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The Surgical Management of the Diabetic Foot and Ankle
by Dolfi HerscoviciOffering up-to-date guidance to surgeons looking for the most current management for the care of Charcot arthropathy and related fractures of the foot and ankle in diabetic patients, this book discusses pathophysiology, recommendations for pre-surgical evaluations, and management strategies for diabetes and Charcot neuroarthropathy, along with demographics and epidemiology of diabetes. Conservative care, total contact casts and footwear are discussed, as well as the management of infections and osteomyelitis. Acute fractures and Charcot arthropathy for the forefoot, midfoot and ankle follow, including plate and axial fixation techniques, with authors' preferred treatment strategies presented in step-by-step fashion. Written and edited by recognized leaders in the field, this is a must-have for orthopedic surgeons and podiatrists, residents, nurse practioners, physician's assistants and all people treating diabetic patients and will be an excellent resource for treating these debilitating afflictions.
The Surrogate's Unexpected Miracle
by Alison RobertsTheir unexpected family Ellie Thomas was meant to be a surrogate mother to the baby growing inside her, but when her best friend abandons her, everything changes. The moment her son is born, Ellie knows she could never give him up! But the one person she can turn to for help is the doctor who delivered her child. Dr. Luke Gilmore didn't have a picture-perfect childhood, but he instinctively wants to protect Ellie and her baby. He was only passing through, but he may have just found a reason to stay...
The Surrogate: A Novel
by Judith Henry WallTo a penniless twenty-year-old like Jamie Long, surrogate motherhood seemed both an act of altruism and a financial opportunity. But once pregnant and under contract to Amanda Hartmann, the head of a famous evangelical family, Jamie realizes that she's getting more than she bargained for. Whisked away to the vast, isolated family ranch, she's closely supervised and carefully cut off from the outside world. She learns the family's dark secrets -- and sees the enormity of their ruthlessness. When Jamie hears Amanda's plan to claim the baby as her natural-born child, she begins to suspect that her own life is in danger and resolves to flee. Alone with a tiny newborn, she calls on the one man in the world she can trust -- her high school crush, Joe Brammer. Their love unites them in a struggle to escape, and soon enough their flight becomes a fight for their lives. Brilliantly weaving some of today's most controversial social issues into a captivating page-turner,The Surrogateis Judith Henry Wall's greatest triumph to date.
The Survival Medicine Handbook: The Essential Guide For When Help Is Not On The Way
by Joseph Alton Amy AltonBlack & White Version. If a disaster took away the high-technology we take for granted, would you be prepared to keep you family healthy? Could you be an effective medic when hospitals are overcrowded and the ambulance is heading in the other direction? Can you take over if you were the highest medical asset left? Medical preparedness advocates Joe Alton, MD and Amy Alton, NP’s award-winning “Survival Medicine Handbook: A guide for when help is NOT on the way” is now out in its greatly expanded and revised 4th edition! Previous editions have been 1st place winners in the Book Excellence Awards in Medicine, and this one has many more topics and almost triple the illustrations to give you the info needed to keep it together, even when everything else falls apart. Called “America’s favorite survival medic” by American Outdoor Guide, NY Times/Amazon bestselling author Dr. Joe Alton and Nurse Practitioner Amy Alton have put together a 700 page book that encompasses trauma care, first aid, chronic care, medical procedures, and much more. It’ll be an essential reference for anyone concerned about the uncertain future. The Survival Medicine Handbook is written in plain English that anyone can understand, but it’s not just another medical first aid book. It’s unique in that it assumes that a disaster, natural or man-made, has removed all access to hospitals or doctors for the foreseeable future; you, the average person, are now the highest medical resource left to your family. The book’s goal is to make you effective in that role.
The Suspect: The white-knuckle thriller behind the ITV series (Joe O'Loughlin #1)
by Michael RobothamThe first book in the Joe O'Loughlin series, from the multi-million-copy bestselling author. NOW A MAJOR ITV DRAMA STARRING AIDAN TURNER.Liar, liar . . .Joe O'Loughlin appears to have the perfect life - a beautiful wife, a loving daughter and a successful career as a clinical psychologist. But nothing can be taken for granted. Even the most flawless existence is only a loose thread away from unravelling. All it takes is a murdered girl, a troubled young patient and the biggest lie of his life. Caught in a complex web of deceit and haunted by images of the slain girl, he embarks upon a search that will take him from London to Liverpool and into the darkest recesses of the human mind. Ultimately, he will risk everything to unmask the killer and save his family.Don't miss the #1 bestseller's new thriller When You Are Mine, out now.Praise for Michael Robotham's thrillers:'I love this guy's books' Lee Child'Will have you turning the pages compulsively' The Times'An absolute master' Stephen King'He writes in a voice with a haunting sense of soul' Peter James'Heart-stopping and heart-breaking' Val McDermid'The real deal' David Baldacci'Superbly exciting . . . a terrific read' Guardian
The Suspect: The white-knuckle thriller behind the ITV series (Joseph O'Loughlin #1)
by Michael RobothamThe first book in the Joseph O'Loughlin series, from the multi-million-copy bestselling author. Don't miss Michael Robotham's new thriller When She Was Good, out now.Liar, liar...Joseph O'Loughlin appears to have the perfect life - a beautiful wife, a loving daughter and a successful career as a clinical psychologist. But nothing can be taken for granted. Even the most flawless existence is only a loose thread away from unravelling. All it takes is a murdered girl, a troubled young patient and the biggest lie of his life. Caught in a complex web of deceit and haunted by images of the slain girl, he embarks upon a search that will take him from London to Liverpool and into the darkest recesses of the human mind. Ultimately, he will risk everything to unmask the killer and save his family.Praise for Michael Robotham's thrillers:'I love this guy's books' Lee Child'Will have you turning the pages compulsively' The Times'An absolute master' Stephen King'He writes in a voice with a haunting sense of soul' Peter James'Heart-stopping and heart-breaking' Val McDermid'The real deal' David Baldacci'Superbly exciting . . . a terrific read' Guardian
The Sutures of the Skull: Anatomy, Embryology, Imaging, and Surgery
by R. Shane Tubbs Mehmet Turgut Ahmet T. Turgut Aaron S. DumontThis book provides an in-depth review of the sutures of the skull. The premature closure of the sutures of the skull (craniosynostosis) due to genetic or metabolic etiologies results in typical progressive skull deformity, due to both the inhibition of growth caused by the affected cranial suture and associated compensatory expansion of the skull along the open ones. Today, it is well known that early diagnosis of craniosynostosis is crucial for the best surgical outcomes and for the normal development of the brain and cosmetic appearance of the skull. As such, in addition to the anatomy, biology, genetics and embryology of the sutures of the skull, the book also covers the diagnosis and treatment of different forms of craniosynostosis such as metopism, and animal models for cranial suture research.This comprehensive work is a valuable resource for neuroscientists at all levels, from graduate students to researchers, as well as neurosurgeons, neuroanatomists, pediatricians, and neurologists seeking both basic and more advanced information on the unique structure of the sutures of the human skull.
The Sweating Sickness Epidemic: Henry VIII's Great Fear
by Stephen PorterAmong the array of diseases which brought death to Tudor England, the sweating sickness stood out, for the speed with which it struck, its dreadful effects on its victims and the death rates which it produced, that together generated a fear verging on panic when it was identified. The sweating sickness attacked the cities, towns and the countryside, not sparing the palaces. It threatened everyone, from the king in his castle to the beggars at his gates, including members of the dynasty and the political structure, the courtiers and those who directed the government, the church and the law. Contemporaries could do little more than make a bolt for it, and that included the king and his closest advisors, who moved furtively in a small group from one house to another away from London. The principal epidemics came between 1485, when it made its first appearance, and 1551, and it was confined to England and Wales, apart from one major eruption across northern Europe in 1529. Known as the English disease, this rapidly acting virus became Henry VIII’s overriding fear, aggravating his well-known hypochondria and controlling his movements. The nature of the sweating sickness, its incidence and impact are all examined in this book, in the context not only of Tudor England and the problems of the Henrician succession, but also in the context of epidemic disease in Europe more widely. This book teases out the similarities and differences between ‘the sweat’ and its better-known, if equally feared, contemporary infectious disease, bubonic plague.
The Sweet Life: Diabetes without Boundaries
by Sam TalbotSam Talbot is a professional chef, restaurateur, surfer, painter, philanthropist, and, since the age of 12, type 1 diabetic. Yet he has not let the disease stop him from living a rich life packed with energy, adventure, and achievement--culinary and otherwise. In his first, much-anticipated book, he recounts how diabetes has affected but not compromised his life or career, and he shares his own tips--alongside those from other famous diabetics like Halle Berry, Larry King, and Tommy Lee--on how to handle everything from work and hobbies to relationships and travel with discipline and enthusiasm. To round out this advice, he offers bits of foodie wisdom and 75 innovative recipes for fresh, all-natural dishes anybody, diabetic or not, can prepare and enjoy. Heartfelt, entertaining, and backed by real-life experience and solid medical expertise, The Sweet Life will give readers hope, inspiration, and the proof they need to realize that life with diabetes isn't about diabetes: It's about living.
The Symbolic Process And Its Integration In Children: A STUDY IN SOCIAL PSYCHOLOGY (Midway Reprint Ser.)
by Markey, John FFirst Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.
The Symbolic Species Evolved
by Theresa Schilhab Frederik Stjernfelt Terrence DeaconThis anthology is a compilation of the best contributions from Symbolic Species Conferences I, II (which took place in 2006, 2007). In 1997 the American anthropologist Terrence Deacon published The Symbolic Species: The Coevolution of Language and the Brain. The book is widely considered a seminal work in the subject of evolutionary cognition. However, Deacons book was the first step - further steps have had to be taken. The proposed anthology is such an important associate. The contributions are written by a wide variety of scholars each with a unique view on evolutionary cognition and the questions raised by Terrence Deacon - emergence in evolution, the origin of language, the semiotic 'missing link', Peirce's semiotics in evolution and biology, biosemiotics, evolutionary cognition, Baldwinian evolution, the neuroscience of linguistic capacities as well as phylogeny of the homo species, primatology, embodied cognition and knowledge types.
The Symbolic Species: The Co-evolution of Language and the Brain
by Terrence W. DeaconTerrence Deacon departs from the conventional theories which state that language arose, somehow, once the human brain became large and complex enough. He argues that the brain and language developed in concert, explains how the process occurred, and draws out the compelling implications of this new view of human origins.
The Symbolism of Globalization, Development, and Aging
by John W. Murphy Steven L. ArxerThis book looks at the symbolic side of globalization, development, and aging. Many of the dimensions that are discussed represent updates of past debates but some are entirely new. In particular, globalization is accompanied by subtle social imagery that profoundly shapes the way institutions and identities are imagined. The process of aging and persons sense of identity is no exception. The underlying assumptions that pervade globalization inform how critical dimensions of aging are discussed and institutionalized. The application of marketplace imagery, for example, may impact attempts for holism in how aging is studied and the prospects for human agency during the aging process. This book offers a special look into how temporality, technology, normativity, and empiricism structure the symbolic side of globalization and influence dominant images of the aging process. Current debates about globalization and aging are expanded by helping readers see the social imagery that is both subtly behind globalization and at the forefront of shaping the aging experience.
The Symptom and the Subject: The Emergence of the Physical Body in Ancient Greece
by Brooke HolmesThe Symptom and the Subject takes an in-depth look at how the physical body first emerged in the West as both an object of knowledge and a mysterious part of the self. Beginning with Homer, moving through classical-era medical treatises, and closing with studies of early ethical philosophy and Euripidean tragedy, this book rewrites the traditional story of the rise of body-soul dualism in ancient Greece. Brooke Holmes demonstrates that as the body (sôma) became a subject of physical inquiry, it decisively changed ancient Greek ideas about the meaning of suffering, the soul, and human nature. By undertaking a new examination of biological and medical evidence from the sixth through fourth centuries BCE, Holmes argues that it was in large part through changing interpretations of symptoms that people began to perceive the physical body with the senses and the mind. Once attributed primarily to social agents like gods and daemons, symptoms began to be explained by physicians in terms of the physical substances hidden inside the person. Imagining a daemonic space inside the person but largely below the threshold of feeling, these physicians helped to radically transform what it meant for human beings to be vulnerable, and ushered in a new ethics centered on the responsibility of taking care of the self. The Symptom and the Subject highlights with fresh importance how classical Greek discoveries made possible new and deeply influential ways of thinking about the human subject.
The Systematic Mistreatment of Children in the Foster Care System: Through the Cracks
by Lois WeinbergThe Systematic Mistreatment of Children in the Foster Care System tells the stories of 10 children in the foster care system from diverse ethnic and cultural backgrounds and the efforts by advocates to find them permanent places to live, appropriate schooling, and other essentials they need to survive. The children’s case studies highlight the difficulties in placing and maintaining them in healthy living situations with supportive educational, mental health, and other services. The book shows how children fall-sometimes over and over again-through the "deep cracks" that exist within and between the various agencies of the multi-agency system of care that was designed to help them. Appropriate placement and services for children in foster care typically requires the coordination and collaboration of several agencies, including the juvenile court, child protective services (CPS), school districts, and departments of mental health (DMH). The Systematic Mistreatment of Children in the Foster Care System shows how these agencies frequently fail to meet their legal obligations to children in the system and what can be done to address these failures-and the outcomes they produce. The Systematic Mistreatment of Children in the Foster Care System includes: an introduction to the child protective services system the general route by which children in the United States are removed from their parents’ custody because or abuse and neglect the major components of the Individuals with Disabilities Education Act and the problems in getting foster children’s educational needs met the difficulties in securing stable out-of-home placements strategies for stabilizing home placements problems in funding for out-of-home placements strategies for advocating the removal of children from inadequate out-of-home placements legislation and practices for bringing about needed policy changes and much more Equally valuable as a professional tool and as a classroom resource, The Systematic Mistreatment of Children in the Foster Care System includes introductions to specific issues presented in each chapter; case studies that illuminate the issues presented; subsections for each case study chapter entitled "Prevention," "Intervention," "Advocacy Considerations," and "What Had Gone Wrong;" boxed items highlighting practical strategies, laws, and other relevant information; and a conclusion and summary of each chapter.
The Systemic Effects of Advanced Cancer: A Textbook on Cancer-Associated Cachexia
by Swarnali AcharyyaThis textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
The T.I.G.E.R. Protocol: An Integrative 5-Step Programme to Treat and Heal Your Autoimmunity
by Dr Akil PalanisamyIncrease your resilience to autoimmune diseases by following Dr Akil's 5-step plan for a balanced and healthy diet.Auto-immune disorders like Graves Disease, Hashimoto's Thyroiditis, Lupus, Coeliac and even Long-Covid, affect an estimated 300 million people worldwide. These disorders can be frustrating as they are difficult to diagnose, painful and often invisible. Now, with this simple yet powerful 5-step plan devised by Dr Akil Palanisamy, readers can learn to treat, tame and potentially reverse painful autoimmune conditions.In The T.I.G.E.R. Protocol, Dr Akil Palanisamy uses his training in Western medicine and complementary therapies to create an integrative approach to treat autoimmune diseases. Addressing five key elements - Toxins, Infections, Gut health, Eating right and Rest and balance - this approach has proved remarkably effective for both patients with full-blown disease and those who had been told they were on the path to autoimmunity.The foundation of this approach is the use of specific healing foods. Diet can be a powerful tool, but autoimmune diets that are typically recommended are often restrictive. Dr Akil's protocol expands the diet to be less draconian while maintaining clinical efficacy, potentially reversing the effects of years of suffering from disease and taking a person off the path to suffering in years to come.The protocol is split into easy-to-follow Phase 1 and Phase 2 diets, allowing you to eliminate the necessary food sensitivities in the short term and then reintroduce foods to achieve a more diverse and balanced diet. It also includes Dr Akil's top 10 healing foods for the microbiome - including mushrooms, artichokes and dark chocolate.(P) 2023 Hachette Audio
The T.I.G.E.R. Protocol: An Integrative 5-Step Programme to Treat and Heal Your Autoimmunity
by Dr Akil PalanisamyAuto-immune disorders like Graves Disease, Hashimoto's Thyroiditis, Lupus, Coeliac and even Long-Covid, affect an estimated 300 million people worldwide. These disorders can be frustrating as they are difficult to diagnose, painful and often invisible. Now, with this simple yet powerful 5-step plan devised by Dr Akil Palanisamy, readers can learn to treat, tame and potentially reverse painful autoimmune conditions.In The T.I.G.E.R. Protocol, Dr Akil Palanisamy uses his training in Western medicine and complementary therapies to create an integrative approach to treat autoimmune diseases. Addressing five key elements - Toxins, Infections, Gut health, Eating right and Rest and balance - this approach has proved remarkably effective for both patients with full-blown disease and those who had been told they were on the path to autoimmunity.The foundation of this approach is the use of specific healing foods. Diet can be a powerful tool, but autoimmune diets that are typically recommended are often restrictive. Dr Akil's protocol expands the diet to be less draconian while maintaining clinical efficacy, potentially reversing the effects of years of suffering from disease and taking a person off the path to suffering in years to come.The protocol is split into easy-to-follow Phase 1 and Phase 2 diets, allowing you to eliminate the necessary food sensitivities in the short term and then reintroduce foods to achieve a more diverse and balanced diet. It also includes Dr Akil's top 10 healing foods for the microbiome - including mushrooms, artichokes and dark chocolate.
The TNF Superfamily
by Jagadeesh BayryExploring these type II trans-membrane proteins, The TNF Superfamily: Methods and Protocols focuses on various techniques to investigate aspects of the TNF Superfamily members in health and disease. Opening with protocols to understand the signaling process of TNF family members, this detailed volume continues with technical examples of investigating the role of TNF family members in physiopathologies, protocols on modulation of TNF signaling by pathogens, experimental applications of TNF-reporter mice, as well as methodologies for various assays of TNF family members and the production of recombinant molecules Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and ready to use, The TNF Superfamily: Methods and Protocols will aid researchers investigating this key family of proteins, involved in vital processes such as providing signals for activation, differentiation, survival and death of cells, modulation of immune response and inflammation, hematopoiesis and osteoclastogenesis.
The Taming of Dr. Alex Draycott
by Joanna NeilThe Taming of Dr Alex Draycott A troublesome little niece and nephew to look after, a crumbling cottage to repair and a busy A&E to run gives Dr Alex Draycott plenty on her plate even before she meets the rebelliously charming Dr Callum Brooksby! Feisty Alex can handle a challenge but it seems Callum is out to tame her heart The Man Behind the Badge However hard citygirl and newdocintown Kayla Morgan tries, she cant resist being impressed by the horseriding, cattleherding, lawenforcing Tom Jamieson! But taking a bullet in the line of duty has made cop Tom rethink his work hard, party harder lifestyle will he ever let Kayla see the real man behind the badge?
The Tantrum Survival Guide: Tune In to Your Toddler's Mind (and Your Own) to Calm the Craziness and Make Family Fun Again
by Daniel J. Siegel Rebecca Schrag HershbergIf you are the parent of a toddler or preschooler, chances are you know a thing or two about tantrums. While those epic meltdowns can certainly be part of "normal" toddler behavior, they are still maddening, stressful, and exhausting--for everyone involved. What can you do to keep your cool and help your child calm down? Rebecca Schrag Hershberg, child psychologist and mother of two, has a unique understanding of both the science behind tantrums and what works in the heat of the moment to nip blowups in the bud. With her customizable plan, you'll learn: *Why your toddler's developing brain is hardwired for "big emotions." *What you may be doing (unintentionally) to encourage outbursts. *Ways to use structure and routines to help your child feel secure. *How to reduce tantrums at tough times of day, from wake-up to bedtime. *Strategies for managing tantrums under difficult circumstances, from travel to moving to divorce. *Ways to deepen your parent–child connection--starting right now.
The Tao of Fertility: A Healing Chinese Medicine Program to Prepare Body, Mind, and Spirit for New Life
by Dana Herko Daoshing NiAn esteemed doctor who has helped countless women achieve their dream of having a child offers his program for enhancing fertility through traditional Chinese medicine (TCM). Dr. Daoshing Ni, descended from more than 70 generations of Taoist masters, has achieved renown among high-tech infertility specialists, TCM practitioners, and his many devoted patients. The Tao of Fertility is the first book combining a practical plan for conceiving using TCM with empowering Taoist principles that can carry you through pregnancy, childbirth, and beyond. Structured according to a woman’s journey to conception, The Tao of Fertility includes: A questionnaire assessing fertility potential A 28-day fertility enhancement programSimple meditations and acupressure points to improve reproductive circulation and relaxationGuidelines for mapping your fertility using Chinese methods of diagnosisInformation on how herbs and acupuncture can increase fertilityEating plans for pregnancy, postpartum, and while breast-feeding. and much moreEnriched by moving stories of women who became pregnant using TCM, this is a compassionate, comprehensive handbook.
The Tao of Natural Breathing
by Dennis Lewis Master Mantak ChiaDennis Lewis draws on his many years of study in the Gurdjieff work, Advaita Vedanta, and Taoism to show how natural, whole-body breathing can improve health, increase energy, and support the quest for inner growth. Along with breathing practices designed to open the three primal energy centers, the book defines natural breathing; provides a clear, illustrated description of the physiology of breathing; and offers suggestions on how to use spacious breathing both in times of stress and in everyday life.
The Tao of Trauma: A Practitioner's Guide for Integrating Five Element Theory and Trauma Treatment
by Kathy L. Kain Alaine D. Duncan M.D. Hollifield MichaelExplains trauma using a combination of the Five Elements (from Traditional Chinese Medicine) and a touch perspective; for practitioners of a variety of modalities, including acupuncturists, somatic therapists, massage therapists, and mental health providers.Combining Eastern and Western trauma physiology, clinician-educators Alaine Duncan and Kathy Kain introduce a new map for acupuncturists, medical practitioners, mental health providers, and body-oriented clinicians to help restore balance in their patients. Using concepts from Acupuncture and Asian Medicine (AAM), alongside descriptions of the threat response from Western bio-behavioral science, they describe common physical symptoms, emotional presentations, and paths for healing for five survivor "types" detailed by the authors and correlated to the Five Elements of AAM. This ancient/modern integrative lens illuminates the diverse manifestations of traumatic stress in its survivors--chronic pain, autoimmune illness, insomnia, metabolic problems, and mental health disorders--and brings new hope to survivors of trauma and those who treat them.
The Tarnished Chalice: The Twelfth Chronicle of Matthew Bartholomew (Chronicles of Matthew Bartholomew #12)
by Susanna GregoryFor the twentieth anniversary of the start of the Matthew Bartholomew series, Sphere is delighted to reissue all of the medieval monk's cases with beautiful new series-style covers.------------------------------------The winter of 1353 has been appallingly wet, there is a fever outbreak amongst the poorer townspeople and the country is not yet fully recovered from the aftermath of the plague. The increasing reputation and wealth of the Cambridge colleges are causing dangerous tensions between the town, Church and University. Matthew Bartholomew is called to look into the deaths of three members of the University of who died from drinking poisoned wine, and soon he stumbles upon criminal activities that implicate his relatives, friends and colleagues - so he must solve the case before matters in the town get out of hand...On a bitter winter evening in 1356, Matthew Bartholomew, Brother Michael and their book-bearer Cynric arrive in Lincoln. Michael is to accept an honour from the cathedral, and Bartholomew is looking for the woman he wants to marry. It is not long before they learn that the friary in which they are staying is not the safe haven they imagine - one guest has already been murdered. It soon emerges that the dead man was holding the Hugh Chalice, a Lincoln relic with a curiously bloody history. Bartholomew and Michael are soon drawn into a web of murder, lies and suspicion in a city where neither knows who can be trusted.