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The big squeeze: a social and political history of the controversial mammogram
by Handel ReynoldsIn 2009, an influential panel of medical experts ignited a controversy when they recommended that most women should not begin routine mammograms to screen for breast cancer until the age of fifty, reversing guidelines they had issued just seven years before when they recommended forty as the optimal age to start getting mammograms. While some praised the new recommendation as sensible given the smaller benefit women under fifty derive from mammography, many women's groups, health care advocates, and individual women saw the guidelines as privileging financial considerations over women's health and a setback to decades-long efforts to reduce the mortality rate of breast cancer.In The Big Squeeze, Dr. Handel Reynolds, a practicing radiologist, notes that this episode was only the most recent controversy in the turbulent history of mammography since its introduction in the early 1970s. In a book written for the millions of women who face the decision about whether to get a mammogram, health professionals interested in cancer screening, and public health policymakers, Reynolds shows how pivotal decisions made during mammography's initial launch made it all but inevitable that the test would be contentious. He describes how, at several key points in its history, the emphasis on mammography screening as a fundamental aspect of women's preventive health care coincided with social and political developments, from the women's movement in the early 1970s to breast cancer activism in the 1980s and '90s.At the same time, aggressive promotion of mammography made the screening tool the cornerstone of a huge new industry. Taking a balanced approach to this much-disputed issue, Reynolds addresses both the benefits and risks of mammography, charting debates, for example, that have weighed the early detection of aggressively malignant tumors against unnecessary treatments resulting from the identification of slow-growing and non-life-threatening cancers. The Big Squeeze, ultimately, helps to evaluate the ongoing public health controversies surrounding mammography and provides a clear understanding of how mammography achieved its current primacy in cancer screening.
The calcitonin gene-related peptide family
by Deborah L. Hay Ian M. DickersonThis book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition. This volume includes chapters on: The adrenomedullin peptides and signalling Ligand binding and activation of the CGRP receptor Understanding amylin receptors The CGRP-receptor component protein The calcitonin peptide family Genetic regulation of CGRP Vascular actions of CGRP and adrenomedullin Intermedin/adrenomedullin 2 function CGRP and adrenomedullin as pain-related peptides Amylinergic control of ingestive behaviour Calcitonin receptors This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.
The end of medicine as we know it - and why your health has a future
by Harald H.H.W. SchmidtMedicine itself is sick. We hardly understand any disease and therefore need to chronically treat symptoms but not the causes. Consequently, drugs and other therapies help only very few patients; yet we are pumping more and more money into our healthcare system without any added value.Thus, the internationally renowned physician researcher, Harald Schmidt, predicts the end of medicine as we know it. On a positive note, digitization will radically change healthcare and lead to one of the greatest socioeconomic revolutions of mankind. He is one of the pioneers of "systems medicine", a complete redefinition of what we actually call a "disease", how we organize medicine and how we use Big Data to heal rather than treat, to prevent rather than cure. In this book the author first proves the deep crisis of medicine, but describes how medicine will become more precise, more uniform, safer and, surprisingly, also more affordable. Making a diagnosis will be taken over by artificial intelligence. Current, mainly organ-based medical specialists, disciplines and hospital departments will disappear. Physicians will become patient coaches working in interdisciplinary teams with pharmacists, physiotherapists, nutritionists, etc. and relieved of their workload. Illnesses, including cancer, will be prevented or cured in a precise manner. We will become 100 years and older. Health care spending will shift from chronic treatment of diseases to prevention and health maintenance, thereby dramatically reducing overall costs. Health will become a common good. But Harald Schmidt also warns that those who are not open to digitization will not benefit from these advances and will be left behind. Anyone who wants to benefit from the revolution of medicine must have a digital twin. Is this futurism? No, each of us can have his or her personal genome sequenced, microbiome analyzed, keep an electronic health record. The future has begun.Schmidt convincingly explains the limitations in the current practice of medicine and the need for big data and a systems approach. Prof. Ferid Murad MD, PhD, Nobel Laureate in Medicine 1998, USA Network Medicine, a new discipline that offers a network-based understanding of the cell and disease, is unavoidable if we wish to translate the advances in genomics into cures. Professor Harald Schmidt, a prominent expert in this space, offers the first coherent treatment of the topic, explaining the potential of a network-based perspective of human disease. Prof. Albert-László Barabási, Northeastern University and Harvard Medical School, Boston, USAVisionary, provocative, and full of insights. Professor Schmidt gives a unique and authoritative perspective to the past, present and future of medical science and clinical practice. And all presented in such an inimitable style. Prof. Robert F.W. Moulds, MBBS PhD FRACP, Former Dean Royal Melbourne Hospital Clinical School, Australia
The knowledge of experience: Exploring epistemic diversity in digital health, participatory medicine, and environmental research
by Dana MahrThis book explores the role of social and epistemic diversity in science, technology, and medicine in the 21st century. It argues that most contemporary endeavours to democratize science are epistemically conservative. Using illustrative case studies, Dr Dana Mahr shows how epistemic diversity can contribute to a renewal of the production of scientific knowledge. Her exploration of online self-help cultures, radical feminist health movements, and grassroots environmentalism in Thailand emphasize that “experiential knowledge“ and “performativity“ are important epistemic strategies for marginalized social groups to critically engage with institutionalized knowledge.
The mRNA Metabolism in Human Disease (Advances in Experimental Medicine and Biology #1157)
by Luísa RomãoThe eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.
The political economy of health care: Where the NHS came from and where it could lead (Health and Society series)
by Julian Tudor HartWith a foreword by Tony Benn. Drawing on clinical experience dating from the birth of the NHS in 1948, Julian Tudor Hart, a politically active GP in a Welsh coal mining community, charts the progress of the NHS from its 19th century origins in workers' mutual aid societies, to its current forced return to the market. His starting point is a detailed analysis of how clinical decisions are made. He explores the changing social relationships in the NHS as a gift economy, how these may be affected by reducing care to commodity status, and the new directions they might take if the NHS resumed progress independently from the market. This edition of this bestselling book has been entirely rewritten with two new chapters, and includes new material on resistance to that world-wide process. The essential principle in the book is that patients need to develop as active citizens and co-producers of health gain in a humanising society and the author's aim is to promote it wherever people recognise that pursuit of profit may be a brake on rational progress.
The ras Superfamily of GTPases (CRC Press Revivals)
by Juan Carlos Lacal Frank Patrick McCormickThe ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.
The world turned upside down in 80 days: PANDEMIC
by Julio Andrade LarreaThis is a testimony of so many that there will be, of how I , one of the 7500 million inhabitants of our planet earth, have had to face and live a pandemic, for which I have been little or not at all prepared and how I lived it, in my own world and environment. If there is something that has made us human beings feel equal for the first time, it has been this virus, which has not distinguished between citizens of the world. Poor or rich, black or white, yellow or brown, Christian, Muslim, Jew or atheist, educated or uneducated, tall or short, fat or thin, young or old, male or female, from the sea or the mountains etc. We have all been affected equally and we have all been led to live days of anguish, desolation, pain, fear and even terror before a situation so unexpected and so little understood. How are we going to live after all this is over? If it ends. How will our lifestyle change from here on? The answers keep leading us into an uncertainty of a post-traumatic situation. This book is a testimony of the daily experiences at home and at hospital where I work as an anaesthesiologist. Sometimes dramatic , sometimes with humor ......
The ‘Kiss’ and the Medicine of Love: A Critical Edition of Francesco Patrizi’s Il Delfino (Palgrave Studies in Medieval and Early Modern Medicine)
by Tommaso GhezzaniThis is a revised critical edition of philosopher and scientist, Francesco Patrizi's manuscript, Il Delfino, overo del bacio (c.1555), with an English translation and commentary. Il Delfino, or ‘The Kiss’ survives in a single manuscript, compiled by an assistant and interspersed with autograph corrections by Patrizi himself. The only modern critical edition of the text, edited by Danilo Aguzzi Barbagli (1975), is known to contain many errors that prevent a correct understanding of the work. This book therefore fills this historiographical gap and at the same time provides a reliable text for further translations of Patrizi's work into other languages.
Theaters of Anatomy: Students, Teachers, and Traditions of Dissection in Renaissance Venice
by Cynthia KlestinecOf enduring historical and contemporary interest, the anatomy theater is where students of the human body learn to isolate structures in decaying remains, scrutinize their parts, and assess their importance. Taking a new look at the history of anatomy, Cynthia Klestinec places public dissections alongside private ones to show how the anatomical theater was both a space of philosophical learning, which contributed to a deeper scientific analysis of the body, and a place where students learned to behave, not with ghoulish curiosity, but rather in a civil manner toward their teachers, their peers, and the corpse. Klestinec argues that the drama of public dissection in the Renaissance (which on occasion included musical accompaniment) served as a ploy to attract students to anatomical study by way of anatomy’s philosophical dimensions rather than its empirical offerings. While these venues have been the focus of much scholarship, the private traditions of anatomy comprise a neglected and crucial element of anatomical inquiry. Klestinec shows that in public anatomies, amid an increasingly diverse audience—including students and professors, fishmongers and shoemakers—anatomists emphasized the conceptual framework of natural philosophy, whereas private lessons afforded novel visual experiences where students learned about dissection, observed anatomical particulars, considered surgical interventions, and eventually speculated on the mechanical properties of physiological functions. Theaters of Anatomy focuses on the post-Vesalian era, the often-overlooked period in the history of anatomy after the famed Andreas Vesalius left the University of Padua. Drawing on the letters and testimony of Padua's medical students, Klestinec charts a new history of anatomy in the Renaissance, one that characterizes the role of the anatomy theater and reconsiders the pedagogical debates and educational structure behind human dissection.
Their Accidental Vegas Vows (Jet Set Docs)
by Amy RuttanIn this Jet Set Docs story by Amy Ruttan, it&’s Vegas, baby! When EMT Grace wakes up in bed with her colleague—and his ring on her finger—they fake their relationship to prevent a scandal. But can they ignore the sizzling-hot chemistry between them?WAKING UP MARRIED! When EMT Grace wakes up in Vegas, she&’s shocked to find her gorgeous but guarded colleague Jonah in her bed…and his wedding ring on her finger! Especially as Grace had sworn off romance after her last workplace relationship ended in disaster. So having a husband—even charming Jonah, who gives her butterflies—is not ideal! Grace fears another hospital scandal, and soon she&’s asking Jonah to keep up their accidental marriage. After all, their vows still stand…but what about the undeniable chemistry that bound them to begin with?From Harlequin Medical: Life and love in the world of modern medicine. Jet Set Docs
Their Baby Surprise
by Jennifer TaylorBy rights, single mother Dr. Rachel Mackenzie and widower Dr. Matthew Thompson should be at odds--the disastrous non-wedding of their respective children has thrown the village of Dalverston into turmoil! But Matt and Rachel are faced with their own emotional upheaval. They turn to each other for friendly support, and unexpectedly find that old friends can make a new beginning!And just when Matt and Rachel begin to believe that their happy ending is in sight, the most remarkable thing happens....
Their Barcelona Baby Bombshell (Night Shift in Barcelona #2)
by Traci DouglassIn USA TODAY bestselling author Traci Douglass's latest Harlequin Medical Romance, one hot night in Barcelona with an irresistible stranger leads to unexpected consequences for the paramedic…One hot encounter…One shocking consequence! Paramedic Isabella Rivas doesn&’t do commitment and entanglement. She had enough of that raising her five siblings after their mother died. But one red-hot night with a sexy stranger doesn&’t count, right? Except that single passionate encounter results in an unexpected pregnancy! And when she meets Carlos Martinez&’s familiar guarded eyes over a patient in the ER, she realizes that life has just got a whole lot more complicated…From Harlequin Medical: Life and love in the world of modern medicine. Night Shift in BarcelonaBook 1: The Night They Never Forgot by Scarlet WilsonBook 2: Their Barcelona Baby Bombshell by Traci DouglassBook 3: Their Marriage Worth Fighting For by Louisa HeatonBook 4: From Wedding Guest to Bride? by Tina Beckett
Their Christmas to Remember (Scottish Docs in New York #1)
by Amalie BerlinA Christmas kiss……with the rebel surgeon!In this Scottish Docs in New York story, Dr. Angel Conley will do anything to bring the joy of Christmas to her young patients! Only she doesn’t count on gorgeous Scottish surgeon Wolfe McKeag being her reluctant partner in crime! They’ve both spent their lives running from relationships, but as their passion for each other turns into so much more, dare they believe in the magic of Christmas? Scottish Docs in New York duetBook 1 — Their Christmas to RememberBook 2 — Healed Under the Mistletoe“Another wonderful second chance book…. Enjoy their journey back to love.” Goodreads on Back in Dr Xenakis’ Arms“I believe readers get an absolutely charming and enthralling read in this book that captivated me right from the start….” Harlequin Junkie on The Rescue Doc’s Christmas Miracle
Their Double Baby Gift
by Louisa HeatonCan two and two really make four? Widower Major Matt Galloway came to London Grace Hospital for his tiny daughter. But he finds himself facing a barrel of emotions on meeting beautiful Dr. Brooke Bailey-his late wife's best friend and single mother to her own baby girl. Brooke can't believe Matt is her new boss. But the feelings she has for him are even more troublesome. Brooke swore she would raise her baby alone, but loving father Matt melts her heart and Brooke starts to hope...could they really make one big happy family after all?
Their Fake Date Rescue
by Alison RobertsA fake relationship quickly spirals into something much more for a widower GP and his nurse colleague. As the flames of desire burn brighter, can they both overcome the pains of the past to find love? Find out in the latest Harlequin Medical Romance novel by Alison Roberts! A PRETEND ROMANCE…STAT! Widowed GP Tom is determined to avoid unwanted questions about his romantic life. And it seems the new nurse, Claire, is too. Their unconventional solution? A fake relationship! Safe and temporary, no strings attached. Except Claire&’s positivity, despite the loss she&’s faced, makes Tom&’s bruised heart race again… And as they slowly lower their carefully constructed walls, the shocking—yet very real—bond between them flourishes. But now will their ruse rescue them from the past and lead to happiness—together?From Harlequin Medical: Life and love in the world of modern medicine.
Their Fate Is Our Fate: How Birds Foretell Threats to Our Health and Our World
by Peter DohertyAt the heart of this book by Nobel Prize–winning immunologist and professor Peter Doherty is this striking observation: Birds detect danger to our health and the environment before we do. Following a diverse cast of bird species around the world—from tufted puffins in Puget Sound to griffon vultures in India, pigeons in East Asia, and wedge-tailed shearwaters off the islands of Australia’s Great Barrier Reef—Doherty illuminates birds’ role as an early warning system for threats to the health of our planet and our own well-being.Their Fate Is Our Fate is an impassioned call not only to attention but to action. As “citizen scientists” we can collect data, vital to cutting-edge research, that depends on the birds that are all around us. Armed with our observations, scientists will continue to uncover new ways to glimpse our future in birds—and to affirm how, truly, their fate is our fate.
Their First Family Christmas
by Alison RobertsHer Christmas past becomes her Christmas present! When Dr. Emma Matthews was entrusted with the guardianship of her best friend's daughter, she promised that every Christmas would be special... But this Christmas Eve, Jack Reynolds-her old flame and Lily's uncle-has walked back into their lives. Both Emma and Jack still bear the scars of this time last year. But now Jack wants to start again-being there for his adorable niece, picking up where he and Emma left off, and giving them all the family Christmas they deserve!
Their Hot Hawaiian Fling
by Traci DouglassAll’s fair in love and war……when passion explodes in paradise!Having survived a horrific car accident as a teen, Dr. Leilani Kim has dedicated her life to saving others. Now her dream job as head of Emergency Medicine is finally in sight…but she has competition! In the form of scarred yet sexy trauma surgeon Dr. Holden Ross. And when their rivalry stirs a desire they can’t escape, Leilani and Holden will have to decide: Business…or pleasure?“A Weekend with Her Fake Fiancé gave me all the feels! I have come to love the Medical Romance books by this author and this one was so fantastic! The writing in this book is excellent with well fleshed out characters and a fun, passionate story line.”—Goodreads“If you like sweet heartwarming stories then you must read this. What a beautifully written and entertaining story so full of love and empathy with loveable characters and a delightful storyline. I highly recommend this to you.”—Goodreads on A Mistletoe Kiss for the Single Dad
Their Marriage Meant To Be
by Louisa HeatonThe only thing that can heal them?Each other!The day they lost their son, veterinary nurse Bex's and vet Ethan&’s worlds were left shattered. Struggling to cope, their marriage fell apart. Now, five years later, Ethan is back in Bex&’s life…to treat a critically ill horse in her care. Being in each other&’s company again reminds Bex of every single thing that she loved about Ethan. But will it prove they are meant to be together—forever? &“I loved this one from page one, Ms. Heaton really knows how to write a beautiful medical romance that has characters that the reader finds very easy to care for…. This is a story that I would highly recommend.&”-Goodreads on Twins for the Neurosurgeon &“…Louisa Heaton is definitely a writer after my own heart, creating heartwarming romance with ambitious conflicts, compelling medical drama and amazing locales. I look forward to escaping with Heaton&’s next release!&”-Goodreads on Risking Her Heart on the Trauma Doc
Their Marriage Worth Fighting For (Night Shift in Barcelona #3)
by Louisa HeatonWill an unexpected chance to work side by side save an estranged couple&’s marriage? Find out in Louisa Heaton&’s emotional reunion romance, the third book in the Night Shift in Barcelona series!A chance to mend their marriage……for good? After experiencing three devastating miscarriages, midwife Grace and neonatal surgeon Diego find their marriage hanging by a thread. But on one summer night at Santa Aelina University Hospital, they are forced to work together on a challenging case. Now, with nowhere to hide, they must finally confront their heartbreak… Can they also rediscover the joy and love that made their marriage so special?From Harlequin Medical: Life and love in the world of modern medicine.Night Shift in Barcelona Book 1: The Night They Never Forgot by Scarlet WilsonBook 2: Their Barcelona Baby Bombshell by Traci DouglassBook 3: Their Marriage Worth Fighting For by Louisa HeatonBook 4: From Wedding Guest to Bride? by Tina Beckett
Their Meant-to-Be Baby
by Caroline AndersonUnexpectedly pregnant! Having discovered her night with surgeon Sam Ryder had unexpected consequences, Kate Ashton is left reeling when he walks into her emergency department. Now she'll have to tell this "emotionally broken" man she's been belatedly warned about that she's pregnant! Sam's feelings might be frozen, but he wants to be a dad. When Kate reveals she's afraid of becoming a mom, her heartrending story opens Sam's heart. He must convince Kate to give them a chance. This baby was meant to be-perhaps their love is, too...
Their Miracle Baby
by Caroline AndersonThe baby they thought they d never have Fran Trevellyan is counting her blessings: her marriage to Mike, her little stepdaughter, her home and friends in Penhally. Yet she is haunted by the one thing she wants most of all a baby Mikes baby. After three years of trying, their marriage is taking the strain until Mike injures his leg and has to rely on Fran for everything. The intimacy rekindles their love and their simmering passion. Can their renewed bond also give them the courage to try one more time to make the baby they ve always longed for? SPECIAL BONUS FEATURES INSIDE Including exclusive free story Making Memories.
Their Miracle Child: A Delightful Medical Romance (Medical Romances #21)
by Gill SandersonAnother heartwarming medical romance from best-selling author Gill Sanderson! Perfect for fans of Mia Faye, Laura Scott, Helen Scott Taylor, Grey's Anatomy and ER.Readers LOVE Gill's gripping medical romances!'Remarkable writer!!' 5* author review 'A truly wonderful writer' 5* author review 'I find all of Gill Sanderson's books very readable and enjoy the escapism they give me' 5* author review'A truly gifted writer with an enormous amount of talent and sensitivity' 5* author Four years before, after the sudden death of her newborn child, Alana Ward had left her husband, Dr Finn Cavendish, and wandered the world, taking nursing jobs wherever she could. Now she was back in the Lake District and thought it time she divorced her husband. She had heard nothing of him since they parted.She meets Finn and he tells her - she had a daughter. There had been a mix-up in the hospital. Alana can hardly cope with the shock. She has a child! Now she has to get to know her daughter. And be helped by the man who is still her husband? It wasn't going to be easy.Don't miss Gill Sanderson's enthralling medical romances, including the A Lakeland Practice and the Good, Bad and Ugly series.
Their Mistletoe Baby
by Karin BaineA Christmas dream come true When handsome pediatrician Lucas Brodie walked out on his wife, Freya, at Christmas, he left her heart and hopes for a family shattered. This year, nurse Freya is determined to put the pain behind her by volunteering on a trip to take sick children to Lapland. But then she discovers Lucas is coming, too! As they begin to fall in love again, Lucas wonders-could he give her a family after all? Can he put his past behind him? Perhaps an unexpected pregnancy could be the Christmas miracle to make Freya's dreams come true...