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Supramolecular Design for Biological Applications
by Nobuhiko YuiSupramolecular chemistry is the outburst topic of the next generation of science. While the majority of biomedical research efforts to date have centered on utilizing well-known polymeric materials, the recent progress in supramolecular chemistry has introduced a fascinating new field of macromolecular architecture. Supramolecular Design fo
Supramolecular Structure and Function 10
by Jasminka Brnjas-Kraljević Greta Pifat-MrzljakThe book is based on lectures presented on the International Summer School on Biophysics held in Croatia in September 2009. The advantage of the School is that it provides advanced training in very broad scope of areas related to biophysics contrary to other similar schools or workshops that are centered mainly on one topic or technique. In this volume, tenth in the row, the papers in the field of biophysics are presented. The topics are biological phenomena from single protein to macromolecular aggregations structure by using variant physical methods (NMR, EPR, FTIR, Mass Spectrometry, etc.). The interrelationship of supramolecular structures and their functions is enlightened by applications of principals of these physical methods in the biophysical and molecular biology context.
Supramolecular Synthons in Crystal Engineering of Pharmaceutical Properties (xx xx)
by Ashwini K. NangiaThis comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers.Key Features Covers the fundamentals of crystal engineering and supramolecular synthons. Details the challenges of low solubility and low permeability facing oral drug formulations. Explains how heterosynthons provide a rational approach to address and implement solutions. Provides case studies from academic and industrial labs to walk the reader through the actual steps. Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry.
Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols (Methods in Molecular Biology #2207)
by Thomas Mavromoustakos Andreas G. Tzakos Serdar DurdagiThis detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact.
Suprapontine Lesions and Neurogenic Pelvic Dysfunctions: Assessment, Treatment and Rehabilitation (Urodynamics, Neurourology and Pelvic Floor Dysfunctions)
by Gianfranco Lamberti Donatella Giraudo Stefania MuscoThis book provides a detailed review of neurogenic pelvic dysfunctions following a suprapontine lesion, since a clear understanding of the pathogenesis of vesical and bowel dysfunctions has become increasingly important in medical education.It covers both urinary incontinence and retention, constipation and faecal incontinence resulting from ischemic, haemorrhagic and traumatic brain injury and Parkinson’s disease. It also offers a concise yet comprehensive summary of the neurologic examination of the pelvis: all chapters include the most up-to-date scientific and clinical information with the relevant level of clinical evidence.The book is divided into three sections, which integrate basic science with clinical medicine. The first section features a general introduction and essential background into micturition and bowel neural control, focusing on cortical control. Section 2 is devoted to common clinical problems regarding the neurologic assessment of the perineum, while the last section summarises urological and bowel dysfunction in suprapontine lesions.Providing a clear, concise and informative introduction to urology, it is a practical guide for professionals, medical students and residents in Physical Medicine and Rehabilitation, Urology and Neurology.
Surely Not, Doctor! (The Dr Clifford Chronicles)
by Dr Robert CliffordDoctor Bob's country practice is in Tadchester on the Somerset coast, but no one can accuse the town of being a sleepy little backwater. All human life is there with its quirks, colour, comedy and richness . . .There's the absent-minded, incontinent vicar of St Peter's; the well-known London publisher whose dog has more taste than most; the lady magistrate who travels for miles for a doctor with warm hands and the packet of suppositories which prompts a bomb scare! Then there's the hairdresser with a penchant for male strippers and the whispering journalist who learnt how to shout. Even off duty, Doctor Bob's life is full of incident and he himself ends up with a long spell in hospital.It all goes to show that truth can be so much stranger than fiction . . .
Surely Not, Doctor!
by Robert CliffordDoctor Bob's country practice is in Tadchester on the Somerset coast, but no one can accuse the town of being a sleepy little backwater. All human life is there with its quirks, colour, comedy and richness . . .There's the absent-minded, incontinent vicar of St Peter's; the well-known London publisher whose dog has more taste than most; the lady magistrate who travels for miles for a doctor with warm hands and the packet of suppositories which prompts a bomb scare! Then there's the hairdresser with a penchant for male strippers and the whispering journalist who learnt how to shout. Even off duty, Doctor Bob's life is full of incident and he himself ends up with a long spell in hospital.It all goes to show that truth can be so much stranger than fiction . . .
Surface Ablation: Techniques for Optimum Results
by Ellen PennoWith Surface Ablation: Techniques for Optimum Results, refractive surgeons will learn efficient pre- and post-op routines that optimize chair time and lead to improved safety and excellent results for patients. Inside Surface Ablation: Techniques for Optimum Results by Dr. Ellen Anderson Penno is joined by 9 contributors who offer a practical approach with clinically useful tips including patient counseling and post-operative care that will improve patient satisfaction. This up-to-date book is an excellent resource for patient assessment of candidacy for refractive surgery or in post-operative co-management. In addition to chapters with information on patient selection, surgical techniques, post-op care, and prevention and management of complications, Surface Ablation: Techniques for Optimum Results includes several articles, contributed by leaders in the refractive surgery field, covering a variety of topics including surface ablation in keratoconus patients, corneal cross-linking, and ectasia. Surface Ablation: Techniques for Optimum Results is a clinically-oriented resource for residents and new refractive surgeons as well as the many seasoned refractive surgeons, general ophthalmologists following the increasing trend of transitioning away from LASIK towards surface ablation for many of their patients.
Surface and Tip-Enhanced Raman Scattering Spectroscopy: Bridging Theory and Applications
by Marek Procházka Janina Kneipp Bing Zhao Yukihiro OzakiThis book describes recent progress in the mechanistic studies and applications of surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS). In this book, various novel techniques in SERS and TERS such as UV resonance TERS, electrochemical TERS, and three-dimensional SERS imaging are outlined. A number of new applications of SERS and TERS such as those to photonics, nanotechnology, microfluidics, and medical diagnosis along with future perspectives are also discussed. Finally, the applications of new data analysis, models, and machine learning in SERS and TERS studies are reviewed. The novelty of this book is the forming of a new bridge between the theory and applications. Also, the importance of chemical mechanism and that of semiconductor-enhanced Raman scattering is emphasized. The main audiences are researchers in academia, research institutes, companies, and graduate students looking for a comprehensive book on the latest studies of SERS and TERS.
Surface Chemistry and Electrochemistry of Membranes
by Torben Smith SørensenAn eclectic mix of studies on chemical and electrochemical behaviour of membrane surfaces. The book looks at membranes - both organic and inorganic - from a host of different perspectives and in the context of many diverse disciplines. It explores the behaviours of both synthetic and biological membranes, employing physical, chemical and physiochem
Surface Engineering and Functional Nanomaterials for Point-of-Care Analytical Devices
by Buddhadev Purohit Pranjal ChandraThis book chronicles the role of advanced nanomaterials and surface engineering technologies in the development of point-of-care biosensors for health and environmental monitoring. All aspects of nanomaterial synthesis and characterization, functionalization methods, sensing surface engineering, signal amplification strategies, use of innovative technologies to enhance sensor efficiency and performances, and innovative applications of nanobiosensors to tackle real-life problems are discussed in this book with a focus on optical and electrochemical based sensing. It also covers the detection of infectious diseases and various disease biomarkers, smartphone-based biosensing, and portable diagnostics module developments with a discussion on the working mechanisms of these devices in various domains. The book also illustrates the recent trends in biosensing, and an overview of the challenges and probable solutions for the translation of biosensors from laboratory prototypes to commercial success.
Surface Engineering of Biomaterials: Synthesis and Processing Techniques (Emerging Materials and Technologies)
by Ajit Behera Debasis Nayak Biswajit Kumar SwainSurface engineering provides one of the most important means of engineering product differentiation in terms of quality, performance, and lifecycle cost. It is essential to achieve predetermined functional properties of materials such as mechanical strength, biocompatibility, corrosion resistance, wear resistance, and heat and oxidation resistance. Surface Engineering of Biomaterials addresses this topic across a diverse range of process technologies and healthcare applications. Introduces biomaterial surface science and surface engineering and includes criteria for biomaterial surface selection Focuses on a broad array of materials including metals, ceramics, polymers, alloys, and composites Discusses corrosion, degradation, and material release issues in implant materials Covers various processing routes to develop biomaterial surfaces, including for smart and energy applications Details techniques for post-modification of biomaterial surfaces This reference work helps researchers working at the intersection of materials science and biotechnology to engineer functional biomaterials for a variety of applications.
Surface Guided Radiation Therapy
by Jeremy D. P. Hoisak Adam B. Paxton Benjamin Waghorn Todd PawlickiSurface Guided Radiation Therapy provides a comprehensive overview of optical surface image guidance systems for radiation therapy. It serves as an introductory teaching resource for students and trainees, and a valuable reference for medical physicists, physicians, radiation therapists, and administrators who wish to incorporate surface guided radiation therapy (SGRT) into their clinical practice. This is the first book dedicated to the principles and practice of SGRT, featuring: Chapters authored by an internationally represented list of physicists, radiation oncologists and therapists, edited by pioneers and experts in SGRT Covering the evolution of localization systems and their role in quality and safety, current SGRT systems, practical guides to commissioning and quality assurance, clinical applications by anatomic site, and emerging topics including skin mark-less setups. Several dedicated chapters on SGRT for intracranial radiosurgery and breast, covering technical aspects, risk assessment and outcomes. Jeremy Hoisak, PhD, DABR is an Assistant Professor in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Dr. Hoisak’s clinical expertise includes radiosurgery and respiratory motion management. Adam Paxton, PhD, DABR is an Assistant Professor in the Department of Radiation Oncology at the University of Utah. Dr. Paxton’s clinical expertise includes patient safety, motion management, radiosurgery, and proton therapy. Benjamin Waghorn, PhD, DABR is the Director of Clinical Physics at Vision RT. Dr. Waghorn’s research interests include intensity modulated radiation therapy, motion management, and surface image guidance systems. Todd Pawlicki, PhD, DABR, FAAPM, FASTRO, is Professor and Vice-Chair for Medical Physics in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Dr. Pawlicki has published extensively on quality and safety in radiation therapy. He has served on the Board of Directors for the American Society for Radiology Oncology (ASTRO) and the American Association of Physicists in Medicine (AAPM).
Surface Modification of Titanium Dental Implants
by Karan GulatiThis book provides a comprehensive technical and scientific overview of the surface modification of titanium dental implants. Coverage ranges from basic concepts of surface modification to advanced micro- and nano-engineering strategies employed to achieve augmented bioactivity to meet the needs of compromised patient conditions.A special focus of the book is advanced state-of-the-art electrochemically anodized nanostructures fabricated on implants towards enhanced bioactivity and local therapy.Surface Modification of Titanium Dental Implants will keep you current in the domain of titanium dental implants and will provide an improved understanding of their performance and application. The book will benefit engineers, clinicians, and researchers in biomaterials, biomedical engineering, dental and bone implants, nano-engineering, and technology.
Surface Plasmon Resonance Imaging: Basic Theory and Practical Methodology (Lecture Notes in Chemistry #95)
by Yi ChenThis book introduces the fundamentals, instruments, methodology, and applications of surface plasmon resonance imaging (SPRi) and related techniques. It provides an overview of SPRi development and an easy-to-understand interpretation of theory and operation principles. Some unique ideas proposed by the authors to design and set up SPRi devices and methods are disclosed for the first time. Crucial manipulation experiences are also summarized here, including chip surface functionalization, sensitivity enhancement and coupling of SPRi with other analytical techniques. The application of SPRi for molecular interaction study, featuring high throughput, label-freeness, and physiologically compatible analysis, is discussed in detail. This book is of interest and useful to a wide readership in bioanalytical chemistry, molecular biology, and many related interdisciplinary fields.
Surfactants and Polymers in Drug Delivery (Drugs and the Pharmaceutical Sciences)
by Martin MalmstenThis reference features the latest findings surrounding the physicochemical aspects of surfactant and polymer systems to facilitate the design and understanding of novel and advanced drug delivery formulations. It covers the basics of surfactant and polymer surface activity and self-assembly, the various types of structures formed by such compounds
Surfactants in Personal Care Products and Decorative Cosmetics (Surfactant Science)
by Linda D. Rhein Mitchell Schlossman Anthony O’Lenick P. SomasundaranFrom anti-aging creams to make-up, surfactants play a key role as delivery systems for skin care and decorative cosmetic products. Surfactants in Personal Care Products and Decorative Cosmetics, Third Edition presents a scientific basis in surfactant science and recent advances in the industry necessary for understanding, formulating, and te
The Surgeon (A Rizzoli & Isles Novel #1)
by Tess Gerritsen<p>He slips into homes at night and walks silently into bedrooms where women lie sleeping, about to awaken to a living nightmare. The precision of his methods suggests that he is a deranged man of medicine, prompting the Boston newspapers to dub him "The Surgeon." <p>Led by Detectives Thomas Moore and Jane Rizzoli, the cops must consult the victim of a nearly identical crime: Two years ago, Dr. Catherine Cordell fought back and filled an attacker before he could complete his assault. Now this new killer is re-creating, with chilling accuracy, the details of Cordell's ordeal. <p>With every new murder he seems to be taunting her, cutting ever closer, from her hospital to her home. And neither Moore nor Rizzoli can protect Cordell from a ruthless hunter who somehow understands--and savors--the secret fears of every woman he kills. <P><b>A New York Times Bestseller</b>
A Surgeon, A Midwife, A Family: A Sweet Medical Romance (Good, Bad and Ugly #1)
by Gill SandersonThe first novel in Gill Sanderson's heartwarming Good, Bad and Ugly series, perfect for fans of Mia Faye, Laura Scott, Helen Scott Taylor, Grey's Anatomy and ER.Readers ADORE Gill's gripping medical romances!'The story was exciting, romantic and I loved every part of it... I had a hard time putting it down' 5* reader review'I find all of Gill Sanderson's books very readable and enjoy the escapism they give me' 5* author review'Remarkable writer!!' 5* author review 'A truly wonderful writer' 5* author reviewIt wasn't a good start when the hospital's newest midwife began work by knocking instruments onto the operating theatre floor. Miranda Gale expected the neonatal surgeon, Jack Sinclair, to take her to task. Instead he suggested ways in which she could further her career. But he was so aloof! Vivacious Miranda would have preferred him to shout at her.Working together led to unexpected intimacy. Jack asked Miranda to marry him, to have the children he felt they both wanted. But Miranda had kept something from him and only the most desperate of remedies could put things right.Don't miss Gill Sanderson's enthralling medical romances, including the A Lakeland Practice and The Wilde Twins series.
A Surgeon, A Midwife, A Family: A Sweet Medical Romance (Good, Bad And Ugly Ser. #1)
by Gill SandersonThe first novel in Gill Sanderson's heartwarming Good, Bad and Ugly series, perfect for fans of Mia Faye, Laura Scott, Helen Scott Taylor, Grey's Anatomy and ER.Readers ADORE Gill's gripping medical romances!'The story was exciting, romantic and I loved every part of it... I had a hard time putting it down' 5* reader review'I find all of Gill Sanderson's books very readable and enjoy the escapism they give me' 5* author review'Remarkable writer!!' 5* author review 'A truly wonderful writer' 5* author reviewIt wasn't a good start when the hospital's newest midwife began work by knocking instruments onto the operating theatre floor. Miranda Gale expected the neonatal surgeon, Jack Sinclair, to take her to task. Instead he suggested ways in which she could further her career. But he was so aloof! Vivacious Miranda would have preferred him to shout at her.Working together led to unexpected intimacy. Jack asked Miranda to marry him, to have the children he felt they both wanted. But Miranda had kept something from him and only the most desperate of remedies could put things right.Don't miss Gill Sanderson's enthralling medical romances, including the A Lakeland Practice and The Wilde Twins series.
The Surgeon and the Princess: The Surgeon And The Princess / Captivated By Her Runaway Doc (Mills And Boon Medical Ser.)
by Karin BaineA wounded princess, an off-limits surgeon Can they heal each other?Adjusting to life as an amputee, independent medic Princess Georgiana refuses help from anyone. Yet using surgeon Edward Lawrence&’s state-of-the-art clinic would speed her recovery and escape from the palace for good… Rehabilitation with the gorgeous—and off-limits—Ed means letting her guard down, something Georgiana finds hard… But can Ed make her see just how strong her scars make her and how much she has to offer? &“Reunion with His Surgeon Princess a sweet and exciting royal romance story. Author Karin Baine has a spell-binding way with her writing. I could visualize the story as it unfolded on the pages. She also did a marvelous job of bringing these two characters together for their happy ever after despite their emotional baggage. Highly recommended for all readers of medical romance.&”-Goodreads&“Emotionally enchanting! The story was fast-paced, emotionally charged and oh so satisfying!&”-Goodreads on Their One-Night Twin Surprise
Surgeon Boss, Surprise Dad
by Janice LynnDedicated surgeon and confirmed bachelor Adam Cline didn't think he'd ever settle down, until beautiful nurse Liz stole his heart away! But when Adam learns he can never give Liz the life she's always dreamed of, he tells her that, for her sake, he must walk away.But Liz has a secret of her own. Putting her broken heart aside, she decides to tell Adam she is expecting his baby. Now, no matter what the future holds, Liz must prove to Adam that their one chance at happiness is to come together--as a family.
A Surgeon for the Single Mom
by Charlotte HawkesFrom bachelor doc……to family man!As a single parent and helicopter rescue doc, fiercely independent Effie Robinson has no time for romance! So when hotshot neurosurgeon Talank Basu proposes a mutually beneficial dating ruse, what could be the harm? Only, Effie’s not prepared for how protected and supported he makes her feel… Tak’s fighting their sizzling attraction just as much as she is—will they finally give in and trust in their once-in-a-lifetime chemistry?“Ms. Hawkes has delivered a fantastic read in this book where the chemistry between this couple was heady and convincing….”— Harlequin Junkie on A Bride to Redeem Him“…it was right at the end that had me smiling a lot, because of how far the hero and heroine have come in their relationship.”— Harlequin Junkie on Tempted by Dr. Off Limits
Surgeon General's Warning
by Mike StobbeWhat does it mean to be the nation's doctor? In this engaging narrative, journalist Mike Stobbe examines the Office of the U.S. Surgeon General, emphasizing that it has always been unique within the federal government in its ability to influence public health. But now, in their efforts to provide leadership in public health policy, surgeons general compete with other high-profile figures such as the secretary of the Department of Health and Human Services and the director of the Centers for Disease Control and Prevention (CDC). Furthermore, in an era of declining budgets, when public health departments have eliminated tens of thousands of jobs, some argue that a lower-profile and ineffective surgeon general is a waste of money. By tracing stories of how surgeons general like Luther Terry, C. Everett Koop, and Joycelyn Elders created policies and confronted controversy in response to issues like smoking, AIDS, and masturbation, Stobbe highlights how this office is key to shaping the nation's health and explailns why its decline is harming our national well-being.
Surgeon, Heal Thyself: Optimising Surgical Performance by Managing Stress
by Uttam ShiralkarSurgeons start their career in the expectation that it will bring personal satisfaction through an unparalleled sense of achievement and professional growth. Nonetheless, a career in surgery carries with it serious challenges: surgical training is rigorous, both emotionally and physically, and demands that the surgeon adjust to unpredictability. Chronic levels of stress can affect surgical performance, the quality of family relationships, and even the nature of the doctor–patient relationship. Unmanaged stress has been shown to contribute to physical illness, emotional problems, absenteeism, poor job performance, drug abuse, and negative social attitudes. With a background in both surgery and psychological medicine, Dr Shiralkar examines the psychosocial burden of being a surgeon and offers insights into the role of intra-human factors in surgery. He reveals surgical performance from a psychological perspective and highlights the factors that cause unsatisfactory performance. He also offers solutions to rectify the problem and prevent burnout. The book will be invaluable to all those embarking on a surgical career, as well as to established surgeons in all specialties who wish to understand how to identify and manage the factors that could lead to career-limiting levels of stress.