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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
by Nosheen Masood Saima Shakil MalikThis book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
'Every Sound There Is': The Beatles' Revolver and the Transformation of Rock and Roll
by Russell Reising'Every Sound There Is': Revolver and the Transformation of Rock and Roll assesses and celebrates the Beatles' accomplishment in their 1966 masterpiece. The essays of Every Sound There Is examine Revolver from a large number of complementary starting points that help us to understand both the album's contemporary creation and reception and the ways in which it continues to shape the creation and reception of popular music in the twenty-first century. Responding to the incredible diversity of Revolver, this gathering of international scholars focuses on the Beatles' 1966 album as one of rock and roll history's threshold moments. Bringing to bear approaches from the disciplines of musicology, cultural studies, poetics, gender studies, these essays address matters as diverse as the influence of American R&B on Revolver as well as its influence on Pink Floyd, each Beatle‘s contributions to the album, the musicological significance of the Beatles' harmonies and chord progressions, its status and coherence as a work of art, the technological and marketing significance of Revolver's recording and distribution, and its influence on the development of rock music.
'Fair and Equitable Treatment' in International Investment Law
by Roland KlägerA breach of fair and equitable treatment is alleged in almost every investor-state dispute. It has therefore become a controversial norm, which touches many questions at the heart of general international law. Roland Kläger sheds light on these controversies by exploring the deeper doctrinal foundations of fair and equitable treatment and reviewing its contentious relationship with the international minimum standard. The norm is also discussed in light of the fragmentation of international law, theories of international justice and rational balancing, and the idea of constitutionalism in international law. In this vein, a shift in the way of addressing fair and equitable treatment is proposed by focusing on the process of justificatory reasoning.
'Flying from My Mind': Innovative and Record-Breaking Microlight and Aircraft Designs
by David G. CookThe memoirs of a hang glider pilot and pioneer and his first-hand account of designing the revolutionary Shadow microlight aircraft. This fascinating story begins in 1973 when David Cook built a glider in an attempt to win the Selsey Birdman Rally—an annual event where all types of creations are launched from the end of Bognor Pier. Between 1975 and 1977 he won every National and International hang gliding competition entered, and then in 1977 he designed and built a power unit for his glider. In 1978 it became the first and lowest-powered microlight to cross the English Channel. Cook&’s successes in this venture led to sponsorship from Duckhams Oils and there followed a period of demonstration flights at major air shows. In 1982 he designed a microlight called Shadow and in 1983 it took the FAI world speed and distance records for the class. In 1992 he took the aircraft to 23,600 ft to claim the world altitude record for the class, beaten later by himself in a newly designed Streak to 27,150 ft. David started a company to build the Shadow in 1984 and has demonstrated its remarkable flying abilities around the world, during which time he had many amusing and some exciting experiences. In 1987 the Shadow won the British Design Award.
'Gilded Prostitution': Status, Money and Transatlantic Marriages, 1870-1914 (Routledge Library Editions: Women's History)
by Maureen E. MontgomeryThis book examines the marriages of British peers to American women within the context of the opening up of London and New York society and the growing competitiveness for high social status. In London, American women were often blamed for the growing hedonism and materialism of smart society and for poaching in the marriage market. They were invariably described as frivolous, vain and calculating – a description which points to the simmering anti-American sentiment in Britain. It was even suggested that titled Americans were having a detrimental effect on the British peerage because of their failure to produce male heirs. A brilliant analysis of the reasons why American women were viewed pejoratively not only in terms of anti-American feeling and the social transformation of the British upper class, but also the threat of women who did not appear to conform to aristocratic notions of a peeress’s duties as a wife and mother.Originally published in 1989, this book has unique appendices listing details of peer marriages in this 1870-1914 period.
'Gold Tried in the Fire'. The Prophet TheaurauJohn Tany and the English Revolution
by Ariel HessayonThis is a study of the most fascinating and idiosyncratic of all seventeenth-century figures. Like its famous predecessor The Cheese and The Worms: The Cosmos of a Sixteenth-Century Miller, it explores the everyday life and mental world of an extraordinary yet humble figure. Born in Lincolnshire with a family of Cambridgeshire origins, Thomas Totney (1608-1659) was a London puritan, goldsmith and veteran of the Civil War. In November 1649, after fourteen weeks of self-abasement, fasting and prayer, he experienced a profound spiritual transformation. Taking the prophetic name TheaurauJohn Tany and declaring himself 'a Jew of the Tribe of Reuben' descended from Aaron the High Priest, he set about enacting a millenarian mission to restore the Jews to their own land. Inspired prophetic gestures followed as Tany took to living in a tent, preaching in the parks and fields around London. He gathered a handful of followers and, in the week that Cromwell was offered the crown, infamously burned his bible and attacked Parliament with sword drawn. In the summer of 1656 he set sail from the Kentish coast, perhaps with some disciples in tow, bound for Jerusalem. He found his way to Holland, perhaps there to gather the Jews of Amsterdam. Some three years later, now calling himself Ram Johoram, Tany was reported lost, drowned after taking passage in a ship from Brielle bound for London. During his prophetic phase Tany wrote a number of remarkable but elusive works that are unlike anything else in the English language. His sources were varied, although they seem to have included almanacs, popular prophecies and legal treatises, as well as scriptural and extra-canonical texts, and the writings of the German mystic Jacob Boehme. Indeed, Tany's writings embrace currents of magic and mysticism, alchemy and astrology, numerology and angelology, Neoplatonism and Gnosticism, Hermeticism and Christian Kabbalah - a ferment of ideas that fused in a millenarian yearning for the hoped for
'Hang Onto These Words': Johnny David's Delgamuukw Evidence
by Antonia MillsIn 1985 and 1986, ninety-year-old Witsuwit'en Chief, Maxlaxlex – or Johnny David as he is better known - was the first Witsuwit'en to give Commission Evidence in the Delgamuukw land claims case in which the Witsuwit'en and Gitxsan of Northern British Columbia were battling for title to their traditional territories. 'Hang Onto These Words' presents the actual transcripts of the questions and answers between lawyers working on both sides and this knowledgeable and outspoken Native elder who spoke in his own language and whose words were then translated by an interpreter into English. The evidence was given in a makeshift courtroom set up in David's own home. Anthropologist Antonia Mills was present during these proceedings, and in this book, she introduces and contextualizes the evidence within the Delgamuukw case. In his testimony, David provides a rich description of the Witsuwit'en way of life as well as the injustices suffered at the hands of Indian agents and settlers. He ends his testimony saying, "If you hang on to these words, everything will be all right." The challenge of hearing his voice, and using it to negotiate the meaning and substance of Aboriginal rights remains unresolved and resonant.
'Hate crime' and the city
by Paul IganskiThe impression often conveyed by the media about hate crime offenders is that they are hate-fuelled individuals who, in acting out their extremely bigoted views, target their victims in premeditated violent attacks. Scholarly research on the perpetrators of hate crime has begun to provide a more nuanced picture. But the preoccupation of researchers with convicted offenders neglects the vast majority of hate crime offenders that do not come into contact with the criminal justice system. This book, from a leading author in the field, widens understanding of hate crime by demonstrating that many offenders are ordinary people who offend in the context of their everyday lives. Written in a lively and accessible style, the book takes a victim-centred approach to explore and analyse hate crime as a social problem, providing an empirically informed and scholarly perspective. Aimed at academics and students of criminology, sociology and socio-legal studies, the book draws out the connections between the individual agency of offenders and the background structural context for their actions. It adds a new dimension to the debate about criminalising hate in light of concerns about the rise of punitive and expressive justice, scrutinizing the balance struck by hate crime laws between the rights of offenders and the rights of victims.
'Hilfe wäre es, wenn es mir was bringt': Unterstützungsmaßnahmen für Drogenkonsumierende in Haft (Sozialwissenschaftliche Gesundheitsforschung)
by Franziska SchneiderDieses Buch bietet einerseits Handlungsempfehlungen zur Verbesserung der Situation drogenkonsumierender Inhaftierter und des Allgemeinen Vollzugsdienstes und andererseits einen Zukunftsausblick für zukünftige Haftanstalten, mit diesem Themenbereich besser umgehen zu können. Das Spannungsfeld zwischen Strafe und Hilfe resultiert aus der Diskrepanz zwischen der strikten Vorgabe, dass eine JVA ein drogenfreier Raum sein sollte, und der Tatsache, dass dies derzeit nicht als gegeben angesehen werden kann. Diesem Umstand kann auf zweierlei Art Rechnung getragen werden: Einerseits kann man versuchen, den Konsum von illegalen Drogen durch strenge Kontrollen einzuschränken und ihn zu bestrafen, anderseits kann man aber auch Hilfsmaßnahmen für Konsumierende anbieten. Folglich stellt sich die Frage, wie Inhaftierte und Angehörige des AVD mit diesem Widerspruch umgehen. Auch ist bisher nicht geklärt, inwieweit Inhaftierte Hilfsmaßnahmen, beispielsweise aus Angst vor möglichen Konsequenzen durch das Bekanntwerden des Konsums illegaler Substanzen, nicht in Anspruch nehmen. Ebenso soll in diesem Rahmen das Interesse drogenkonsumierender Inhaftierter an Hilfsangeboten sowie ihre Beweggründe für oder gegen eine Teilnahme an Maßnahmen herausgearbeitet werden. Ziel des Projektes war es, das Spannungsfeld zwischen Strafe und Hilfe in der intramuralen Gesundheitsfürsorge im deutschen Justizvollzug zu erforschen. Hierbei wurde vor allem der Konsum illegaler Substanzen in einer deutschen JVA durch die Analyse von Gesprächen mit Inhaftierten und Angehörigen des AVD in den Fokus gerückt. Substanzkonsum in Haft geht häufig sowohl mit Repression als auch mit dem Angebot von Hilfsmaßnahmen einher. Die sozialen Gruppen, die von diesem Spannungsfeld besonders betroffen sind, wurden in dieser Arbeit eingehend betrachtet. Besonders relevant ist dieses Buch sowohl für die Mitarbeitenden des Vollzugs selbst, die dadurch einen reflektierten Blick auf ihre Aufgaben und die an sie gestellten Erwartungen erhalten als auch für Politik und Öffentlichkeit: Es zeigt sich, wie groß das Spannungsfeld zwischen Strafe und Hilfe bei Drogenkonsum in Haft ist und welche Möglichkeiten es gibt, diese Kluft zu überwinden und drogenkonsumierenden Inhaftierten aber auch den Mitarbeitenden einen guten Umgang damit zu ermöglichen.
'Hind Swaraj' and Other Writings
by Mahatma Gandhi Anthony J. ParelHind Swaraj is Mahatma Gandhi's fundamental work. Not only is it key to understanding his life and thoughts, but also the politics of South Asia in the first half of the twentieth century. Celebrating 100 years since Hind Swaraj was first published in a newspaper, this centenary edition includes a new Preface and Editor's Introduction, as well as a new chapter on 'Gandhi and the 'Four Canonical Aims of Life''. The volume presents a critical edition of the 1910 text of Hind Swaraj, fully annotated and including Gandhi's own Preface and Foreword (not found in other editions). Anthony J. Parel sets the work in its historical and political contexts and analyses the significance of Gandhi's experiences in England and South Africa. The second part of the volume contains some of Gandhi's other writings, including his correspondence with Tolstoy and Nehru.
'Holy' Johnson, Pioneer of African Nationalism, 1836-1917
by E.A. AyandeleA biography of one of the great 19th-century Africans and an insightful analysis of one of the earlier phases of African nationalism.
'Honest Enough to Be Bold': The Life and Times of Sir James Pliny Whitney
by Charles HumphriesOn a promise of 'Clean, Uncorrupt, and Incorruptible Government,' James Pliny Whitney marked the end of an era of Liberal rule that had lasted for over three decades, and introduced to the province a new, 'progressive' brand of conservatism. As this lively biography demonstrates, Whitney was a gruff and forceful leader. He had a keen understanding of the social and technological forces that were changing Ontario so dramatically in the early twentieth century; he also understood, better than the Liberals, the political implications of those forces. The policies of his government extended to hydroelectric power, bilingual schools, northern development, automobile regulation, temperance (he dealt with the advocates of prohibition 'through gritted teeth'), imperial unity, housing, workmen's compensation, and the suffrage movement. (In a lapse from progressiveness, he argued that women should not be exposed to 'the unlovely influence of party politics.') He had a lasting influence on higher education in the province through the establishment of a Board of Governors for the University of Toronto, then unmistakably the provincial university of Ontario, and the provision of tenure for its full professors. Whitney liked to describe himself as 'bold enough to be honest ... honest enough to be bold.' Humphries concludes that as premier from 1905 to 1914 Whitney lived up to his self-description. The boldness of his legislative programs recognized the evolution of a new industrial society and paved the way for government to intervene in economic and social affairs. The success of his progressive conservatism laid the foundation for decades of Tory success in Ontario.
'Honour' Killing and Violence: Theory, Policy and Practice
by Aisha K. Gill Carolyn Strange Karl RobertsIn this interdisciplinary collection leading experts and scholars from criminology, psychology, law and history provide a compelling analysis of practices and beliefs that lead to violence against women, men and children in the name 'honour'.
'Household Business'
by Viviana ComensoliThe domestic play flourished on the English popular stage during the late sixteenth and early seventeenth centuries. Its roots were predominantly native, rather than classical, and its mainspring was the staging of domestic conflict amongst English characters from the middle ranks of society. Household Business traces the genre's origins in the cycle plays of medieval England and examines its aesthetic configurations in relation to extra-literary discourses and practices that underwrote Renaissance ideologies of private life. At a time when the orthodox view of the family defined it as the foundation of the social order, a number of domestic dramas took a more critical perspective, stressing the contradictions and struggles that attend marriage and the patriarchal family.In addition to well-known domestic dramas as A Woman Killed with Kindness, Arden of Feversham, The Witch of Edmonton, and A Yorkshire Tragedy, Viviana Comensoli analyzes less well-studied plays as A Warning for Fair Women, Two Lamentable Tragedies, and The Late Lancashire Witches. The book also provides an extensive and timely assessment of domestic comedy, demonstrating how plays such as The London Prodigal, The Fair Maid of Bristow, and The Honest Whore (Parts I and II) resist homiletic paradigms in favour of a more dialectical dramaturgy.
'How Best Do We Survive?': A Modern Political History of the Tamil Muslims (South Asian History and Culture)
by Kenneth McPhersonThis book traces the social and political history of the Muslims of south India from the later nineteenth century to Independence in 1947, and the contours that followed. It describes a community in search of political survival amidst an ever-changing climate, and the fluctuating fortunes it had in dealing with the rise of Indian nationalism, the local political nuances of that rise, and its own changing position as part of the wider Muslim community in India. The book argues that Partition and the foundation of Pakistan in 1947 were neither the goal nor the necessarily inescapable result of the growth of communal politics and sentiment, and analyses the post-1947 constructions of events leading to Partition. Neither the fact of Muslim communalism per se before 1947 nor the existence of separate Muslim electorates provide an explanation for Pakistan. The book advances the theory that micro-level studies of the operation of the former, and the defence of the latter, in British India can lead to a better understanding of the origins of communalism. The book makes an important contribution to understanding and dealing with the complexities of communalism — be it Hindu, Muslim or Christian — and its often tragic consequences.
'I Follow Aristotle': How William Harvey Discovered the Circulation of the Blood (The History of Medicine in Context)
by Andrew CunninghamThis book presents a new interpretation of how and why the discovery of the circulation of the blood in animals was made. It has long been known that the English physician William Harvey (1578–1657) was a follower of Aristotle, but his most strikingly ‘modern’ and original discovery – of the circulation of the blood – resulted from Harvey following Aristotle’s ancient programme of investigation into animals. This is a new reading of the most important discovery ever made in anatomy by one man and produces not only a radical re-reading of Harvey as anatomist, but also of Aristotle and his investigations of animals.
'I Love Me County': Waterford Sporting Stories
by Cian ManningWaterford, the Gentle County, can boast a proud sporting tradition that is as long as it is unusual. Ireland’s oldest city has witnessed many trends, from blood sports like bull-baiting in Ballybricken to roller hockey at the Olympia Ballroom. But the towns and villages of County Waterford were not to be overshadowed, producing notable sports people such as basketballers and boxers.In ‘I Love Me County’, learn about everyone from camogie pioneers to World Champions, as this collection of stories records the lives, loves and losses of some of Waterford’s forgotten sporting heroes, demonstrating the importance of sport and leisure in the history of the county.
'I Wish I Had Your Wings': A Spitfire Pilot and Operation Pedestal, Malta 1942
by Angus MansfieldIn August 1942, British launched Operation Pedestal in an attempt to deliver supplies to the stricken island of Malta, an Allied base which had been under Axis blockade for months. From 9–15 August a convoy of some 50 ships ran the gauntlet of Axis bombers, submarines, E-boats and minefields. Of the original fourteen merchant vessels, only five reached Malta Grand Harbour. In 'I Wish I Had Your Wings', Angus Mansfield relates the experiences of two men involved in Pedestal, Captain David Macfarlane of MV Melbourne Star and his nephew David Mejor, one of the Spitfire pilots who fought to protect the convoy. Told using their log books, letters and papers, this is the story of one family’s contribution to a relief operation that cost over 400 Allied lives, but which has gone down in history as one of the most important British strategic victories of the Second World War.
'If I Were Education Secretary...': Views from the frontline
by Geoff Barton"Why do they have to keep on changing things?" It's a characteristic complaint from teachers and leaders in all parts of the UK, but especially in England.Our political system means we are locked into short-term cycles. Politicians come and politicians go. In education departments it means there is a revolving door of ministers, each often eager to implement their own priorities and projects.Civil servants jump, new directions are announced, plans are made ... and then suddenly the minister is promoted, moved to a new department, or dismissed.It's no wonder that lurches in education policy can feel so bewilderingly frequent and uncoordinated. And it's also no wonder that teachers can become demoralised, be left feeling deskilled, and feel cynical about the role of politicians.So how can we change this?This book collects the views of serving school and college leaders, of policy-makers, and of former education secretaries. It asks them what they would do if they were in charge, and it asks those who were once in charge what they would do differently.'If I Were Education Secretary ...' provides a fascinating glimpse into education policy as it is now - but also a template for how it could become more powerfully coherent in the future, moving a good education system to genuinely world class.
'If I Were Education Secretary...': Views from the frontline
by Geoff Barton"Why do they have to keep on changing things?" It's a characteristic complaint from teachers and leaders in all parts of the UK, but especially in England.Our political system means we are locked into short-term cycles. Politicians come and politicians go. In education departments it means there is a revolving door of ministers, each often eager to implement their own priorities and projects.Civil servants jump, new directions are announced, plans are made ... and then suddenly the minister is promoted, moved to a new department, or dismissed.It's no wonder that lurches in education policy can feel so bewilderingly frequent and uncoordinated. And it's also no wonder that teachers can become demoralised, be left feeling deskilled, and feel cynical about the role of politicians.So how can we change this?This book collects the views of serving school and college leaders, of policy-makers, and of former education secretaries. It asks them what they would do if they were in charge, and it asks those who were once in charge what they would do differently.'If I Were Education Secretary ...' provides a fascinating glimpse into education policy as it is now - but also a template for how it could become more powerfully coherent in the future, moving a good education system to genuinely world class.
'Inflation Targeting Lite' in Small Open Economies: The Case of Mauritius
by Nathan Porter James Yudong YaoA report from the International Monetary Fund.
'Infosys' Narayana Murthy
by N. ChokkanThis book tells the biography of N. R. Narayana Murthy , the Founder of Infosys Technologies Limited, (a global software consulting company) and how by simple living and great thinking he was able to tread the path of success. It records as well the role of his wife Sudha Murthy who stood by him in all his endeavor.
'Innocent Women and Children': Gender, Norms and the Protection of Civilians (Gender in a Global/Local World)
by R. Charli CarpenterExamining the influence of gender constructs on the international regime protecting war-affected civilians, R. Charli Carpenter examines how in practice belligerents, advocates and humanitarian players interpret civilian immunity so as to leave adult civilian men and older boys at grave risk in conflict zones. Providing a wealth of ground-breaking case studies, the author argues that in order to understand the way in which laws of war are implemented and promoted in international society we must understand how gender ideas affect the principle of civilian immunity. Each case study demonstrates the importance of assumptions about gender relations in shaping international politics, and in developing a framework for incorporating an attention to gender into the often gender-blind scholarship on international norms. As such, this book will be of interest to international relations theorists and to human rights scholars, students and activists alike.
'Integration through Law' Revisited: The Making of the European Polity
by Daniel AugensteinOver the last twenty years, processes of pluralization, differentiation and trans-nationalization in the European Union have arguably challenged the centrality of law to European integration. Yet these developments also present opportunities to investigate new understandings of law triggered by European integration. The contributors to this book revisit one of the first academic projects to conceptualise and study European legal integration - the early 'Integration through Law' School. On this basis, they consider continuities and discontinuities in the underlying social and political landscape which the law is to integrate (the 'object' of integration), the forms and capacities of the law itself (the 'agent' of integration), and the way these two dimensions reflect on each other. Displaying different normative concerns and varied theoretical starting points, all contributors maintain that 'integration through law' remains of enduring significance to the European integration process. The volume provides a valuable reference for scholars in the field of European integration studies and European legal and political theory.
'Isms & 'Ologies
by Arthur GoldwagHave you ever wondered about the difference between Fundamentalism and Evangelicalism and which influenced the other? Do you know where Post-modernism stops and Post-structuralism begins? Would you like to? From Platonism to New Historicism, humankind is constantly coming up with fresh schools of thought to help explain (or at least describe) the mysterious world around us. Here is the ultimate guide to over 450 of the most significant intellectual terms, movements, and religions that help shape the society we live in. Simply, concisely, and with personality, 'Isms and 'Ologies clarifies buzz terms like jihad, often defined as "holy war" but which literally means "striving" ;and illustrates the differences between Conservatism, Paleoconservatism, and Neoconservatism. It explains String Theory (which attempts to unify Quantum Mechanics and Einsteinian Relativity); describes Fauvism (an artistic movement that paved the way for Expressionism and Cubism); defines Locofocoism (an American political ideology named after a "self-lighting cigar)"; and identifies and explores so much more. Helpfully divided into categories-including politics, history, philosophy and the arts, economics, religion, science, and medicine-cross referenced, and thoroughly indexed, 'Isms and 'Ologies is a must have for the budding intellectual in everyone.