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Cyclic Peptide Design (Methods in Molecular Biology #2001)
by Gilles GoetzThis book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.
Cyclic β-Glucans from Microorganisms: Production, Properties and Applications (SpringerBriefs in Microbiology #0)
by Sathyanarayana Gummadi Mukesh Doble Geetha Venkatachalamto Cyclic glucans are polysaccharides that are predominantly produced by Agrobacterium, Bradyrhizobium and Rhizobium sp. and widely used in the pharmaceutical and food industries. In this book, the applications, properties, analytical tools, production and genes of four main cyclic β-glucans from microorganisms are highlighted and critically evaluated. As biocompatible and biodegradable renewable resources, they have an immense potential for future applications, which has not yet been fully exploited. This concise review will help to bridge this gap.
Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System
by Anthony R. West Nicholas J. BrandonThis book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Cyclin Dependent Kinase 5 (Cdk5)
by Nancy Y. Ip Li-Huei TsaiCyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Cycling & Walking for Regional Development: How Slowness Regenerates Marginal Areas (Research for Development)
by Paolo Pileri Rossella MoscarelliThis book investigates why and how cycle and walking paths can help to promote the regeneration of marginalized areas facing depopulation and economic decline. In addition, it offers a broad overview of recent scientific research into slow tourism and marginality/spatial inequality and explores the linkages between these topics. Key issues are addressed by experts from various disciplinary backgrounds, and potential measures are proposed for the integration of slow tourism into strategies for regional development. Particular attention is devoted to the VENTO project, which involves the creation of a 700-km-long cycle route from Venice to Turin that passes through various rural and marginalized areas of northern Italy. The goal, research process, design, and early lessons from this important project are all discussed in detail. Moreover, the book describes policies and strategies that have successfully been used to enhance the slow tourism infrastructure in other European countries. Given its scope, the book will appeal to researchers, professionals, and students interested in e.g. policymaking, tourism planning, regional development, and landscape and urban planning.
Cycling Societies: Innovations, Inequalities and Governance (Routledge Studies in Transport, Environment and Development)
by Dennis Zuev; Katerina Psarikidou; Cosmin PopanThis book examines emerging debates and questions around cycling to critically analyse and challenge dominant framings and prevalent conventions of ‘good cycling’. Cycling Societies brings to light the plurality of voices and forms of cycling in other societies, revealing the diversity and complexity of cycling across different socio-political regimes, geographies and cultures. It presents case studies from five continents and demonstrates the need of thinking comparatively about cycling and urban environments. The book pivots around the three themes of innovations, inequalities and governance and engages a diversity of voices: world-renowned academics in the field of cycling and urban mobility, cycling activists and transportation consultants. Synthesising academic contributions with policy briefs, this innovative book will be of great interest to students, scholars and practitioners of sustainable transportation, urban planning and mobility studies.
Cycling and Recycling: Histories of Sustainable Practices (Environment in History: International Perspectives #7)
by Ruth Oldenziel Helmuth TrischlerTechnology has long been an essential consideration in public discussions of the environment, with the focus overwhelmingly on creating new tools and techniques. In more recent years, however, activists, researchers, and policymakers have increasingly turned to mobilizing older technologies in their pursuit of sustainability. In fascinating case studies ranging from the Early Modern secondhand trade to utopian visions of human-powered vehicles, the contributions gathered here explore the historical fortunes of two such technologies—bicycling and waste recycling—tracing their development over time and providing valuable context for the policy successes and failures of today.
Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications
by Hui Zhao Zigang Li Chuan WanAn important and timely guide to the progress being made on constrained helical peptidesConstraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors—noted experts on the topic—include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity.The book examines the therapeutic applications of the constraint helices and includes comparison with existing small molecule modulators or antibodies. Designed as a useful resource for both those outside and inside the field. Those new to the field will find a comprehensive introduction to cyclized helical peptide and those inside the field will find a deeper understanding of the topic.This important book:Offers a practical introduction to constrained helical peptidesIncludes all aspects of constrained helical peptidesIncludes information on the most recent methods that have emergedPresents a guide to help solve practical problems in the fieldWritten for academics, pharmaceutical professional, Cyclized Helical Peptides is a comprehensive guide to the developments of constrained helical peptides.
Cyclodextrin Applications in Medicine, Food, Environment and Liquid Crystals (Environmental Chemistry for a Sustainable World #17)
by Eric Lichtfouse Sophie Fourmentin Grégorio CriniThis book is the second volume of two volumes on cyclodextrins published in the series Environmental Chemistry for a Sustainable World. This volume focuses on cyclodextrin applications. The first chapter by Divya Arora and Sundeep Jaglan presents cyclodextrin-based carriers for delivery of dietary phytochemicals. The second chapter by Éva Fenyvesi et al. describes the interactions of steroids with cyclodextrins and their applications to pharmaceuticals, food, biotechnology and environment. Nazli Erdoğar and Erem Bilensoy discuss cyclodextrin-based nanosystems in targeted cancer therapy. Miriana Kfoury et al. review the use of cyclodextrins for essential oils applications in chapter 4. Hiroshi Ikeda demonstrates in chapter 5 that chromophore-appended cyclodextrins are effective for chemosensors to detect organic molecules by fluorescence or absorbance changes. Then Grégorio Crini et al. describe silica materials-containing cyclodextrin for pollutant removal. The final chapter by Chang-Chun Ling et al. summarizes the synthesis and characterization of supramolecular liquid crystals based on cyclodextrins and their applications.
Cyclodextrin Fundamentals, Reactivity and Analysis (Environmental Chemistry for a Sustainable World #16)
by Eric Lichtfouse Sophie Fourmentin Grégorio CriniThis book is the first volume of two volumes on cyclodextrins published in the series Environmental Chemistry for a Sustainable World. After a brief description of the cyclodextrin fundamentals, the first chapter by Grégorio Crini et al. provides an overview of cyclodextrin research during the last 5 years. The second chapter by Michal Řezanka discusses the synthesis of novel cyclodextrin systems by selective modifications. Then Eric Monflier et al. describes the synthesis of nanostructured porous materials based on cyclodextrins, and applications in heterogeneous catalysis and photocatalysis. The use of thermal analyses for assessing cyclodextrin inclusion complexes is reviewed in chapter 4 by Daniel Hădărugă et al. Experimental methods for measuring binding constants of cyclodextrin inclusion compounds are presented by David Landy. The second volume reviews cyclodextrin applications in medicine, food, environment and liquid crystals.
Cyclodextrins for Chemosensing
by Sivakumar KrishnamoorthyThis book covers the fundamental as well as the advanced aspects of using cyclodextrins effectively for the selective sensing of analytes, designing sensory systems using cyclodextrins, and the mechanisms of cyclodextrins-based sensors. It ultimately provides a holistic and collective understanding on the various chemosensory systems based on cyclodextrins, which will help readers in designing and developing new sensors. This book serves as an invaluable single-point reference material for researchers working in both academia and industry, as well as to students and librarians. Readers will gain valuable insights into selecting suitable cyclodextrins based on the size of the analyte, optimizing sensitivity and selectivity, comparing LOD/LOQ, and more.
Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine
by Erem BilensoyCyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine covers a wide range of knowledge on cyclodextrins, from an overview of molecular and supramolecular aspects of cyclodextrin physicochemistry, to the latest outcomes in cyclodextrin use and future possibilities in the employment of these systems. This book focuses on the derivatives and physicochemical and biological properties of cyclodextrins, and considers drug delivery through topical, mucosal, and oral via cyclodextrin complexes.
Cyclodextrins: Properties and Applications
by Tomasz Girek Wanda SliwaAuthored by two experts working in this important field of research, the timely book covers the latest advances in the synthesis of cyclodextrins, their properties and important industrial applications. To this end, the authors describe covalent and non-covalent assemblies, cyclodextrin inclusion complexes, cyclodextrin polymers, and modified cyclodextrins, resulting in an up-to-date overview of cyclodextrin chemistry. An invaluable reference for organic and polymer chemists in academia as well as those researchers in industry working in polymer, supramolecular and pharmaceutical chemistry, as well as food, textile and cosmetic science.
Cyclodextrins: Properties and Industrial Applications
by Sahar Amiri Sanam AmiriThe comprehensive resource for understanding the structure, properties, and applications of cyclodextrins Cyclodextrins: Properties and Industrial Applications is a comprehensive resource that includes information on cyclodextrins (CDs) structure, their properties, formation of inclusion complex with various compounds as well as their applications. The authors Sahar Amiri and Sanam Amiri, noted experts in the field of cyclodextrins, cover both the basic and applied science in chemistry, biology, and physics of CDs and offers scientists and engineers an understand of cyclodextrins. Cyclodextrins are a family of cyclic oligosaccharides consisting of (α-1,4)-linked α-D-glucopyranose units. The formation of inclusion complex between CDs as host and guest molecules is based on non-covalent interaction such as hydrogen bonding or van der waals interactions and lead to the formation of supramolecular structures. These supramolecular structures can be used as macroinitiator for initiating various type of reactions. CDs are widely used in many industrial products such as pharmacy, food and flavours, chemistry, chromatography, catalysis, biotechnology, agriculture, cosmetics, hygiene, medicine, textiles, drug delivery, packing, separation processes, environment protection, fermentation, and catalysis. This important resource: Offers a basic understanding of cyclodextrins for researchers and engineers Includes information of the basic structure of cyclodextrins and their properties Reviews how cyclodextrins can be applied in a variety of fields including medicine, chemistry, textiles, packing, and many others Shows how encapsulate corrosion inhibitors became active in corrosive electrolytes to ensure delivery of the inhibitors to corrosion sites and long-term corrosion protection Cyclodextrins offers research scientists and engineers a wealth of information about CDs with particular focus on how cyclodextrins are applied in various ways including in drug delivery, the food industry, and many other areas.
Cyclolinear Organosilicon Copolymers: Synthesis, Properties, Application
by O.V. Mukbaniani G.E. ZaikovThe demand for organosilicon elastomers used in the production of thermally resistant rubbers and organosilicon polymers for making non-metal composite materials is increasing from year to year.This monograph presents a discussion on the methods used for synthesizing and studying properties of newly designed organosilicon polymers, namely organosil
Cyclometalation Reactions: Five-Membered Ring Products as Universal Reagents
by Iwao OmaeThis book provides a review of cyclometalation reactions and organometallic intramolecular-coordination five-membered ring products, the most active type of reactions in synthetic organic reactions and their products. Included is the discovery of intramolecular-coordination bonds in cyclometalation reactions and the characteristics of those reactions, as well as the reasons that their five-membered ring compounds are very easily synthesized through such reactions. In addition, the applications of cyclometalation reactions and five-membered ring products, synthetic applications, catalysts, and other products are described. These topics are of special interest for industrial researchers.
Cyclones in Southern Africa: Volume 1: Interfacing the Catastrophic Impact of Cyclone Idai with SDGs in Zimbabwe (Sustainable Development Goals Series)
by Godwell Nhamo David ChikodziThere is evidence that the world has been witnessing more intense tropical cyclones. Accompanying these tropical cyclones are heightened levels of devastation that witness the loss of human life and wildlife, destruction of natural resources and property and the disruption of major economic and social activities. To this end, there is a growing demand for publications focusing on tropical cyclones at various levels that include regional, national and local levels, especially from Africa. One sub-region that has been witnessing the harsh realities of the increasing intensity of tropical cyclones in southern Africa. However, within this region, countries are usually impacted at varying degrees of damage. Among the countries that usually encounter the harshness of these tropical cyclones are the Comoros, Botswana, Madagascar, Mauritius, Malawi, Mozambique, Reunion, the Seychelles, South Africa and Zimbabwe. From the history books, the following tropical cyclones made landfall and hit southern Africa: Eline (2000), Favio (2007), Dineo (2017), Idai (2019), Kenneth (2019), Eliose (2021), and Chalane (2020). Although all these tropical cyclones had negative impacts, it is undoubtedly Tropical Cyclone Idai that shocked the world with its devastation mainly in Mozambique, Malawi and Zimbabwe in March 2019. Key infrastructure was destroyed, livelihoods were lost, and the environment was degraded. Thousands of people died, many more were injured, many remain unaccounted for and others remained homeless as of the time of finalising this book in February 2021. This book, therefore focuses on the devastating impacts of Tropical Cyclone Idai in Zimbabwe. The book interfaces Tropical Cyclone Idai’s impacts with the 2030 Agenda for Sustainable Development and some of the 17 Sustainable Development Goals (SDGs). This linkage was deliberate given that there is still time remaining until 2030, and the world has generally agreed to move into the future along the pathways of sustainable development and sustainability. The book adds to the first comprehensive profiling of the impacts of tropical cyclones on southern African economies, particularly that of Zimbabwe. It also comes up as the first in a three-volume series. The other volumes to look out for are Cyclones in Southern Africa Vol 2: Foundational and Fundamental Topics; and Cyclones in Southern Africa Vol 3: Implications for the Sustainable Development Goals. To this end, this book is suitable as a read for several professionals and disciplines such as tourism and hospitality studies, economics, sustainable development, development studies, environmental sciences, arts, geography, life sciences, politics, planning and public health.
Cyclones in Southern Africa: Volume 2: Foundational and Fundamental Topics (Sustainable Development Goals Series)
by Godwell Nhamo Kaitano DubeThe subject of tropical cyclones in Southern Africa, also known as hurricanes or typhoons in other regions of the world, has been growing over the past few decades. However, there is still limited literature on foundational and fundamental topics on the matter. To this end, this book addresses this gap, citing some examples from both historic and recent tropical cyclones. The book presents meteorological and climatic aspects of tropical cyclones, including reviews on forecasting, warning message dissemination and public response aspects of early warning systems with a focus on the Tropical Cyclones Idai and Kenneth. Fundamentals in disaster risk reduction (DRR) are also discussed moving from the provisions of the Hyogo Framework for Action (2005–2015), to the Sendai Framework for Disaster Risk Reduction (2015–2030). Climate change issues are central to the publication, as well as the role of information and communication technologies in DRR and management. The book also tackles some challenges and opportunities associated with the implementation of regional legal and institutional frameworks on DRR. The book comes as part of a series with three volumes. The other volumes include “Cyclones in Southern Africa Vol. 1: Interfacing the Catastrophic Impact of Cyclone Idai with SDGs in Zimbabwe” and “Cyclones in Southern Africa Vol 3: Implications for the Sustainable Development Goals”. To this end, this book is suitable as a read for several professionals and disciplines such as tourism and hospitality studies, economics, sustainable development, development studies, environmental sciences, arts, geography, life sciences, politics, planning and public health.
Cyclones in Southern Africa: Volume 3: Implications for the Sustainable Development Goals (Sustainable Development Goals Series)
by Godwell Nhamo David ChikodziTropical cyclones in Southern Africa, also known as hurricanes or typhoons in other regions of the world, is a hot subject for academic research. This focus has been magnified by the need to consider tropical cyclones in the context of other global development agendas, that includes the 2030 Agenda for Sustainable Development and its inseparable 17 Sustainable Development Goals (SDGs), the Paris Agreement, the Sendai Framework for Disaster Risk Reduction and Habitat III’s New Urban Agenda. The ambitious SDGs challenge global and community leaders to make sure development addresses the nexus among poverty, inequality and employment creation, as well as care for the earth and its natural resources and biodiversity. The SDGs further present an agenda to eradicate hunger, bring quality education and sustain water and sanitation. The infrastructure development, human settlements, sustainable consumption and production, climate change, biodiversity and the ocean (blue) economy agendas are also pitched. Lastly, the 2030 Agenda for Sustainable Development encourages partnerships on delivering various programmes and projects at all spatial levels. However, as tropical cyclones continue to make multiple landfalls and ravage Southern Africa and other parts of the world, the achievement of the 2030 Agenda for Sustainable Development is threatened. To this end, this book addresses this gap by documenting the implications of tropical cyclones, drawing examples and case studies from recent tropical cyclones such as cyclone Idai and cyclone Kenneth that resulted in catastrophic impacts in 2019. The book comes as part of a series with three volumes. The other volumes include “Cyclones in Southern Africa Vol. 1: Interfacing the Catastrophic Impact of Cyclone Idai with SDGs in Zimbabwe” and “Cyclones in Southern Africa Vol 2: Foundational and Fundamental Topics”. Given the foregoing, the book is suitable as a read for several professionals and disciplines such as tourism and hospitality studies, economics, sustainable development, development studies, environmental sciences, arts, geography, life sciences, politics, planning and public health.
Cyclooxygenases: Methods and Protocols (Methods in Molecular Biology #644)
by Samir S. Ayoub Roderick J. Flower Michael SeedSince the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular BiologyTM series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.
Cyclopolymerization and Cyclocopolymerization
by George ButlerThis broadly-based work gathers the vast bulk of information published on cyclopolymerization since its discovery - including the symmetrical diene counterparts of all classical monomers that can undergo addition polymerization, all unsymmetrical dienes, and cyclopolymerizable monomers such as dialdehydes, diynes, diisocyanates, diepoxides, dinitriles, and some organometallic monomers.;Providing access to contemporary knowledge in the field and offering discussions of interest to a wide variety of polymer scientists, Cyclopolymerization and Cyclocopolymerization: delineates theory; summarizes polymerization procedures; furnishes theoretical justification for mechanistic proposals; details commercial applications; and describes new monomer syntheses. Supplying over 2700 references as well as chemical abstract citations, Cyclopolymerization and Cyclocopolymerization is a resource which should be of practical value to polymer, academic, theoretical and industrial chemists; chemical and plastics engineers; research and development directors in chemistry and chemical engineering programmes; and graduate-level students in these disciplines
Cyclopropanes in Organic Synthesis
by Oleg G. KulinkovichThis is a practical guidebook about cyclopropanes that thoroughly surveys derivatives and transformations, synthetic methods, and experimental efficiency as a gateway for further research and development in the field.* Provides comprehensive lists and synthetically-oriented synopses of cyclopropane chemistry review references along with publication data on applications in the syntheses of natural and related biologically active compounds* Acts as a resource to help readers better understand cyclopropane applications for the efficient realization of synthetically important organic transformations and popular experimental procedures* Includes new developments and up-to-date information that will lead to original methodologies for complex organic synthesis* Stresses universality, flexibility, and experimental efficiency of a strategy based on preparing cyclopropane derivatives and performing ring cleavage reactions with inexpensive reagents* Focuses on the synthetic potential of cyclopropane applications, for example the synthesis of natural compounds and other target-oriented syntheses via cyclopropane intermediaries, as well on their planning by retrosynthetic analysis
Cyclospora cayetanensis as a Foodborne Pathogen (SpringerBriefs in Food, Health, and Nutrition)
by Lucy J. Robertson Ynés R. OrtegaThis Brief provides a comprehensive overview of Cyclospora cayetanensis, a protozoan apicomplexan parasite that leads to outbreaks of traveler's diarrhea in consumers. The main characteristics of Cyclospora cayetanensis infection are covered, including documented outbreaks, regional patterns and statistics. Various transmission routes for this parasite are outlined, with a focus on foodborne transmission. A major focus of Cyclospora Cayetanensis As A Foodborne Pathogen is the detection of Cyclospora cayetanensis in different food matrices. Decontamination procedures for the occurrence of this parasite in all major food types are outlined in detail, as well as current risk assessment procedures and regulations. The difficulty in minimizing the risk of infection in fresh produce is covered, plus potential solutions for this problem. This Brief not only comprehensively covers the current state of foodborne Cyclospora cayetanensis but also looks to future challenges in the detection, prevention and removal of this parasite in foods.
Cyclostationarity: Theory And Methods (Lecture Notes in Mechanical Engineering #3)
by Antonio Napolitano Fakher Chaari Jacek Leśkow Andrea Sanchez-RamirezIn the last decade the research in signal analysis was dominated by models that encompass nonstationarity as an important feature. This book presents the results of a workshop held in Grodek--Poland in February 2013 which was dedicated to the investigation of cyclostationary signals. Its main objective is to highlight the strong interactions between theory and applications of cyclostationary signals with the use of modern statistical tools. An important application of cyclostationary signals is the analysis of mechanical signals generated by a vibrating mechanism. Cyclostationary models are very important to perform basic operations on signals in both time and frequency domains. One of the fundamental problems in diagnosis of rotating machine is the identification of significant modulating frequencies that contribute to the cyclostationary nature of the signals. The book shows that there are modern tools available for analyzing cyclostationary signals without the assumption of gaussianity. Those methods are based on the ideas of bootstrap, subsampling and Fraction-of-time (FOT) models. The book is organised in two parts. The first part will be dedicated to pure theory on cyclostationarity. Applications are presented in the second part including several mechanical systems such as bearings, gears, with or without damages.
Cylindrical Liner Z-pinches as Drivers for Converging Strong Shock Experiments (Springer Theses)
by Guy C. BurdiakThe thesis represents the development of an entirely new experimental platform for generating and studying converging radiative shock waves. It was discovered that the application of large magnetic pressures to gas-filled cylindrical metallic tubes could sequentially produce three shocks within the gas. A comprehensive set of instrumentation was devised to explore this system in detail and an exceptionally thorough experimental and theoretical study was carried out in order to understand the source of the shock waves and their dynamics. The research is directed towards some of the most interesting topics in high energy density physics (HEDP) today, namely the interaction of HED material with radiation and magnetic fields, with broad applications to inertial confinement fusion (ICF) and laboratory plasma astrophysics. The work has already generated significant international interest in these two distinct research areas and the results could have significant importance for magnetic ICF concepts being explored at Sandia National Laboratories in the US and for our understanding of the very strong shock waves that are ubiquitous in astrophysics.