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Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology
by Bruno Mondovi Giovanni FlorisAlthough the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual co
Copper Proteins and Copper Enzymes: Volume I
by Rene LontieThese volumes of Copper Proteins and Copper Enzymes are intended to describe the contemporary spectroscopy and other biophysical chemistry now being applied to copper proteins in order to determine the structures of their active sites. Several chapters of the treatise describe the functional understanding which is emerging from the new work. The authors are all major contributors to research progress on copper proteins and the volumes will be found to be definitive and authoritative.
Copper Proteins and Copper Enzymes: Volume II
by Rene LontieThese volumes of Copper Proteins and Copper Enzymes are intended to describe the contemporary spectroscopy and other biophysical chemistry now being applied to copper proteins in order to determine the structures of their active sites. Several chapters of the treatise describe the functional understanding which is emerging from the new work. The authors are all major contributors to research progress on copper proteins and the volumes will be found to be definitive and authoritative.
Copper Proteins and Copper Enzymes: Volume III
by Rene LontieThese volumes of Copper Proteins and Copper Enzymes are intended to describe the contemporary spectroscopy and other biophysical chemistry now being applied to copper proteins in order to determine the structures of their active sites. Several chapters of the treatise describe the functional understanding which is emerging from the new work. The authors are all major contributors to research progress on copper proteins and the volumes will be found to be definitive and authoritative.
Copper Wire Bonding
by Zhaowei Zhong Preeti S Chauhan Anupam Choubey Michael G PechtThis critical volume provides an in-depth presentation of copper wire bonding technologies, processes and equipment, along with the economic benefits and risks. Due to the increasing cost of materials used to make electronic components, the electronics industry has been rapidly moving from high cost gold to significantly lower cost copper as a wire bonding material. However, copper wire bonding has several process and reliability concerns due to its material properties. Copper Wire Bonding book lays out the challenges involved in replacing gold with copper as a wire bond material, and includes the bonding process changes--bond force, electric flame off, current and ultrasonic energy optimization, and bonding tools and equipment changes for first and second bond formation. In addition, the bond-pad metallurgies and the use of bare and palladium-coated copper wires on aluminum are presented, and gold, nickel and palladium surface finishes are discussed. The book also discusses best practices and recommendations on the bond process, bond-pad metallurgies, and appropriate reliability tests for copper wire-bonded electronic components. In summary, this book: Introduces copper wire bonding technologies Presents copper wire bonding processes Discusses copper wire bonding metallurgies Covers recent advancements in copper wire bonding including the bonding process, equipment changes, bond-pad materials and surface finishes Covers the reliability tests and concerns Covers the current implementation of copper wire bonding in the electronics industry Features 120 figures and tables Copper Wire Bonding is an essential reference for industry professionals seeking detailed information on all facets of copper wire bonding technology.
Copper Zinc Tin Sulfide Thin Films for Photovoltaics: Synthesis and Characterisation by Electrochemical Methods (Springer Theses)
by Jonathan J. ScraggJonathan Scragg documents his work on a very promising material suitable for use in solar cells. Copper Zinc Tin Sulfide (CZTS) is a low cost, earth-abundant material suitable for large scale deployment in photovoltaics. Jonathan pioneered and optimized a low cost route to this material involving electroplating of the three metals concerned, followed by rapid thermal processing (RTP) in sulfur vapour. His beautifully detailed RTP studies - combined with techniques such as XRD, EDX and Raman - reveal the complex relationships between composition, processing and photovoltaic performance. This exceptional thesis contributes to the development of clean, sustainable and alternative sources of energy
Copper and Bacteria: Evolution, Homeostasis and Toxicity (SpringerBriefs in Molecular Science)
by Marc SoliozIn the past two decades, great progress has been made in the understanding of copper as a bioelement. The book summarizes the current knowledge of copper toxicity, homeostasis and resistance in bacteria, in which proteins like copper ATPases, copper chaperones and copper-responsive regulators of gene expression play major roles. The author also discusses the metallation of cuproenzymes. The evolution of the use of copper by cells and of copper-homeostatic proteins are is also considered in this Brief.
Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles
by Scott E. Denmark Engelbert Ciganek Kevin H. Shaughnessy Rebecca B. DeVasherThe metal-catalyzed amination of aryl and alkenyl electrophiles has developed into a widely used methodology for the synthesis of natural products, active pharmaceutical ingredients, agricultural chemicals, and materials for molecular electronics. Copper catalysts promote the coupling of a wide range of nitrogen nucleophiles, including amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in many cases. Copper catalysts are highly effective with less nucleophilic nitrogen nucleophiles, such as amides and azoles, whereas palladium catalysts are more effective with more nucleophilic amine nucleophiles. Copper is an attractive alternative to palladium due to its significantly lower cost. In addition, high activity palladium catalysts require expensive and often air-sensitive ligands, whereas the modern copper systems use relatively stable and inexpensive diamine or amino acid ligands. Copper-catalyzed C?N coupling reactions are tolerant of a wide range of functional groups and have been applied to the synthesis of a variety of complex natural products. Significant work has also been done to understand the mechanism of these reactions. Current mechanistic understanding of these methodologies is covered in this monograph. The contents of the book are taken from the comprehensive review of the topic in the Organic Reactions series. Optimal experimental conditions for the amination of aryl and alkenyl halides with all classes of nitrogen nucleophiles are presented. Specific experimental procedures from the literature are provided for the major classes of copper-catalyzed C?N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is presented in 35 tables organized by nitrogen nucleophile and electrophilic coupling partner. The literature is covered through December 2015 and provides 300 recent citations to supplement the 680 citations of the original hardbound chapter. These latest literature references have been collected in separate sections according to the sequence of the tables in the tabular survey section. In each of the sections, the individual citations have been arranged in alphabetic order of the author names. Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is intended to provide organic chemists with an accessible, but detailed, introduction to this important class of transformations.
Copper-Catalyzed Asymmetric Synthesis
by Simon Woodward Norbert Krause Alexandre AlexakisCopper-Catalyzed Asymmetric Synthesis reflects the increasing interest among the chemical synthetic community in the area of asymmetric copper-catalyzed reactions, and introduces readers to the latest, most significant developments in the field.The contents are organized according to reaction type and cover mechanistic and spectroscopic aspects as well as applications in the synthesis of natural products. A whole chapter is devoted to understanding how primary organometallics interact with copper to provide selective catalysts for allylic substitution and conjugate addition, both of which are treated in separate chapters. Another is devoted to the variety of substrates and experimental protocols, while an entire chapter covers the use on non-carbon nucleophiles. Other chapters deal with less-known reactions, such as carbometallation or the additions to imines and related systems, while the more established reactions cyclopropanation and aziridination as well as the use of copper (II) Lewis acids are warranted their own special chapters. Two further chapters concern the processes involved, as determined by mechanistic studies. Finally, a whole chapter is devoted to the synthetic applications.This book is essential reading for researchers at academic institutions and professionals at pharmaceutical or agrochemical companies.
Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C--H Bonds (Springer Theses)
by Stacey L. McdonaldThis thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald's findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Copper-Catalyzed Multi-Component Reactions: Synthesis of Nitrogen-Containing Polycyclic Compounds (Springer Theses)
by Yusuke OhtaA copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Copper-Mediated Cross-Coupling Reactions
by Gwilherm Evano Nicolas BlanchardProviding comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.
Copper-Oxygen Chemistry (Wiley Series of Reactive Intermediates in Chemistry and Biology #8)
by Kenneth D. Karlin Shinobu ItohCovers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry: Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.
Copper: Multisubstituted Alkenyl and Allylic Boronates (Springer Theses)
by Yu OzawaThis book focuses on the development of novel functionalized organoboron compounds and those synthetic methods. High degrees of chemo-, regio-, and stereoselectivities of the borylation reactions are attained through catalyst design and optimization. Furthermore, the selectivity-determining mechanisms are analyzed with state-of-the-art DFT and other computational methods. In this book, the author synthesizes some multi-substituted alkenyl and allylic boronates via borylation reactions using a copper(I)/diboron catalyst system. Those compounds contain novel densely substituted and distorted structures, which have not been accessed by other methods. The high stereoselectivities are achieved by the optimization of the catalyst, especially the ligand. Some new ligands are also developed in this book. Furthermore, the derivatization of the borylation products is demonstrated to access the sterically demanding complex molecules. Also, the author performs computational analysis to reveal how the catalyst controls the selectivities. The deep insight into the reaction mechanism provides guides for rational catalyst design for not only copper(I) catalysis but also other transition metal catalysis. Thus, the content should be of interest to academic and industrial scientists in a wide range of areas.
Copula-Based Markov Models for Time Series: Parametric Inference and Process Control (SpringerBriefs in Statistics)
by Takeshi Emura Li-Hsien Sun Xin-Wei Huang Mohammed S. Alqawba Jong-Min KimThis book provides statistical methodologies for time series data, focusing on copula-based Markov chain models for serially correlated time series. It also includes data examples from economics, engineering, finance, sport and other disciplines to illustrate the methods presented. An accessible textbook for students in the fields of economics, management, mathematics, statistics, and related fields wanting to gain insights into the statistical analysis of time series data using copulas, the book also features stand-alone chapters to appeal to researchers. As the subtitle suggests, the book highlights parametric models based on normal distribution, t-distribution, normal mixture distribution, Poisson distribution, and others. Presenting likelihood-based methods as the main statistical tools for fitting the models, the book details the development of computing techniques to find the maximum likelihood estimator. It also addresses statistical process control, as well as Bayesian and regression methods. Lastly, to help readers analyze their data, it provides computer codes (R codes) for most of the statistical methods.
Copy Number Variants: Methods and Protocols (Methods in Molecular Biology #1833)
by Derek M. BickhartThis volume offers detailed step-by-step instructions to allow beginners and experts alike to run appropriate copy number variants (CNV) detection software on a dataset of choice and discern between false positive noise and true positive CNV signals. Chapters guide readers through single nucleotide polymorphism (SNP) chips, optical mapping assembly techniques, and current open-source programs specializing in CNV detection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Copy Number Variants: Methods and Protocols aims to provide guidance to Bioinformaticians and Molecular Biologists who are interested in identifying copy number variants (CNV) with a wide variety of experimental media
Copyright and Popular Media
by Trajce CvetkovskiCopyright governance is in a state of flux because the boundaries between legal and illegal consumption have blurred. Trajce Cvetkovski interrogates the disorganizational effects of piracy and emerging technologies on the political economy of copyright in popular music, film and gaming industries.
Copyright and Tertiary Education Regimes in Ethiopia: Exploring Interfaces for Human Development
by Sileshi Bedasie HirkoThis book explores the interlinkages between copyright and tertiary education regimes, and their complementary roles for sustainable human development. Emphasizing issues that are not addressed in-depth in the existing works, this book employs a new theoretical perspective in order to inform the exploration of the interlinkages through the lens of human development. To this effect, the book adopts the capabilities approach (CA) as an inclusive development framework that is suitable for examining the interfaces among copyright, tertiary education, and human development in Ethiopia.
Coral Bleaching: Patterns, Processes, Causes and Consequences (Ecological Studies #233)
by Madeleine J. van Oppen Janice M. LoughOne of the most serious consequences of global climate change for coral reefs is the increased frequency and severity of mass coral bleaching events and, since the first edition of this volume was published in 2009, there have been additional mass coral bleaching events. This book provides comprehensive information on the causes and consequences of coral bleaching for coral reef ecosystems, from the genes and microbes involved in the bleaching response, to individual coral colonies and whole reef systems. It presents detailed analyses of how coral bleaching can be detected and quantified and reviews future scenarios based on modeling efforts and the potential mechanisms of acclimatisation and adaptation. It also briefly discusses emerging research areas that focus on the development of innovative interventions aiming to increase coral climate resilience and restore reefs.
Coral Lives: Literature, Labor, and the Making of America
by Michele Currie NavakasA literary and cultural history of coral—as an essential element of the marine ecosystem, a personal ornament, a global commodity, and a powerful political metaphorToday, coral and the human-caused threats to coral reef ecosystems symbolize our ongoing planetary crisis. In the nineteenth century, coral represented something else; as a recurring motif in American literature and culture, it shaped popular ideas about human society and politics. In Coral Lives, Michele Currie Navakas tells the story of coral as an essential element of the marine ecosystem, a cherished personal ornament, a global commodity, and a powerful political metaphor. Drawing on a wide range of sources, including works by such writers as Sarah Josepha Hale, Harriet Beecher Stowe, Frances Ellen Watkins Harper, and George Washington Cable, Navakas shows how coral once helped Americans to recognize both the potential and the limits of interdependence—to imagine that their society could grow, like a coral reef, by sustaining rather than displacing others.Navakas shows how coral became deeply entwined with the histories of slavery, wage labor, and women’s reproductive and domestic work. If coral seemed to some nineteenth-century American writers to be a metaphor for a truly just collective society, it also showed them, by analogy, that society can seem most robust precisely when it is in fact most unfree for the laborers sustaining it. Navakas’s trailblazing cultural history reveals that coral has long been conceptually indispensable to humans, and its loss is more than biological. Without it, we lose some of our most complex political imaginings, recognitions, reckonings, and longings.
Coral Reef
by Martin Šodjr Radka PíroDive into the ocean, explore the colorful coral reef, and learn about the sea animals who call it home in this amazing picture book.The ocean is a magical place with so much to see. So, grab your snorkel and swim around a beautiful coral reef where you&’ll discover all the amazing sea creatures who live there! From hermit crabs, fish, and eels to sea horses, octopuses, dolphins, and so much more, this picture book lets you peek inside while learning tons of fun facts about these stunning animals and their lives inside a coral reef.&“Engaging, informative, and best of all—fun!&” —Cheryl Butler, host of The Mighty Mommy podcastThis is a fixed-format ebook, which preserves the design and layout of the original print book
Coral Reef Conservation and Restoration in the Omics Age (Coral Reefs of the World #15)
by Madeleine J. H. van Oppen Manuel Aranda LastraThe rapid demise of coral reefs worldwide has spurred efforts to develop innovative conservation and restoration methods. Many of these rely on omics approaches to produce genetic, genomic, transcriptomic, epigenomic or metabolomic data to inform conservation and restoration interventions. This book provides the state of play of this field. It discusses topics ranging from how genomic and environmental DNA (eDNA) data can be used to inform marine protected area design and cryopreservation strategies, the use of knowledge on adaptive genetic and epigenetic variation to maximise environmental stress tolerance of coral stock, harnessing transcriptome data to develop early warning markers, the use of microbial symbiont omics data in guiding restoration strategies, to applications of metabolomics and genetic engineering. How best to translate omics data to resource managers is also discussed.
Coral Reef Microbiome (Coral Reefs of the World #20)
by Christian R. Voolstra Raquel S. PeixotoMicroorganisms, the catalysts of all biogeochemical cycles on Earth, are the origin and essence of life—an invisible yet powerful force sustaining all living organisms. The health of both individual organisms and ecosystems critically depends on functional microbiomes that drive essential processes such as nutrient cycling, pathogen control, detoxification, and resilience. However, like their macroorganism counterparts, these beneficial microbes are vulnerable to environmental changes, and their decline often accelerates ecosystem degradation. Anthropogenic impacts have profoundly altered and often degraded most ecosystems and their microbiomes, with coral reefs being no exception. Stony corals, the foundation of these vibrant ecosystems, are among the most threatened marine organisms. Shifts in coral microbiomes toward dysbiotic (harmful) assemblages are increasingly recognized as both a cause and consequence of coral mortality. In response, active intervention strategies are being developed to restore and rehabilitate degraded microbiomes, aiming to restore and re-establish the beneficial microbial communities that sustain the health of both their host organisms and ecosystems. The success of these approaches depends on our understanding of the distribution, ecological roles, and interactions between corals and their associated microbiomes, as well as how environmental factors influence them and their potential to either amplify or mitigate anthropogenic impacts. This book delves into these topics, examining how they shape coral holobiont assemblages and offer pathways for active intervention. In addition, this book provides a practical, tailored, and adaptable roadmap for stakeholders to integrate the latest insights into a broader One Health framework and ecosystem perspective.
Coral Reef Remote Sensing: A Guide for Mapping, Monitoring and Management
by James A. Goodman Samuel J. Purkis Stuart R. PhinnRemote sensing stands as the defining technology in our ability to monitor coral reefs, as well as their biophysical properties and associated processes, at regional to global scales. With overwhelming evidence that much of Earth's reefs are in decline, our need for large-scale, repeatable assessments of reefs has never been so great. Fortunately, the last two decades have seen a rapid expansion in the ability for remote sensing to map and monitor the coral reef ecosystem, its overlying water column, and surrounding environment. Remote sensing is now a fundamental tool for the mapping, monitoring and management of coral reef ecosystems. Remote sensing offers repeatable, quantitative assessments of habitat and environmental characteristics over spatially extensive areas. As the multi-disciplinary field of coral reef remote sensing continues to mature, results demonstrate that the techniques and capabilities continue to improve. New developments allow reef assessments and mapping to be performed with higher accuracy, across greater spatial areas, and with greater temporal frequency. The increased level of information that remote sensing now makes available also allows more complex scientific questions to be addressed. As defined for this book, remote sensing includes the vast array of geospatial data collected from land, water, ship, airborne and satellite platforms. The book is organized by technology, including: visible and infrared sensing using photographic, multispectral and hyperspectral instruments; active sensing using light detection and ranging (LiDAR); acoustic sensing using ship, autonomous underwater vehicle (AUV) and in-water platforms; and thermal and radar instruments. Emphasis and Audience This book serves multiple roles. It offers an overview of the current state-of-the-art technologies for reef mapping, provides detailed technical information for coral reef remote sensing specialists, imparts insight on the scientific questions that can be tackled using this technology, and also includes a foundation for those new to reef remote sensing. The individual sections of the book include introductory overviews of four main types of remotely sensed data used to study coral reefs, followed by specific examples demonstrating practical applications of the different technologies being discussed. Guidelines for selecting the most appropriate sensor for particular applications are provided, including an overview of how to utilize remote sensing data as an effective tool in science and management. The text is richly illustrated with examples of each sensing technology applied to a range of scientific, monitoring and management questions in reefs around the world. As such, the book is broadly accessible to a general audience, as well as students, managers, remote sensing specialists and anyone else working with coral reef ecosystems.
Coral Reef Resilience in the Anthropocene: A History of Discovery and Research in the Eastern Tropical Pacific Region
by Peter W. GlynnThis book chronicles six decades of exploration and ecological studies of Western American coral reefs, a vibrant and diverse ecosystem in a marginal tropical Pacific region that has long been overlooked. It begins with the discovery of pristine coral reefs in Panama in the 1960s, follows the impact of stressful El Niño warming events that caused widespread coral bleaching and mortality in the 1980s-1990s, documents coral recovery in the late 1990s and early 2000s, and addresses the recent resurgence (2023-24) of extreme El Niño events leading to renewed coral mortality and setbacks in reef recovery. The book delves into the challenges posed by the physical environment, including recurring ENSO activity and increasing ocean acidification, and examines key ecological research topics such as coral reproduction, predation, bioerosion, symbioses, and biodiversity. It also highlights recent molecular genetic advancement in understanding coral endosymbionts, species identification, and phylogenetic relationships. Along the way, personal anecdotes from the eastern Pacific coral research team – ranging from exhilarating to amusing, frightening, and occasionally embarrassing – are shared throughout this scientific journey. This narrative offers a glimpse into the community composition of species and their interactions before severe bleaching and widespread coral mortality, information that is necessary to help guide restoration work. Sketches of coral reef animal associates by Peter W. Glynn and the late Charles Messing add an artistic dimension, highlighting the ecological roles of various species within the reef ecosystem. Many students have made significant contributions to the understanding and conservation of eastern Pacific coral reefs, with several going on to pursue careers in academia, research, and restoration, emerging as the next generation of reef scientists. The book concludes with a cautiously optimistic hope that humanity will shift away from reliance on fossil fuels, and that Generation Z (and their future students) will discover ways to restore coral reefs for future generations.