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Can a Smart Person Believe in God?: Five Equations That Changed The World
by Michael GuillenAs Christians, we are often urged to turn away from scientific discovery and rely solely on the Bible as the source of our faith. On the other hand, many people in areas such as science, law, and education insist that Christian faith is lowbrow or unintelligent. But is it possible to reconcile science with what you believe about God? As someone who has grappled with the issues of science and faith in the public eye for more than a decade as a television journalist, Dr. Michael Guillen believes it is possible. In fact, by embracing the discoveries of science we can see God, the universe, and humanity in full, multidimensional glory.Fortunately, you don't have to be a genius to enjoy this book. The bite-sized chapters are full of fascinating scientific tidbits in an easy-to-understand format. Captivating stories of the author's childhood in the Mexican barrio of East L.A. and his work in television and research are woven throughout. There is even an entertaining SQ (Spiritual Quotient) test for readers to take.
Can't Remember What I Forgot
by Sue HalpernBehind the Scenes of Cutting-Edge Memory Research When Sue Halpern decided to emulate the first modern scientist of memory, Hermann Ebbinghaus, who experimented on himself, she had no idea that after a day of radioactive testing, her brain would become so “hot” that leaving through the front door of the lab would trigger the alarm. This was not the first time while researchingCan’t Remember What I Forgotthat Halpern had her head examined, nor would it be the last. Like many of us who have had a relative or friend succumb to memory loss, who are getting older, and who are hearing statistics about our own chances of falling victim to dementia, Halpern wanted to find out what the experts really knew, how close science is to a cure, to treatment, to accurate early diagnosis, and, of course, whether the crossword puzzles, sudokus, and ballroom dancing we’ve been told to take up can really keep us lucid or if they're just something to do before the inevitable overtakes us. Sharply observed and deeply informed,Can’t Remember What I Forgotis a book full of vital information and a solid dose of hope.
Canadian Climate of Mind: Passages from Fur to Energy and Beyond
by Timothy B. LeducThe twenty-first century is a period of great environmental and social transformation as climate change increasingly marks lives at levels that are personal, familial, communal, national, and global. A Canadian Climate of Mind presents stories that emerge from the waters, lands, and climate of Canada, and which have the potential to renew a compassionate energy for changing human relations with each other and with our world. The turbulent effects of climate change are popularly discussed in the modern language of scientific knowledge, political policies, economic mechanisms, and technological innovation. While there is much to be learned from these views, Timothy Leduc suggests a more profound call for change by returning to past understandings of the land and climate. He argues that the world is initiating us into a broader and humbler sense of what it is to be human in an interconnected reality. The world is doing this by responding to unsustainable practices such as our devastating reliance on fossil fuels. Weaving together voices from numerous backgrounds and time periods with Indigenous views on present and past environmental challenges, A Canadian Climate of Mind illuminates a world that is being shaken to its core while we hesitate to act.
Canadian Climate of Mind: Passages from Fur to Energy and Beyond
by Timothy B. LeducThe twenty-first century is a period of great environmental and social transformation as climate change increasingly marks lives at levels that are personal, familial, communal, national, and global. A Canadian Climate of Mind presents stories that emerge from the waters, lands, and climate of Canada, and which have the potential to renew a compassionate energy for changing human relations with each other and with our world. The turbulent effects of climate change are popularly discussed in the modern language of scientific knowledge, political policies, economic mechanisms, and technological innovation. While there is much to be learned from these views, Timothy Leduc suggests a more profound call for change by returning to past understandings of the land and climate. He argues that the world is initiating us into a broader and humbler sense of what it is to be human in an interconnected reality. The world is doing this by responding to unsustainable practices such as our devastating reliance on fossil fuels. Weaving together voices from numerous backgrounds and time periods with Indigenous views on present and past environmental challenges, A Canadian Climate of Mind illuminates a world that is being shaken to its core while we hesitate to act.
Canadian Failures: Stories of Building Toward Success
by Alex BenayThe Hill Times: Best Books of 2017 Successful Canadians write about failure, and how it got them where they are today. What does it mean to fail? To some of the most successful Canadians, it was a rite of passage, a stepping stone to greater things, or even a brilliant source of inspiration. Olympic golds, successful businesses, pioneering medical advances — all came about after a series of missteps and countless attempts. Canadian Failures gathers ten experts from the private, public, and not-for-profit sectors and academia, all of whom have grappled with failures and success throughout their lives. Their powerful argument: that Canada, and Canadians, must be willing to learn from failure if we hope to succeed. With Chapters By … astronaut Robert Thirsk Olympic gold medalist, wrestler Erica Wiebe Chair of OpenText and of the National Research Council, Tom Jenkins co-founder of the Just for Laughs comedy festival, Andy Nulman … and others at the top of their fields.
Canadians Who Innovate: The Trailblazers and Ideas That Are Changing the World
by Roseann O'Reilly RunteProfiles of some of the most inventive and creative Canadians and the ideas that are making Canada a leading nation in innovation.From saving lives to saving harvests... From discovering ancient diamonds to identifying the first exo-planet... From driverless cars to quantum computers... From Nobel laureates to your next-door neighbor... This book offers uplifting stories of innovative Canadians. Canadians Who Innovate includes two Nobel laureates, an astronaut, extraordinary business leaders, the godfathers of artificial intelligence, and top quantum experts, including the inventor of what may be the next quantum computer. It features profiles of the first director of engineering at Google, who is now working on nuclear fusion; a medical researcher who communicates on TikTok about the efficacy and potential for RNA vaccine technology; and a PhD in nuclear physics who has twice won the Scotiabank Giller Prize. Meet the linguist who works with Indigenous people to make online dictionaries, an internationally consulted specialist on migration, an agri-tech investor, a world specialist on permafrost, and the expert in systems and number theory who has a way to fix health care. And don&’t forget the engineer who grew human cells on apples, a feat that is leading to the creation of replacement organs that do not require donors—not to be confused with the aerospace technology developer who created a tethering system to clean up space debris and a 3-D printer that prints biological tissue. Featuring brilliant thinkers from coast to coast to coast, and others from around the world who now call Canada home, Canadians Who Innovate paints a promising picture of a cleaner, healthier, more innovative future for us all.
Canal Irrigation Systems in India: Operation, Maintenance, and Management (Water Science and Technology Library #126)
by Vijay P. Singh Ashish Pandey Umesh Chandra ChaubeThe book focuses broadly on the preliminaries of the canal irrigation systems in India with a focus on their operation, maintenance, and management of the canal systems. The chapters in this book are classified under four sections, viz., (i). preliminaries of the canal irrigation systems, (ii) operation of the canal irrigation systems, (iii) maintenance of the canal irrigation systems, and (iv) management of the canal irrigation systems. The preliminaries of the canal irrigation systems include an integrated view of irrigation and agriculture, irrigation management in India: problems, issues, a brief history, and some lessons, irrigation administration, organizational structure for management of irrigated agriculture, and farmers’ participation. The operation of the canal irrigation systems includes the operation of dams and barrages, canal operation, water distribution planning, measurement of flow and sediment in canals, and performance evaluation of the canal irrigation system, use of groundwater in the canal command area. The canal irrigation systems' maintenance includes dams, barrages, related equipment, canals and related structures, field drainage, diagnostic analysis of canal irrigation system, soil and water quality management, soil moisture, and measurement. The management of the canal irrigation systems includes rehabilitation and modernization and a case study on rehabilitation, conjunctive use management, operation, and maintenance budgeting, and financing. The book is expected to be useful for academicians, water practitioners, scientists, water managers, environmentalists, administrators, NGOs, researchers, and students who are actively involved in the operation, maintenance, and management of the canal irrigation system for addressing the challenges being faced in the irrigated agricultural while addressing issues of canal irrigation systems in South East Asia.
Cancer
by Paul ScottingCancer is the second biggest killer in the world, but few of us understand how it works or how it is treated. In this illuminating introduction, Paul Scotting explains the science behind the disease and explores why some of us are more likely to develop it than others. Arguing that we're in a new age of understanding that will revolutionize the fight againtst cancer, Scotting maps out the promising future strategies for its prevention, treatment, and cure.
Cancer Bioinformatics (Methods in Molecular Biology #2932)
by Alexander Krasnitz Pascal BelleauThis second volume covers state-of-the-art cancer-related methods and tools for data analysis and interpretation. Chapters detail methods on cancer-related software repositories, databases, cloud computing resources, genomic alterations caused by cancer, methods on evaluate findings from liquid biopsies, and prognostic tools for immunotherapies. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to the material, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section which highlights tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Bioinformatics, Second Edition aims to be comprehensive guide for researchers in the field.
Cancer Biology and Advances in Treatment (Advances in Experimental Medicine and Biology #1292)
by Phuc Van PhamThis new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Cancer Biology and Advances in Treatment is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Tissue Engineering and Regenerative Medicine and Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.
Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (Advances in Experimental Medicine and Biology #773)
by Eric C. Schirmer Jose I. de las Heras"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer. "
Cancer Biomarkers: Minimal and Noninvasive Early Diagnosis and Prognosis
by Mukesh Verma Debmalya Barh Mehmet Gunduz Angelo CarpiGleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer m
Cancer Care in the United Arab Emirates
by Humaid O. Al-ShamsiThis open access book is an unprecedented and comprehensive book that delves deeply into the landscape of cancer care in the United Arab Emirates (UAE). This ground-breaking book is set to become a go-to resource for those interested in gaining an in-depth understanding of the status quo of cancer care across the seven emirates. The book, edited by Prof. Humaid O. Al- Shamsi, a leading oncologist in the region and the President of the Emirates Oncology Society, embarks on a compelling journey by meticulously examining the evolving cancer policies, treatment modalities, and innovative approaches while celebrating notable success stories. At the same time, it sheds light on the persistent challenges and unmet needs that continue to impact cancer care in the UAE. Authored by a distinguished group of experts hailing from various sectors within the UAE, the book brings together perspectives from oncology specialists, researchers, healthcare policymakers, patient advocates, and other key stakeholders involved in patient management. It covers a diverse range of topics crucial to cancer care, including early detection, diagnosis, treatment options, supportive care services, survivorship, palliative care, and ongoing research initiatives. In addition to addressing the general aspects of cancer care, this pioneering book focuses on the unique factors and challenges specific to the UAE. It explores the impact of cultural and social factors, healthcare infrastructure, regulatory frameworks, and the integration of technological advancements in cancer management. The book also examines the role of patient support organizations, patient empowerment, and community engagement in tackling the cancer burden. Each chapter in "Cancer Care in the UAE" offers valuable insights into the challenges faced by different disciplines involved in cancer care and provides a roadmap for transformative change. By presenting an overarching vision and strategic outlook for the next generation, the book serves as a catalyst for positive change in cancer care across the UAE. Endorsed by prestigious organizations such as the Emirates Oncology Society and the Emirates Medical Association, "Cancer Care in the UAE" stands as a testament to its credibility and relevance. This comprehensive book will undoubtedly contribute significantly to enhancing cancer care, fostering collaboration among stakeholders, and ultimately improving outcomes for individuals affected by cancer in the UAE and wider region.
Cancer Cell Biology: Methods and Protocols (Methods in Molecular Biology #2508)
by Sherri L. ChristianThis volume provides detailed methods on the mechanisms of underlying cancer cell biology. Chapters guide readers through techniques for culturing cancer cell lines, xenografts, cryopreservation of tumor cells, analyzing the co-culture of breast cancer cells, protein secretion by ELISA, flow cytometry-based, multi-parametric immunofluorescence analysis, protein expression by western blot, analysis of surface protein levels, protein recycling by biotinylation assay, and proteomics analysis by liquid chromatography-mass spectrometry. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Cancer Cell Biology: Methods and Protocols aims to provide a comprehensive set of tools for the analysis of cancer cell biology in the lab.
Cancer Cell Culture: Methods and Protocols (Methods in Molecular Biology #2645)
by Dania Movia Adriele Prina-MelloThis volume explores the latest collection of cell models that are used in preclinical cancer research, and covers both two-dimensional and three-dimensional culturing techniques. The chapters in this book are divided into two parts. Part One discusses two-dimensional cancer cell culture, cell models at the Air-Liquid Interface, and the latest advancements in three-dimensional complex spheroid models and dedicated disease animal models. Part Two contains technical chapters that illustrate step-by-step methodologies for specific cancer cell culture methods. The methods discussed range from the generation of isogenic cancer cell lines, the use of serum-free growth conditions, and three-dimensional cell cultures and their specific assays for the efficacy assessment of new anticancer therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Cancer Cell Culture: Methods and Protocols is a valuable tool to help researchers involved in this important field to further improve or advance their models for cancer research.
Cancer Cell Culture: Methods and Protocols (Methods in Molecular Biology #731)
by Ian A. CreeWith many recent advances, cancer cell culture research is more important than ever before. This timely edition of Cancer Cell Culture: Methods and Protocols covers the basic concepts of cancer cell biology and culture while expanding upon the recent shift in cell culture methods from the generation of new cell lines to the use of primary cells. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided for the evaluation of clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Other methods permit the modification of cells for transfection, drug resistance, immortalization, and transfer in vivo, the co-culture of different cell types, and the detection and treatment of contamination. In this new edition, specific emphasis is placed on safe working practice for both cells and laboratory researchers. These chapters contain the information critical to success - only by good practice and quality control will the results of cancer cell culture improve. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Cancer Cell Culture: Methods and Protocols serves as a practical guide for scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this research field.
Cancer Cell Metabolism: A Potential Target for Cancer Therapy
by Dhruv KumarThis book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.
Cancer Cell Signaling: Methods and Protocols (Methods in Molecular Biology #1165)
by Martha Robles-FloresCancer Cell Signaling: Methods and Protocols, Second Edition brings together the most recent advances in cancer cell signaling knowledge along with recent progress in the development of novel strategies and experimental cell models to study human cancer. Opening with a section on targeting cancer cell metabolism as an anticancer strategy, this detailed volume continues with parts describing protocols to study epigenetic control of cancer, protocols to study cancer metastasis, as well as two new techniques for cancer study Written for the highly successful Methods in Molecular Biology series, chapters include introductions for their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Cancer Cell Signaling: Methods and Protocols, Second Edition is an ideal guide to the techniques that will aid researchers in exploiting our current knowledge in order to make a profound impact in cancer prevention and treatment.
Cancer Chemoprevention and Treatment by Diet Therapy (Evidence-based Anticancer Complementary and Alternative Medicine #5)
by William C.S. ChoCancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past few years, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.
Cancer Cytogenetics and Cytogenomics: Methods and Protocols (Methods in Molecular Biology #2825)
by Jing Christine Ye Henry H. HengThis detailed volume explores the frontiers of this new era in cancer cytogenetics and cytogenomics, focusing on establishing a karyotype as an information-based genomic framework, as well as presenting technological platforms for collecting and analyzing data at the genome level. It begins with several conceptual chapters that introduce ideas such as the Genome Architecture Theory, forcefully emphasizing the importance of cytogenomics in the post-genomics era. The book then proceeds with protocols covering both basic and advanced cytogenetic and cytogenomic methods, as well as diverse experiments beyond traditional cytogenetic platforms, and bioinformatics techniques and resources. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cancer Cytogenetics and Cytogenomics: Methods and Protocols serves as an ideal guide to the unique power of this area of research in spatial biology and system-integrated genomics.
Cancer Cytogenetics: Chromosomal and Molecular Genetic Abberations of Tumor Cells
by Sverre Heim Felix MitelmanThe preeminent book on cancer cytogenetics--now in a valuable new editionLike its successful predecessors, Cancer Cytogenetics, Third Edition continues to offer authoritative coverage of neoplastic processes at the chromosomal level of genomic organization. Now updated and expanded, this new edition includes detailed information on the most recent advances in the field, incorporating a vast amount of new cytogenetic as well as molecular genetic data from the latest basic and clinical investigations.Edited by two leading authorities, who are now aided by a panel of internationalexperts, this new edition has been updated to include:Greatly expanded coverage of solid tumorsEnhanced coverage of acute and chronic myeloproliferative disordersThe latest findings on acute and chronic lymphoproliferative disordersCancer Cytogenetics, Third Edition is a valuable resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology. With its complete coverage of thecytogenetic mechanisms underlying neoplasia, and always with a keen eye on the clinical consequences of the various acquired genetic aberrations, this text will alsobe an indispensable reference for all clinicians involved in the diagnosis and treatment of cancer patients.
Cancer Detection and Diagnosis: A Handbook of Emerging Technologies
by Avraham Rasooly Ben Prickril Miguel OssandonEmerging technologies for cancer detection and diagnosis are providing more and more advance warning of pathologies of clinical significance. Research devoted to cancers are revealing new ways of finding and treating these complex diseases. This volume reviews a broad array of new technologies for cancer detection and diagnosis. While there are several clinical books describing cancer diagnosis, and general molecular analytical technologies, these books are not focused on cancer detection and diagnosis. The aim of this book is to describe emerging cancer detection and diagnosis technologies.Key Features Presents myriad new experimental cancer detection technologies Describes technology so the reader may conduct similar analyses Outlines clinical applications of technology for specific cancer and summarizes results Discusses pitfalls and limitations, future trends and potential technological developments
Cancer Diagnostics and Therapeutics: Current Trends, Challenges, and Future Perspectives
by Subrata Goswami S. K. Basu Chinmay Kumar PandaThis book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.
Cancer Drug Delivery Systems Based on the Tumor Microenvironment
by Yasuhiro Matsumura David TarinThis book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.
Cancer Epigenetics
by Trygve TollefsbolDuring the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de