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The Master Builder: How the New Science of the Cell is Rewriting the Story of Life
by Alfonso Martinez AriasWhat defines who we are? Until now, the biological answer has been our genes. Leading biologist Alfonso Martinez Arias breaks with popular tradition to make a bold argument: what defines us is our cells. Drawing on groundbreaking research, he reveals that we are composed of a thrillingly complex, constantly rearranging symphony of cells that know how to count, feel, and give form to our bodies. While DNA is important, nothing in your genes explains why your heart is on the left, why you have five fingers and not ten, why genetically identical twins have different sets of fingerprints, or why it's possible for a mother to apparently share no DNA with the children she gave birth to! At the heart of it all is a powerful new conception of the essence of life. Our identities are shaped by the interconnections between cells, working cooperatively, creating something greater than its parts - the unbroken lineage that connects us to the fertilized egg from which we developed and back through the billions of years of our planet's history, to the very first cell of all life on Earth. A sweeping revision of both the present and the history of life, The Master Builder puts forward a new paradigm for understanding biology, transforming our approach to where we come from, what shapes us, and where we are going - as individuals, a species, and the community of life itself.
The Master and His Emissary
by Iain McgilchristWhy is the brain divided? The difference between right and left hemispheres has been puzzled over for centuries. In a book of unprecedented scope, Iain McGilchrist draws on a vast body of recent brain research, illustrated with case histories, to reveal that the difference is profound--not just this or that function, but two whole, coherent, but incompatible ways of experiencing the world. The left hemisphere is detail oriented, prefers mechanisms to living things, and is inclined to self-interest, where the right hemisphere has greater breadth, flexibility, and generosity. This division helps explain the origins of music and language, and casts new light on the history of philosophy, as well as on some mental illnesses.In the second part of the book, McGilchrist takes the reader on a journey through the history of Western culture, illustrating the tension between these two worlds as revealed in the thought and belief of thinkers and artists, from Aeschylus to Magritte. He argues that, despite its inferior grasp of reality, the left hemisphere is increasingly taking precedence in the modern world, with potentially disastrous consequences. This is truly a tour de force that should excite interest in a wide readership.
The Masters of Medicine: Our Greatest Triumphs in the Race to Cure Humanity's Deadliest Diseases
by Andrew LamAn in-depth look at the mavericks, moments, and mistakes that sparked the greatest medical discoveries in modern times—plus the cures that will help us live longer and healthier lives in this century . . . and beyond. Human history hinges on the battle to confront our most dangerous enemies—the half-dozen diseases responsible for killing almost all of mankind. And while the story of our triumphs over these afflictions reveals an inspiring tapestry of human achievement, the journey was far from smooth. In The Masters of Medicine, Dr. Andrew Lam distills the long arc of medical progress down to the crucial moments that were responsible for the world&’s greatest medical miracles. Discover fascinating true stories of scientists and doctors throughout history, including: Rival surgeons who killed patient after patient in their race to operate on beating hearts—and put us on the path toward the heart transplant A quartet of Canadians whose miraculous discovery of insulin was marred by jealousy and resentment The doctors who discovered penicillin, but were robbed of the credit The feud between two Americans in the quest for the polio vaccine A New York surgeon whose &“heretical&” idea to cure patients by deliberately infecting them has now inspired our next-best hope to defeat cancer A Hungarian doctor who solved the greatest mystery of maternal deaths in childbirth, only to be ostracized for his discovery The Masters of Medicine is a fascinating chronicle of human courage, audacity, error, and luck. This riveting ode to mankind reveals why the past is prelude to the game-changing breakthroughs of tomorrow.
The Match
by Susan Whitman HelfgotJoseph Helfgot, the son of Holocaust survivors, worked his way from a Lower East Side tenement to create a successful Hollywood research company. But his heart was failing. After months of waiting for a heart transplant, he died during the operation. Hours after his death, his wife Susan was asked a shocking question: would she donate her husband’s face to a total stranger?The stranger was James Maki, the adopted son of parents who spent part of World War II in an internment camp for Japanese Americans. Rebelling against his stern father, a professor, by enlisting to serve in Vietnam, he returned home a broken man, addicted to drugs. One night he fell facedown onto the electrified third rail of a Boston subway track. A young Czech surgeon who was determined to make a better life on the other side of the Iron Curtain was on call when the ambulance brought Maki to the hospital. Although Dr. Bohdan Pomahac gave him little chance of survival, Maki battled back. He was sober and grateful for a second chance, but he became a recluse, a man without a face. His only hope was a controversial face transplant, and Dr. Pomahac made it happen. InThe Match,Susan Whitman Helfgot captures decades of drama and history, taking us from Warsaw to Japan, from New York to Hollywood. Through wars and immigration, poverty and persecution, from a medieval cadaver dissection to a stunning seventeen-hour face transplant, she weaves together the story of people forever intertwined—a triumphant legacy of hope.
The Match
by William Novak Susan Whitman HelfgotJoseph Helfgot, the son of Holocaust survivors, worked his way from a Lower East Side tenement to create a successful Hollywood research company. But his heart was failing. After months of waiting for a heart transplant, he died during the operation. Hours after his death, his wife Susan was asked a shocking question: would she donate her husband's face to a total stranger? The stranger was James Maki, the adopted son of parents who spent part of World War II in an internment camp for Japanese Americans. Rebelling against his stern father, a professor, by enlisting to serve in Vietnam, he returned home a broken man, addicted to drugs. One night he fell facedown onto the electrified third rail of a Boston subway track. A young Czech surgeon who was determined to make a better life on the other side of the Iron Curtain was on call when the ambulance brought Maki to the hospital. Although Dr. Bohdan Pomahac gave him little chance of survival, Maki battled back. He was sober and grateful for a second chance, but he became a recluse, a man without a face. His only hope was a controversial face transplant, and Dr. Pomahac made it happen. In The Match, Susan Whitman Helfgot captures decades of drama and history, taking us from Warsaw to Japan, from New York to Hollywood. Through wars and immigration, poverty and persecution, from a medieval cadaver dissection to a stunning seventeen-hour face transplant, she weaves together the story of people forever intertwined--a triumphant legacy of hope.
The Match: Savior Siblings and One Family's Battle to Heal Their Daughter
by Beth WhitehouseMy Sister's Keeper in nonfiction: a family's real-life struggle to cure their daughter by creating her genetic match Katie Trebing was diagnosed at three months old with Diamond Blackfan anemia, a rare form of anemia that prevents bone marrow from producing red blood cells. Even with a lifetime of monthly blood transfusions, she faced a poor prognosis. Pulitzer Prize-winning journalist Beth Whitehouse follows the Trebings as they make the decision to create a genetically matched sibling using preimplantation genetic diagnosis (PGD) and in vitro fertilization, and proceed with a risky bone-marrow transplant that could kill their daughter rather than save her. The Match is a timely and provocative look at urgent issues that can only become more complex and pressing as genetic and reproductive technologies advance.From the Trade Paperback edition.
The Maternal Imprint: The Contested Science of Maternal-Fetal Effects
by Sarah S. RichardsonLeading gender and science scholar Sarah S. Richardson charts the untold history of the idea that a woman's health and behavior during pregnancy can have long-term effects on her descendants' health and welfare. The idea that a woman may leave a biological trace on her gestating offspring has long been a commonplace folk intuition and a matter of scientific intrigue, but the form of that idea has changed dramatically over time. Beginning with the advent of modern genetics at the turn of the twentieth century, biomedical scientists dismissed any notion that a mother—except in cases of extreme deprivation or injury—could alter her offspring’s traits. Consensus asserted that a child’s fate was set by a combination of its genes and post-birth upbringing. Over the last fifty years, however, this consensus was dismantled, and today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Collectively, these sciences argue that a woman’s experiences, behaviors, and physiology can have life-altering effects on offspring development. Tracing a genealogy of ideas about heredity and maternal-fetal effects, this book offers a critical analysis of conceptual and ethical issues—in particular, the staggering implications for maternal well-being and reproductive autonomy—provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.
The Maternal Imprint: The Contested Science of Maternal-Fetal Effects
by Sarah S. RichardsonLeading gender and science scholar Sarah S. Richardson charts the untold history of the idea that a woman's health and behavior during pregnancy can have long-term effects on her descendants' health and welfare. The idea that a woman may leave a biological trace on her gestating offspring has long been a commonplace folk intuition and a matter of scientific intrigue, but the form of that idea has changed dramatically over time. Beginning with the advent of modern genetics at the turn of the twentieth century, biomedical scientists dismissed any notion that a mother—except in cases of extreme deprivation or injury—could alter her offspring’s traits. Consensus asserted that a child’s fate was set by a combination of its genes and post-birth upbringing. Over the last fifty years, however, this consensus was dismantled, and today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Collectively, these sciences argue that a woman’s experiences, behaviors, and physiology can have life-altering effects on offspring development. Tracing a genealogy of ideas about heredity and maternal-fetal effects, this book offers a critical analysis of conceptual and ethical issues—in particular, the staggering implications for maternal well-being and reproductive autonomy—provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.
The Maternal Imprint: The Contested Science of Maternal-Fetal Effects
by Sarah S. RichardsonLeading gender and science scholar Sarah S. Richardson charts the untold history of the idea that a woman's health and behavior during pregnancy can have long-term effects on her descendants' health and welfare. The idea that a woman may leave a biological trace on her gestating offspring has long been a commonplace folk intuition and a matter of scientific intrigue, but the form of that idea has changed dramatically over time. Beginning with the advent of modern genetics at the turn of the twentieth century, biomedical scientists dismissed any notion that a mother—except in cases of extreme deprivation or injury—could alter her offspring’s traits. Consensus asserted that a child’s fate was set by a combination of its genes and post-birth upbringing. Over the last fifty years, however, this consensus was dismantled, and today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Collectively, these sciences argue that a woman’s experiences, behaviors, and physiology can have life-altering effects on offspring development. Tracing a genealogy of ideas about heredity and maternal-fetal effects, this book offers a critical analysis of conceptual and ethical issues—in particular, the staggering implications for maternal well-being and reproductive autonomy—provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.
The Maternal Sensitivity Program: A Model for Promoting Infant Development in Challenging Contexts
by Patrícia Alvarenga M. Ángeles Cerezo Yana KuchirkoThis book presents the Maternal Sensitivity Program (MSP), an eight-session home-delivered intervention designed to enhance overall maternal sensitivity to infant behavior between the third and the tenth month of life using video feedback and live modeling strategies. The intervention was based on successful international programs but was specifically developed to fit the realities and needs of low-income countries, whose public health services rely on scarce human and economic resources. The program aims to promote maternal acknowledgment of infant mental activity and model responses that encourage infants' communication of intentions, needs, desires, and emotions.The first part of the book provides an overview of core theories related to the concept of maternal sensitivity, illustrating how it varies across cultural contexts, and how it is shaped by economic scarcity. The second part of the book presents evidence of the effectiveness of sensitivity-based interventions, describes and provides a rationale for the Maternal Sensitivity Program (MSP), and proposes a framework for training interventionists seeking to implement the program in different contexts. The third part of the book presents the intervention manual, describing in detail the procedures in each of the eight sessions of the program. The Maternal Sensitivity Program: A Model for Promoting Infant Development in Challenging Contexts will be an invaluable resource for developmental psychologists, health care providers, and social workers who work with families in low-income countries and in contexts of social vulnerability and need to implement low-cost interventions to foster healthy child development.
The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective
by William C Klingensmith IIIThis book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective - from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e. g. , renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.
The Mathematics of Mechanobiology: Cetraro, Italy 2018 (Lecture Notes in Mathematics #2260)
by Benoît Perthame Alfio Quarteroni Lev Truskinovsky Antonio DeSimoneThis book presents the state of the art in mathematical research on modelling the mechanics of biological systems – a science at the intersection between biology, mechanics and mathematics known as mechanobiology. The book gathers comprehensive surveys of the most significant areas of mechanobiology: cell motility and locomotion by shape control (Antonio DeSimone); models of cell motion and tissue growth (Benoît Perthame); numerical simulation of cardiac electromechanics (Alfio Quarteroni); and power-stroke-driven muscle contraction (Lev Truskinovsky).Each section is self-contained in terms of the biomechanical background, and the content is accessible to all readers with a basic understanding of differential equations and numerical analysis. The book disentangles the phenomenological complexity of the biomechanical problems, while at the same time addressing the mathematical complexity with invaluable clarity. The book is intended for a wide audience, in particular graduate students and applied mathematicians interested in entering this fascinating field.
The Mathematics of Medical Imaging
by Timothy G. FeemanThe basic mathematics of computerized tomography, the CT scan, are aptly presented for an audience of undergraduates in mathematics and engineering. Assuming no prior background in advanced mathematical analysis, topics such as the Fourier transform, sampling, and discrete approximation algorithms are introduced from scratch and are developed within the context of medical imaging. A chapter on magnetic resonance imaging focuses on manipulation of the Bloch equation, the system of differential equations that is the foundation of this important technology. Extending the ideas of the acclaimed first edition, new material has been adeed to render an even more accessible textbook for course usage. This edition includes new discussions of the Radon transform, the Dirac delta function and its role in X-ray imaging, Kacmarz's method and least squares approximation, spectral filtering, and more. Copious examples and exercises, new computer-based exercises, and additional graphics have been added to further delineate concepts. The use of technology has been revamped throughout with the incorporation of the open source programming environment R to illustrate examples and composition of graphics. All R code is available as extra source material on SpringerLink. From the reviews of the first edition: "This book is valuable, for it addresses with care and rigor the relevance of a variety of mathematical topics to a real-world problem. . . . T his book is well written. It serves its purpose of focusing a variety of mathematical topics onto a real-world application that is in its essence mathematics. " -The Journal of Nuclear Medicine, Vol. 51 (12), December, 2010 "This new book by Timothy Feeman, truly intended to be a beginner's guide, makes the subject accessible to undergraduates with a working knowledge of multivariable calculus and some experience with vectors and matrix methods. . . . author handles the material with clarity and grace. . . " -The Mathematical Association of America, February, 2010
The Matter of the Heart: A History of the Heart in Eleven Operations
by Thomas Morris“More than a litany of medical advances—it’s the story of the gritty, bloody and deadly experiences that underlie scientific progress.” —Washington PostAn eye-opening and heroic story of pioneering heart surgeons, structured around eleven operations.For thousands of years the human heart remained the deepest of mysteries; both home to the soul and an organ too complex to touch, let alone operate on.Then, in the late nineteenth century, medics began going where no one had dared go before. The following decades saw the mysteries of the heart exposed, thanks to pioneering surgeons, brave patients and even sacrificial dogs.In eleven landmark operations, Thomas Morris tells us stories of triumph, reckless bravery, swaggering arrogance, jealousy and rivalry, and incredible ingenuity: the trail-blazing ‘blue baby’ procedure that transformed wheezing infants into pink, healthy children; the first human heart transplant, which made headline news around the globe. And yet the heart still feels sacred: just before the operation to fit one of the first artificial hearts, the patient’s wife asked the surgeon if he would still be able to love her.The Matter of the Heart gives us a view over the surgeon’s shoulder, showing us the heart’s inner workings and failings. It describes both a human story and a history of risk-taking that has ultimately saved millions of lives.“A thoroughly engaging history.” —The Wall Street Journal“Morris’s expert guided tour of cardiac surgery and its quirky, brilliant innovators covers a dazzling and dizzying array of procedures and hints at tantalizing prospects for future surprises.” —Publishers Weekly, starred review“A well-developed narrative with no end of heroes.’“ —Kirkus Reviews“Gripping.” —John Crace, The Guardian
The Mature Mind: The Positive Power of the Aging Brain
by Gene D. CohenPsychological aspects of the aging brain
The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs (The Maudsley Prescribing Guidelines Series)
by David M. Taylor Mark HorowitzThe Maudsley® Deprescribing Guidelines Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more. Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so. The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment. This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts). Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse. Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
The Maudsley Guidelines on Advanced Prescribing in Psychosis
by Paul Morrison David M. Taylor Phillip McGuireA guide to treating psychosis that provides information on drug options and side-effects in order to allow for weighing treatment options knowledgably The Maudsley Guidelines on Advanced Prescribing in Psychosis offers a resource that puts the focus on the need to treat the individual needs of a patient. The authors – noted experts on the topic – offer an alternative to the one-size-fits-all treatment of psychosis and shows how to build psychiatrist and patient relationships that will lead to effective individual treatment plans. The book provides up-to-date data and information about commonly used anti-psychotic drugs and drugs used in bipolar disorder. The text weighs both the upsides and downsides of each pharmaceutical presented, and helps prescribers and patients weigh the costs and benefits of various options to reach an appropriate treatment plan. The authors highlight the treatment at a population level and the systems in which individual treatments take places. This important resource: Facilitates the tailoring of an appropriate treatment plan for clients manifesting signs of psychosis Offers a comparative strategy that helps gauge the suitability of one treatment plan over another Provides at-hand data and information about commonly used anti-psychotic drugs Includes an understanding of the origins and side-effects of each drug presented The Maudsley Guidelines on Advanced Prescribing in Psychosis offers psychiatrists and other mental health practitioners an essential guide for treating psychosis on an individualized level.
The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry (The\maudsley Prescribing Guidelines Ser.)
by Fiona Gaughran David M. Taylor Toby PillingerLearn to improve your assessment, investigation, and management of physical health conditions in people with severe mental illness The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry offers psychiatric and general practitioners an evidence-based and practical guide for the appropriate assessment, investigation, and management of common physical health conditions seen in people with severe mental illness. Written by a renowned team of respected experts in medicine, surgery, pharmacy, dietetics, physiotherapy, and psychiatry, the book bridges the gap between psychiatric and physical health services for the severely mentally ill. The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry also provides practitioners with expert guidance on making effective referrals to other medical and surgical subspecialties, telling readers what information subspecialties would expect to receive. Its use will improve the quality of clinical care received by mentally ill patients and, by promoting a holistic approach to treatment that considers both body and mind, will enhance the therapeutic relationship between patient and practitioner. The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry covers the following: Guidance on assessment and management of well over a hundred different medical and surgical presentations commonly seen in people with serious mental illness Management of physical health emergencies in a psychiatric setting Evidence-based approaches to management of physical side effects of psychiatric medications Advice on approaches to promote a healthy lifestyle in people with serious mental illness, such as smoking cessation and changes to diet and physical activity Perfect for both psychiatrists and general practitioners who wish to improve the quality of care they provide to people with serious mental illness, The Maudsley Practice Guidelines for Physical Health Conditions in Psychiatry will be of use to anyone setting out to navigate the divide between the treatment of psychiatric and physical health conditions.
The Maudsley Prescribing Guidelines for Mental Health Conditions in Physical Illness (The Maudsley Prescribing Guidelines Series)
by David M. Taylor Siobhan GeeMeet the challenges of mental health prescribing in the physically unwell with this essential guide Treating mental health conditions in physically unwell patients presents unique challenges for clinicians and other practitioners. The efficacy and safety of psychotropic medications is established in physically healthy patients. In physically unwell people, psychotropics can have different outcomes and give rise to serious adverse effects that can complicate or worsen physical health conditions. Many clinicians face difficult decisions about prescribing for mental health conditions in such cases, and reliable information for them is scarce. The Maudsley® Prescribing Guidelines for Mental Health Conditions in Physical Illness meets this urgent need with a comprehensive guide to the safe and effective pharmacological management of mental illness in physically unwell patients. Covering a wide range of physical health conditions and comorbidities, the book makes evidence-based recommendations on pharmacological interventions. It’s an essential resource for any clinical practitioner looking to balance the physical and mental wellbeing of people with concurrent physical and mental health conditions. The Maudsley® Prescribing Guidelines for Mental Health Conditions in Physical Illness readers will also find: Prescribing recommendations for mental health conditions including depression, anxiety, psychosis and bipolar affective disorderDetailed discussion of the consequences for mental health prescribing in physical health conditions such as cardiac disease, diabetes, chronic obstructive pulmonary disease, and many moreTreatment of complex and frequently encountered clinical scenarios such as restarting psychotropics after overdose and steroid-induced psychiatric conditions The Maudsley® Prescribing Guidelines for Mental Health Conditions in Physical Illness is an essential reference for all prescribers, clinical pharmacists and nurses who work with patients with comorbid mental and physical illnesses.
The Maudsley Prescribing Guidelines in Psychiatry
by Allan H. Young David M. Taylor Thomas R. BarnesThe revised 13th edition of the essential reference for the prescribing of drugs for patients with mental health disorders The revised and updated 13th edition of The Maudsley Prescribing Guidelines in Psychiatry provides up-to-date information, expert guidance on prescribing practice in mental health, including drug choice, treatment of adverse effects and how to augment or switch medications. The text covers a wide range of topics including pharmacological interventions for schizophrenia, bipolar disorder, depression and anxiety, and many other less common conditions. There is advice on prescribing in children and adolescents, in substance misuse and in special patient groups. This world-renowned guide has been written in concise terms by an expert team of psychiatrists and specialist pharmacists. The Guidelines help with complex prescribing problems and include information on prescribing psychotropic medications outside their licensed indications as well as potential interactions with other medications and substances such as alcohol, tobacco and caffeine. In addition, each of the book’s 165 sections features a full reference list so that evidence on which guidance is based can be readily accessed. This important text: Is the world’s leading clinical resource for evidence-based prescribing in day-to-day clinical practice and for formulating prescribing policy Includes referenced information on topics such as transferring from one medication to another, prescribing psychotropic medications during pregnancy or breastfeeding, and treating patients with comorbid physical conditions, including impaired renal or hepatic function. Presents guidance on complex clinical problems that may not be encountered routinely Written for psychiatrists, neuropharmacologists, pharmacists and clinical psychologists as well as nurses and medical trainees, The Maudsley Prescribing Guidelines in Psychiatry are the established reference source for ensuring the safe and effective use of medications for patients presenting with mental health problems.
The Maudsley Prescribing Guidelines in Psychiatry
by David Taylor Carol Paton Shitij KapurHelps with complex prescribing needs The evidence base for drug treatments in psychiatry ranges from meta-analyses and randomised controlled clinical trials to single case reports, and from NICE guidelines to individual SPCs. Where do you look for information when transferring a patient from one drug to another? Where do you find a clear overview when dealing with a complex patient (e. g, with co-morbid epilepsy or liver disease or HIV infection)? Where can you seek advice on prescribing psychotropics during pregnancy? The Maudsley Prescribing Guidelines in Psychiatry! The leading clinical reference for handling prescribing problems as encountered in daily practice and for formulating prescribing policy. Evidence-based and written by experts This book is the essential guide for anyone responsible for prescribing, dispensing or administering drugs for patients with mental health disorders. All the evidence has been reviewed and summarized succinctly by an expert team of psychiatrists and pharmacists. New content and improved format This new edition makes greater use of tables and boxes to facilitate quick reference and includes new sections on cytochrome-mediated interactions and psychiatric side effects of non-psychotropic drugs. Clinically relevant Chapters address plasma monitoring, schizophrenia, bipolar disorder, depression and anxiety, children and adolescents, substance abuse and special patient groups. Each section has a full reference list. The book covers prescribing drugs outside their licensed indications and their interaction with substances such as alcohol, nicotine and caffeine. Useful for all levels of experience Trainees will gain important information regarding the rational, safe and effective use of medications for patients with mental illness. Experienced clinicians will find excellent guidance regarding more complex issues that they may not encounter regularly. Why the Maudsley Prescribing Guidelines in Psychiatry? Long recognized as an international trailblazer in mental health care, the Maudsley Hospital earned its reputation for excellence in both in-patient and community care. It is highly regarded for its research, and pioneered the use of clinical neuroscience. You can trust The Maudsley Prescribing Guidelines in Psychiatry to be scientifically sound and clinically effective.
The Maudsley Prescribing Guidelines in Psychiatry
by David Taylor Carol Paton Shitij KapurHelps with complex prescribing needs The evidence base for drug treatments in psychiatry ranges from meta-analyses and randomised controlled clinical trials to single case reports, and from NICE guidelines to individual SPCs. Where do you look for information when transferring a patient from one drug to another? Where do you find a clear overview when dealing with a complex patient (e.g, with co-morbid epilepsy or liver disease or HIV infection)? Where can you seek advice on prescribing psychotropics during pregnancy? The Maudsley Prescribing Guidelines in Psychiatry! The leading clinical reference for handling prescribing problems as encountered in daily practice and for formulating prescribing policy. Evidence-based and written by experts This book is the essential guide for anyone responsible for prescribing, dispensing or administering drugs for patients with mental health disorders. All the evidence has been reviewed and summarized succinctly by an expert team of psychiatrists and pharmacists. New content and improved format This new edition makes greater use of tables and boxes to facilitate quick reference and includes new sections on cytochrome-mediated interactions and psychiatric side effects of non-psychotropic drugs. Clinically relevant Chapters address plasma monitoring, schizophrenia, bipolar disorder, depression and anxiety, children and adolescents, substance abuse and special patient groups. Each section has a full reference list. The book covers prescribing drugs outside their licensed indications and their interaction with substances such as alcohol, nicotine and caffeine. Useful for all levels of experience Trainees will gain important information regarding the rational, safe and effective use of medications for patients with mental illness. Experienced clinicians will find excellent guidance regarding more complex issues that they may not encounter regularly. Why the Maudsley Prescribing Guidelines in Psychiatry? Long recognized as an international trailblazer in mental health care, the Maudsley Hospital earned its reputation for excellence in both in-patient and community care. It is highly regarded for its research, and pioneered the use of clinical neuroscience. You can trust The Maudsley Prescribing Guidelines in Psychiatry to be scientifically sound and clinically effective.
The Maudsley Prescribing Guidelines in Psychiatry (The Maudsley Prescribing Guidelines Series)
by Allan H. Young David M. Taylor Thomas R. BarnesThe Maudsley® Prescribing Guidelines in Psychiatry The new edition of the world-renowned reference guide on the use of medications for patients presenting with mental health problems The Maudsley Prescribing Guidelines in Psychiatry is the essential evidence-based handbook on the safe and effective prescribing of psychotropic agents. Covering both common and complex prescribing situations encountered in day-to-day clinical practice, this comprehensive resource provides expert guidance on drug choice, minimum and maximum doses, adverse effects, switching medications, prescribing for special patient groups, and more. Each clear and concise chapter includes an up-to-date reference list providing easy access to the evidence on which the guidance is based. The fourteenth edition has been fully updated to incorporate the latest available research, the most recent psychotropic drug introductions, and all psychotropic drugs currently used in the UK, USA, Canada, Australia, New Zealand, and Japan. Several new sections cover topics such as deprescribing of major psychiatric drugs, prescribing psychotropics at the end of life, the treatment of agitated delirium, the genetics of clozapine prescribing, the use of weekly penfluridol, and the treatment of psychotropic withdrawal. Featuring contributions by an experienced team of psychiatrists and specialist pharmacists, the new edition of The Maudsley Prescribing Guidelines in Psychiatry: Provides succinct coverage of drug treatment of psychiatric conditions and formulating prescribing policy in mental health Covers a wide range of psychiatric conditions including schizophrenia, bipolar disorder, depression and anxiety, borderline personality, eating disorders, and many others Provides advice on prescribing for children and adolescents, older people, pregnant women, and other special patient groups Offers new sections on genetic prescribing, long-acting injectable formulations, ketamine administration and uses, and dopamine super-sensitivity Includes referenced information on off-label prescribing, potential interactions with other substances such as alcohol, tobacco, and caffeine, and treating patients with comorbid physical conditions Whether in the doctor’s office, in the clinic, or on the ward, The Maudsley Prescribing Guidelines in Psychiatry, Fourteenth Edition is a must-have for psychiatrists, pharmacists, neuropharmacologists, clinical psychologists, nurses, and other healthcare professionals working in mental health, as well as trainees and students in medicine, pharmacy, and nursing.
The Maudsley Prescribing Guidelines in Psychiatry (The Maudsley Prescribing Guidelines Series)
by Allan H. Young David M. Taylor Thomas R. BarnesThe most up-to-date edition of the gold-standard handbook on the safe and effective prescribing of psychotropic agents Prescribing medications that treat mental illness is a challenging but essential component of clinical practice. Successful treatment outcomes require careful drug choice and dosage, and other considerations can also have an important impact on patient experiences and long-term care. In the newly revised fifteenth edition of The Maudsley Prescribing Guidelines in Psychiatry, you will find up-to-date and authoritative guidance on prescribing psychotropic medications to patients. It is an indispensable evidence-based handbook that will continue to serve a new generation of clinicians and trainees. The book includes analyses of all psychotropic drugs currently used in the United States, the United Kingdom, Canada, Australia, New Zealand, and Japan. It also contains detailed discussions of common and uncommon adverse effects, the ramifications of switching medications, special patient groups, and other clinically relevant subjects. A fully updated reference list closes out each section, as well. The Maudsley Prescribing Guidelines in Psychiatry is perfect for trainees seeking essential and accurate information on the rational, safe, and effective use of medications for patients with mental illness. Practising clinicians will also benefit from the included guidance on complex issues that might arise less frequently.
The Maudsley Trainee Guide to the CASC: Preparing for the MRCPsych CASC Examination
by Dan Cleall Samantha Perera Christopher TraversWritten by graduates of the internationally renowned Maudsley Training Programme, who have all recently sat the CASC examination, this book provides clear, practical guidance to passing the Royal College of Psychiatrists' CASC. Divided according to psychiatric subspecialties, each chapter includes practice clinical scenarios. These clinical scenarios are broken down into candidate instructions, actor instructions and constructive candidate feedback. This enables candidates to practice not only with their clinical peers, but with friends and family as well. An additional chapter is dedicated to practical information about the exam and tips for the day to further equip readers in what to expect, and reduce anxieties about the exam itself. Another chapter is specifically devoted to addressing the needs of international and BAME medical graduates. Relevant and reliable throughout, this is a must-have resource for psychiatric trainees looking to improve their clinical skills and gain their MRCPsych qualification.