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Voice Work
by Christina ShewellVoice Work: Art and Science in Changing Voices is a key work that addresses the theoretical and experiential aspects common to the practical vocal work of the three major voice practitioner professions - voice training, singing teaching, and speech and language pathology.The first half of the book describes the nature of voice work along the normal-abnormal voice continuum, reviews ways in which the mechanism and function of the voice can be explored, and introduces the reader to an original model of voice assessment, suitable for all voice practitioners. The second half describes the theory behind core aspects of voice and provides an extensive range of related practical voice work ideas. Throughout the book, there are a number of case studies drawn from the author's own experiences and a companion website, providing audio clips to illustrate aspects of the text, can be found at www.wiley.com/go/shewell.
Voice Work: Art and Science in Changing Voices
by Christina Shewell Rockford SansomVoice Work Second Edition The voice is one of the fundamental modes of self-expression, a key touchstone of identity and sense of self. Many people in all walks of life are looking to change their voices, whether to modify a speaking challenge of some kind, to cultivate a professional skill, or for other reasons. Voice practitioners have an invaluable role in guiding clients along the path to their desired voice outcomes. Building on the success of the first edition, Voice Work continues to offer a wide-ranging introduction to the repair, improvement, development, and exploration of the spoken and sung voice. Balancing rigorous scholarship with practical insights, the book draws from all major vocal professions and paths within voice work. It offers guidance for developing the voice alongside detailed, up-to-date insights into the work of voice instruction. Readers of the second edition of Voice Work will also find: Numerous new colour illustrationsExtensive chapter revisions and reference updatesOriginal chapters on the history of voice work, public speaking and voice work onlineUpdated material on voice and emotions, mindfulness and imagery, voice work and well-being, the applications of technology and the value of practitioner supervisionAdditional techniques and exercises Voice Work is a valuable resource for spoken voice teachers, singing teachers, and speech and language therapists and pathologists. Endorsements from leading members of these professions for both the first and second editions are featured inside.
Voice and Communication in Transgender and Gender Diverse Individuals: Evaluation and Techniques for Clinical Intervention
by Mark S. Courey Sarah K. Rapoport Leanne Goldberg Sarah K. BrownThis book serves as a guide to any patient, clinician, or person who desires to understand how transgender and gender diverse individuals can be assisted in achieving voice and communication congruity with gender. Voice and communication style serve as intricate links to one’s identity and are central aspects of the gender transition process. Guiding a transgender or gender diverse patient through this transition is complex, requiring an understanding of the patient’s desires, the ability to identify and work with patients to achieve sustainable patterns of behavioral modification that affect voice in a positive manner, and an understanding of the role of newly emerging surgical techniques. This is best addressed by an interdisciplinary team, and this book makes this material available in one source. The first section of the book consists of introductory chapters written by primary care physicians, endocrinologists, and psychiatrists addressing the complex nature of transition from the medical standpoint. A review of hormonal replacement therapies, psychological evaluations, and potential effects of hormone replacement on voice is included. The second section describes the behavioral techniques available in speech and voice therapy for voice change and addresses outcomes that can be expected from behavioral intervention. Each chapter addresses the physiologic principles of therapeutic techniques for effecting change, techniques of instruction, nuances for transgender and gender diverse patients, methods of generalization, and methods of maintenance. Finally, the third section of the book details the surgical techniques available to assist patients in voice transition and their expected outcomes for voice modification. Each chapter includes an introduction, preoperative assessment, role of preoperative therapy, surgical technique, postoperative management, and expected outcome. This section also includes a surgical atlas. This is an ideal guide for otolaryngologists, speech-language pathologists, primary care providers, as well as psychiatrists and endocrinologists caring for transgender and gender nonconforming patients.
Voices From the Field: Group Work Responds
by Albert S Alissi Catherine C MerginsVoices From the Field is the book to challenge you from your cozy position of complacency! By simply opening its pages, you will learn about fascinating developments in group work sequences in group care, empowerment groups in action, and a whole spectrum of practice and education-oriented themes you may have never considered before. A compilation of work from the XVI Annual Symposium of the Association for the Advancement of Social Work with Groups, this book reflects on social work’s rich tradition of diversity and offers you insight that will expand your horizons and encourage you to incorporate different techniques into your repertory. You will learn about contemporary practice, the profession’s historic mission and commitment, and the evolution of group work practice and techniques with different populations. This practical collection allows you to examine a broad spectrum of professional practice and educational themes. Chapters in Voices From the Field explore theory building, qualitative research, mutual aid, time-limited groups, adventure groups, psychodrama, groups for addicted persons and their families, group work with adolescents, and skill development. At the same time you refresh your grounding in the basic principles of social work, you will learn about: a group work forum on-line the importance of empowering individuals through group experiences group treatment for alcoholism group work with juvenile sex offenders international, contemporary practices of social group work establishing group norms in conflictual situationsClinicians, neighborhood and community activists, students, professors, researchers, therapists, old timers, and newcomers will find Voices From the Field an extraordinary compilation of the basic principles and concepts underlying group work, contemporary practice and applications for group social work, and ways for enhancing practice knowledge and skills. Whether you are reading it as a reference text in a methods course or reading it independently, you will find this book reminds you of certain fundamentals long-forgotten, yet also inspires you to take on new challenges and different techniques for meeting the challenges of group social work.
Voices from the Pandemic: Americans Tell Their Stories of Crisis, Courage and Resilience
by Eli SaslowFrom the Pulitzer Prize-winning Washington Post reporter, a powerful and cathartic portrait of a country grappling with the Covid-19 pandemic—from fear and overwhelm to extraordinary resilience—told through voices of people from all across AmericaThe Covid-19 pandemic was a world-shattering event, affecting everyone in the nation. From its first ominous stirrings, renowned journalist Eli Saslow began interviewing a cross-section of Americans, capturing their experiences in real time: An exhausted and anguished EMT risking his life in New York City; a grocery store owner feeding his neighborhood for free in locked-down New Orleans; an overwhelmed coroner in Georgia; a Maryland restaurateur forced to close his family business after forty-six years; an Arizona teacher wrestling with her fears and her obligations to her students; rural citizens adamant that the whole thing is a hoax, and retail workers attacked for asking people to wear masks; patients struggling to breathe and doctors desperately trying to save them.Through Saslow's masterful, empathetic interviewing, we are given a kaleidoscopic picture of a people dealing with the unimaginable. These deeply personal accounts make for cathartic reading, as we see Americans at their worst, and at their resilient best.
Voices in Disability and Spirituality from the Land Down Under: Outback to Outfront
by Dr Christopher Newell Andy CalderAn excellent source of information and ideas on the relationship between disability and spirituality-and how to improve itThis one-of-a-kind collection explores the relationship between spirituality and disability from a variety of Australian religious and spiritual viewpoints. Authors from a wide range of backgrounds-some with disabilities, some without-draw remarkable insights from Christian, Jewish, Buddhist (and even non-religious) spirituality. These uniquely Australian perspectives provide practical and spiritual lessons that can be applied in any part of the world.Voices in Disability and Spirituality from the Land Down Under presents an unflinching look at the shortcomings of many established church ministries when it comes to serving people with disabilities. There&’s also an extraordinary interview with a severely disabled nonreligious woman in the final stage of her life and her caretaker, which presents a very revealing look at the essence of human spirituality as it exists even in the absence of religious dogma. In addition, you&’ll find a revealing case study focusing on the Uniting Church in Australia (UCA), which looks at the gap between its official theology and its actual policy and practice, and outlines a project designed to move the Church forward to more inclusive practices.Additionally, Voices in Disability and Spirituality from the Land Down Under: Outback to Outfront examines: why platitudes that are intended to give comfort, like "God has chosen this for you," "It&’s a test of your faith," or "We all have our crosses to carry" are at best problematic, and at worst damaging-with suggestions for pastoral responses that offer alternatives to "God-is-on-your-side" clichés the spiritual meaning and importance of community for people with disabilities, and the impact of community on their vitality and resiliency the Buddhist teaching called sunyata, or emptiness, and its potential to positively impact the lives of people with intellectual disabilities and those who know them wisdom contained in the ancient Jewish system of laws called Halacha-and its potential for empowering people with disabilities today how a pastoral care program that is flexible, accommodating, and relevant for disabled people was created at a small metropolitan school in New South Wales-and the effect of the program on the community the work of the Personal Advocacy Service, which recruits volunteers to be companions to people with intellectual disabilities the role of religion and philanthropy in the creation of educational programs for blind or vision-impaired students and more
Voices in the Band: A Doctor, Her Patients, and How the Outlook on AIDS Care Changed from Doomed to Hopeful
by Susan C. Ball"I am an AIDS doctor. When I began that work in 1992, we knew what caused AIDS, how it spread, and how to avoid getting it, but we didn't know how to treat it or how to prevent our patients' seemingly inevitable progression toward death. The stigma that surrounded AIDS patients from the very beginning of the epidemic in the early 1980s continued to be harsh and isolating. People looked askance at me: What was it like to work in that kind of environment with those kinds of people? My patients are 'those kinds of people.’ They are an array and a combination of brave, depraved, strong, entitled, admirable, self-centered, amazing, strange, funny, daring, gifted, exasperating, wonderful, and sad. And more. At my clinic most of the patients are indigent and few have had an education beyond high school, if that. Many are gay men and many of the patients use or have used drugs. They all have HIV, and in the early days far too many of them died. Every day they brought us the stories of their lives. We listened to them and we took care of them as best we could."—from the Introduction In 1992, Dr. Susan C. Ball began her medical career taking care of patients with HIV in the Center for Special Studies, a designated AIDS care center at a large academic medical center in New York City. Her unsentimental but moving memoir of her experiences bridges two distinct periods in the history of the epidemic: the terrifying early years in which a diagnosis was a death sentence and ignorance too often eclipsed compassion, and the introduction of antiviral therapies that transformed AIDS into a chronic, though potentially manageable, disease. Voices in the Band also provides a new perspective on how we understand disease and its treatment within the context of teamwork among medical personnel, government agencies and other sources of support, and patients. Deftly bringing back both the fear and confusion that surrounded the disease in the early 1990s and the guarded hope that emerged at the end of the decade, Dr. Ball effectively portrays the grief and isolation felt by both the patients and those who cared for them using a sharp eye for detail and sensitivity to each patient’s story. She also recounts the friendships, humor, and camaraderie that she and her colleagues shared working together to provide the best care possible, despite repeated frustrations and setbacks. As Dr. Ball and the team at CSS struggled to care for an underserved population even after game-changing medication was available, it became clear to them that medicine alone could not ensure a transition from illness to health when patients were suffering from terrible circumstances as well as a terrible disease.
Voices in the Code: A Story about People, Their Values, and the Algorithm They Made
by David G. RobinsonAlgorithms—rules written into software—shape key moments in our lives: from who gets hired or admitted to a top public school, to who should go to jail or receive scarce public benefits. Such decisions are both technical and moral. Today, the logic of high stakes software is rarely open to scrutiny, and central moral questions are often left for the technical experts to answer. Policymakers and scholars are seeking better ways to share the moral decisionmaking within high stakes software—exploring ideas like public participation, transparency, forecasting, and algorithmic audits. But there are few real examples of those techniques in use. In Voices in the Code, scholar David G. Robinson tells the story of how one community built a life-and-death algorithm in an inclusive, accountable way. Between 2004 and 2014, a diverse group of patients, surgeons, clinicians, data scientists, public officials and advocates collaborated and compromised to build a new kidney transplant matching algorithm—a system to offer donated kidneys to particular patients from the U.S. national waiting list. Drawing on interviews with key stakeholders, unpublished archives, and a wide scholarly literature, Robinson shows how this new Kidney Allocation System emerged and evolved over time, as participants gradually built a shared understanding both of what was possible, and of what would be fair. Robinson finds much to criticize, but also much to admire, in this story. It ultimately illustrates both the promise and the limits of participation, transparency, forecasting and auditing of high stakes software. The book’s final chapter draws out lessons for the broader struggle to build technology in a democratic and accountable way.
Voices in the History of Madness: Personal and Professional Perspectives on Mental Health and Illness (Mental Health in Historical Perspective)
by Robert Ellis Steven J. Taylor Sarah KendalThis book presents new perspectives on the multiplicity of voices in the histories of mental ill-health. In the thirty years since Roy Porter called on historians to lower their gaze so that they might better understand patient-doctor roles in the past, historians have sought to place the voices of previously silent, marginalised and disenfranchised individuals at the heart of their analyses. Today, the development of service-user groups and patient consultations have become an important feature of the debates and planning related to current approaches to prevention, care and treatment. This edited collection of interdisciplinary chapters offers new and innovative perspectives on mental health and illness in the past and covers a breadth of opinions, views, and interpretations from patients, practitioners, policy makers, family members and wider communities. Its chronology runs from the early modern period to the twenty-first century and includes international and transnational analyses from Europe, North America, Asia and Africa, drawing on a range of sources and methodologies including oral histories, material culture, and the built environment.Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Voices of Innovation - AI: Fulfilling the Promise of AI in Healthcare (Voices of Innovation in Healthcare)
by Edward W. Marx Piyush Mathur Frank Papay Sakshika DhingraInnovation in healthcare has been both fast and slow.As an industry, we have clearly made great technological advancements, and yet we find ourselves behind peer industries when it comes to innovation with patient care, customer experience, augmented intelligence, virtual care, and cybersecurity. One reason for the lack of innovation velocity is the need for a universally adopted model or best practice framework. The time has come for Voices of Innovation – AI. Artificial intelligence is what some call the fourth transformative revolution in human history. Healthcare is among the many industries with significant opportunities for the use of AI and machine learning, as the convergence of technology and healthcare will result in significant innovation. This book is both practical and inspirational. Using the HIMSS model for innovation as the structural framework, Voices of Innovation – AI will showcase the great AI innovations being implemented across healthcare globally.With contributions from leading authorities in this field, this book will become the de facto resource for any organization seeking to leverage AI effectively. Loaded with numerous case studies and stories of successful innovation projects, this book helps the reader understand how to leverage AI to help fulfill the promise of technology in enabling superior business and clinical outcomes.
Voices of Innovation - Payers: Opportunities for Creating Solutions to Improve Member Experience and Health
by Edward W. Marx Sakshika DhingraAs the health delivery landscape in the United States evolves in a post-COVID-19 era, both incumbents and new entrants are reimagining models of care. Technology and medical advancements are transforming the way care is delivered and experienced, and changes in regulations and incentives across the industry are redefining how the healthcare system works and interacts. As a result, care delivery is undergoing several transformations: from sick care to preventative whole-person care, from intermittent to continuous care, from facility-based settings to omnichannel offerings through virtual care and video or telephonic technologies, and from standardized to personalized solutions. In addition to healthcare providers, payers are also redefining their role in care delivery through provider ownership, technology, and provider enablement to deliver higher-value care to members. While the payer community has been slow to innovate, they now have an opportunity and an incentive to play an active role in reimagining the future of care delivery. In the past year alone, significant disruptors have entered the provider space threatening the existence of payers, specifically self-funded programs such as Amazon and Walmart. This has served as a giant wake-up call that healthcare has shifted. Now, more than ever, there is an emphasis on the patient and clinician experience. Perhaps hastened by the pandemic, the race is on for innovations from the payer community to improve patient and provider engagement. Unlike other players, payers have end-to-end visibility into individual care needs and utilization patterns across providers and settings. This perspective can provide informed choices around optimal care models, unlock value through improved health outcomes, and lower the total cost of care for members and customers. This book is loaded with numerous case studies and interviews with healthcare leaders from the payer community, helping stakeholders understand how to leverage innovation leading them to superior business and clinical outcomes. The book also discusses how and why data is key to innovation activities and how partnerships are key to using data effectively.
Voices of Innovation: Fulfilling the Promise of Information Technology in Healthcare (HIMSS Book Series)
by Edward W. MarxWe can all point to random examples of innovation inside of healthcare information technology, but few repeatable processes exist that make innovation more routine than happenstance. How do you create and sustain a culture of innovation? What are the best practices you can refine and embed as part of your organization's DNA? What are the potential outcomes for robust healthcare transformation when we get this innovation mystery solved? Loaded with numerous case studies and stories of successful innovation projects, this book helps the reader understand how to leverage innovation to help fulfill the promise of healthcare information technology in enabling superior business and clinical outcomes.
Voices of Long-Term Care Workers: Elder Care in the Time of COVID-19 and Beyond (Life Course, Culture and Aging: Global Transformations #10)
by Dena Shenk Andrea FreidusThere were many challenges, successes, and concerns in providing long-term care to older adults during the COVID-19 pandemic. Looking at central North Carolina, the authors highlight the implications of providing long-term care to older Americans, with an emphasis on the importance of communication, resilience of staff, and value of human infrastructure. Based on extensive interviews, this collection of essays reflects on the participants’ individual experiences and represents the voices of staff and caregivers working in long-term residential care communities, in-home and community-based programs, as well as regional aging service providers and advocates.
Voices of Mental Health: Medicine, Politics, and American Culture, 1970-2000
by Dr Martin HalliwellThis dynamic and richly layered account of mental health in the late twentieth century interweaves three important stories: the rising political prominence of mental health in the United States since 1970; the shifting medical diagnostics of mental health at a time when health activists, advocacy groups, and public figures were all speaking out about the needs and rights of patients; and the concept of voice in literature, film, memoir, journalism, and medical case study that connects the health experiences of individuals to shared stories. Together, these three dimensions bring into conversation a diverse cast of late-century writers, filmmakers, actors, physicians, politicians, policy-makers, and social critics. In doing so, Martin Halliwell’s Voices of Mental Health breaks new ground in deepening our understanding of the place, politics, and trajectory of mental health from the moon landing to the millennium.
Voices of Multiple Sclerosis: Stories for Courage, Comfort and Strength
by Richard Day GoreOffering candid, heartfelt, and inspiring stories of 40 diverse individuals who have been affected by multiple sclerosis (MS), this compilation creates a connection that is vital to those dealing with the mysterious and difficult symptoms of this nerve condition. With 10,000 new cases diagnosed in the United States each year and its causes still not fully understood, these stories of personal experience act as a support group by offering advice and encouragement and creating a sense of community. The collection also features current medical information by noted experts in the fields of MS research and treatment. The resource section is packed with organizations offering hope and help for those with MS and their families and friends.
Voices of the Massachusetts General Hospital 1950-2000: Wit, Wisdom, and Untold Tales
by Massachusetts General Hospital Willard M. Daggett Stephen P. Dretler Lloyd Axelrod Georgia W. PeirceVoices of the Massachusetts General Hospital 1950-2000 contains revealing quotations, intimate and previously untold stories of many of the physicians, nurses and other clinicians who dedicated themselves to the pursuit of excellence on behalf of their patients and families, their colleagues and the world beyond the hospital. What started as an email solicitation for stories and anecdotes turned into a moving and instructive portrait of the daily life of a storied institution in the last half of the 20th century.
Voicing Consent: Sex Workers, Sexual Violation and Legal Consciousness in Cross-National Contexts (Palgrave Advances in Sex Work Studies)
by Teela Sanders Jane Scoular Barbara G. Brents Gillian Abel Susie BalderstonThis open access book draws on an international research project, using extensive and multiple methods to explore unwanted sexual contact and violence in sex work populations. A project delivered by a large team of sex workers, peer researchers, and academics, and with practitioner input over a four-year period, the central question they explore is: how do social, legal, and judicial contexts shape the safety and well-being of people engaging in sex work? The book compares survey and interview data conducted in 2023 across four different legal environments: legalisation (Nevada, USA), criminalisation (Northern Ireland), decriminalisation (New Zealand) and partial criminalisation (UK). It explores how the interaction between legal consciousness (how people in sex work interpret law, consent, their rights, and how or whether to report), legal norms (legal theory, case rulings, legal codes) and legal practices (what police, lawyers, and judges actually do) affects unwanted contact against sex workers. This book advances understanding of the various layers regulating sexual autonomy for marginalised peoples — the specific factors that impact the negotiation, experiences, and disposition of crimes of sexual violence in different socio-legal contexts.
Voigt's Pharmaceutical Technology
by Alfred FahrA textbook which is both comprehensive and comprehensible and that offers easy but scientifically sound reading to both students and professionals Now in its 12th edition in its native German, Voigt's Pharmaceutical Technology is an interdisciplinary textbook covering the fundamental principles of pharmaceutical technology. Available for the first time in English, this edition is produced in full colour throughout, with a concise, clear structure developed after consultation with students, instructors and researchers. This book: Features clear chapter layouts and easily digestible content Presents novel trends, devices and processes Discusses classical and modern manufacturing processes Covers all formulation principles including tablets, ointments, capsules, nanosystems and biopharmaceutics Takes account of legal requirements for both qualitative and quantitative composition Addresses quality assurance considerations Uniquely relates contrasting international pharmacopeia from EU, US and Japan to formulation principles Includes examples and text boxes for quicker data assimilation Written for both students studying pharmacy and industry professionals in the field as well as toxicologists, biochemists, medical lab technicians, Voigt’s Pharmaceutical Technology is the essential resource for understanding the various aspects of pharmaceutical technology.
Volatile Organic Compounds: New Potential Biomarkers for Colorectal Cancer
by Donato F. Altomare Arcangelo PicciarielloThis book is a ground-breaking exploration into the world of volatile organic compounds (VOCs) and their potential as novel biomarkers for colorectal cancer. Throughout this book, readers will learn about the latest research on VOCs, their production, release, and detection in various body fluids. At the heart of this book is the matter of early diagnosis and screening for colorectal cancer using these biomarkers. The chapters cover topics such as the production of VOCs in neoplasia, their release into the gut and bloodstream, and their detection in feces, exhaled breath, and urine. The authors provide an expert analysis of various analytical platforms used for VOC detection and identification, including gas sensors array-based E-noses and gas chromatography. Particular attention is given to how VOCs can be used as potential biomarkers for colorectal cancer. In addition to this, the work explores alternative strategies for colorectal cancer screening and early diagnosis. This book is a must-read for researchers in the field of cancer research, oncology, gastroenterology, and medical diagnostics. It provides valuable insights into novel methods for early detection of colorectal cancer, making it a valuable resource for academics across the disciplines of medical science.
Volksgezondheid en gezondheidszorg
by D. Mheen Karien Stronks J. R. Anema W. Brink J. Brug A. Burdorf C. Das N. S. Klazinga H. J. Koning J. Legemaate J. P. Mackenbach W. Mechelen B.J.C. Middelkoop J. J. Polder S. A. Reijneveld J. H. Richardus H. A. Smit M.B.M. Soethout K. Stronks J. Velden G. P. Westert M. J. Berg M. C. Cornel M.L. Essink-Bot F.J.M. Feron C.T.J. Hulshof P.P.T. Jeurissen U.J.L. Reijnders A. P. Verhoeff H. WindJohan P. MackenbachHoe heeft de gezondheid van de wereldbevolking zich de afgelopen decennia ontwikkeld, en hoe is de situatie in Nederland in vergelijking met andere landen? Wat zijn de belangrijkste gezondheidsrisico's, nu en in de komende jaren? Wat is de bijdrage van preventieve en curatieve gezondheidszorg aan onze gezondheid en hoe kan die verder worden verbeterd? Wat houdt de stelselwijziging in de Nederlandse gezondheidszorg eigenlijk in? Deze en veel andere vragen worden in dit boek helder geanalyseerd en beantwoord. In deze nieuwe druk zijn flink wat wijzigingen aangebracht. Het internationale karakter van het boek is versterkt en de centrale thema's worden meer vanuit een analytische invalshoek behandeld. Ook zijn veel feitelijke gegevens geactualiseerd. Zo is de gezondheid van de Nederlandse bevolking op veel fronten aanzienlijk vooruitgegaan, en is de financiering van de Nederlandse gezondheidszorg op een aantal punten gewijzigd. Volksgezondheid en gezondheidszorg is primair geschreven als leerboek voor studenten geneeskunde en studenten gezondheidswetenschappen, maar is ook goed leesbaar voor iedereen die, al dan niet beroepshalve, op de hoogte wil blijven van recente ontwikkelingen in de volksgezondheid en de gezondheidszorg. Dit boek slaat een brug tussen medische en epidemiologische kennis enerzijds en kennis over de structuur en het functioneren van de gezondheidszorg anderzijds. Het boek bevat een schat aan actuele gegevens over alle besproken onderwerpen. Het omvat drie delen: volksgezondheid, preventie en gezondheidszorg. Verder zijn er zeven thematische bijdragen, onder andere over genetica en volksgezondheid, forensische geneeskunde, gezondheidsrecht en etnische verschillen in gezondheid. Maak ook gebruik van de digitale verrijkingen bij deze titel: samenvattingen/leerdoelen, oefenvragen en deeplinks. Dat zijn links naar bijvoorbeeld korte videoclips met uitleg van een twintigtal ge#65533;ntroduceerde begrippen en methoden in dit boek. Deze zijn ook allemaal direct te benaderen vanaf de pagina digitaal verder studeren direct na de inhoud.
Voltage Gated Sodium Channels
by Peter C. RubenA number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Voltage-Gated Calcium Channels (Molecular Biology Intelligence Unit Ser.)
by Norbert Weiss Gerald Werner ZamponiThis book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease (Handbook of Experimental Pharmacology #279)
by Jörg StriessnigThe aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
Voltage-gated Sodium Channels: Structure, Function and Channelopathies (Handbook of Experimental Pharmacology #246)
by Mohamed ChahineThis book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Voltammetric Methods in Brain Systems
by Alan A. Boulton Glen B. Baker Ralph AdamsVoltammetric Methods in Brain Systems offers neuroscientists at all levels of expertise a combination of theory and practical how-to instructions for using in vivo and on-line neurotransmitter measurements in their experimental brain systems. Coverage includes the entire spectrum of applications for in situ, brain slices, transplant media, cell cultures, and single cells. Emphasis is on fast measurements that reveal release-reuptake information on transmitter systems. How-to information ranges from ample detail on the preparation of electrodes, to practical experimental details, to the interpretation of results. Written by many of the world's leading experts-often those whose laboratories have spearheaded work in the area-Voltammetric Methods in Brain Systems provides insightful views on all the best approaches and experimental techniques, with sufficient introductory material and practical detail to satisfy both newcomers and experienced researchers.