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Telling Genes: The Story of Genetic Counseling in America
by Alexandra Minna SternThe history of contemporary genetic counseling, including its medical, personal, and ethical dimensions.Winner of the CHOICE Outstanding Academic Title of the Choice ACRLFor sixty years genetic counselors have served as the messengers of important information about the risks, realities, and perceptions of genetic conditions. More than 2,500 certified genetic counselors in the United States work in clinics, community and teaching hospitals, public health departments, private biotech companies, and universities. Telling Genes considers the purpose of genetic counseling for twenty-first century families and society and places the field into its historical context.Genetic counselors educate physicians, scientific researchers, and prospective parents about the role of genetics in inherited disease. They are responsible for reliably translating test results and technical data for a diverse clientele, using scientific acumen and human empathy to help people make informed decisions about genomic medicine.Alexandra Minna Stern traces the development of genetic counseling from the eugenics movement of the early twentieth century to the current era of human genomics. Drawing from archival records, patient files, and oral histories, Stern presents the fascinating story of the growth of genetic counseling practices, principles, and professionals.
Telling Tales About Dementia
by Edited by Lucy WhitmanHow does it feel when someone you love develops dementia? How do you cope with the shock, the stress and the grief? Can you be sure that you and your family will receive the support you need? In Telling Tales About Dementia, thirty carers from different backgrounds and in different circumstances share their experiences of caring for a parent, partner or friend with dementia. They speak from the heart about love and loss: 'I still find it hard to believe that Alzheimer's has happened to us,' writes one contributor, 'as if we were sent the wrong script. ' The stories told here vividly reflect the tragedy of dementia, the gravity of loss, and instances of unsatisfactory diagnosis, treatment and care. But they contain hope and optimism too: clear indications that the quality of people's lives can be enhanced by sensitive support services, by improved understanding of the impact of dementia, by recognising the importance of valuing us all as human beings, and by embracing and sustaining the connections between us. This unique collection of personal accounts will be an engaging read for anyone affected by dementia in a personal or professional context, including relatives of people with dementia, social workers, medical practitioners and care staff.
Telling the Stories of Life through Guided Autobiography Groups
by James E. Birren Kathryn N. CochranTelling the Stories of Life through Guided Autobiography Groups, based on James Birren's 25 years of conducting autobiography groups, discusses all the topics an organizer faces while developing a program for adults who want to recall and write down their life histories. This book is ideal for adult education programs, church groups, social workers, psychologists, gerontologists, and others who work with adults who might be interested in exploring, recording, or sharing their personal histories. It helps professionals and trained workshop leaders at community centers, senior centers, schools and other settings guide group participants in exploring major themes of their lives so that they can organize and write their stories and share them in a group with others on the same journey. This exercise is rewarding for adults of any age in a period of transition or with interest in gaining insight from their own stories. Personal development and a feeling of connection to other participants and their stories is a natural outcome of this process. This book provides background material and detailed lesson plans for those who wish to develop and lead an autobiography group.The authors explain the concept of guided autobiography, discuss the benefits to the group participants, and provide logistical information on how to plan, organize, and set up a group. An appendix provides exercises, handouts, and suggested adaptations for specific groups. The book also explains a systematic method of priming memories, including the history of family and of one's life work, the role of money, health and the body, and ideas about death.At a time when rapid change has created a widespread yearning to write down and exchange personal accounts, sharing life stories can reveal a great deal about how we have come to be the persons we are. Telling the Stories of Life through Guided Autobiography Groups shows how to organize, record, and share life experiences through a proven and effective technique.
Telltale Hearts: A Public Health Doctor, His Patients, and the Power of Story
by Dean-David SchillingerIn this illuminating work, a doctor and public health advocate reveals what his patients have taught him about patience and healing. For over three decades, Dr. Dean-David Schillinger has served in one of the country&’s busiest and most important public hospitals. A public health leader and primary care physician for underserved patients, Schillinger learned that high-tech tests and novel medications are often not enough to save lives. Rather, accurate diagnosis, treatment and true healing come from listening deeply to patients and their stories. In Telltale Hearts, Schillinger reveals what is lost when patients&’ stories are ignored or overlooked, and how much is gained when these stories are actively elicited. The stories themselves, at times shocking and always revelatory, disclose secrets, prompt awe, forge unexpected connections, and even catalyze public health action.Telltale Hearts serves as a call to action, urging us to reshape public policy to improve the nation's health.
Telomerase Inhibition
by Lucy Andrews Trygve O. TollefsbolThis volume presents a compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition. The techniques described provide the researcher with a diverse and comprehensive set of tools for the study of telomerase inhibition. The volume is aimed at biochemists, molecular biologists, cancer researchers, and geneticists.
The Telomerase Revolution: The Enzyme That Holds the Key to Human Aging . . . and Will Soon Lead to Longer, Healthier Lives
by Michael FosselOne of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body's trillions of cells. But some of our cells don't age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer
by Dr Elizabeth Blackburn Dr Elissa EpelHave you ever wondered why some sixty-year-olds look and feel like forty-year-olds, and why some forty-year-olds look and feel like sixty-year-olds? More importantly - can you choose which outcome will happen to you? Written by Nobel Prize winner Elizabeth Blackburn and health psychologist Elissa Epel, The Telomere Effect reveals the ground-breaking science at the heart of ageing - and what you can do to help reverse it.While many factors contribute to ageing and illness, Elizabeth and Elissa's award-winning research has revealed that the length of our telomeres - the part of our chromosomes which determine how fast our cells age and die - can have a direct effect on how quickly or slowly we age. In this pioneering book, discover for the first time the many simple changes you can make to your diet, sleep and mental wellbeing to look after your telomeres. From which foods to eat, types of exercise to practise, various mind tricks to prevent stress - and how to shield your children from developing shorter telomeres from conception through to adolescence - start protecting your telomeres and your youth today.
The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer
by Dr Elizabeth Blackburn Dr Elissa EpelOne of the Best 'Brainy' Books of This Decade - The GuardianA ground breaking book on the history of Telomeres offering fresh advice on how to slow down aging and lengthen life. Nobel prize winning Doctor Elizabeth Blackburn and leading health psychologist Dr Elissa Epel have discovered biological markers called Telomeres which can help to understand how healthy our cells are and what we can do to improve them. The book specifically looks ideas including; how biological age is not chronological age; a biological basis for the mind-body connection, how sleep and diet can affect telomeres and shockingly how mothers who are highly stressed during pregnancy have children with shorter telomeres. It also offers tools and advice on how to determine cellular age and telomere health. Doctor Elizabeth Blackburn was awarded the Nobel Prize in Physiology or Medicine in 2009 for her discovery of telomeres and their role in the ageing process and has previously been named in TIME magazine's 100 Most Influential People.Dr. Elissa Epel is a leading health psychologist who has conducted pioneering research uncovering the psychobiological mechanisms related to how stress ages us and compromises our health-from emotional eating to unhealthy storage of abdominal fat to telomere shortening.
The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer
by Dr Elizabeth Blackburn Dr Elissa EpelNobel prize winning Dr Elizabeth Blackburn and leading health psychologist Dr Elissa Epel have discovered biological markers called telomeres, which can help to understand how healthy our cells are and what we can do to improve them. THE TELOMERE SOLUTION looks at ideas including: how biological age is not chronological age, a biological basis for the mind-body connection and how sleep and diet can affect telomeres. It also offers tools and advice on how to determine cellular age and telomere health.Read by Suzanne Toren(p) 2017 Hachette Audio
Telomere Territory and Cancer
by Parvin MehdipourTiming, racing, combating, struggling and targeting are some actions through which cellular fate could be reflected and evaluated. Interaction between cell territory and environment occur during pre-embryonic, fetal development, and post-natal periods. What the researchers observe as the outcome of telomeres behavior is only the peak of an ice mountain within a stormy ocean. Cellular life depends on programmed behavior of telomeres, capable to surprise the cells. Telomeres provide an introduction to the history of our cells which govern the quality of life and status of health. Telomeres as the cooperative territory are capable of stabilizing the chromosomal territory. The status of telomeres reflects the key information, announcing the real age of individuals, and may be a valuable marker for prognosis and predicting cancer. Telomere territory is characterized with a multi-disciplinary manner. Therefore, this book is aimed to offer a wide range of chapters, hoping to be useful for diverse audiences, including hematologists-oncologists, radiotherapists, surgeons, cancer researchers, and all the sectors who affect the macro- and micro- environmental domains. Finally, telomeres are sensitive, cooperative, and trustable targets. It is worth to state that 'telomeres are messengers of NATURE', let's to know them as they are.
Telomeres and Telomerase in Cancer
by Keiko HiyamaTelomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in "cancer stem cells" has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities
by Amelia Marti Guillermo ZalbaThe maintenance of telomeres—repetitive sequences at the end of chromosome—is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how lifestyle and dietary factors could modify the telomerase maintenance process. The book examines the mechanisms involved, the primary of which are oxidative stress and the role of sirtuins, and how they can be modified by dietary patterns such as Mediterranean diet.
Telsa
by Diana Cooper Rosemary StephensonThrough this touching account of the life and work of a boxer named Telsa, the powerful relationship between humans and animals is explored, and the unconditional love shown by a pet is demonstrated as a force that can improve the emotional, mental, and physical well-being of the people around them. The beloved pet of a spiritual healer, Telsa became instrumental in amplifying healing energies throughout her life and even after her passing. Her connection with others and the world around her was unique and immensely positive, and the book follows her story, from her life as a puppy and her invaluable service to nursing home patients to Telsa''s connection to her owner in the after-life.
Temperament and Children: Profiles of Individual Differences
by Roy P. Martin A. Michele Lease Helena R. SlobodskayaThe book presents an empirical model of commonly occurring individual differences in children that is derived from a large-scale research effort assessing parental and teacher perceptions of children in middle childhood. It examines eight characteristic behavioral traits, most of which have been widely shown to be present in infants, toddlers, and preschool-aged children. The book demonstrates the importance of considering profiles of these relatively stable individual differences for the educational, social, and emotional life of the child. It describes characteristic behaviors of children within each profile – emphasizing the assets and liabilities of each – and how they are perceived by their parents, teachers, and peers. Chapters explore issues related to the most developmentally effective management of children exhibiting each profile type.In addition, the book addresses a critical need in child development, parenting, and teaching to understand the wide range of individual differences observed every day in school-aged children. Not only does this volume underscore that commonly occurring differences can be understood as being normal and do not suggest a pathology, it also discusses implications of the model in diagnosing pathology. The book describes what is known about the stability of temperament behaviors and profiles across the lifespan as well as the origins of these behaviors.Key topics addressed include:Nurturing development of well-adjusted children.Causes of individual differences in children’s behavior.Temperamental tendencies and profiles of children.Diagnosing psychopathology in children.This book is a must-have resource for researchers, professors, and graduate students as well as clinicians and related professionals in developmental, clinical child and school psychology, social work, public health, pediatrics, family studies, educational psychology and counseling, and all other interrelated disciplines.
Temperament Based Therapy with Support for Anorexia Nervosa: A Novel Treatment
by Laura L. Hill Stephanie Knatz Peck Christina E. WierengaAnorexia Nervosa has one of the highest death rates of all mental illnesses and one of the poorest treatment outcomes. However, one novel treatment, the neurobiologically-based treatment Temperament-Based Therapy with Supports (TBT-S), works with clients' temperament and traits to motivate change, ultimately managing and reducing symptoms. This practical and accessible book is the first guide to delivering TBT-S that addresses the underlying traits leading to symptoms of anorexia nervosa and helps people to manage symptoms long-term. It offers background information on the role of temperament in anorexia nervosa, the development of the TBT-S protocol and the evidence gathered. Chapters also covers how to augment this therapy into existing treatment. A valuable resource for clinicians involved in the treatment of anorexia nervosa, including psychologists, psychiatrists, psychotherapists, specialist nurses, dieticians, and educators.
Temperament und Kinder: Profile der individuellen Unterschiede
by Roy P. Martin A. Michele Lease Helena R. SlobodskayaDas Buch stellt ein empirisches Modell der häufig vorkommenden individuellen Unterschiede bei Kindern vor, das aus einer groß angelegten Forschungsarbeit abgeleitet wurde, bei der die Wahrnehmungen von Eltern und Lehrern von Kindern in der mittleren Kindheit untersucht wurden. Es werden acht charakteristische Verhaltensmerkmale untersucht, von denen die meisten nachweislich bei Säuglingen, Kleinkindern und Kindern im Vorschulalter vorhanden sind. Das Buch zeigt, wie wichtig die Berücksichtigung von Profilen dieser relativ stabilen individuellen Unterschiede für das pädagogische, soziale und emotionale Leben des Kindes ist. Es beschreibt charakteristische Verhaltensweisen von Kindern innerhalb jedes Profils - wobei die Vorzüge und Nachteile jedes Profils hervorgehoben werden - und wie sie von ihren Eltern, Lehrern und Gleichaltrigen wahrgenommen werden. In den Kapiteln werden Fragen im Zusammenhang mit dem entwicklungsmäßig effektivsten Umgang mit Kindern, die die einzelnen Profiltypen aufweisen, untersucht.Darüber hinaus befasst sich das Buch mit dem kritischen Bedürfnis in der kindlichen Entwicklung, der Elternschaft und dem Unterricht, die große Bandbreite individueller Unterschiede zu verstehen, die täglich bei Kindern im Schulalter beobachtet werden. Dieser Band unterstreicht nicht nur, dass häufig auftretende Unterschiede als normal angesehenwerden können und nicht auf eine Pathologie hindeuten, sondern erörtert auch die Auswirkungen des Modells auf die Diagnose von Pathologien. Das Buch beschreibt, was über die Stabilität von Verhaltensweisen und Profilen des Temperaments über die gesamte Lebensspanne hinweg bekannt ist, sowie die Ursprünge dieser Verhaltensweisen. Zu den wichtigsten Themen gehören: Förderung der Entwicklung von Kindern, die sich gut entwickeln. Ursachen für individuelle Unterschiede im Verhalten von Kindern. Temperamentvolle Tendenzen und Profile von Kindern. Diagnose von Psychopathologie bei Kindern. Dieses Buch ist ein unverzichtbares Hilfsmittel für Forscher, Professoren und Studenten sowie für Kliniker und verwandte Berufsgruppen in den Bereichen Entwicklungs-, klinische Kinder- und Schulpsychologie, Sozialarbeit, öffentliches Gesundheitswesen, Pädiatrie, Familienstudien, pädagogische Psychologie und Beratung sowie allen anderen verwandten Disziplinen.
Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach
by Christopher J. GordonThermoregulation is vital for survival but the interplay between toxic insults and thermoregulatory mechanisms is often poorly understood. Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach is the first major text to study the integrative thermoregulatory responses of mammals that are exposed to toxicants. Because e
Temple Grandin: Voice for the Voiceless
by Annette WoodSince Temple Grandin's life story was told in the 15 x Emmy-nominated film Temple Grandin, and since her heartwarming speech at the award ceremony, she has become one of the world's most well-known members of its community. In this fascinating biography, Annette Wood delves deep into Grandin's life from childhood to adulthood. Wood tells of the trials and tribulations of the icon: What difficulties Grandin struggled with and how she's become a hero for the autistic community. She also tells what Temple has done since the movie came out, where she is today, what kind of difference she's made, and what her future holds. For the 22 million people worldwide afflicted by autism and the countless friends and family members who support them, this brilliant portrait presents an up-close look at the disorder and renewed hope for what the future could bring for those on all levels of the spectrum.
Temporal Bone
by Robert J. Witte John I. LaneImaging of the temporal bone has recently been advanced with multidetector CT and high-field MR imaging to the point where radiologists and clinicians must familiarize themselves with anatomy that was previously not resolvable on older generation scanners. Most anatomic reference texts rely on photomicrographs of gross temporal bone dissections and low-power microtomed histological sections to identify clinically relevant anatomy. By contrast, this unique temporal bone atlas uses state of the art imaging technology to display middle and inner ear anatomy in multiplanar two- and three-dimensional formats. In addition to in vivo imaging with standard multidetector CT and 3-T MR, the authors have employed CT and MR microscopy techniques to image temporal bone specimens ex vivo, providing anatomic detail not yet attainable in a clinical imaging practice. Also included is a CD that allows the user to scroll through the CT and MR microscopy datasets in three orthogonal planes of section.
Temporal Bone Cancer
by Paul W. Gidley Franco DeMonteThis volume comprehensively reviews the current literature on temporal bone cancer and the multidisciplinary approaches used to managing these rare tumors. The text will review important medical issues as they specifically relate to temporal bone cancer such as advanced imaging, pathologic classification, skull base surgery, plastic reconstructive surgery, and advances in osseointegrated implants for hearing restoration. Additional chapters are dedicated to the evaluation and management, diagnostic radiology, surgical planning and techniques, radiotherapy, chemotherapy, and rehabilitation. An emphasis is placed on the multidisciplinary approach required for the optimal care of these rare tumors. Written by leaders in the field, Temporal Bone Cancer will be an invaluable resource for residents and fellows in Otolaryngology, Neurosurgery and Neurotology, and clinicians with interest in the primary tumors of the temporal bone.
Temporal Bone CT and MRI Anatomy
by Jan Kopřiva Jan ŽižkaThis book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i. e. , on the screens of diagnostic workstations or picture archiving and communication systems (PACS).
Temporal Bone CT and MRI Anatomy: A Guide to 3D Volumetric Acquisitions
by Jan Kopřiva Jan ŽižkaThis book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i.e., on the screens of diagnostic workstations or picture archiving and communication systems (PACS).
Temporal Bone Imaging
by Marc Lemmerling Bert FoerThis book provides a complete overview of imaging of normal and diseased temporal bone. After description of indications for imaging and the cross-sectional imaging anatomy of the area, subsequent chapters address the various diseases and conditions that affect the temporal bone and are likely to be encountered regularly in clinical practice. The classic imaging methods are described and discussed in detail, and individual chapters are included on newer techniques such as functional imaging and diffusion-weighted imaging. There is also a strong focus on postoperative imaging. Throughout, imaging findings are documented with the aid of numerous informative, high-quality illustrations. Temporal Bone Imaging, with its straightforward structure based essentially on topography, will prove of immense value in daily practice.
Temporal Bone Imaging Made Easy (Medical Radiology)
by Geoiphy George Pulickal Tiong Yong Tan Ashish ChawlaThis book presents standard imaging techniques, basic anatomy and an approach to common pathology encountered in temporal bone imaging. Intended as a survival guide for residents and general radiologists, it covers all topics comprehensively, and provides intuitive point-by-point summaries, similar to those of popular radiology reference sites, for easy comprehension at a glance. The book also offers guidance on the pertinent points that need to be included in a report and how to answer basic questions that are likely to be asked by the referring clinician or supervising radiologist. This book will be a valuable resource for general radiologists, radiology residents, ENT residents, otology surgeons and anyone involved in the occasional temporal bone study.
Temporal Modelling of Customer Behaviour (Springer Theses)
by Ling LuoThis book describes advanced machine learning models – such as temporal collaborative filtering, stochastic models and Bayesian nonparametrics – for analysing customer behaviour. It shows how they are used to track changes in customer behaviour, monitor the evolution of customer groups, and detect various factors, such as seasonal effects and preference drifts, that may influence customers’ purchasing behaviour. In addition, the book presents four case studies conducted with data from a supermarket health program in which the customers were segmented and the impact of promotional activities on different segments was evaluated. The outcomes confirm that the models developed here can be used to effectively analyse dynamic behaviour and increase customer engagement. Importantly, the methods introduced here can also be used to analyse other types of behavioural data such as activities on social networks, and educational systems.