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Case for Interferon: How a 1980s Cancer Drug Might Be the Wonder Therapy for the Twenty-First Century
by Kent Heckenlively Dr. Joseph CumminsTouted as a potential breakthrough cancer therapy in the 1980s by the scientific community and publications such as TIME and Newsweek magazine, the reputation of interferon has not lived up to its early promise. Interferons are small proteins with anti-viral and anti-cancer effects, which have the power to modulate the functioning of the immune system. But Dr. Joseph Cummins, an early interferon pioneer, holder of sixteen US medical patents, author of more than sixty scientific publications, as well as having taught veterinary medicine at the University of Missouri, University of Illinois, and Texas A & M University, argues that the current thinking on interferon is fundamentally flawed. Interferon is created in small quantities in the body in response to infection, and seems to work best at these low dosages. However, the public health cowboys, working under the assumption that anything good in tiny amounts must be better in massive amounts, pursued exactly the wrong strategy. High-dose interferon does not work in the body and may even cause problems. The first remarkable results for interferon and the flu were reported by the Soviets in the 1970s, but Western medicine discounted these findings because they believed the dosages were so low they couldn&’t possibly be effective. In the 1980s, when interferon was expensive to produce and only small quantities could be manufactured, the results were remarkable. Dr. Cummins was an early pioneer of low-dose interferon, and his remarkable findings among animals led to collaborations with medical doctors for human trials, even going so far as Africa at the height of the HIV-AIDS epidemic. Cummins reviews the evidence for this inexpensive, safe treatment and makes an eloquent argument for medical science to take another look at interferon to tackle today&’s most challenging health conditions, including COVID-19.
Case for Mars: The Plan To Settle The Red Planet And Why We Must
by Robert ZubrinSince the beginning of human history Mars has been an alluring dream-the stuff of legends, gods, and mystery. The planet most like ours, it has still been thought impossible to reach, let alone explore and inhabit.Now with the advent of a revolutionary new plan, all this has changed. Leading space exploration authority Robert Zubrin has crafted a daring new blueprint, Mars Direct, presented here with illustrations, photographs, and engaging anecdotes.The Case for Mars is not a vision for the far future or one that will cost us impossible billions. It explains step-by-step how we can use present-day technology to send humans to Mars within ten years; actually produce fuel and oxygen on the planet's surface with Martian natural resources; how we can build bases and settlements; and how we can one day "terraform" Mars-a process that can alter the atmosphere of planets and pave the way for sustainable life.
Case for Space: How the Revolution in Spaceflight Opens Up a Future of Limitless Possibility
by Robert ZubrinA noted space expert explains the current revolution in spaceflight, where it leads, and why we need it. A new space race has begun. But the rivals in this case are not superpowers but competing entrepreneurs. These daring pioneers are creating a revolution in spaceflight that promises to transform the near future. Astronautical engineer Robert Zubrin spells out the potential of these new developments in an engrossing narrative that is visionary yet grounded by a deep understanding of the practical challenges. Fueled by the combined expertise of the old aerospace industry and the talents of Silicon Valley entrepreneurs, spaceflight is becoming cheaper. The new generation of space explorers has already achieved a major breakthrough by creating reusable rockets. Zubrin foresees more rapid innovation, including global travel from any point on Earth to another in an hour or less; orbital hotels; moon bases with incredible space observatories; human settlements on Mars, the asteroids, and the moons of the outer planets; and then, breaking all limits, pushing onward to the stars. Zubrin shows how projects that sound like science fiction can actually become reality. But beyond the how, he makes an even more compelling case for why we need to do this--to increase our knowledge of the universe, to make unforeseen discoveries on new frontiers, to harness the natural resources of other planets, to safeguard Earth from stray asteroids, to ensure the future of humanity by expanding beyond its home base, and to protect us from being catastrophically set against each other by the false belief that there isn't enough for all.
Case-based Atlas of Cardiovascular Magnetic Resonance
by Gianluca Pontone Andrea Barison Santo Dellegrottaglie Ciro IndolfiThis book offers a practical guidance to healthcare professionals interested in learning how to make adequate clinically-oriented use of cardiovascular MRI. Thanks to its case-based approach, it provides a detailed guide to MRI applications in the most common clinical cardiovascular scenarios. Chapters describe a number of real clinical cases, including concise clinical data, clear descriptions of the most relevant information obtained from MRI and of their meaning in terms of patient management. Emphasis is placed on traditional as well as newer MRI techniques, always keeping a practical format, focused on the hands-on knowledge required for an accurate image interpretation. In the online version, the text of each case is supplemented with additional images and videos, certainly making this book a useful resource for understanding how MRI principles apply to real clinical cardiovascular situations.
Case-based Atlas of Cardiac Imaging
by Sanjiv SharmaThis case-based atlas encompasses all aspects of imaging in congenital cardiac defects, cardiac masses, inflammatory and acquired heart diseases, cardiomyopathies and coronary-related pathologies. The chapters begin with a description of the imaging approach, followed by cases comprehensively covering the gamut of clinical scenarios that may be encountered in clinical practice. The atlas provides pertinent information about each discussed disease state, its imaging diagnosis and recent advances, including role of radiology in management, follow up and prognostication. Cases that may pose as imaging differentials accompany the index case, followed by a variety of companion cases illustrating the possible spectrum of abnormalities that the reader may be confronted with while dealing with the index case. It acts as a guide for the cardiovascular radiologist, physician, paediatrician, internist, cardiologist, cardiothoracic surgeon as well as radiology residents for inculcating an evidence-based approach for choosing the right imaging algorithm in the given clinical situation. The highly visual design of the atlas enables it to act as a quick and ready reference.
Cases in Clinical Infectious Disease Practice
by Okechukwu EkennaIn the era of cost cutting and lack of adequate health insurance for many patients, clinical skills and time spent with patients are not adequately compensated. Yet, these dwindling and underpaid skills - good history taking, observation of and listening to patients, and physical examination of patients - remain very essential to making and reaching a complete and accurate diagnosis. Expensive laboratory and imaging diagnostics while very relevant, should not replace these age-old skills that have served to enhance and maintain the doctor-patient relationship and human connection, a connection that is often necessary for healing.Cases in Clinical Infectious Disease Practice uses case studies to illustrate how the infectious disease clinician processes and integrates data to arrive at a diagnosis. This type of hands-on approach, invaluable in training programs, is utilized to take the reader through initial patient encounter, through the history and physical examination, to simple laboratory findings and stains, to a final diagnosis, in a way that is easily accessible to clinicians, students, and laboratory personnel working with clinical specimens. * Appeals to practitioners of all levels, with focus on patients with common problems or complications of common infections without heavy technical language* Emphasizes basic clinical skills including history taking, observation, epidemiology, and physical exam, as well as simple laboratory tests, explaining how they lead to a reasonable diagnosis* Presents cases seen first-hand within the community setting, reflective of cases or situations a resident or student is likely to encounter in the real world after training Cases in Clinical Infectious Disease Practice is an essential resource for clinicians, graduate and medical school students, and others conducting medical and clinical microbiology or infectious disease research on real patients. About the AuthorOkechukwu Ekenna, MD, MPH, D(ABMM), FACP is a Consultant in Infectious Diseases at Singing River Health System, Ocean Springs and Pascagoula, MS, USA and an Adjunct Associate Professor of Medicine at the University of South Alabama in Mobile, AL, USA
Casey Jones
by Larry Dane BrimnerThe legend of Casey Jones has been around for more than 100 years. It started when, after a horrible train accident in April 1900, a train worker named Wallace Saunders wrote a little ballad to honor the great trainman, Casey Jones. Over the years, verses were added to the original and the legend of Casey Jones grew until it became a tall tale. It's true that investigators said that Casey was responsible for the accident that April night because he was driving too fast and failed to respond to flag signals. Casey will be remembered as a hero, though, because he saved the lives of the train's 300 passengers. Casey's actions also made it possible for his fireman, Sim Webb, to escape the wreck. That's just the sort of thing that turns an ordinary person into a legend -- one fit for a tall tale. Learn more about Casey Jones's wild adventures inside, where you will also find a great recipe for Hobo Beans. Casey himself would have loved them! A glossary and places to discover more information are also included.
Cash Crops: Genetic Diversity, Erosion, Conservation and Utilization
by P. M. Priyadarshan S. Mohan JainCash crops are grown and sold for monetary gain and not necessarily for sustenance. They include coffee, tea, coconut, cotton, jute, groundnut, castor, linseed, cocoa, rubber, cassava, soybean, sweet potato, potato, wheat, corn and teff. While some of these crops have been improved for realizing yield potential, breeding of many of them is still in infancy. Crops that underwent rigorous breeding have eventually lost much of the diversity due to extensive cultivation with a few improved varieties and the diversity in less bred species is to be conserved. Over the past years, scholars and policy makers have become increasingly aware of the short and long-run impact of climatic factors on economic, food security, social and political outcomes . Genetic diversity, natural and induced, is much needed for the future generations to sustain food production with more climate resilient crops. In contrast, crop uniformity produced across the farm fields in the form of improved varieties is genetically vulnerable to biotic and abiotic stresses. Thus, it is essential and challenging to address the issue of compromising between maximizing crop yield under a given set of conditions and minimizing the risk of crop failure when conditions change. Cash crops are grown in an array of climatic conditions. Many of the world’s poor still live in rural areas. Many are subsistence farmers, operating very small farms using very little agricultural inputs for achieving marketable outputs. Conserving the diversity of these crops and addressing all issues of crop culture through modern tools of biotechnology and genomics is a real challenge. We believe the focus of this book is to fill an unmet need of this and other grower communities by providing the necessary knowledge, albeit indirectly via the academics, to manage the risks of cash crops breeding through managing genetic diversity.
Casimir Physics (Lecture Notes in Physics #834)
by David Roberts Diego Dalvit Felipe Da Rosa Peter MilonniCasimir effects serve as primary examples of directly observable manifestations of the nontrivial properties of quantum fields, and as such are attracting increasing interest from quantum field theorists, particle physicists, and cosmologists. Furthermore, though very weak except at short distances, Casimir forces are universal in the sense that all material objects are subject to them. They are thus also an increasingly important part of the physics of atom-surface interactions, while in nanotechnology they are being investigated not only as contributors to 'stiction' but also as potential mechanisms for actuating micro-electromechanical devices. While the field of Casimir physics is expanding rapidly, it has reached a level of maturity in some important respects: on the experimental side, where most sources of imprecision in force measurements have been identified as well as on the theoretical side, where, for example, semi-analytical and numerical methods for the computation of Casimir forces between bodies of arbitrary shape have been successfully developed. This book is, then, a timely and comprehensive guide to the essence of Casimir (and Casimir-Polder) physics that will have lasting value, serving the dual purpose of an introduction and reference to the field. While this volume is not intended to be a unified textbook, but rather a collection of largely independent chapters written by prominent experts in the field, the detailed and carefully written articles adopt a style that should appeal to non-specialist researchers in the field as well as to a broader audience of graduate students.
Casino Security and Gaming Surveillance
by Derk J. Boss Alan W. ZajicAlmost all incidences of cheating, theft, fraud, or loss can be detected through the surveillance of critical transactions, audit observations, and reviews of key metrics. Providing proven-techniques for detecting and mitigating the ever-evolving threats to casino security, this book covers the core skills, knowledge, and techniques needed to protect casino assets, guests, and employees. Drawing on the authors six decades of combined experience in the industry, Casino Security and Gaming Surveillance identifies the most common threats to casino security and provides specific solutions for addressing these threats. From physical security and security management to table and gaming surveillance, it details numerous best practice techniques, strategies, and tactics, in addition to the metrics required to effectively monitor operations. The authors highlight valuable investigation tools, including interview techniques and evidence gathering. They also cover IOU patrol, tri-shot coverage, surveillance audits, threat analysis, card counting, game protection techniques, players club theft and fraud, surveillance standard operating procedures, nightclub and bar security, as well as surveillance training. Complete with a glossary of gaming terms and a resource-rich appendix that includes helpful forms, this book covers everything surveillance and security professionals need to know to avoid high-profile incidents, costly compliance violations and damage to property and revenue. It‘s professionals like Al and Derk who personify the professionalism that is crucial when establishing and operating modern casino security and surveillance departments. This book will quickly become the Bible for any security and surveillance officer.
Casino and Gaming Resort Investigations
by Derk J. Boss Alan W. ZajicCasino and Gaming Resort Investigations addresses the continued and growing need for gaming security professionals to properly and successfully investigate the increasing and unique types of crime they will face in their careers. As the gaming industry has grown, so has the need for competent and highly skilled investigators who must be prepared to manage a case of employee theft one day to a sophisticated sports book scam the next. This book provides the reader with the fundamental knowledge needed to understand how each gaming and non-gaming department functions and interacts within the overall gaming resort, allowing the investigator to determine and focus on the important elements of any investigation in any area. Each chapter delivers a background of a department or type of crime normally seen in the gaming environment, and then discusses what should be considered important or even critical for the investigator to know or determine in the course of the investigation. Likely scenarios, case histories, and tips, as well as cautions for investigators to be aware of, are used throughout the book. This book was written for and directed at gaming security and surveillance professionals, including gaming regulators, and tribal gaming authorities, who are almost daily confronted by the ingenious and the most common scams, theft, and frauds that are perpetrated in the gaming world.
Caspases,Paracaspases, and Metacaspases: Methods and Protocols (Methods in Molecular Biology #1133)
by Peter V. Bozhkov Guy Salvesen"Caspases, Paracaspases, and Metacaspacses: Methods and Protocols" isa collection of laboratory protocols covering current methods that are employed to measure and detect activities of these proteases in diverse biological systems, ranging from unicellular organisms to mammals. Broken into two parts, the first part focuses on methods to measure, detect, and inhibit activation and activity of a subset of or specific caspases "in vitro" and in several model systems and organisms, primarily in the context of programmed cell death. The second part of the book provides experimental protocols for purification and "in vitro" and "in vivo" analysis of yeast, protozoan and plant metacaspases, as well as of a human paracaspase MALT1. Written in the highly successful "Methods in Molecular Biology" series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and practical, "Caspases, Paracaspases, and Metacaspacses: Methods and Protocols" seeks to aid scientists easy-to-follow techniques. "
Cassava in Food, Feed and Industry
by C. BalagopalanCassava (Manihot esculenta Crantz) is the staple food of more than 300 million people in the world. Though cassava is utilized in a variety of ways, scientific books of any category written on the postharvest aspects of cassava are relatively few. The effect of this paucity was strikingly felt during recent years. This was one of the impelling reasons behind the present venture which, it is hoped, will stimulate other publications on this neglected crop.
Cassava: New Potential For A Neglected Crop
by James H. CockIn this book, the author brings together the latest information on improved strains, modem production systems, better processing methods, innovations in storage and marketing, and the prospects for using cassava to produce fuel alcohol.
Cassidy and Allanson's Management of Genetic Syndromes
by Suzanne B. Cassidy John C. Carey Agatino Battaglia David ViskochilThe most recent update to one of the most essential references on medical genetics Cassidy and Allanson's Management of Genetic Syndromes, 4th Edition is the latest version of a classic text in medical genetics. With newly covered disorders and cutting-edge, up-to-date information, this resource remains the most crucial reference on the management of genetic syndromes for students, clinicians, and researchers in the field of medical genetics. The 4th edition includes current information on the identification of genetic syndromes (including newly developed diagnostic criteria), the genetic basis (including diagnostic testing), and the routine care and management for more than 60 genetic disorders. Each, "expert authored", chapter includes sections on: Incidence Diagnostic criteria Etiology, pathogenesis and genetics Diagnostic testing Differential diagnosis Manifestations and Management (by system) The book focuses on genetic syndromes, primarily those involving developmental disabilities and congenital defects. The chapter sections dealing with Manifestations and Management represents the centerpiece of each entry and is unmatched by other genetic syndrome references. Management of Genetic Syndromes is perfect for medical geneticists, genetic counselors, primary care physicians and all health care professionals seeking to stay current on the routine care and management of individuals with genetic disorders.
Cassirer’s Transformation: From a Transcendental to a Semiotic Philosophy of Forms (Studies in Applied Philosophy, Epistemology and Rational Ethics #55)
by Jean LassègueThis book presents the transformation of Cassirer’s transcendental point of view. At an early stage, Cassirer was confronted with a scientific crisis triggered by the emergence of various forms of objective knowledge, such as the plurality of geometric axiom systems and non-Euclidean geometry in relativistic physics. He finally developed a solution to the problematic unity of objective knowledge by replacing the overarching notion of objectivity with that of forms of objectification. This led him to consider the notion of “symbolic forms” as the driving force in the objectification process. This concept would become instrumental in demonstrating that the objective and human sciences are not adversaries; they merely differ in their modes of semiotic construction. These modes cannot be summarized in a fixed list of symbolic forms but operate transversally, at a level where Cassirer distinguishes between three specific operators: Expression, Evocation and Objectification. The last part of the book investigates how the relationships between these three operators stabilize specific symbolic forms. Four of these forms are then studied as examples: Myth and Ritual, Language, Scientific Knowledge, and Technology.
Cast and Wrought Aluminium Bronzes: Properties, Processes and Structure
by Harry MeighContinuous casting of non-ferrous metals has been practised for well over 100 years. It has many advantages over static ingot and book mould casting, the most important being improved yield, reduced energy consumption and reduction of manpower, with a consequent reduction in cost. This book shows how the prrocess can be used in an engineering environment for casting a wide range of copper based alloys and precious metals, including gold and silver, and selected nickel alloys.
Castable Polyurethane Elastomers
by I.R. ClemitsonThis second edition of a bestseller is a practical guide to the production of castable polyurethane articles. The book shows the progression from raw materials to prepolymer production, including the chemistry and functionality of the processes. It provides a comprehensive look at various problem-solving and processing techniques, examining the selection of different systems on both the micro and macro levels. Reorganized for better flow, this edition describes new processing methods, expands coverage of health and safety aspects, and brings all standards up to date.
Cat Body, Cat Mind
by Michael W. FoxWith extraordinary insight and renowned veterinarian and animal behaviorist Dr. Michael W. Fox explores the minds, hearts, and bodies of cats. Fox believes that cats, and all animals, have much to teach their human companions-if only humans learn how to listen. In CAT BODY, CAT MIND, Fox not only teaches readers to communicate with their cats, he illuminates the extraordinary powers that cats possess--from their amazing ability to empathize to their mysterious ability to find their way home. Fox makes a terrific case for the right of cats and all animals to live safe, healthy lives, free from fear and harm. Only by better understanding and appreciating our cats and by strengthening the cat- human bond, Fox explains, can we do right by them. CAT BODY, CAT MIND also offers a holistic approach to companion-animal care and preventive medicine, including essential nutritional guidelines, as well as behavioral advice and troubleshooting that will help guarantee a healthy and happy pet. Between understanding your cat's mind and learning how to best take care of his or her body, Fox makes certain that cats and their people will enjoy long and loving lives together. Michael W. Fox has been called "America's best-known veterinarian." With doctoral degrees in medicine and animal behavior, Dr. Fox has authored more than forty books on animals and holistic subjects and provides advice in his Q&A newspaper column, "Animal Doctor" (nationally syndicated by United Media). He lives in Golden Valley, Minnesota.
Cat Daddy: What the World's Most Incorrigible Cat Taught Me About Life, Love, and Coming Clean
by Jackson Galaxy"Mr. Galaxy--shaved head, arms full of tattoos--seems physically at odds with his gentle voice and gentle approach to animals. . . . But though he may be dealing with humans who have been terrorized and even bloodied by their out-of-control pets, he's a model of consistency. The cats, not the people, are his No. 1 priority. "--The New York Times "Galaxy is not your average animal behaviorist. He speaks Cat. And cats listen. He works miracles in saving death-row cats in shelters by helping them get over their fears and increase their self-esteem, and coaching them to 'work it' with potential adopters. "--mousebreath. com "He's the kind of magic man who can lull a shelter's roomful of ferocious felines to sleep. "--Yahoo! "Each of us sheds light on our subject from our own particular point of view. Fortunately for us all Jackson Galaxy's light is very bright. His success at resolving behavioral difficulties in cats stems from his ability to slide his mind into the cat's point of view and proceed from there. His insights into both human and cat behavior are right on. "--Anitra Frazier, author of The Natural Cat Cat behaviorist and star of Animal Planet's hit television showMy Cat from Hell,Jackson Galaxy, a. k. a. "Cat Daddy," isn't what you might expect for a cat expert (asTheNew York Timesnoted, with his goatee and tattoos he "looks like a Hells Angel"). Yet Galaxy's ability to connect with even the most troubled felines--not to mention the stressed-out humans living in their wake--is awe-inspiring. In this book, Galaxy tells the poignant story of his thirteen-year relationship with a petite gray-and-white short-haired cat named Benny, and gives singular advice for living with, caring for, and loving the feline in your home. When Benny arrived in his life, Galaxy was a down-and-out rock musician with not too much more going on than a part-time job at an animal shelter and a drug problem. Benny's previous owner brought the cat to the shelter in a cardboard box to give him up. Benny had seen better days--his pelvis had just been shattered by the wheels of a car--and his owner insisted he'd been "unbondable" from day one. Nothing could have been further from the truth. An inspiring account of two broken beings who fixed each other,Cat Daddyis laced throughout with Galaxy's amazing "Cat Mojo" advice for understanding what cats need most from us humans in order to live happier, healthier lives.
Cat Fact Frenzy! (Fact Frenzy)
by Nikki PottsBrace yourself for a CAT FACT FRENZY! Did you know that some cats can reach speeds of 35 miles per hour? Or that cats can make more than 100 sounds? Dozens of bite-size cat facts are paired with fun feline photos, welcoming in even the most reluctant readers. Whether kids are in the mood to browse or to devour a book from cover to cover, even a dedicated cat fan is sure to learn something surprising as they flip through these pages.
Cat Fact Frenzy! (Fact Frenzy)
by Nikki PottsBrace yourself for a CAT FACT FRENZY! Did you know that some cats can reach speeds of 35 miles per hour? Or that cats can make more than 100 sounds? Dozens of bite-size cat facts are paired with fun feline photos, welcoming in even the most reluctant readers. Whether kids are in the mood to browse or to devour a book from cover to cover, even a dedicated cat fan is sure to learn something surprising as they flip through these pages.
Cat Musculature A Photographic Atlas, Second Edition
by Gordon M. GreenblattThis series of brilliant photographs shows the dissection of the cat musculature. It is designed for use in conjunction with the third edition of Hyman's Comparative Vertebrate Anatomy, edited by Marvalee Wake, although it can be used with other textbooks. Every possible step has been taken to make the photographs easy to interpret and to follow. Reference indications to the Wake texts are included, and also concise data on the origin, insertion, and action of each muscle. The scale is such that in most cases no more than five muscles are shown per photograph, thus simplifying the task of visualizing the individual muscles. An invaluable aid for every student of cat anatomy.
Cat Musculature: A Photographic Atlas
by Gordon GreenblattThis series of brilliant photographs shows the dissection of the cat musculature. It is designed for use in conjunction with the third edition of Hyman's Comparative Vertebrate Anatomy, edited by Marvalee Wake, although it can be used with other textbooks. Every possible step has been taken to make the photographs easy to interpret and to follow. Reference indications to the Wake texts are included, and also concise data on the origin, insertion, and action of each muscle. The scale is such that in most cases no more than five muscles are shown per photograph, thus simplifying the task of visualizing the individual muscles. An invaluable aid for every student of cat anatomy.
Cat Sense: How the New Feline Science Can Make You a Better Friend to Your Pet
by John BradshawCats have been popular household pets for thousands of years, and their numbers only continue to rise. Today there are three cats for every dog on the planet, and yet cats remain more mysterious, even to their most adoring owners. In "Cat Sense," renowned anthrozoologist John Bradshaw takes us further into the mind of the domestic cat than ever before, using cutting-edge scientific research to explain the true natureuand needsuof our feline friends. Tracing the catOCOs evolution from solitary hunter to domesticated companion, Bradshaw shows that cats remain independent, predatory, and wary of social contact, qualities that often clash with the demands of our modern lifestyles. If weOCOre to live in harmony with cats, Bradshaw contends, we first need to understand and adapt to their ancient quirks. A must-read for any cat lover, "Cat Sense" challenges our most basic assumptions about cats and promises to dramatically improve their livesuand ours. "