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Therapeutic Progress in Oncology: Towards a Revolution in Cancer Therapy?
by Jacques Barbet Adrien Foucquier Yves ThomasThe combined effects of population growth and aging have led to an increase in the number of cancers. Preventing, diagnosing, treating and curing cancer are therefore, more than ever, imperatives facing medicine – especially to continue the decrease in cancers' mortality rates and to improve the quality of survival. Over time, the "classic" modes of treatment (surgery, external beam radiotherapy, chemotherapy) have become more refined and efficient. From the beginning of this century, new therapeutic options have been developed: targeted cancer therapy, targeted radionuclide therapy and immunologic therapies based on monoclonal antibodies, cellular therapy and vaccinations. Artificial intelligence and machine learning are also being introduced to the field of oncology. Starting with the basic scientific principles relevant to oncology, this book explains and makes these concepts and innovations accessible to a wide audience – especially in the interest of patients. It also contributes to the oncological field of 4P medicine – with 4P standing for predictive, preventive, personalized and participative.
Therapeutic Proteins: Methods and Protocols (Methods in Molecular Biology #2720)
by Millicent O. Sullivan Bryce Chackerian Wilfred ChenThis volume covers the latest key aspects of therapeutic protein applications. Chapters in this book cover topics such as the discovery, production, and conjugation of protein-proteins with discussions on the direction of future development and advancements; ways to use these engineering proteins for therapeutic and vaccine applications; and the use of modified protein nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Therapeutic Proteins: Methods and Protocols is a valuable resource for any researcher who are interested in learning more about the field of therapeutic proteins.
Therapeutic Proteins
by Vladimir Voynov Justin A. CaravellaAfter the identification of a potential protein drug, the next critical step is the production of sufficient authentic material for testing, characterization, and clinical trials, which, when successful, leads to the need for robust methodologies for large-scale production, purification, characterization, viral inactivation, and continued testing of the final protein product. Building on the valuable first edition, Therapeutic Proteins: Methods and Protocols, Second Edition aims to cover each of these key aspects of protein drug production through the contributions of authors from highly esteemed industrial and academic institutions around the world. Emphasizing the newest developments in the field, this second edition also includes additional emphasis on discovery, including new display and screening methods as well as the design and engineering of new types of therapeutic proteins. There is also discussion of computational and bioinformatics methods, and chapters on safety aspects of therapeutic protein development. Written in the highly successful Methods in Molecular BiologyTM format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and practical, Therapeutic Proteins: Methods and Protocols, Second Edition provides an essential resource to all scientists working in the field of therapeutic proteins.
Therapeutic Proteins Against Human Diseases
by Fahmida Khatoon Zahid BalouchThis book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics.This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.
Therapeutic Recreation: A Practical Approach (Fourth Edition)
by Marcia Jean Carter Glen E. Van AndelThe fourth edition of Therapeutic Recreation: A Practical Approach reflects the still-evolving nature of this health-care profession and practice in a diverse global world. Social, cultural, demographic, and economic shifts, as well as technological advancements, have created demand for fiscal accountability by informed consumers/clients who expect safe, quality health and human services that are reliable, responsive to their needs, and have proven benefits. Thus our intention is to provide, in a practical, student-oriented fashion, a comprehensive overview of the fundamentals of therapeutic recreation as a health and human service profession and as a career choice. This revised edition is primarily designed for an introductory course in therapeutic recreation at the undergraduate level. Students majoring in health and human service programs or recreation may also find the text useful, particularly if they anticipate careers in health-care settings and agencies that offer inclusionary programs.
The Therapeutic Relationship in Cognitive-Behavioral Therapy: A Clinician's Guide
by Nikolaos Kazantzis Keith S. Dobson Judith S. Beck Frank M. DattilioFrom leading cognitive-behavioral therapy (CBT) experts, this book describes ways to tailor empirically supported relationship factors that can strengthen collaboration, empiricism, and Socratic dialogue and improve outcomes. In an accessible style, it provides practical clinical recommendations accompanied by rich case examples and self-reflection exercises. The book shows how to use a strong case conceptualization to decide when to target relationship issues, what specific strategies to use (for example, expressing empathy or requesting client feedback), and how to navigate the therapist's own emotional responses in session. Special topics include enhancing the therapeutic relationship with couples, families, groups, and children and adolescents. Reproducible worksheets can be downloaded and printed in a convenient 8 1/2" x 11" size.
Therapeutic Relationships with Offenders: An Introduction to the Psychodynamics of Forensic Mental Health Nursing
by Jenifer Clarke-Moore Valerie Anne Brown Anne Aiyegbusi Tom Clarke Gwen AdsheadWorking in any area of mental health nursing presents complex issues regarding the nurse-patient relationship. For those working in prolonged clinical contact with offenders, relationships with patients and colleagues can be particularly emotionally intense and sometimes difficult to express. This book attempts to understand and articulate the emotional labour of forensic nursing and explores the challenge of establishing and maintaining therapeutic relationships with offenders. The first book to consider the emotional and relational component of forensic mental health nursing, the chapters cover a number of specialist forensic areas from this psychodynamic perspective, such as women's services, services for people with personality disorders, intensive care, high security psychiatric hospitals, medium secure units and services for adolescent offenders. A chapter on therapeutic communities is also included, along with chapters on challenging relational phenomena such as working with hate and the difficulties of managing difference when working in environments that produce high levels of anxiety. Therapeutic Relationships with Offenders provides essential information for mental health nurses working in the forensic field and will be of interest to any professionals working with challenging populations and people with personality disorders.
Therapeutic Revolutions: Pharmaceuticals and Social Change in the Twentieth Century
by Elizabeth Siegel Watkins Flurin Condrau Jeremy A. GreeneWhen asked to compare the practice of medicine today to that of a hundred years ago, most people will respond with a story of therapeutic revolution: Back then we had few effective remedies, but now we have more (and more powerful) tools to fight disease, from antibiotics to psychotropics to steroids to anticancer agents. This collection challenges the historical accuracy of this revolutionary narrative and offers instead a more nuanced account of the process of therapeutic innovation and the relationships between the development of medicines and social change. These assembled histories and ethnographies span three continents and use the lived experiences of physicians and patients, consumers and providers, and marketers and regulators to reveal the tensions between universal claims of therapeutic knowledge and the actual ways these claims have been used and understood in specific sites, from postwar West Germany pharmacies to twenty-first century Nigerian street markets. By asking us to rethink a story we thought we knew, Therapeutic Revolutions offers invaluable insights to historians, anthropologists, and social scientists of medicine.
Therapeutic Ribonucleic Acids in Brain Tumors
by Volker A. Erdmann Guido Reifenberger Jan BarciszewskiIn the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication.
Therapeutic rTMS in Neurology
by Thomas PlatzThis comprehensive reference on therapeutic repetitive transcranial magnetic stimulation (rTMS) documents the current status in the field. The main focus is the clinical applications of rTMS tested to date, including treatment of paresis, aphasia, and visual neglect in stroke patients, therapy for motor impairment in Parkinson's disease, and applications for tinnitus and neuropathic pain. Based on the available clinical evidence (RCTs, meta-analyses, and systematic reviews), combined with the personal experience of experts, a clinically oriented best evidence synthesis is provided for each application, together with a clear description of rTMS algorithms that generate clinical benefits in the target domain. A further feature is the presentation of a theoretical model of therapeutic action for each therapeutic target. The book will be invaluable for clinicians and researchers in neurology and related fields, including neurologists, physiatrists, as well as ENT and pain specialists.
Therapeutic Strategies for Heart Failure
by Naoki SatoThis book introduces practical heart failure (HF) managements at the acute, in-hospital stages during hospitalization and also in the end-stages of HF, including the difference compared to the rest of the world. Given its increasing incidence and prevalence, we live in a world facing an HF pandemic. As one of the countries with outstanding longevity, Japan has unique characteristics concerning the selection of medical treatment, diagnostic techniques, team managing and other treatments. This book sheds light on the clinical challenges involved in reducing re-hospitalization and improving the prognosis and the ADL/QOL of the patients, and reports on the status quo in Japan, comparing to the rest of the world. Sharing these challenges and methods used to address them should encourage the world's experts to intensively discuss and accelerate research on the clinic in this field. The editors and authors have taken on central roles in managing HF in Japan. It will be indispensable not only for clinicians, technicians and nurses in this field, but also for general physicians, emergency physicians and others who are involved in intensive care.
Therapeutic Strategies in Veterinary Oncology
by Nicole Amato Jacob Cawley Steven Dow Joelle Fenger Andi Flory Ira Gordon Kayla Harding Kelvin Kow Cheryl London Nicola Mason Arata Matsuyama Jonathan Mochel Anthony Mutsaers Henrik Rönnberg Wesley WiersonThis book is a comprehensive resource for veterinary oncologists and trainees, covering therapeutic strategies used in the treatment of veterinary patients. In the setting of a rapidly changing field like oncology, this timely text focuses on mechanisms of action and biological rationale rather than current specific clinical recommendations, allowing current and future clinicians to adapt treatment approaches as our understanding of the biology of cancer evolves. With each chapter written by experts in their field, this book provides informative figures that convey this biological understanding and rationale of therapy. It starts from the mechanisms of treatment as we currently understand them, covering radiation therapy, chemotherapy, immunotherapy, targeted therapy, and many more. Dispensing vital, detailed and practical information about the different therapeutic strategies available, this book is a vital resource for practicing veterinarians, while also providing students of veterinary oncology with a better understanding of the key differences between different treatment strategies.
Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
by Edward C. Stites Kendra Paskvan Shumei KatoThe KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
Therapeutic Targets
by Mabel Loza Luis M. BotanaThe Latest Applications For Cellmechanism Research in Drug DiscoveryDesigned to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe.The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more.Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
Therapeutic Targets in Airway Inflammation (Lung Biology in Health and Disease)
by N. Tony Eissa David P. HustonThis reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Therapeutic Treatment for Benign Prostatic Hyperplasia
by Roger S Kirby John D McConnell John M Fitzpatrick Claus G Roehrborn Michael G Wyllie Peter BoyleThe spectrum of available treatment options for benign prostatic hyperplasia (BPH) is matched by the spectrum of disease severity, and with up to 90% of men in their 80s suffering from BPH to some extent, it is imperative that patients are offered the full range of options to manage the disease. Pharmacologic therapies available for the treatment o
Therapeutic Ultrasound
by Jean-Michel Escoffre Ayache BouakazThis book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i. e. , high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i. e. , tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i. e. , chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.
Therapeutic Ultrasound in Dentistry: Applications for Dentofacial Repair, Regeneration, and Tissue Engineering
by Tarek El-Bialy Eiji Tanaka Dror AizenbudThis book highlights the potential of low-intensity pulsed ultrasound, or LIPUS, to introduce a new era in dentistry by revolutionizing the approach to dental treatment and providing a cure for pathologic conditions long considered untreatable. Readers will find information on all aspects of LIPUS, from its mode of action and biologic mechanisms to the full range of emerging clinical applications. The role of LIPUS in promoting dental tissue repair and regeneration and in tissue engineering is fully explained in a series of chapters focusing on stimulation of cell metabolism in the dentocraniofacial region, bone healing, periodontal regeneration, the temporomandibular joint, pulp cell differentiation, the salivary glands, and orthodontics. The past two decades have witnessed numerous discoveries that have enhanced the scope for use of therapeutic ultrasound in dentistry. In summarizing the latest knowledge in this exciting field, the book will be of interest to dental surgeons, orthodontists, periodontists, and other practitioners.
The Therapeutic Use of Ayahuasca
by Beatriz Caiuby Labate Clancy CavnarThis book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
The Therapeutic Use of Ayahuasca
by Beatriz Caiuby Labate Clancy CavnarThis book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
Therapeutic Use of Medicinal Plants and their Extracts: Phytochemistry and Bioactive Compounds (Progress in Drug Research #74)
by A.N.M. AlamgirThis book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents.Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine
by Richard Eugene Frye Michael BerkFocusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.
Therapeutic Uses of Cannabis
by British Medical AssociationAt the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.
Therapeutic Uses of Music with Older Adults
by Alicia Clair Jenny MemmottIn this comprehensively updated second edition, written by Alicia Ann Clair and Jenny Memmott the extraordinary benefits of music therapy for older adults are detailed. <p><p>Therapeutic Uses of Music with Older Adults not only examines these benefits but also clarifies the reasons that music is beneficial. This important book shows both informal and formal caregivers how to use music to enhance the quality of life of older adults - including people with physical impairments and people with dementia. <p><p>Written by two of the nation's leading music therapists, Therapeutic Uses of Music with Older Adults offers strategies for using music to: provide diversion for inactivity, discomfort, and daily routine; decrease symptoms of depression, anxiety insomnia, and agitation; handle problem behaviors; provide physical and emotional stimulation; help in the rehabilitation of people with cardiac disease, Parkinson's disease, and impairments related to stroke; help in the management of pain; facilitate social integration; communication; and the expression of feelings, including anger and grief; and relieve the stress and tension associated with caring for older adults.
Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts
by Hironori NakagamiThis book offers an excellent introduction to the use of novel therapeutic vaccines for common diseases based on their ability to induce antibody production. While the role of vaccines in the treatment of infectious diseases and cancer is well known, vaccines have also recently been developed for a variety of other conditions, including Alzheimer’s disease, hypertension, diabetes, and spondyloarthritis. These therapeutic advances are fully and clearly documented by acknowledged experts in the field, who explain the relevant biology and highlight the challenges involved in deploying this treatment approach effectively and safely. In addition, recent progress in the construction and delivery of DNA vaccines is documented, and the process of developing new peptide vaccines is explored in depth. While the book will be particularly valuable for researchers and scholars interested in immunotherapy, it will also appeal to clinicians seeking effective new medicines to treat patients suffering from chronic diseases.