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Trust Me, I'm a (Junior) Doctor
by Max Pemberton'Very funny and frank' Independent'Reads like Scrubs: The Blog ... funny and awful in equal measure' Observer* * * * * * *The bestselling real life story of a hapless junior doctor, based on his columns written anonymously for the Telegraph. IF YOU'RE GOING to be ill, it's best to avoid the first Wednesday in August. This is the day when junior doctors graduate to their first placements and begin to face having to put into practice what they have spent the last six years learning. Starting on the evening before he begins work as a doctor, this book charts Max Pemberton's touching and funny journey through his first year in the NHS. Progressing from youthful idealism to frank bewilderment, Max realises how little his job is about 'saving people' and how much of his time is taken up by signing forms and trying to figure out all the important things no one has explained yet -- for example, the crucial question of how to tell whether someone is dead or not. Along the way, Max and his fellow fledgling doctors grapple with the complicated questions of life, love, mental health and how on earth to make time to do your laundry. All Creatures Great and Small meets Bridget Jones's Diary, this is a humorous and accessible peek into a world which you'd normally need a medical degree to witness.(P)2018 Hodder & Stoughton Limited
Trust Your Gut: Get Lasting Healing from IBS and Other Chronic Digestive Problems Without Drugs
by Gregory Plotnikoff Mark B. Weisberg Steve LeBeauA personalized plan to restore gut harmony—and natural remedies for GERD or IBS pain—from two leading doctors in integrative medicine. Of the main human body systems, our digestive system is our center. If you&’ve been diagnosed with a gastrointestinal disease or exhibit symptoms like chronic bad breath, gastritis, nausea, bloating, gas, cramping, constipation, or even incontinence—your gut is trying to tell you something. Work towards lasting, natural pain relief with renowned mind-body specialists, Gregory Plotnikoff, MD and Mark Weisberg, PhD. Based on years of clinical research, their revolutionary CORE program offers a comprehensive, drug-free approach to healing. Inside learn how to reclaim your life by making simple changes in your diet and sleep and: · Reduce pain and other gut symptoms naturally · Promote a healthy digestion process without drugs · Rewire your brain-gut connection · Recognize and manage the five forms of stress that lead to digestive disorders If you benefited from books such as The Mind-Gut Connection; Gut; or Heal Your Body, Cure Your Mind; then you&’ll want to read Trust Your Gut. &“If you or a loved one have suffered too long from gut distress, this book is for you. Trust Your Gut is a great resource for recovery. It will show you how to use scientifically grounded, natural methods that are easily accessible. I recommend it highly.&”—Andrew Weil, MD, #1 New York Times bestselling author of Spontaneous Healing &“Finally a book with clear guidelines for people wanting to solve their gastrointestinal distress and disease.&”—Bill Manahan, MD, assistant professor emeritus, University of Minnesota Academic Health Center
Trust in Experience: Transferable Learning for Primary Care Trusts
by Geoff Meads Tricia MeadsPrimary Care Trusts are a flagship initiative of government policy for modernising the NHS. The new requirement for frontline healthcare professionals to work together stretches across both community care and public health, and as a result traditional boundaries are being blurred and new local roles and resources are emerging right across the primary care sector. This book draws practical lessons for Primary Care Trusts from applied research and development programmes in other parts of the NHS, other parts of the public sector, parallel developments in the private sector and relevant international experience. With contributions from the Health Management Group and its associates, this book provides a comprehensive approach and practical guidance. It includes new specific models for local development on clinical governance, evidence-based medicine, use of applied health services research, social services collaboration, new organisational partnerships, public health alliances, community hospital usage and managed care. Trust in Experience will enable readers to create PCTs as their own organisations and not simply as local agents of central policy, and perceive changes as positive opportunities whilst recognising the risks involved.
Trusting Doctors
by Jonathan B. ImberFor more than a century, the American medical profession insisted that doctors be rigorously trained in medical science and dedicated to professional ethics. Patients revered their doctors as representatives of a sacred vocation. Do we still trust doctors with the same conviction? In Trusting Doctors, Jonathan Imber attributes the development of patients' faith in doctors to the inspiration and influence of Protestant and Catholic clergymen during the nineteenth and early twentieth centuries. He explains that as the influence of clergymen waned, and as reliance on medical technology increased, patients' trust in doctors steadily declined. Trusting Doctors discusses the emphasis that Protestant clergymen placed on the physician's vocation; the focus that Catholic moralists put on specific dilemmas faced in daily medical practice; and the loss of unchallenged authority experienced by doctors after World War II, when practitioners became valued for their technical competence rather than their personal integrity. Imber shows how the clergy gradually lost their impact in defining the physician's moral character, and how vocal critics of medicine contributed to a decline in patient confidence. The author argues that as modern medicine becomes defined by specialization, rapid medical advance, profit-driven industry, and ever more anxious patients, the future for a renewed trust in doctors will be confronted by even greater challenges. Trusting Doctors provides valuable insights into the religious underpinnings of the doctor-patient relationship and raises critical questions about the ultimate place of the medical profession in American life and culture.
Trusting Medicine
by Patricia IllingworthProviding a fascinating overview of healthcare spending and cost-containment mechanisms in the US, this book explores the consequences of managed care for the community with particular attention paid to doctor-patient relationships. The author studies this significant relationship from a social perspective arguing that shifting financial risk onto doctors in a profit-making system seriously damages patient trust. In addition this undermines overall social capital, which in turn has been linked to health outcomes. Including case study examples and policy implications, this insightful text explores an important, though little-discussed outcome of healthcare reform and will be a welcome addition to the current healthcare literature.
Trusting Recovery and Desistance: The Social Components Model of Recovery from Addiction and Desistance from Crime (International Series on Desistance and Rehabilitation)
by Lauren HallThe social processes which underpin and shape our lives have the power to significantly transform the trajectories of people experiencing recovery from addiction and desistance from crime. Recovery from addiction and desistance from crime are processes which are often experienced and supported in the same physical spaces and are also frequently experienced by the same people. This book therefore synthesises and presents research on the social influences of recovery and desistance. This book presents the social component model of recovery from addiction and desistance from crime: a strength-based approach presenting case studies to better understand the social factors of both recovery from addiction and desistance from crime and therefore a step towards enhancing evidence-based policy and practice. The social components that have emerged and will be discussed within this book include relationships and social bonds; social identity, group membership, and social networks; and social capital. Compiled based on observations, interviews, and social identity mapping methods, this work combines and presents theory and research to enhance and strengthen the evidence available for people who are already teaching about, supporting, and experiencing both desistance from crime and recovery from addiction in practice.
Trustworthy AI in Cancer Imaging Research
by Ioanna Chouvarda Guang Yang Sara Colantonio Gianna TsakouThe book covers multiple aspects and challenges, from legal to technical and validation, in the emerging topic of AI in cancer imaging, bringing together the experience of top researchers and flagship projects. The aim of this book is to address the important questions: &“How to design AI that is trustworthy&”, and &“How to validate AI trustworthiness&” in the scope of AI for cancer imaging research. The book discusses overall considerations and the generation of a framework; preparing for trustworthy AI, including the data and metadata for quality, transparency and traceability; implementing trustworthy AI with algorithms and Decision Support Systems; and validating trustworthy AI. This is an ideal resource for researchers from technical and clinical research sites, postgraduate students, and healthcare professionals in cancer imaging and beyond.
Truth Doesn't Have a Side: My Alarming Discovery about the Danger of Contact Sports
by Bennet OmaluOne day in 2002 the fifty-year old body of former Pittsburgh Steeler and hall of famer Mike Webster was laid on a cold table in front of pathologist Dr. Bennet Omalu. Webster&’s body looked to Omalu like the body of a much older man, and the circumstances of his behavior prior to his death were clouded in mystery. But when Omalu cut into Webster&’s brain, it appeared to be normal. Something didn&’t add up.It was at this moment, Omalu studying slides of Webster&’s brain tissue under a microscope, that the world of contact sports would never be the same: the discovery of Chronic Traumatic Encephalopathy. CTE can result in an array of devastating consequences including deterioration in attention, memory loss, social instability, depression, and even suicide. And Omalu&’s discovery of CTE in the brain of an American football player has become the catalyst of a blazing controversy across all contact sports.At the center of that controversy stands the unlikely Dr. Bennet Omalu, a Nigerian-born American citizen, a mild-mannered, gentle man of faith. It is fascinating that it would take someone on the outside of American culture to make this amazing discovery, and refuse to let it be kept hidden. Dr. Omalu began his life in strife, growing up in war-torn Nigeria. But his medical studies in forensic pathology proved to be a lifeline. It fed his natural curiosity and awakened within a deeper desire to always search for the truth. Who would have thought that such an unexpected character would play such a role in bringing to life this world-changing data?In Truth Doesn&’t Have a Side, discover the truth about CTE: Its causes and symptoms, how we might keep our children safe and guide professional athletes when CTE sets in. The problem of CTE is coming to light with each new story about an athlete&’s concussion problem, and we are likely facing dramatic changes to professional sports. You&’ll be inspired by Dr. Bennet Omalu a man driven by his love and concern for the welfare of all people, and his professional vow to speak the truth.
Trypanosoma cruzi as a Foodborne Pathogen
by Lucy J. Robertson Belkisyolé De Noya Oscar GonzálezThis Brief provides a comprehensive overview of Trypanosoma cruzi, a parasite that is traditionally considered as exclusively vectorborne, but can be foodborne, and may lead to outbreaks of Chagas disease in consumers. The characteristics of Trypanosoma cruzi and the clinical effects of the disease are covered, including documented outbreaks, regional patterns, and epidemiology. The various transmission routes are outlined, but with specific focus on foodborne transmission. A major emphasis of this text is contamination of fruit juices with Trypanosoma cruzi in, a transmission vehicle with increasing significance in the spread of this parasite. Also outlined is the difficulty of establishing a protocol for detection in food samples. Results on survival of Trypanosoma cruzi in food matrices is considered, as well as current risk assessment procedures and regulations. Different approaches to preventing transmission, including inactivation and decontamination are introduced, but also the importance of targeted educational initiatives, and also with a focus on future detection, prevention, and prevention of contamination of foods with this parasite.
Trypanosomatid Diseases
by Paul M. Selzer Timo Jäger Oliver Koch Leopold FlohéThis is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, itcovers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.
Trypanosomatids: Methods and Protocols (Methods in Molecular Biology #2116)
by Paul A. M. Michels Michael L. Ginger Dan ZilbersteinThis volume explores the latest methods used by researchers to study different trypanosomatid parasites. These methods cover numerous disciplines, from organismal biology to molecular mechanism. The chapters in this book cover topics such as high-throughput sequencing; next-generation analysis of trypanosomatid genome stability and instability; DNA repair in cell extracts; ribosome profiling; and the use of CRISPR/Cas9 technology for gene editing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Trypanosomatids: Methods and Protocols is a valuable resource for any researcher working with trypanosomatids and trypanosomatid-borne diseases. Chapters 14, 15, 16, 23, 24, 30, and 48 are open access under a CC BY 4.0 license.
Trypanosomes and Trypanosomiasis
by Stefan Magez Magdalena RadwanskaThis new volume written by experts in the field of trypanosome research covers every aspect of trypanosome-vector-host biology. It is a must read for basic researchers working with trypanosomes and related organisms, infection and drug development as well as parasitology in a broader sense.
Tryptophan Metabolism: Implications for Biological Processes, Health and Disease
by Atilla Engin Ayse Basak EnginThis book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.
Tryptophan in Animal Nutrition and Human Health
by Yulong Yin Sung Woo Kim Xiongzhuo TangThis book integrates the research progress of Tryptophan (Trp) and its metabolites in animal nutrition and human health. It recapitulates the effects of Trp nutrition on the regulation of various physiological functions in farmed animals as well as the clinical connections between Trp metabolism and human diseases. Furthermore, this book includes detailed information about the manufacturing process of industrial Trp production and methodologies to study Trp metabolism. This book not only brings numerous benefits to academic communities worldwide but also provides practical values for industrial professionals/companies. Both of these two aspects will expand our understanding of how amino acid metabolism contributes to the maintenance of host health.
Tryptophan: Biochemical and Health Implications (Modern Nutrition)
by Herschel SidranskyHistorically, the amino acid tryptophan has been considered to play a role in cancer development and the aging process. In recent times, this nutrient has been associated with eosinophila myalgia syndrome - a new human disease that attacks the muscular system. This detailed book examines the implications of the large measure of fresh information ga
Trümmerfeld Ellenbogengelenk
by Fabrizio Moro Rainer-Peter Meyer Andreas LütscherSelbst ein mit bestem Wissen durchgeführter Eingriff ist bei komplexen Ellenbogenläsionen keine Garantie für den Erfolg. Bei über einem Drittel der hier vorgestellten Ellenbogenläsionen musste nach der Erstbehandlung nochmals eine operative Revision durchgeführt werden. Die Komplexität dieser Verletzungen ist in dem Buch illustriert. Die Fallbeispiele sollen ellenbogenchirurgisch interessierte Ärzte für mögliche Verläufe sensibilisieren und zeigen notwendig werdende Reinterventionen auf.
Tscherne Unfallchirurgie
by Norbert P. Haas Christian KrettekDer Band zum Bereich Hüfte und Oberschenkel innerhalb der Reihe Tscherne Unfallchirurgie bietet eine präzise Darstellung aller wichtigen chirurgischen Herausforderungen: von der Ätiologie über effiziente Diagnostik, State-of-the-art-Versorgungskonzepte mit Zugang und Implantatauswahl bis zur Nachbehandlung. Text und Bild sind präzise strukturiert und orientieren sich an der Praxis, so dass die Inhalte schnell erfassbar und umsetzbar sind. Auch aktuelle Entwicklungen wie beispielsweise die Applikation von Wachstumsfaktoren wurden berücksichtigt.
Tubercular Drug Delivery Systems: Advances in Treatment of Infectious Diseases
by Yashwant Pathak Ranjita ShegokarThe book targets new advances in areas of treatment and drug delivery sciences for tuberculosis. It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies and drug delivery platforms in the understanding of host-pathogens relationship for providing better therapy. A wide variety of novel and nano-formulations using promising technologies are being explored to deliver the drug via different administration routes. This book It addresses the gap between new approaches and old treatment modalities and how they are superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and current research advances in the field of tuberculosis research..
Tuberculosis
by Stephen Gillespie Dick Van Soolingen Leonid Heifits Michael Hoelscher Ajit Lalvani Simon Waddell Timothy Mchugh Mike Barer Leonor Amaral Helen Mcshane Isobel Honeyborne Pablo Bifani M Boeree Gerry Davies Andrew Ramsay Paul Van Helden Clare Ling Ruth Mcnerney Geoff Coxon Marc LipmanTuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.
Tuberculosis Control in Migrating Population
by Pu-Xuan Lu Wei-Ye Yu Wei-Guo TanWith the rapid development of economy and international communication, world population mobility increase significantly. As migrating population is one of vulnerable populations to infectious diseases, strengthening monitoring system and intervention approaches will be a key factor in controlling the spread of infectious diseases. This book is intended to provide valuable information on creating effective prevention and intervention strategies of tuberculosis, taking Shenzhen, one of typical immigrant cities, as an example. Followed by overview of tuberculosis, the control strategy, diagnosis and treatment of tuberculosis, drug resistant tuberculosis, and HIV-associated tuberculosis in migrating population is introduced. In addition, application of innovative technologies, for example, internet, molecular biology, and artificial intelligence in tuberculosis control is presented. It will be a useful reference for practitioners in centers for infectious disease control and prevention, hospitals, academic institutions, as well as staff in government agencies and non-government organizations with interests in tuberculosis prevention and control.
Tuberculosis Host-Pathogen Interactions
by Jeffrey D. Cirillo Ying KongThis book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide.
Tuberculosis Vaccines
by Paulo J.G. BettencourtTuberculosis (TB) is the leading cause of death by an infectious agent worldwide. The Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against TB and the most widely used vaccine in history. Since 1921, billions of people have been vaccinated with BCG, resulting in a remarkable decline in infant mortality. However, although BCG's efficacy to prevent TB meningitis and disseminated disease in children is well established, its efficacy to prevent infection, disease or reactivation in adolescents and adults is variable. Therefore, novel TB vaccines are urgently needed. Recent clinical trials have shown promising results, offering hope for the introduction of a new generation of vaccines to replace or boost BCG. The book is structured into five sections, each providing sequential relevance to understanding the current landscape and future developments in TB vaccines. Section 1 introduces TB and the causative agent, Mycobacterium tuberculosis. Section 2 presents historical perspectives on BCG and TB vaccine candidates. Section 3 focuses on pre-clinical vaccines against TB. Section 4 examines vaccines against TB currently in clinical trials. Finally, section 5 discusses public health and societal challenges associated with the development of TB vaccines. This book is an essential tool for students, clinicians, and scientists working in the fields of mycobacteriology, vaccine immunology, vaccine development, and TB vaccines, and it is anticipated to stimulate future research in TB vaccine development.
Tuberculosis and Nontuberculous Mycobacterial Infections: And Non Tuberculous Myobacterial Infections (ASM Books #36)
by David SchlossbergFor Tuberculosis and Nontuberculous Mycobacterial Infections, Dr. Schlossberg assembled an international team of experts to write about nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, four new chapters cover topics of critical importance: The role of therapeutic drug monitoring in mycobacterial infections The public health issues of refugees and migrants, and their exposure and transmission of tuberculosis resulting from humanitarian crises Diabetes mellitus as a significant risk factor for tuberculosis The increased risk of tuberculosis reactivation in people taking tumor necrosis factor alpha inhibitors and other biopharmaceuticals Other chapters provide detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis, including: The many presentations of tuberculosis, from pulmonary to ocular and cardiovascular to urogenital The complications that tuberculosis and antituberculosis therapy cause to the hematologic and endocrine systems Tuberculosis during pregnancy and in infants and children Treatment of multidrug-resistant tuberculosis and extensively drugresistant tuberculosis Development of new vaccines Nontuberculous infections caused by mycobacteria found throughout our environment The seventh edition of Tuberculosis and Nontuberculous Mycobacterial Infections is an essential resource for anyone working to prevent and treat tuberculosis and associated infections, from infectious disease specialists to scientists, policymakers, and epidemiologists.
Tuberculosis and the Tubercle Bacillus (ASM Books #37)
by Jr. Et Al. Helen McShane William R. Jacobs Valerie MizrahiCan today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Tuberculosis in Adults and Children
by Jeremy Farrar Dorothee Heemskerk Maxine Caws Ben MaraisThis work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.