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Vascular Protection: Molecular Mechanisms, Novel Therapeutic Principles and Clinical Applications
by Victor J. Dzau Gabor M. Rubanyi John P. CookeVascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter e
Vascular Proteomics
by Fernando VivancoProteomics is a rapidly expanding investigation platform in cardiovascular medicine. Driven by major improvements in mass spectrometry (MS) instrumentation and data analysis, the proteomics field has flourished in recent years particularly in the study of complex diseases. These recent advances are characterized by the development of quantitative MS-based methods that promoted the field from primarily identifying proteins to also providing measurements of relative changes in protein levels between different cell states. This progress is reflected in the application of proteomic techniques to vascular pathology. Vascular Proteomics: Methods and Protocols provides up-to-date methods and protocols for the analysis of arteries, cells, lipoproteins, body fluids, and metabolites, with a particular focus on MS-based methods of protein and peptide quantification. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Vascular Proteomics: Methods and Protocols is a representative selection of methods that can be a useful resource for experienced proteomics practitioners as well as newcomers interested in becoming acquainted with the practice of proteomic techniques for cardiovascular research.
Vascular Reconstructions: Anatomy, Exposures and Techniques
by Jamal J. Hoballah Carlos F. BecharaWhen the first edition of Vascular Reconstructions was published almost twenty years ago, endovascular surgery was still in its infancy. Endovascular approaches became the preferred initial intervention for many vascular pathologies resulting in a major decrease in open vascular surgical procedures. In order to build upon changes in the management of vascular pathology over the past two decades, this second edition of Vascular Reconstructions was conceived. The first part starts with a review of commonly used vascular instruments and an overview of grafts and sutures used in vascular reconstructions. A detailed chapter on vascular anatomy and exposures is provided to serve as a quick reference before starting a vascular procedure. The remaining chapters in the first part of this book review the basic steps usually performed before and after constructing a vascular anastomosis in addition to thrombectomy and endarterectomy. The second part of this book focuses on the various methods used to conduct a vascular reconstruction, which include primary closure, closure with a patch angioplasty, end-to-end, end-to-side, and side- to-side anastomoses. The various possible modifications used are outlined. The third part of this book reviews the various adjunctive methods used when constructing the proximal or distal anastomoses of an infrainguinal bypass. The fourth part of the book reviews the various modifications that are carried out when constructing the proximal and distal anastomoses of an aortic occlusive or aneurysmal pathology. The vascular anastomoses workshop that inspired the conception of this book is included as an appendix. The fifth part focuses on endovascular therapy and imaging.Vascular Reconstructions: Anatomy, Exposures, and Techniques 2nd Edition aims to make the vascular rotation a pleasant experience for surgical residents, the vascular faculty, recent graduates embarking on conducting vascular reconstructions independently, and healthcare providers who wish to be familiar with the various steps involved in conducting a vascular procedure.
Vascular Surgery
by Alan B. Lumsden Jamal J. HoballahVascular care has evolved from conservative therapy and open surgical therapy to a minimally invasive approach using endovascular techniques, laparoscopic or thoracoscopic techniques as well as hybrids of open and endovascular techniques. This volume provides up-to-the-minute information and details new developments and procedures.
Vascular Surgery
by Alan DardikVascular surgery has experienced remarkable growth and diversification in the last decade, especially with its embracing the disruptive endovascular technological revolution. Vascular surgeons remain the only group of specialists capable of total treatment of patients with vascular disease, providing medical, minimally invasive, and surgical therapy. Although vascular surgeons practice in all areas of the world, practice patterns in different areas naturally have both similarities and differences that reflect both regional patterns of disease, genetic characteristics of local peoples, cultural preferences for treatment, local political and economic situations, different access to resources and devices, as well as different training paradigms. Thus, the practice of vascular surgery has diversified and evolved in parallel in many areas, converging and diverging in many ways. Vascular Surgery: A Global Perspective provides the first review and comparison of the diversity of vascular surgery practice around the world. The book is grouped according to common vascular diseases such as aneurysmal and occlusive arterial disease, as well as venous and lymphatic disease and dialysis access. Each major disease topic includes multiple chapters written by expert specialists from around the world, each discussing their local approach to the disease and its treatment. Similarly, the status of vascular surgery practice is addressed, including discussion of the influence of payment systems on practice, patient access to the internet for information, training paradigms, and the legal system including malpractice. This textbook provides the first worldwide summary of the care of patients with vascular disease and will be of interest to a wide audience including vascular surgeons, vascular medical specialists, cardiologists, radiologists, internists, and family practice physicians.
Vascular Surgery
by Bauer Sumpio George GeroulakosThis updated and revised third edition of Vascular Surgery: Cases, Questions and Commentaries provides a unique collection of real-life case histories, written by experts, that highlights the diversity of problems encountered in vascular surgery. With an international panel of contributors, many of whom are also examiners on the UK, European or American Boards in Vascular Surgery, this book familiarizes the reader quickly with day-to-day clinical practice. Case studies are presented in question-and-answer format and have been widely referenced to reassure the reader that their contents are established best practice. Most cases are accompanied by multiple x-rays or color illustrations for visual clarity. This book serves as a teaching resource for vascular trainees or practitioners who are reviewing for the oral board exam or practitioners who wish to refresh their expertise with an interactive source of information. It also provides established practitioners the wherewithal to review the current standards of practice in vascular surgery.
Vascular Surgery in Oncology
by Nelson Wolosker Antonio Eduardo Zerati Kenji NishinariCirculatory conditions are involved both in the oncologic disease itself and in its treatment, with a direct impact on therapeutic planning for patients. At the same time, it goes without saying that cancer and its treatment affect the circulatory system, be it arterial, venous or lymphatic.This book explores the interface between vascular surgery and the various clinical and surgical oncological specialties, highlighting which types of neoplasm are most common and focusing on those that more frequently cause or are influenced by vascular diseases. The diagnostic procedures for these tumors and the most suitable types of treatment are also discussed.The content is divided into three sections: I – Surgical Oncology, II – Clinical Oncology and Oncohematology, and III – Vascular and Endovascular Surgery. The first section presents the most common types of tumor in each surgical oncology specialty, and the most frequent tumors associated with vascular complications. The diagnosis, staging, prognosis and oncological treatments are discussed, while associated vascular complications, such as vascular invasion, venous thrombosis, and arterial thrombosis, are described. The second section focuses on general aspects of Clinical Oncology and Oncohematology in addition to the most frequent vascular complications related to solid and hematological cancers and its treatment (chemotherapy, radiotherapy, bone marrow transplantation). The third section includes a more detailed approach to vascular events and diseases commonly found in cancer patients, in addition to technical discussions regarding vascular reconstructions associated with tumor resection, vascular access, among other topics.At the end of each chapter, the editors comment and highlight the most important challenges for vascular surgeons who dedicate their lives to treating cancer patients.Given its scope, the book offers a valuable resource for medical specialists and professionals in training in the fields of vascular surgery and angiology, clinical oncology, oncohematology and surgical oncology.
Vascular Surgery, Neurosurgery, Lower Extremity Ulcers, Antimicrobials, Wound Assessment, Care, Measurement and Repair (Recent Clinical Techniques, Results, and Research in Wounds #5)
by Melvin A. Shiffman Mervin LowThis book introduces readers to the latest developments regarding pressure injury wounds, diabetic wounds, and negative pressure wound therapy. The first part exclusively deals with wounds from pressure ulcers, describing in detail their prevention, classification, and treatment. In turn, chapters addressing diabetic wounds form the middle part of the book. Here, the authors provide guidance on the medication and treatment (e.g. stem cells, laser) of patients suffering from this disease. The book’s last part, which focuses on negative pressure wound therapy, addresses all major aspects of this approach, reflecting the latest research. Illustrated with a wealth of high-quality pictures throughout, the book offers a unique resource for both beginners and experienced plastic surgeons.
Vascular Surgery: Cases, Questions And Commentaries
by Bauer Sumpio George GeroulakosThis updated volume acknowledges new data and techniques in the area of vascular surgery. New chapters have been added and previous chapters have been updated to cover recent developments in vascular and endovascular surgery. The book aims to bring together a unique collection of real life cases that highlight the diversity of problems encountered in vascular surgery. This book is written along evidence based medicine principles and will be relevant to vascular practitioners, as well as medical trainees.
Vascular Surgery: Illustrated Clinical Cases (ISSN)
by James ForsythProviding real-world case examples and realistic mock examples of vascular surgery emergencies and clinical scenarios, this illustrated text supports trainees and residents in their daily clinical practice. However, the focus on senior decision-making and complex clinical management scenarios will also help trainees prepare for the FRCS (Vasc) and other specialist Vascular Surgery exams.Indeed, making efficient and appropriate clinical decisions is one of the most important and challenging parts of postgraduate vascular surgical training. These realistic cases will teach trainee vascular surgeons to develop their diagnostic and management skills, expand their experience, and ultimately should empower them to form more advanced clinical management plans that reflect higher level thinking.Key Features Teaches the surgical trainee how to navigate real-world clinical scenarios Reinforces the practical application of basic principles Encompasses challenging cases Provides question and answer options Case reflections indicate the rationale behind the decision-making A broad range of clinical conditions are covered to ensure that the trainee vascular surgeon can respond with confidence when presented with difficult new case scenarios.
Vascular Surgery: Principles and Practice, Fourth Edition (Oxford Textbooks In Surgery Ser. #Vol. 4)
by Juan Jimenez Samuel Wilson Frank Veith A. Naylor John BuckelsVascular surgery has seen a remarkable evolution. A discipline focused on the natural history and treatment of vascular disease by open operation is now primarily a minimally invasive specialty. Mastery of the basic pathophysiology has been retained while the transformation by improved imaging and endovascular intervention has been integrated into practice. This fourth edition of Vascular Surgery: Principles and Practice has incorporated these advances building on the specialty’s past assets. Knowledge of natural history and open surgery will always have an essential role in optimal care of patients with vascular diseases. The authors’ exposition of the old and the new will make this edition a valuable resource for vascular surgeons and all others dedicated to the care of vascular patients.
Vascular Tumors and Developmental Malformations
by Paula E. North Tara SanderThis book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention. Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies.
Vascular and Endovascular Complications: A Practical Approach
by Sachinder Singh Hans Mark F. ConradPrevention of complications in vascular and endovascular surgery is an important consideration for all practicing surgeons. The keys to achieving clinical success are based on careful selection of both patient and procedure, along with meticulous operative and endovascular techniques. Management of complications requires careful planning and urgent intervention. This concise, practical text provides the reader with A stepwise approach to diagnosis Guidance on avoiding technical pitfalls Advice on re-interventions Case examples to aid clinical practice The early diagnosis of complications, followed by prompt action and intervention, is key to improving clinical outcomes. This well-illustrated, concise, and practical book ensures that vascular and endovascular surgeons will be able to optimize clinical results and patient care.
Vascular and Endovascular Surgery at a Glance
by Matthew Stephenson Morgan McmonagleFollowing the popular and accessible at a Glance format, Vascular and Endovascular Surgery at a Glance demystifies the important concepts of vascular disease and vascular surgery. Featuring in-depth details of common vascular topics, to rarer presentations, this is an ideal guide for those interested in a variety of subjects relating to this rapidly expanding area. This is a must-read for any specialist at all levels who has an on-going commitment to vascular disease management and medical education.Vascular and Endovascular Surgery at a Glance:* Comprehensively covers the key concepts and core practical procedures with superb illustrations* Is a brilliant companion to the emerging curriculum for specialist vascular training* Is an excellent source of information and management guidelines for interdisciplinary specialties* Includes a companion website atwww.ataglanceseries.com/vascular featuring a wide range of interactive multiple choice questionsThis title forms a succinct overview of vascular disease management, giving salient points relevant to general surgery examinations, for those requiring an in-depth yet manageable introduction to vascular diseases, and for those entering this prevalent field as a stand-alone specialty.
Vascular and Interventional Radiology: A Core Review
by Brian Strife Jeffrey ElbichDesigned specifically for the Core Exam, Vascular and Interventional Radiology : A Core Review covers all key aspects of the field, mimicking the image-rich, multiple-choice format of the actual test. Ideal for residents preparing for the Core Examination, as well as practitioners taking recertification exams, this unique review follows the structure and content of what you’ll encounter on the test, effectively preparing you for Core Exam success!
Vascularization: Regenerative Medicine and Tissue Engineering
by Eric M. BreyA Complex and Growing FieldThe study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration. Designed specifically for researchers in TERM fields, Vascularization: Regenerative M
Vasculitis in Clinical Practice
by Richard A. Watts David G. ScottThe systemic vasculitides are a group of disorders which are of increasing importance, many of which present significant diagnostic challenges. Vasculitis in Clinical Practice provides insights into the diagnosis and management of these conditions from a group of experts in the field. Both comprehensive and concise, this volume covers the full range of vasculitides including the rarer diseases, while summarizing each chapter with a list of key points for quick revision or reference. In addition, full color illustrations throughout provide a valuable diagnostic aid.
Vasculitis in Clinical Practice, 2nd Edition
by Richard A. Watts David G. I. Scott Chetan MukhtyarThis book focuses on clinical presentation, diagnostic processes and current management of systematic vasculitis, and for this second edition the Editors have updated the treatment approach and nomenclature in line with current practice. Systemic vasculitides are a group of disorders which are of increasing importance. Many of these conditions are only rarely encountered by general physicians and often present significant diagnostic challenges. The Editors aim to provide easily accessible information in a pocket sized format. In doing so they hope to help both the generalist but also rheumatologists who only encounter these problems occasionally.
Vasculogenic Mimicry: Methods and Protocols (Methods in Molecular Biology #2514)
by Emily Marques dos Reis Fernanda BertiThis volume provides detailed protocols for the identification and understanding of vasculogenic mimicry process in vitro and in vivo, in addition to protocols for microscopy and histology. Chapters guide readers through different materials, commercial and homemade scaffolds, Matrigel, cancer spheroids, 3D tissue constructs, vasculogenic processes, and mathematical model building. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Vasculogenic Mimicry: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Vasculopathies: Behavioral, Chemical, Environmental, and Genetic Factors (Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems #8)
by Marc ThirietThis volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms.
Vasectomy Reversal: Manual Of Vasovasostomy And Vasoepididymostomy
by Sheldon H.F. MarksThis text will fill that void and provide the reader with a user-friendly, step-by-step illustrated manual of how to prepare for and perform the state-of-the-art microsurgical techniques in vasovasostomy and vasoepididymostomy used by leading international experts. Initial chapters will address appropriate training, tools of the trade to include important points and use of the surgical microscope, microsutures and microsurgical instrumentation. Additional chapters will address pre-operative issues and concerns, intra-operative challenges and complications, and post-operative dilemmas and care. Written by a leading international expert who teaches classes and writes courses and book chapters on state-of-the-art reversal techniques, with additional commentary and alternative suggestions woven throughout the book chapters from other world leaders in urologic microsurgery, this novel title will include the most up-to-date information and advances in care and management of men before, during and after vasectomy reversal.
Vaskuläre Biomechanik: Konzepte, Modelle und Anwendungen
by T. Christian GasserDieses Lehrbuch dient als moderne Einführung in die vaskuläre Biomechanik und bietet den umfassenden Überblick über das gesamte Gefäßsystem, der für die Durchführung erfolgreicher vaskulärer biomechanischer Simulationen erforderlich ist. Es zielt darauf ab, dem Leser eine ganzheitliche Analyse des Gefäßsystems in Richtung seiner biomechanischen Beschreibung zu vermitteln und enthält zahlreiche vollständig durchgerechnete Beispiele. Zu den verschiedenen behandelten Themen gehören die Beschreibung des Gefäßsystems, der Gefäßaustausch, die Mechanik der Blutgefäße, die Charakterisierung des Gefäßgewebes, die Mechanik des Blutflusses sowie das Wachstum und der Umbau des Gefäßgewebes.Dieses Lehrbuch ist ideal geeignet für Studenten und Forscher, die sich mit klassischer und rechnerischer vaskulärer Biomechanik beschäftigen. Das Buch könnte auch für Entwickler von vaskulären Geräten und für Experten, die sich mit der Zulassung biomedizinischer Simulationen befassen, von Interesse sein.Folgt dem Prinzip des "learning by doing" und bietet zahlreiche vollständig durchgerechnete Beispiele für aktives Lernen, sofortiges Erinnern und Selbstüberprüfung;Vermittelt ein ganzheitliches Verständnis der Funktionsweise von Gefäßen und die Integration von Informationen aus verschiedenen Disziplinen, um die Studierenden in die Lage zu versetzen, anspruchsvolle numerische Methoden zur Simulation der Reaktion des Gefäßsystems einzusetzen;Enthält mehrere Fallstudien, die das vorgestellte Material integrieren. Die Fallstudien befassen sich mit Problemen wie der biomechanischen Bewertung des Rupturrisikos von Bauchaortenaneurysmen, der Finite-Elemente-Analyse von Struktur- und Blutflussproblemen sowie der Berechnung von Wandspannung und Wandschubspannung in der Aorta.
Vasoplegic Endothelial Dysfunction: Circulatory Shock and Methylene Blue
by Paulo Roberto Barbosa Evora Andrea Carla Celotto Agnes Afrodite Sumarelli Albuquerque Patricia Martinez ÉvoraThis unique work presents one of the most significant organ failure condition – cardiocirculatory shock – and the prominent role of Methylene Blue (MB). Through their extensive experience, the authors’ consider that the lifesaving feature of MB is still underestimated. For this reason they outline key concepts of MB, mentioning essential experimental data, yet focusing mainly on its application in the care of critically ill patients. In an easy-to-read format, the 18 chapters were organized in a didactically structured order, distributed in four parts. The first part introduces the general conceptual aspects and physiology of the endothelium. The second part presents the particularities of endothelial dysfunction in different types of shock. Methylene blue is discussed in detail in the third part. In the fourth part, particular situations of endothelial dysfunction, such as heart surgery and organ transplantation, are described. Additionally, the two complementary subjects of acid-base balance and the therapeutic use of inhaled nitric oxide are mentioned. Finally, looking for therapeutic alternatives for what we classify as "vasoplegic endothelial dysfunction", MB remains promising as an adjuvant to sympathomimetic amines. The combination of three recently proposed concepts may be useful in obtaining better results against the high mortality rates in critically ill patients. These three concepts are "wide-spectrum vasopressors", vasopressor economy strategies, and microcirculation protection against the harmful effects of using high concentrations of amines. This book´s translational approach will appeal to a variety of readers within the health specialties of medicine, biomedicine, physiotherapy, nursing, odontology, and basic science.
Vasovagal Syncope
by Paolo Alboni Raffaello FurlanThis book is exceptional in being devoted solely to vasovagal syncope (VVS), the most frequent cause of transient loss of consciousness in the general population. All aspects of VVS are covered, including epidemiology, pathophysiology, diagnosis and differential diagnosis, prognosis, therapy and implications for particular activities such as work, driving and physical activity. The context for the book is that about half of the population suffer from this type of loss of consciousness during their lifetime and then often call for general practitioner and/or emergency room assistance. While many pathophysiological aspects of VVS have been clarified, others remain elusive. The diagnosis of VVS may be easy, but it is sometimes challenging. From the therapeutic standpoint, few evidence-based therapies have been established and the large majority of treatments remain unsatisfactory. Vasovagal Syncope presents the latest evidence on all these issues and will be of value for internists, cardiologists, neurologists, emergency physicians and general practitioners.
Vaughan & Asbury's General Ophthalmology (Eighteenth Edition)
by Paul Riordan-Eva Emmett T. CunninghamGeneral Ophthalmology is a concise, current, and authoritative review of the subject for medical students, ophthalmology residents, practicing ophthalmologists, nurses, optometrists, and colleagues in other fields of medicine and surgery, as well as health-related professionals.