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Vaccines: A Biography
by Andrew W. ArtensteinThe History and Biography of Vaccines against Infectious Diseases is a multi-authored book, written for an academic audience but accessible to a general readership as well. The book examines the human stories that underlie the development of vaccines against infectious diseases. Each chapter traces the lineage of a vaccine by examining the people behind the scientific hypotheses and discoveries that led to vaccine breakthroughs. These stories are firmly anchored in their historical context, as the "biography" of a vaccine generally has its origins in a medical problem rooted within a social context that subsequently engages scientists and enlists others in the eventual solution. A prominent theme woven throughout the book is the interdependence of incremental scientific advances and investigators on one another and how such advances ultimately led to practical, preventive solutions to major public health problems in society. Additionally, the human aspect of various pivotal events in the histories of specific vaccines are illustrated--this includes scientific and political hurdles and details of clinical trial controversies. In this fashion the work interweaves scientific themes, personal stories of those involved, and the sociohistorical context in which they worked in a manner that illustrates their inter-relatedness and provides the reader with exciting accounts of these advances.
Vaccines: A Clinical Overview and Practical Guide
by Joseph Domachowske Manika SuryadevaraThis book is designed to provide easy-to-read and basic information about vaccines for those undertaking a vaccine course or for medical providers seeking to improve their skills. Written by expert medical educators in the areas of infectious diseases, medical microbiology, and pediatrics, this book begins by establishing the fundamentals of vaccines such as what constitutes a vaccine, how they are manufactured and composed, how they are tested for safety and efficacy, and how vaccine recommendations are developed and conveyed to health care providers and their patients. The book then explains the composition, safety profile, effectiveness, and current recommendations for use of every available vaccine, alphabetized by infection. The concluding section illuminates practical concerns every vaccinating clinician experiences, including vaccine confidence and hesitancy, misconceptions, and patient communication. Vaccines: A Clinical Overview and Practical Guide is an excellent learning tool for all students and providers administering vaccines to patients, including infectious disease specialists and other internal medicine subspecialists, pediatricians, geriatricians, as well as all other primary care physicians, nurse practitioners, physician’s assistants, and nurses.
Vaccines: A Safer World, One Shot at a Time (Fountas & Pinnell LLI Purple #Level W)
by Miles ZapataVaccines: A Safer World, One Shot at a Time by Miles Zapata *** SOLVING PROBLEMS SERIES
Vaccines: Are they Worth a Shot?
by Andrea Grignolio Joan RundoThe dangerous decline in vaccinations in many developed countries is at the heart of a lively debate that confirms how important the subject is today. Vaccinations are among mankind’s most important scientific discoveries, yet they continue to be viewed with suspicion by part of the public – the victims of disinformation campaigns, instrumentalization and unfounded fears. There is, however, also an evolutionary explanation for these irrational beliefs, and countering the growing social opposition will be extremely difficult without grasping it. This book, which sheds new light on the safety and importance of vaccinations, is intended both for parents and those readers who want to understand the role of vaccinations in contemporary society, where the ease of access to knowledge is both a great opportunity and a great responsibility. The chapters follow a historical progression and conclude with a discussion of the most recent cognitive theories on how to overcome this opposition to vaccinations.
Vaccinia Virus and Poxvirology
by Stuart N. IsaacsA comprehensive collection of cutting-edge methods to study and work with the vaccinia virus and other poxvirus gene transcriptions. These readily reproducible techniques can be used for the construction and characterization of recombinant viruses; for the study of poxvirus gene transcription and DNA replication; for the investigation of the binding, entry, and movement of the virus in host cells; and for the use of the virus in immunologic and cell-cell fusion assays. Other methods cover poxvirus bioinformatics, aspects of viral pathogenesis at both a protein and an animal model level, and the study of immune responses to poxviruses-the latter a critical ability given the important role of vaccinia virus in smallpox vaccination and their potential role as vaccine vectors directed against infectious agents and cancer.
Vaccinia Virus and Poxvirology, 2nd Edition
by Stuart N. IsaacsSince the first edition of Vaccinia Virus and Poxvirology: Methods and Protocols was published, a number of important events related to poxvirology have occurred, such as FDA approval of a culture-based live smallpox vaccine and the vaccination of large numbers of U.S. military and relatively large numbers of U.S. civilians. Novel anti-poxvirus therapeutics have been developed and have been used in emergency settings. The second edition of Vaccinia Virus and Poxvirology expands upon the previous edition with entirely new sets of protocols. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.<P><P> Authoritative and practical, Vaccinia Virus and Poxvirology: Methods and Protocols, Second Edition seeks to aid scientists in continuing to study poxviruses using new tools and approaches.
Vaccinia Virus: Methods and Protocols (Methods in Molecular Biology #2023)
by Jason MercerThis detailed book provides practical information for the laboratory that can be applied to the study of vaccinia and other poxviruses while emphasizing long-standing field standards and focusing on emerging new technologies applied in the field of poxvirology. The methods and protocols have been designed with the bench scientist in mind, being presented in a fashion that makes them useful for both starting and veteran poxvirus researchers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Vaccinia Virus: Methods and Protocols serves as a valuable resource for scientists looking to bring new methods and procedures into their lab in order to make exciting discoveries that will continue to deepen our understanding of this fascinating virus family.
Vaccinology
by Gregg N. Milligan Alan D. BarrettVaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens.Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes.Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.
Vaccinology
by Clint S. Schmidt W. John Morrow D. Huw Davies Nadeem A. SheikhCovering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human applicationIncludes evaluation of vaccine efficacy and safetyDetails clinical trial design, including regulatory requirementsDiscusses the emerging field of active cellular immunotherapyVaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
Vaccinophobia and Vaccine Controversies of the 21st Century
by Archana ChatterjeeVaccinophobia and Vaccine Controversies of the 21st Century Archana Chatterjee, editor Once hailed as a medical miracle, vaccination has come under attack from multiple fronts, including occasionally from within medicine. And while the rates of adverse reactions remain low, suggestions that vaccines can cause serious illness (and even death) are inspiring parents to refuse routine immunizations for their children--ironically, exposing them and others to potentially serious illness. Vaccinophobia and Vaccine Controversies of the 21st Century explains clearly how this state of affairs came into being, why it persists, and how healthcare professionals can best respond. Current findings review answers to bedrock questions about known adverse events, what vaccine additives are used for, and real and perceived risks involved in immunization. Perspectives representing pediatricians, family practitioners, nurses, parents, pharmacy professionals, the CDC, and the public health community help the reader sort out legitimate from irrational concerns. In-depth analyses discuss the possibility of links with asthma, cancer, Guillain-Barre syndrome, SIDS, and, of course, autism. Included in the coverage: Communicating vaccine risks and benefitsThe vaccine misinformation landscape in family medicinePerceived risks from live viral vaccinesThe media's role in vaccine misinformationAutoimmunity, allergies, asthma, and a relationship to vaccinesVaccines and autism: the controversy that won't go awayThe conundrums described here are pertinent to practitioners in pediatrics, family medicine, primary care, and nursing to help families with informed decision making. In addition, Vaccinophobia and Vaccine Controversies of the 21st Century should be read by trainees and researchers in child development and maternal and child health as the book's issues will have an impact on future generations of children and their families.
Vagina Obscura: An Anatomical Voyage
by Rachel E. GrossA myth-busting voyage into the female body. A camera obscura reflects the world back but dimmer and inverted. Similarly, science has long viewed woman through a warped lens, one focused narrowly on her capacity for reproduction. As a result, there exists a vast knowledge gap when it comes to what we know about half of the bodies on the planet. That is finally changing. Today, a new generation of researchers is turning its gaze to the organs traditionally bound up in baby-making—the uterus, ovaries, and vagina—and illuminating them as part of a dynamic, resilient, and ever-changing whole. Welcome to Vagina Obscura, an odyssey into a woman’s body from a fresh perspective, ushering in a whole new cast of characters. In Boston, a pair of biologists are growing artificial ovaries to counter the cascading health effects of menopause. In Melbourne, a urologist remaps the clitoris to fill in crucial gaps in female sexual anatomy. Given unparalleled access to labs and the latest research, journalist Rachel E. Gross takes readers on a scientific journey to the center of a wonderous world where the uterus regrows itself, ovaries pump out fresh eggs, and the clitoris pulses beneath the surface like a shimmering pyramid of nerves. This paradigm shift is made possible by the growing understanding that sex and gender are not binary; we all share the same universal body plan and origin in the womb. That’s why insights into the vaginal microbiome, ovarian stem cells, and the biology of menstruation don’t mean only a better understanding of female bodies, but a better understanding of male, non-binary, transgender, and intersex bodies—in other words, all bodies. By turns funny, lyrical, incisive, and shocking, Vagina Obscura is a powerful testament to how the landscape of human knowledge can be rewritten to better serve everyone.
Vagina Problems: Endometriosis, Painful Sex, and Other Taboo Topics
by Lara Parker“In Vagina Problems…Lara Parker unpacks the personal and economic costs of endometriosis.” —Vanity Fair“A refreshingly honest read about living with chronic pain.” —Hello GigglesWith unflinching honesty, Lara Parker, the Deputy Director for BuzzFeed, shares her day-to-day challenges of living, working, and loving with chronic pain caused by endometriosis in this raw, darkly humorous, and hopeful memoir.I wasn’t ready to be completely honest about my vagina yet, and the world wasn’t ready for that either. But I was getting there. I wanted the world to know that all of this pain I had been feeling…that it was related to my vagina. Thus, Vagina Problems was born. It was a cutesy name. It was my way of taking this pain and saying, “Whatever. I’m here. I have it. It sucks. Let’s talk about it.”In April 2014, Deputy Editorial Director at BuzzFeed Lara Parker opened up to the world in an article on the website: she suffers from endometriosis. And beyond that? She let the whole world know that she wasn’t having any sex, as sex was excruciatingly painful. Less than a year before, she received not only the diagnosis of endometriosis, but also a diagnosis of pelvic floor dysfunction, vulvodynia, vaginismus, and vulvar vestibulitis. Combined, these debilitating conditions have wreaked havoc on her life, causing excruciating pain throughout her body since she was fourteen years old. These are her Vagina Problems. It was five years before Lara learned what was happening to her body. Five years of doctors insisting she just had “bad period cramps,” or implying her pain was psychological. Shamed and stigmatized, Lara fought back against a medical community biased against women and discovered that the ignorance of many doctors about women’s anatomy was damaging more than just her own life. One in ten women have endometriosis and it takes an average of seven years before they receive an accurate diagnosis—or any relief from this incurable illness’ chronic pain. With candid revelations about her vaginal physical therapy, dating as a straight woman without penetrative sex, coping with painful seizures while at the office, diet and wardrobe malfunctions when your vagina hurts all the time, and the depression and anxiety of feeling unloved, Lara tackles it all in Vagina Problems: Endometriosis, Painful Sex, and Other Taboo Topics with courage, wit, love, and a determination to live her best life.
Vaginal Hysterectomy
by Frcog Facs DSc Shirish S. Sheth Fics Ficog Fcps Fams Fsogc John StuddIn recent years advances in laparoscopic technologies have led to renewed interest in the vaginal approach to hysterectomy, which has many proven benefits for patients. This volume, dedicated to explaining and promoting the vaginal route of hysterectomy, is written and edited by an international team of experts and provides a much-needed source of
Vaginal Pessaries
by Teresa Tam Matthew F. DaviesWith mesh surgery for prolapse sometimes proving problematic, there has been a resurgence of professional medical interest in more traditional methods for the management of prolapse and of stress urinary incontinence. This concise guide to the practical aspects of pessary use will be of interest to all gynecologists involved in the clinical management of the patient with these problems. Contents: Historical review * Pessaries for pelvic organ prolapse * Incontinence pessaries * Pessary fitting * Pessary care * Outcomes of pessary use * Current clinical studies on vaginal pessaries Cover image of vaginal pessaries © 2019 Rick Hicaro, Jr., Chicago, IL 60647, USA
Vagus Nerve Stimulation
by James Robertson Claude Roux Kenneth G. WigginsThis second edition presents a timely and practical discussion of vagal nerve stimulation in a clear and well-illustrated format. It provides a clinical approach to the treatment of patients with medically-intractable seizures, as well as for those with depression (a new indication since the publication of first edition). The book's focus has made
Vagus Nerve Stimulation (Neuromethods #205)
by Martin G. Frasch Eric C. PorgesThis volume covers the latest research and development in the areas of Vagus Nerve Stimulation (VNS) as it relates to bioelectronic medicine from neonate to adult. The chapters in this book cover topics such as invasive and non-invasive VNS including methodological considerations (study design, stimulation parameters, and use of heart rate variability metrics); mechanisms of action (automatic regulation and immune plasticity); and disorders where VNS approaches may be therapeutic (migraine and cluster headaches, mood disorders, trauma-related disorders, and language learning). In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Comprehensive and thorough, Vagus Nerve Stimulation is a valuable resource for both novice and expert preclinical and clinical scientists, clinicians, physicians, and scholars who are interested in learning more about this exciting and developing field.
Vakbekwaam indiceren: Een handreiking voor wijkverpleegkundigen
by Henk Rosendal José van DorstDit boek helpt bij het indiceren van ‘verpleging en verzorging zonder verblijf’. Het 7-stappenmodel zorgt ervoor dat er onderbouwd en transparant geïndiceerd wordt. Deze handreiking is bedoeld voor wijkverpleegkundigen en studenten verpleegkunde.Deze geheel herziene versie van Vakbekwaam Indiceren is overzichtelijker doordat stappen uit het 11-stappenmodel zijn samengevoegd. Het nieuwe 7-stappenmodel is ook in lijn met het verpleegkundig proces, de basis van verpleegkundig handelen. Hoewel in deze handreiking in eerste instantie is uitgegaan van Nanda-I, Noc en Nic, wordt per stap ook aangegeven hoe gebruikers van het Omaha-systeem hiermee om kunnen gaan.Aan de hand van het verpleegkundig proces worden de volgende stappen besproken: anamnese/assessment, verpleegkundige diagnoses, bepalen zorgresultaten, indiceren, organiseren/uitvoeren, monitoren/evalueren en borgen kwaliteit. Dit is de meest logische en meest gebruikte volgorde. Toch moet het in de praktijk wel eens anders. Daarom sluit het boek af met een hoofdstuk over een alternatieve werkwijze.Vakbekwaam Indiceren is geschreven door Henk Rosendal, lector De Gezonde Wijk bij Kenniscentrum Zorginnovatie van Hogeschool Rotterdam en José van Dorst, vakinhoudelijk manager bij TWB Thuiszorg met Aandacht.
Valentino's Pregnancy Bombshell
by Amy AndrewsOne danceWhen Paige buttons up her silk bridesmaid dress she feels beautiful for the first time in years-giving her the courage to take deliciously dangerous Valentino Lombardi's hand on the dance floor.One kissPaige spends one incredible night with Valentino. Until the cold light of dawn reminds her she's a single mom with a daughter who really needs her care. As the sun rises she creeps away.One baby!Then Valentino arrives as the new surgeon at her hospital, with his playboy reputation in tow! But the bombshells don't stop there-now Paige must tell Valentino she's expecting his baby....
Validated Cleaning Technologies for Pharmaceutical Manufacturing
by Destin A. LeBlancWritten by an expert for those who must design validatable cleaning processes and then validate those processes, this book discusses interdependent topics from various technical areas and disciplines. It shows how each piece of the cleaning process fits into the validation program, making it more defensible in both internal quality audits and exter
Validating Corporate Computer Systems: Good IT Practice for Pharmaceutical Manufacturers
by Guy WingateOne of the biggest computer validation challenges facing pharmaceutical manufacturers is the large corporate system. This book provides practical information and advice on good IT practice and validation principles. Written by experts, it includes case studies on EDMSs, EAM systems, LIMSs, and MRP II systems.
Validating Medical Packaging
by Ronald PilchikAccording to the FDA Quality System Regulations, manufacturers must ensure that "device packaging and shipping containers are designed and constructed to protect the device from alteration or damage during the customary conditions of processing, storage, handling, and distribution." As specific as this statement is, the FDA does not provide instruc
Validating Neuro-Computational Models of Neurological and Psychiatric Disorders
by Basabdatta Sen Bhattacharya Fahmida N. ChowdhuryThis book is a collection of articles by leading researchers working at the cutting edge of neuro-computational modelling of neurological and psychiatric disorders. Each article contains model validation techniques used in the context of the specific problem being studied. Validation is essential for neuro-inspired computational models to become useful tools in the understanding and treatment of disease conditions. Currently, the immense diversity in neuro-computational modelling approaches for investigating brain diseases has created the need for a structured and coordinated approach to benchmark and standardise validation methods and techniques in this field of research. This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.
Validating Pharmaceutical Systems: Good Computer Practice in Life Science Manufacturing
by John AndrewsAll too often, the words "computer validation" strike terror into the hearts of those new to the process and may even cause those familiar with it to tremble. Validating Pharmaceutical Systems: Good Computer Practice in Life Science Manufacturing delineates GCP, GLP, and GMP regulatory requirements and provides guidance from seasoned practitioners
Validation Standard Operating Procedures: A Step by Step Guide for Achieving Compliance in the Pharmaceutical, Medical Device, and Biotech Industries
by Syed Imtiaz HaiderSpanning every critical element of validation for any pharmaceutical, diagnostic, medical device or equipment, and biotech product, this Second Edition guides readers through each step in the correct execution of validating processes required for non-aseptic and aseptic pharmaceutical production. With 14 exclusive environmental performance evaluati
Validation and Qualification in Analytical Laboratories
by Ludwig HuberThis Second Edition discusses ways to improve pharmaceutical product quality while achieving compliance with global regulatory standards. With comprehensive step-by-step instructions, practical recommendations, standard operating procedures (SOPs), checklists, templates, and graphics for easy incorporation in a laboratory. This title