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Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols (Methods in Molecular Biology #2138)
by Paul C. GuestThis book presents a series of protocols in multiple disease areas affected by the aging process along with several methods which have shown progress in nutrient- or intervention-based approaches to maximize the healthspan. Of interest to researchers in the areas of chronic disease, gerontology, physical exercise, and nutrition as well as to clinical scientists, physicians, and pharmacologists, this volume also provides important information on disease mechanisms and novel drug targets as each protocol will be presented in the context of specific chronic diseases or different therapeutic areas. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols is an ideal guide for preclinical and clinical researchers working toward the discoveries needed to lead to a world society in which individuals are not only living longer lives but more productive and healthier ones.
Clinical and Radiological Examination of the Foot and Ankle: The Path to Definitive Diagnosis
by Siddhartha Sharma Bedri Karaismailoglu Soheil Ashkani-EsfahaniThe foot and ankle are among the most complicated anatomical regions of the human body, making their examination challenging. The perfect equilibrium between bones, tendons, ligaments, and other anatomical structures can be disturbed by pathological processes leading to complex disorders. The path to definitive diagnosis passes through a comprehensive clinical and radiological examination. However, the sources focusing on examining the foot and ankle pathologies are limited. Hence, this book aims to cover all aspects of clinical and radiological examination of the foot and ankle, including basics, general approach, and a closer look at the different foot and ankle pathologies. It will include the most up-to-date diagnostic methods, special tests, and radiological evaluations and give clues about the various situations that should be considered before going into surgery. With a broad range of clinical and radiological images, the path to diagnosis gets simpler! Chapters provide a systematic approach to evaluating various foot and ankle problems such as instabilities, tendinopathies, deformities, trauma, neuropathies, cartilage disorders, impingement, heel pain, etc. Moreover, it includes a chapter emphasizing the emerging technologies used for more precise clinical evaluation.This book will aid foot & ankle surgeons, podiatrists, and general orthopedic surgeons in understanding clinical and radiological examination for improved diagnosis, as well as fellows, residents, and medical students interested in foot and ankle pathologies.
Clinical, Biological and Molecular Aspects of COVID-19 (Advances in Experimental Medicine and Biology #1321)
by Paul C. GuestThe novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as heart disease, asthma, and diabetes. As the peak begins to slow in many countries, the death rates remain high amidst justified fears of a second wave. A rapid worldwide mobilization has begun to identify effective treatments and develop vaccines.This new volume will increase readers’ understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss the effects of the virus in cases of co-morbidities, new treatment approaches, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.
Clinical-MRI Correlations of Anterior Knee Pain: Common and Uncommon Causes
by Ioan I. Codorean Ion Bogdan CodoreanThe book addresses comprehensively the normal and pathological MRI appearance of the structures of the anterior compartment of the knee, potential sources of pain, in a systematic way, on anatomical layers, from superficial to deep, respectively, from prepatellar soft tissues to intra-articular structures (the synovial lining, patellar and trochlear cartilage). Anterior knee pain can affect any age group and causes a non-specific clinical picture, making it difficult to establish a precise diagnosis and proper management. MRI is currently the standard gold investigation and findings of common an uncommon causes of anterior knee pain are presented.Written by a radiologist and an orthopaedic surgeon with longstanding experience in MRI of musculoskeletal pathology and in sports traumatology, respectively, the book also presents a unique selection of 80 clinical cases of common and less common pathological conditions of anterior knee pain and subdivided in four groups, according to age, from children and adolescents to older adults.Radiologists and orthopaedic surgeons, as well as sport medicine specialists and physiatrists, will find in this book an invaluable tool for their clinical practice.
Clinician's Guide To Neuropsychological Assessment
by Rodney D. VanderploegNeuropsychological assessment is a difficult and complicated process. Often, experienced clinicians as well as trainees and students gloss over fundamental problems or fail to consider potential sources of error. Since formal test data on the surface appear unambiguous and objective, they may fall into the habit of overemphasizing tests and their scores and underemphasizing all the factors that affect the validity, reliability, and interpretability of test data. But interpretation is far from straightforward, and a pragmatic application of assessment results requires attention to a multitude of issues. This long-awaited, updated, and greatly expanded second edition of the Clinician's Guide to Neuropsychological Assessment, like the first, focuses on the clinical practice of neuropsychology. Orienting readers to the entire multitude of issues, it guides them step by step through evaluation and helps them avoid common misconceptions, mistakes, and methodological pitfalls. It is divided into three sections: fundamental elements of the assessment process; special issues, settings, and populations; and new approaches and methodologies. The authors, all of whom are actively engaged in the clinical practice of neuropsychological assessment, as well as in teaching and research, do an outstanding job of integrating the academic and the practical. The Clinician's Guide to Neuropsychological Assessment, Second Edition will be welcomed as a text for graduate courses but also as an invaluable hands-on handbook for interns, postdoctoral fellows, and experienced neuropsychologists alike. No other book offers its combination of breadth across batteries and approaches, depth, and practicality.
Clinician's Guide to Diagnostic Imaging
by William R. ReinusThis book is a concise guide to ordering radiology tests for diagnosis and treatment and provides best practice guidelines for patients whose management depends on a clinical question that is best approached through imaging. Organized primarily by organ system, it outlines considerations in selecting the most efficacious imaging studies based on the clinical history, laboratory values, and physical findings to arrive cost-effectively at a correct diagnosis. It also explores the current limitations of each imaging modality and presents evidence-based information to insure that patient safety considerations are observed when ordering potentially dangerous examinations. Clinician's Guide to Diagnostic Imaging is a valuable resource for all physicians who regularly order imaging studies, including primary care physicians, family practitioners, internists, and surgeons alike. Further, this volume serves as an invaluable reference for medical students who are exposed to medical imaging for their first time or who are rotating through a radiology elective in medical school.
Clinician's Guide to Validity Assessment and Management in Neuropsychology (Evidence-Based Practice in Neuropsychology Series)
by Ryan W. Schroeder Phillip K. MartinThis unique hands-on guide walks neuropsychologists through the process of validity assessment and management in real-world clinical settings. Emphasizing the medical necessity of evaluating validity, the authors provide detailed examples, procedural tips, and downloadable practical tools. Step-by-step guidelines are presented for managing potentially complicated referrals, using the clinical interview to gain awareness of possible concerns, choosing and administering performance and symptom validity tests, and providing feedback and treatment recommendations when invalidity is identified. Clinician–patient relationship issues are sensitively addressed. The book concludes with a chapter-length case example.
Clinicians in Court, Second Edition
by Allan E. BarskyInteracting with the legal system can be stressful and intimidating for mental health professionals. This trusted book provides user-friendly strategies to help clinicians prepare for testimony in court and other legal proceedings. Using vivid case scenarios from family law and other areas, the author explains legal terms and offers practical suggestions for avoiding pitfalls and managing ethical dilemmas. Clear guidelines are presented for record keeping, responding to subpoenas, preparing reports, and performing effectively on the stand as a fact witness or expert witness. Reproducible agreements and other sample documentation can be photocopied from the appendices or downloaded and printed in a convenient 8 1/2" x 11" size. New to This Edition Incorporates updates in research, case law, statutes, and practice. Examines the developing role of mental health professionals as forensic consultants. Increased attention to ethical issues, such as dual relationships, professional boundaries, confidentiality, and competence. An appendix with reflection questions that extend the scope of each chapter. Explores special issues that may arise in cases involving children Supplemental materials for course use-including an instructor's manual-are available at the author's website.
Clockwork Futures: The Science Of Steampunk And The Reinvention Of The Modern World
by Brandy SchillaceAirships and electric submarines, automatons and mesmerists?welcome to the wild world of steampunk. It is all speculative?or is it? Meet the intrepid souls who pushed Victorian technology to its limits and paved the way for our present age. The gear turns, the whistle blows, and the billows expand with electro-mechanical whirring. The shimmering halo of Victorian technology lures us with the stuff of dreams, of nostalgia, of alternate pasts and futures that entice with the suave of James Bond and the savvy of Sherlock Holmes. Fiction, surely. But what if the unusual gadgetry so often depicted as “steampunk” actually made an appearance in history? Zeppelins and steam-trains; arc-lights and magnetic rays: these fascinating (and sometimes doomed) inventions bounded from the tireless minds of unlikely heroes. Such men and women served no secret societies and fought no super-villains, but they did build engines, craft automatons, and engineer a future they hoped would run like clockwork. Along the way, however, these same inventors ushered in a contest between desire and dread. From Newton to Tesla, from candle and clockwork to the age of electricity and manufactured power, technology teetered between the bright dials of fantastic futures and the dark alleyways of industrial catastrophe. In the mesmerizing Clockwork Futures, Brandy Schillace reveals the science behind steampunk, which is every bit as extraordinary as what we might find in the work of Jules Verne, and sometimes, just as fearful. These stories spring from the scientific framework we have inherited. They shed light on how we pursue science, and how we grapple with our destiny—yesterday, today, and tomorrow.
Clone: The Road To Dolly, And The Path Ahead
by Gina KolataThe birth of Dolly -- the world's first clone -- placed in our hands the secret of creation. Few discoveries have so altered our notion of what it means to be human, or presented such a Gordian knot of ethical, spiritual, and scientific questions. Noted science journalist Gina Kolata broke the news nationally in The New York Times and was the first reporter to speak with Dr. Ian Wilmut, the embryologist who cloned Dolly. Now Kolata reveals the story behind Dolly, interweaving the social and cultural tales of our fear and fascination with cloning, reaching back nearly a century, with the riveting scientific accountof how a clone came to be and the mind-boggling questions Dolly presents for our future.Clone is a compelling blend of scientific suspense, dreams dashed, and frauds exposed, with provocative philosophical questions and an astute assessment of why Dolly's birth was only possible now. Like The Making of the Atomic Bomb, Lucy, and Chaos, this book gives us a window on history in the making, and an understanding of its profound effect on our lives.
Clones vs. Aliens (The Clone Chronicles #4)
by M. E. CastleFisher, Two, Amanda, and Veronica are happy to spend their holiday break at Fisher's parents' new amusement park. But when aliens crash-land on Fisher's favorite roller coaster, mistaking it for their home planet, it spells the end of R&R for our heroes. Meet the Gemini: not only are all the aliens identical twins, they're also all beautiful girls. The crew decides the best way to encourage the Gemini girls to vacate the stratosphere is to give them a taste of middle school. But Fisher and his crew learn quickly that the Geminis are not to be messed with, not when they might literally explode at any moment. That's right, the Geminis are like puberty times one million. They can seem sweet as pie, but when they turn on you, they're deadly.
Clones vs. Aliens: The Clone Chronicles #4
by M. E. CastleAliens join in the fun in this fourth book of The Clone Chronicles, a series that "strikes just the right balance between over-the-top adventure and real-life middle school drama," mixing Alex Rider, Diary of a Wimpy Kid, and Michael Buckley's NERD series to create an "action-packed success." Fisher, Two, Amanda, and Veronica are happy to spend their holiday break at Fisher's parents' new amusement park. But when aliens crash-land on Fisher's favorite roller coaster, mistaking it for their home planet, it spells the end of R&R for our heroes. Meet the Gemini: not only are all the aliens identical twins, they're also all beautiful girls. If Fisher and Two already thought girls were hard to understand, wait until they meet alien girls. Now Fisher, Two, Amanda, and Veronica must convince the aliens that Earth is the worst place ever and help them fix their ship. The crew decides the best way to encourage the Gemini girls to vacate the stratosphere is to give them a taste of middle school. And Wompalog Middle School tastes pretty disgusting. But Fisher and his crew learn quickly that the Geminis are not to be messed with, not when they might literally explode at any moment. That's right, the Geminis are like puberty times one million. They can seem sweet as pie, but when they turn on you, they're deadly.
Cloneward Bound (The Clone Chronicles #2)
by M. E. CastleThe second book in the hilarious middle-grade adventure series The Clone Chronicles. Fisher Bas and Two were able to thwart the evil Dr. X, but after somehow surviving the explosion at TechX Enterprises, Two is in Hollywood looking for his "mother." Fisher must bring him back to Palo Alto before his cloning secret is discovered. When a class field trip to see the Dr. Devilish science show arises, it becomes the perfect opportunity for Fisher to find his clone. But all kinds of complications will get in the way—including Amanda Cantrell, who knows more than Fisher would like about Two's identity. As Fisher, FP, and Amanda team up to find Two, they find trouble, hijinx, and the return of an evil mastermind—all set in the glitz of Hollywood.
Cloneward Bound: The Clone Chronicles #2
by M. E. CastleFisher Bas and Two were able to thwart the evil Dr. X, but after somehow surviving the explosion at TechX Enterprises, Two is in Hollywood looking for his "mother." Fisher must bring him back to Palo Alto before his cloning secret is discovered. When a class field trip to see the Dr. Devilish science show arises, it becomes the perfect opportunity for Fisher to find his clone. But all kinds of complications will get in the way--including Amanda Cantrell, who knows more than Fisher would like about Two's identity. As Fisher, FP, and Amanda team up to find Two, they find trouble, high jinx, and the return of an evil mastermind--all set in the glitz of Hollywood.
Cloning Agricultural Plants Via in Vitro Techniques
by Bob V. CongerThe purpose of this book is to provide a reference guide on principles and practices of cloning agricultural plants via in vitro techniques for scientists, students, commercial propagators, and other individuals who are interested in plant cell and tissue culture especially its application for cloning.Plant cell and tissue culture generated much excitement during 1970‘s concerning the potential application of the technology for improving important agricultural crop plants. This originates from the demonstration of cellular totipotency, or the ability to regenerate whole plants from single cells, and the successful creation of hybrids by somatic cell fusion in some species. There are several areas of in vitro culture which have potential practical application. The most practical application is deemed as cloning or mass propagation of selected genotypes. This is evidenced by the large number of commercial firms engaged in propagating a variety of plants through tissue culture.
Cloning: A Beginner's Guide (Beginner's Guides)
by Aaron LevineShould we clone extinct or endangered species? Are we justified in using stem cells to develop cures? When will we clone the first human? Ever since Dolly the sheep, questions like these have rarely been far from the public consciousness, and cloning is now poised to revolutionize medicine, healthcare, and even the food we eat. Aaron Levine offers a masterful and accessible introduction to the science and development of cloning, right up to the present-day scandals surrounding attempts to clone humans. Guiding readers around the thorny political and ethical issues raised by such progress, Levine dispels the myths perpetuated by the media and sheds new light on the pros and cons of this fascinating and controversial topic. Aaron Levine is currently conducting research on the impact of public policy on biomedical research at the Woodrow Wilson School of Public and International Affairs, Princeton University.
Close Encounters of Art and Physics: An Artist's View
by Laura PesceClose Encounters of Art and Physics is a voyage in time through the abstract ideas harboured in the minds of humans, starting from the graffiti art of cave dwellers and extending to the street art of contemporary men and women. In seeking parallels with science, the author looks far back to the first geometric ideas of our ancestors as well as ahead to the contemporary science of present-day physicists. The parallelism and analogies between these two fields bear witness to a real entanglement in the human brain. The second part of the book contains about 25 colour images showing the author's stunning glass artwork representing ideas such as dark matter, quantum entanglement, cellular automata and many others that are almost impossible to capture in words. Furthermore, many of the physicists who have themselves made major contributions in these fields provide their comments and analysis of the works. The book provides entertaining and informative reading, not only for practicing artists and physicists, but also anyone curious about art and physics.
Close Encounters with Humankind: A Paleoanthropologist Investigates Our Evolving Species
by Sang-Hee Lee Shin-Young YoonIn this captivating bestseller, Korea’s first paleoanthropologist offers fresh insights into humanity’s dawn and evolution. What can fossilized teeth tell us about the life expectancy of our ancient ancestors? How did farming play a problematic role in the history of human evolution? How can simple geometric comparisons of skull and pelvic fossils suggest a possible origin to our social nature? And what do we truly have in common with the Neanderthals? In this captivating international bestseller, Close Encounters with Humankind, Korea’s first paleoanthropologist, Sang-Hee Lee, explores some of our greatest evolutionary questions from new and unexpected angles. Through a series of entertaining, bite-sized chapters, we gain fresh perspectives into our first hominin ancestors and ways to challenge perceptions about the traditional progression of evolution. By combining anthropological insight with exciting, cutting-edge research, Lee’s surprising conclusions shed new light on our beginnings and connect us to a faraway past. For example, our big brains may have served to set our species apart and spur our societal development, but perhaps not in the ways we have often assumed. And it’s possible that the Neanderthals, our infamous ancestors, were not the primitive beings portrayed by twentieth-century science. With Lee as our guide, we discover that from our first steps on two feet to our first forays into toolmaking and early formations of community, we have always been a species of continuous change. Close Encounters with Humankind is the perfect read for anyone curious about where we came from and what it took to get us here. As we mine the evolutionary path to the present, Lee helps us to determine where we are heading and tackles one of our most pressing scientific questions—does humanity continue to evolve?
Close to Home: The Wonders of Nature Just Outside Your Door
by Thor HansonAn award-winning natural-history writer presents "the perfect mix of science and story" (Sy Montgomery), opening the door to the nature that thrives in our yards, gardens, and parks: "I couldn't put it down" (Doug Tallamy). We all live on nature&’s doorstep, but we often overlook it. From backyards to local parks, the natural places we see the most may well be the ones we know the least. In Close to Home, biologist Thor Hanson shows how retraining our eyes reveals hidden wonders just waiting to be discovered. In Kansas City, migrating monarch butterflies flock to the local zoo. In the Pacific Northwest, fierce yellowjackets placidly sip honeydew, unseen in the treetops. In New England, a lawn gone slightly wild hosts a naturalist's life's work. And in the soil beneath our feet, remedies for everything from breast cancer to the stench of skunks lie waiting for someone&’s searching shovel. Close to Home is a hands-on natural history for any local patch of Earth. It shows that we each can contribute to science and improve the health of our planet. And even more, it proves that the wonders of nature don&’t lie in some far-off land: they await us, close to home.
Close to the Machine: Technophilia and Its Discontents
by Ellen UllmanWith a New Introduction by Jaron Lanier A Salon Best Book of the Year In 1997, the computer was still a relatively new tool---a sleek and unforgiving machine that was beyond the grasp of most users. With intimate and unflinching detail, software engineer Ellen Ullman examines the strange ecstasy of being at the forefront of the predominantly male technological revolution, and the difficulty of translating the inherent messiness of human life into artful and efficient code. Close to the Machine is an elegant and revelatory mediation on the dawn of the digital era.
Close-Up: A Critical Introduction to Film
by Craig PadawerClose-Up: A Critical Introduction to Film 1st Edition
Closed Loop Control and Management: Introduction to Feedback Control Theory with Data Stream Managers
by Serge ZacherThe block diagrams as engineering means for closed loop control, which have been established by classic control theory for decades, are replaced in the above mentioned book by networks, the signals are replaced by data. It corresponds to the „Industry 4.0“ and to the structure of today’s automatic control systems. Thereby a classic closed loop is treated not isolated from other elements of nowadays automation like bus communication and process logical control, and is completed in proposed book with new control elements, so called data stream managers (DSM). The proposed book treats the control theory systematically like it is done in classical books considering the new concept of data management. The theory is accompanied in the book with examples, exercises with solutions and MATLAB®-simulations.
Closed Power Cycles: Thermodynamic Fundamentals and Applications (Lecture Notes in Energy #11)
by Costante Mario InvernizziWith the growing attention to the exploitation of renewable energies and heat recovery from industrial processes, the traditional steam and gas cycles are showing themselves often inadequate. The inadequacy is due to the great assortment of the required sizes power and of the large kind of heat sources. Closed Power Cycles: Thermodynamic Fundamentals and Applications offers an organized discussion about the strong interaction between working fluids, the thermodynamic behavior of the cycle using them and the technological design aspects of the machines. A precise treatment of thermal engines operating in accordance with closed cycles is provided to develop ideas and discussions strictly founded on the basic thermodynamic facts that control the closed cycles operation and design. Closed Power Cycles: Thermodynamic Fundamentals and Applications also contains numerous examples which have been carried out with the help of the Aspen Plus®R program. Including chapters on binary cycles, the organic Rankine cycle and real closed gas cycles, Closed Power Cycles: Thermodynamic Fundamentals and Applications acts a solid introduction and reference for post-graduate students and researchers working in applied thermodynamics and energy conversion with thermodynamic engines.
Closed-Loop Supply Chains: New Developments to Improve the Sustainability of Business Practices (Supply Chain Integration Modeling, Optimization and Application)
by Mark E. Ferguson Gilvan C. SouzaClosed-loop supply chain activities such as remanufacturing, recycling, dismantling for spare parts, and reverse logistics have helped many companies tap into new revenue streams by finding secondary markets for their products, all while reducing their overall carbon footprint. Written by academic experts, in language that is accessible to practitioners, this authoritative resource examines recent research and case studies of companies running profitable reuse/remanufacture operations in various industries. It illustrates profitable practices in returned and recovered products, clearly explaining how to: design a reverse logistics network, conduct production planning, implement effective marketing strategies, and apply closed-loop supply chain strategies in industries besides manufacturing. From product development to materials to assembly and profitability, this complete resource explores the impact of these processes across all aspects of the supply chain.
Closed-form Solutions for Drug Transport through Controlled-Release Devices in Two and Three Dimensions
by Laurent Simon Juan OspinaProvides solutions for two- and three-dimensional linear models of controlled-release systems Real-world applications are taken from used to help illustrate the methods in Cartesian, cylindrical and spherical coordinate systems Covers the modeling of drug-delivery systems and provides mathematical tools to evaluate and build controlled-release devices Includes classical and analytical techniques to solve boundary-value problems involving two- and three-dimensional partial differential equations Provides detailed examples, case studies and step-by-step analytical solutions to relevant problems using popular computational software