: disparities of specialty and practice ownership, female physicians and family life, dual-physician marriages, specialty choice among female doctors, and whether or not they are changing the way medicine is practiced in the US, among others. ILR Pres is an imprint of Cornell U. Press. Annotation ©2009 Book News, Inc. , Portland, OR (booknews. com)
The Changing Faces of Childhood Cancer
by Emm Barnes JohnstoneThis book traces the development of British answers to the problem of childhood cancer. The establishment of the NHS and better training for paediatricians, meant children were given access to experimental chemotherapy, sending cure rates soaring. Children with cancer were thrust into the spotlight as individuals' stories of hope hit the headlines.
The Changing Role of the Hospital in European Health Systems (European Observatory on Health Systems and Policies)
by Ellen Nolte Sherry Merkur Martin McKee Nigel EdwardsHospitals today face a huge number of challenges, including new patterns of disease, rapidly evolving medical technologies, ageing populations and continuing budget constraints. This book is written by clinicians for clinicians and hospital managers, and those who design and operate hospitals. It sets out why hospitals need to change as the patients they treat and the technology to treat them changes. In a series of chapters by leading authorities in their field, it challenges existing models, reviews best practice from many countries and presents clear policy recommendations for policymakers and hospital administrators. It covers the main patient groups and conditions as well as those departments that make modern effective care possible, in imaging and laboratory medicine. Each chapter looks at patient pathways, aspects of workforce, required levels of specialisation and technology, and the opportunities and challenges for optimising the delivery of services in the hospital of the future. This title is also available as Open Access on Cambridge Core.
The Changing Roles of Doctors
by Amanda Howe Mick Collins Ann Barrett Penny Cavenagh Sam Leinster Veena Rodrigues Susanne Lindqvist Andrea Stockl Alistair LeinsterThis fascinating new book describes the evolution of the medical profession and how the role of the doctor and expectations of that role have changed over time. It critically examines developments in the light of both external influences such as the ageing population, patient attitudes and knowledge and government regulation, and internal changes such as the increasing knowledge base, advances in technology and changes in recruitment. Challenges in management, working environment, education and training are considered and practical recommendations for both practising and student doctors are offered. The holistic approach is supported with contributions from both primary and secondary care practitioners together with academics and educationalists. It is highly recommended for doctors and medical students seeking new strategies for understanding and managing change. Sociologists and policy makers, too, will find the wide-ranging perspectives enlightening.