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Biomimetic Materials And Design: Biointerfacial Strategies, Tissue Engineering And Targeted Drug Delivery
by Angela K. Dillow Anthony M. LowmanDetailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.
Biomimetic Medical Materials: From Nanotechnology to 3D Bioprinting (Advances in Experimental Medicine and Biology #1064)
by Insup NohThis volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.
Biomimetic Membrane Technology: Biological Engineering and Nanomedicine
by Donald Martin Isabelle VilgrainThis book provides an up-to-date description of the biomimetic membrane technology that is essential for medical diagnostics and therapeutics. Fundamental and background information on the latest biomimetic membrane technology will be enhanced by descriptions of the medical diagnostic and therapeutic systems that include biomimetic membrane technology at the core of the systems. This is an ideal book for biomedical scientists, clinicians and scientists who design devices for medical technology, and graduate students and academics in bioengineering, nanotechnology, biotechnology and related fields. This book also: Provides detailed coverage of the diagnostic and therapeutic medical devices based on biomimetic membrane technology Enriches understanding of the benefits of advanced microfabrication techniques for the self-assembly of biomimetic membranes Broadens reader understanding of the role of biomimetic membrane technology for diagnosis and treatment in nanomedicine.
Biomimetic Membranes for Sensor and Separation Applications (Biological and Medical Physics, Biomedical Engineering)
by Claus Hélix-NielsenThis book addresses the possibilities and challenges in mimicking biological membranes and creating membrane-based sensor and separation devices. Recent advances in developing biomimetic membranes for technological applications will be presented with focus on the use of integral membrane protein mediated transport for sensing and separation. It describes the fundamentals of biosensing as well as separation and shows how the two processes are working in a cooperative manner in biological systems. Biomimetics is a truly cross-disciplinary approach and this is exemplified using the process of forward osmosis will be presented as an illustration of how advances in membrane technology may be directly stimulated by an increased understanding of biological membrane transport. In the development of a biomimetic sensor/separation technology, both channels (ion and water channels) and carriers (transporters) are important. An ideal sensor/separation device requires the supporting biomimetic matrix to be virtually impermeable to anything but the solute in question. In practice, however, a biomimetic support matrix will generally have finite permeabilities to water, electrolytes, and non-electrolytes. These non-protein mediated membrane transport contributions will be presented and the implications for biomimetic device construction will be discussed. New developments in our understanding of the reciprocal coupling between the material properties of the biomimetic matrix and the embedded proteins will be presented and strategies for inducing biomimetic matrix stability will be discussed. Once reconstituted in its final host biomimetic matrix the protein stability also needs to be maintained and controlled. Beta-barrel proteins exemplified by the E. Coli outer membrane channels or small peptides are inherently more stable than alpha-helical bundle proteins which may require additional stabilizing modifications. The challenges associated with insertion and stabilization of alpha-helical bundle proteins including many carriers and ligand and voltage gated ion (and water) channels will be discussed and exemplified using the aquaporin protein. Many biomimetic membrane applications require that the final device can be used in the macroscopic realm. Thus a biomimetic separation device must have the ability to process hundred of liters of permeate in hours - effectively demanding square-meter size membranes. Scalability is a general issue for all nano-inspired technology developments and will be addressed here in the context biomimetic membrane array fabrication. Finally a robust working biomimetic device based on membrane transport must be encapsulated and protected yet allowing massive transport though the encapsulation material. This challenge will be discussed using microfluidic design strategies as examples of how to use microfluidic systems to create and encapsulate biomimetic membranes. The book provides an overview of what is known in the field, where additional research is needed, and where the field is heading.
Biomimetic Microengineering
by Hyun Jung KimThis book will examine the relevant biological subjects involved in biomimetic microengineering as well as the design and implementation methods of such engineered microdevices. Physiological topics covered include regeneration of complex responses of our body on a cellular, tissue, organ, and inter-organ level. Technological concepts in cell and tissue engineering, stem cell biology, microbiology, biomechanics, materials science, micro- and nanotechnology, and synthetic biology are highlighted to increase understanding of the transdisciplinary methods used to create the more complex, robust biomimetic engineered models. The effectiveness of the new bioinspired microphysiological systems as replacements for existing in vitro or in vivo models is explained through sections that include the protocols to reconstitute three-dimensional (3D) structures, recapitulate physiological functions, and emulate the pathophysiology of human diseases. This book will also discuss how researchers can discover bridge technologies for disease modeling and personalized precision medicine. Features Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner. Incorporates research on reverse engineering of comples microenvironmental factors in human diseases. Highlights technologies related to patient-specific personalized medicine and their potential uses. Written by chapter authors who are highly respected researchers in science and engineering. Includes extensive references at the end of each chapter to enhance further study. Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving hois Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancers at UT Austin. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement in pharmaceutical and clinical fields. • Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner. • Incorporates research on reverse engineering of complex microenvironmental factors in human diseases. • Highlights technologies related to patient-specific personalized medicine and their potential uses. • Written by chapter authors who are highly respected researchers in science and engineering. • Includes extensive references at the end of each chapter to enhance further study. Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving his Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdoctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new
Biomimetic Microsensors Inspired by Marine Life
by Ajay Giri Prakash Kottapalli Mohsen Asadnia Jianmin Miao Michael S. TriantafyllouThis book narrates the development of various biomimetic microelectromechanical systems (MEMS) sensors, such as pressure, flow, acceleration, chemical, and tactile sensors, that are inspired by sensing phenomena that exist in marine life. The research described in this book is multi-faceted and combines the expertise and understanding from diverse fields, including biomimetics, microfabrication, sensor engineering, MEMS design, nanotechnology, and material science. A series of chapters examine the design and fabrication of MEMS sensors that function on piezoresistive, piezoelectric, strain gauge, and chemical sensing principles. By translating nature-based engineering solutions to artificial man-made technology, we can find innovative solutions to critical problems.
Biomimetic Nanomaterials: Inorganic and Macromolecular structures, Catalytic Processes
by Zhicheng Zhang Bing NiAn accurate and authoritative discussion of the structure, fabrication, and applications of biomimetic materials In Biomimetic Nanomaterials: Inorganic and Macromolecular Structures, Catalytic Processes, a team of distinguished researchers delivers an up-to-date discussion of select emerging topics in nature-inspired approaches to biomimetic nanomaterials. The authors focus on two core subjects: mimicking biological structures and replicating biological functions. The book begins with an exploration of bio-inorganic structures and biomineralization processes, including biominerals and bio-inspired architectures like aerogels and chiral nanoparticles. It continues on to discuss biomacromolecule-based materials and synthetic mimics, as well as their structural and functional attributes. Finally, it covers bio-inspired functional materials, including nanozymes and catalytic systems for applications, like artificial photosynthesis, CO2 conversion, and N2 fixation. Readers will also find: A thorough introduction to the foundational concepts and the latest developments in biomimetic nanomaterialsComprehensive explorations of the latest applications of biomimetic nanomaterials, including artificial muscles, protective coatings, and catalytic processesPractical discussions of the structures of biomimetic inorganic nanomaterials, like biominerals, biomorphs, artificial plastic materials, and chiral nanoparticlesComplete treatments of particularly remarkable uses of biomimetic materials, including water splitting catalysis nanozymes Perfect for materials scientists, bioinorganic chemists, and biotechnologists, Biomimetic Nanomaterials will also benefit bioengineers, polymer chemists, and biochemists.
Biomimetic Organic Synthesis
by Bastien Nay Erwan PouponIn this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature. Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.
Biomimetic Principles and Design of Advanced Engineering Materials
by Zhenhai XiaThis book explores the structure-property-process relationship of biomaterials from engineering and biomedical perspectives, and the potential of bio-inspired materials and their applications. A large variety of natural materials with outstanding physical and mechanical properties have appeared in the course of evolution. From a bio-inspired viewpoint, materials design requires a novel and highly cross disciplinary approach. Considerable benefits can be gained by providing an integrated approach using bio-inspiration with materials science and engineering. The book is divided into three parts; Part One focuses on mechanical aspects, dealing with conventional material properties: strength, toughness, hardness, wear resistance, impact resistance, self-healing, adhesion, and adaptation and morphing. Part Two focuses on functional materials with unique capabilities, such as self-cleaning, stimuli-response, structural color, anti-reflective materials, catalytic materials for clean energy conversion and storage, and other related topics. Part Three describes how to mimic natural materials processes to synthesize materials with low cost, efficient and environmentally friendly approaches.For each chapter, the approach is to describe situations in nature first and then biomimetic materials, fulfilling the need for an interdisciplinary approach which overlaps both engineering and materials science.
Biomimetic Research for Architecture and Building Construction: Biological Design and Integrative Structures (Biologically-Inspired Systems #8)
by Jan Knippers Klaus G. Nickel Thomas SpeckThis book comprises a first survey of the Collaborative Research Center SFB-TRR 141 'Biological Design and Integrative Structures - Analysis, Simulation and Implementation in Architecture', funded by the Deutsche Forschungsgemeinschaft since October 2014. The SFB-TRR 141 provides a collaborative framework for architects and engineers from the University of Stuttgart, biologists and physicists from the University of Freiburg and geoscientists and evolutionary biologists from the University of T#65533;bingen. The programm is conceptualized as a dialogue between the disciplines and is based on the belief that that biomimetic research has the potential to lead everyone involved to new findings far beyond his individual reach. During the last few decades, computational methods have been introduced into all fields of science and technology. In architecture, they enable the geometric differentiation of building components and allow the fabrication of porous or fibre-based materials with locally adjusted physical and chemical properties. Recent developments in simulation technologies focus on multi-scale models and the interplay of mechanical phenomena at various hierarchical levels. In the natural sciences, a multitude of quantitative methods covering diverse hierarchical levels have been introduced. These advances in computational methods have opened a new era in biomimetics: local differentiation at various scales, the main feature of natural constructions, can for the first time not only be analysed, but to a certain extent also be transferred to building construction. Computational methodologies enable the direct exchange of information between fields of science that, until now, have been widely separated. As a result they lead to a new approach to biomimetic research, which, hopefully, contributes to a more sustainable development in architecture and building construction.
Biomimetic Sensing: Methods and Protocols (Methods in Molecular Biology #2027)
by Jessica E. Fitzgerald Hicham FenniriThis book highlights the potential of e-device technology to serve as a successful platform for multiplexed sensing, along with the methods for device fabrication, calibration, and assays in multiple applications. The subsequent sections describe e-device sensing platforms, explore their use, and outline existing limitations and future directions in device development. This work mainly focuses on optical and electrochemical methods of sensing, as these are at the forefront of e-device technology, while also addressing cutting-edge mechanochemical sensing and methods to optimize e-device data and technology via drift correction and calibration and computer modelling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Biomimetic Sensing: Methods and Protocols is an ideal guide for researchers working in a wide variety of fields with a desire to utilize this inexpensive and less specialized technology in their studies.
Biomimetic and Biohybrid Systems: 11th International Conference, Living Machines 2022, Virtual Event, July 19–22, 2022, Proceedings (Lecture Notes in Computer Science #13548)
by Tony Prescott Anna Mura Vasiliki Vouloutsi Paul F. M. J. Verschure Alexander Hunt Kenneth Moses Roger QuinnThis book constitutes the proceedings of the 11th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022, held as virtual event, in July 19–22, 2022. The conference was held virtually due to the COVID-19 crisis.The 30 full papers and 8 short papers presented were carefully reviewed and selected from 48 submissions. They deal with research on novel life-like technologies inspired by the scientific investigation of biological systems; biomimetics; and research that seeks to interface biological and artificial systems to create biohybrid systems.
Biomimetic and Biohybrid Systems: 12th International Conference, Living Machines 2023, Genoa, Italy, July 10–13, 2023, Proceedings, Part I (Lecture Notes in Computer Science #14157)
by Anna Mura Laura Margheri Fabian Meder Alexander Hunt Barbara MazzolaiThis book constitutes the proceedings of the 12th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022, in Genoa, Italy, held in July 19–22, 2022.The 44 full papers and 14 short papers presented were carefully reviewed and selected from 67 submissions. They deal with research on novel life-like technologies inspired by the scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems. The conference aims to highlight the most exciting research in both fields united by the theme of “Living Machines.”
Biomimetic and Biohybrid Systems: 12th International Conference, Living Machines 2023, Genoa, Italy, July 10–13, 2023, Proceedings, Part II (Lecture Notes in Computer Science #14158)
by Anna Mura Laura Margheri Fabian Meder Alexander Hunt Barbara MazzolaiThis book constitutes the proceedings of the 12th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022, in Genoa, Italy, held in July 19–22, 2022. The 44 full papers and 14 short papers presented were carefully reviewed and selected from 67 submissions. They deal with research on novel life-like technologies inspired by the scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems. The conference aims to highlight the most exciting research in both fields united by the theme of “Living Machines.”
Biomimetic and Biohybrid Systems: 13th International Conference, Living Machines 2024, Chicago, IL, USA, July 8–11, 2024, Proceedings (Lecture Notes in Computer Science #14930)
by Anna Mura Nicholas S. Szczecinski Victoria Webster-Wood Matthew Tresch William R. P. Nourse Roger D. QuinnThis proceeding constitutes the 13th International Conference on Biomimetic and Biohybrid Systems, held in Chicago, IL, USA, during July 8–11, 2024. The 27 full papers and 4 short papers were carefully reviewed and selected from 35 submissions. They were categorized under the following topics: Brain Network Modeling; Tools for Studying Behaviors; Sensors and Sensing, Navigational Systems; Control and Mechanics of Soft and Continuum Systems; System Design; Neural Networks for Computation; Bio Inspired Neural Networks for Control; Biohybrid Systems; and Biomechanics.
Biomimetic and Biohybrid Systems: 5th International Conference, Living Machines 2016, Edinburgh, UK, July 19-22, 2016. Proceedings (Lecture Notes in Computer Science #9793)
by Tony J. Prescott Michael Mangan Nathan F. Lepora Anna Mura Paul F.M.J. Verschure Marc DesmulliezThis book constitutes the refereed proceedings of the second International Conference on Biomimetic and Biohybrid Systems, Living Machines 2013, held in London, UK, in July/August 2013. The 65 revised full papers presented were carefully reviewed and selected from various submissions. The papers are targeted at the intersection of research on novel live-like technologies inspired by scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems
Biomimetic and Biohybrid Systems: 6th International Conference, Living Machines 2017, Stanford, CA, USA, July 26–28, 2017, Proceedings (Lecture Notes in Computer Science #10384)
by Michael Mangan, Mark Cutkosky, Anna Mura, Paul F.M.J. Verschure, Tony Prescott and Nathan LeporaThis book constitutes the proceedings of the 6th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2017, held in Stanford, CA, USA, in July 2017.The 42 full and 19 short papers presented in this volume were carefully reviewed and selected from 63 submissions. The theme of the conference encompasses biomimetic methods for manufacture, repair and recycling inspired by natural processes such as reproduction, digestion, morphogenesis and metamorphosis.
Biomimetic and Biohybrid Systems: 7th International Conference, Living Machines 2018, Paris, France, July 17–20, 2018, Proceedings (Lecture Notes in Computer Science #10928)
by Tony J. Prescott Michael Mangan Anna Mura Paul F.M.J. Verschure Nathan Lepora Vasiliki Vouloutsi José HalloyThis book constitutes the proceedings of the 7th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2018, held in Paris, France, in July 2018.The 40 full and 18 short papers presented in this volume were carefully reviewed and selected from 60 submissions. The theme of the conference targeted at the intersection of research on novel life-like technologies inspired by the scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems.
Biomimetic and Biohybrid Systems: 8th International Conference, Living Machines 2019, Nara, Japan, July 9–12, 2019, Proceedings (Lecture Notes in Computer Science #11556)
by Tony J. Prescott Michael Mangan Minoru Asada Anna Mura Vasiliki Vouloutsi Uriel Martinez-Hernandez Paul F. M. J. VerschureThis book constitutes the proceedings of the 8th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2019, held in Nara, Japan, in July 2019. The 26 full and 16 short papers presented in this volume were carefully reviewed and selected from 45 submissions. They deal with research on novel life-like technologies inspired by the scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems.
Biomimetic and Biohybrid Systems: 9th International Conference, Living Machines 2020, Freiburg, Germany, July 28–30, 2020, Proceedings (Lecture Notes in Computer Science #12413)
by Tony J. Prescott Anna Mura Thomas Speck Vasiliki Vouloutsi Paul F. M. J. Verschure Falk TauberThis book constitutes the proceedings of the )th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2020, held in Freiburg, Germany, in July 2020. Due to COVID-19 pandemic the conference was held virtually. The 32 full and 7 short papers presented in this volume were carefully reviewed and selected from 45 submissions. They deal with research on novel life-like technologies inspired by the scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems.
Biomimetic, Bioresponsive, and Bioactive Materials
by Matteo Santin Gary J. PhillipsThe accessible introduction to biomaterials and their applications in tissue replacement, medical devices, and more Molecular and cell biology is being increasingly integrated into the search for high-performance biomaterials and biomedical devices, transforming a formerly engineering- and materials science-based field into a truly interdisciplinary area of investigation. Biomimetic, Bioresponsive, and Bioactive Materials presents a comprehensive introduction to biomaterials, discussing how they are selected, designed, and modified for integration with living tissue and how they can be utilized in the development of medical devices, orthopedics, and other related areas. Examining the physico chemical properties of widely used biomaterials and their uses in different clinical fields, the book explores applications including soft and hard tissue replacement; biointeractive metals, polymers, and ceramics; and in vitro, in vivo, and ex vivo biocompatibility tests and clinical trials. The book critically assesses the clinical level of research in the field, not only presenting proven research, but also positing new avenues of exploration. Biomimetic, Bioresponsive, and Bioactive Materials contains everything needed to get a firm grasp on materials science, fast. Written in an accessible style and including practice questions that test comprehension of the material covered in each chapter, the book is an invaluable tool for students as well as professionals new to the field.
Biomimetics
by Murugan Ramalingam Guoping Chen Peter Ma Fu-Zhai Cui Xiumei WangThis book compiles all aspects of biomimetics from fundamental principles to current technological advances and their future trends in the development of nanoscale biomaterials and tissue engineering. The scope of this book is principally confined to biologically-inspired design of materials and systems for the development of next generation nanobiomaterials and tissue engineering. The book addresses the state-of-the-art of research progress in the applications of the principles, processes, and techniques of biomimetics. The prospective outcomes of current advancements and challenges in biomimetic approaches are also presented.
Biomimetics Through Nanoelectronics: Development of Three Dimensional Macroporous Nanoelectronics for Building Smart Materials, Cyborg Tissues and Injectable Biomedical Electronics (Springer Theses)
by Jia LiuThis thesis presents original research on how to seamlessly integrate electronics with living biological systems. Jia Liu has used silicon nanowires as active sensors to investigate biological signals at the cellular level. He has also designed nanoelectronic networks into flexible, three-dimensional (3D) and macroporous architectures, which mimic the structure of tissue scaffolds for in vitro 3D integrations with synthetic tissues and in vivo implantation by means of syringe injection. Importantly, the results demonstrate 3D interpenetrations of nanoelectronic networks with neural networks, 3D mapping of tissue activity and long-term implantation with minimal immunoresponses. Further, the book discusses potential applications for pharmacological studies, brain activity mapping and nanoelectronics enabled therapies. The findings presented here have gained wide recognition, including a top research ranking by Chemical & Engineering News and being listed among Scientific American's 10 world changing ideas in 2015.
Biomimetics and Bionic Applications with Clinical Applications (Series in BioEngineering)
by Birgit Weyand Meir Israelowitz Herbert P. von Schroeder Peter Vogt Matthias Reuter Kerstin ReimersThis book presents current trends and developments in the rapidly growing field of biomimetics. It takes an application-oriented approach to reflect the interdisciplinary nature of this field: Experts, from academic as well as professional backgrounds, contribute to this book by describing and presenting state-of-the-art experiments and practical developments. A strong emphasis is put on the various possibility to apply biomimetics in tissue engineering, regenerative surgery, neurosurgery for clinical applications.
Biomimetics and Stem Cells: Methods and Protocols (Methods in Molecular Biology #1202)
by Kursad Turksen Gordana Vunjak-NovakovicBiomimetics and Stem Cells: Methods and Protocols collects a series of approaches to demonstrate the role and value of biomimetics for the better understanding of stem cell behavior and the acceleration of their application in regenerative medicine. Recent advances in tissue engineering are enabling scientists to ''instruct'' stem cells toward differentiating into the right phenotypes, in the right place and at the right time. Given these advances, biomimetic environments are being designed to recapitulate, in vitro, the combinations of factors known to guide tissue development and regeneration in vivo and thereby help unlock the full potential of the stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and essential, Biomimetics and Stem Cells: Methods and Protocols focuses on the use of biomimetic systems for stem cells in order to aid in moving this vital field of study forward.