- Table View
- List View
G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols
by Mark P. RunningRemarkably, while G protein-coupled receptors (GPCRs) are highly prevalent in animals and yeast, very few candidate GPCRs have been identified in plants. In G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols, experts in the field describe techniques used in the study of small GTPases and related proteins. Beginning with a chapter on bioinformatics approaches for GPCR discovery, this detailed volume continues with chapters on heterotrimeric G protein subunits, Rab-GTPases, as well as lipid modifications, including myristoylation, acylation, and prenylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and dependable, G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols aims to aid further studies into the roles of small GTPases which will help elucidate numerous key processes in plants.
G Protein-Coupled Receptors - Modeling and Simulation
by Marta FilizolaG protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.
G Protein-Coupled Receptors in Drug Discovery
by Kenneth H. Lundstrom Mark L. ChiuThe broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs
G Protein-Coupled Receptors in Drug Discovery
by Marta FilizolaThis detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets. --
G Protein-Coupled Receptors: Immobilization and Applications in Drug Discovery (SpringerBriefs in Molecular Science)
by Jing Wang Qian Li Xinfeng Zhao Qi Liang Jia QuanThis book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the “post-structural biology” era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.
G Protein-Coupled Receptors: Structure, Function, And Ligand Screening (Methods in Signal Transduction Series)
by Tatsuya Haga Gabriel BersteinCovering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction.G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the r
G Protein-Coupled Receptors: Structure, Function, and Ligand Screening
by Tatsuya Haga Shigeki TakedaThis book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.
G ProteinsTechniques of Analysis (Methods in Signal Transduction Series)
by David R. ManningIncorporating a bench-top format, G Proteins: Techniques of Analysis covers essential methods - with a commitment to those techniques of proven and current utility. It offers an in-depth description of protocols, together with theory and representative data. It includes expression and functional analysis of G proteins; evaluation of covalent modifications and other regulatory phenomena; and, mapping pathways established among receptors, G proteins, and effectors. Incorporating contributors from key institutions, each contributor offers clear instructions to establish a synthesized, concise and consistent approach to each chapter, which is beneficial to both students and professionals.
G-Quadruplex DNA
by Peter BaumannRecent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.
G-Quadruplex Nucleic Acids: Methods and Protocols (Methods in Molecular Biology #2035)
by Danzhou Yang Clement LinThis volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.
G. Evelyn Hutchinson and the Invention of Modern Ecology
by Nancy G. SlackStephen J. Gould declared G. Evelyn Hutchinson the most important ecologist of the twentieth century. E.O. Wilson pronounced him "one of the few scientists who could unabashedly be called a genius." In this fascinating book, Nancy G. Slack presents for the first time the full life story of this brilliant scientist who was also a master teacher, a polymath, and a delightful friend and correspondent. Based on full access to Hutchinson's archives and extensive interviews with him and many who knew him, the author evaluates his important contributions to modern ecology and his profound influence as a mentor. Filled with information available nowhere else, the book draws a vibrant portrait of an original scientific thinker who was also a man of remarkable personal appeal.
G. V. Schulz: Leben und Forschen eines Polymer-Pioniers im 20. Jahrhundert
by Sebastian SeiffertProf. Dr. Günther Viktor Schulz, ein bedeutender Wissenschaftler des 20. Jahrhunderts, prägte ganz wesentlich das Gebiet der Polymerchemie. Sein Leben und Wirken in den Wirren dieser Epoche war erfüllt von wissenschaftlichen Entdeckungen und schicksalhaften Begegnungen. Das vorliegende Werk stellt eine private Niederschrift seiner persönlichen Lebens- und Arbeitserinnerungen bereit.
GABA in Plants: Biosynthesis, Plant Development, and Food Security
by Samiksha Singh Vijay Pratap Singh Durgesh Kumar TripathiA comprehensive overview of the role played by GABA as a signaling molecule in plants In GABA in Plants: Biosynthesis, Plant Development, and Food Security, the editors deliver an expertly balanced discussion of the role played by GABA as a signaling molecule in plants, plant development, stress acclimation, as well as its potential impact on crop productivity under changing environmental conditions. From explorations of the discovery of GABA in plants to presentations of GABA biosynthesis pathways, GABA crosstalk with other metabolites, and GABA’s role in programmed cell death in plants, this book is an essential treatment of a four-carbon signaling molecule that may yet prove pivotal in sustaining crop production in the face of climate change. Readers will also find: A thorough introduction to GABA and its involvement in nodulation in and wounding stress in plants Comprehensive explorations of plant stress responses and tolerance mechanisms Practical discussions of GABA priming induced modulations in the redox homeostasis of plants under osmotic stress Complete treatments of GABA and heat, oxidative, cold, bacterial, mediated salt, and chilling stressors Perfect for students and scientists working in plant biology and physiology, crop protection, food security, nutrition, and biotechnology, GABA in Plants will also benefit professionals working in the agricultural, food, and pharmaceutical industries.
GABAB Receptor
by Giancarlo ColomboAn up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
GABAB Receptor (The Receptors)
by Giancarlo ColomboThis new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators.
GAPDH: Biological Properties and Diversity
by Norbert W. SeidlerThe book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein's involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.
GC-MS Guide to Ignitable Liquids
by Michael W. Gilbert Reta Newman Kevin LothridgeThe rapidly increasing number of different ignitable liquid formulations available today poses a new challenge to fire debris analysts and other forensic chemistry specialists - that of accurately identifying and classifying ignitable liquids with unfamiliar chromatographic patterns. GC-MS Guide to Ignitable Liquids addresses that challenge with a selection of more than 100 different ignitable liquid formulations designed to supplement the laboratory's standard collection. Both total ion chromatograms and extracted ion chromatograms (mass chromatograms) are included. Written by authors who are also experienced forensic chemists, this complete reference is the only single source of information on ignitable liquids - a must for students of fire science, forensic chemists, and anyone conducting fire debris analysis.
GC/MS
by Marvin McmasterUpdated and expanded, the classic guide to GC/MS helps chromatographers quickly learn to use this technique for analyzing and identifying compounds. After explaining the fundamentals, it discusses optimizing, tuning, using, and maintaining GC/MS equipment; explores advances in miniaturized and field-portable GC/MS systems and microfluidic components; and more. Complete with a CD-ROM, it covers applications in the environmental laboratory and in forensics, toxicology, and space science. This is the premier resource for professionals in those fields and for students.
GCSE Science Single Award for CCEA: Foundation and Higher Tier Revision Book
by James NapierHelp your students perfect their understanding and prepare for examinations with accessible science content presented at the right level. An accessible Revision Guide that completely covers the most recent specification with up-to-date revision questions. Written by best-selling authors with substantial examining experience at both Foundation and Higher level for CCEA. - Ensures students' understanding with clear worked examples and content written at the correct level - Provides practice for assessment with lots of Revision Questions - Enables students to improve their grade with helpful exam tips that covers key terminology and guidance on preparing for assessment - Helps students to practise and remember key terms with a full Glossary
GCSE Test Prep Flash Cards: Biology Essentials (Exambusters GCSE Workbook #2)
by Ace Inc.<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 450 questions and answers. Essential definitions and concepts. <P><P>Topics: Cells, Biochemistry and Energy, Evolution and Classification, Kingdoms: Bacteria, Fungi, Protista; Kingdom: Plantae, Kingdom: Animalia, Human Locomotion, Human Circulation and Immunology, Human Respiration and Excretion, Human Digestion, Human Nervous System, Human Endocrinology, Reproduction and Development, Genetics, Ecology <P> Exambusters GCSE Prep Workbooks provide comprehensive GCSE review--one fact at a time--to prepare students to take practice GCSE tests. Each GCSE study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the GCSE exam. Up to 600 questions and answers, each volume in the GCSE series is a quick and easy, focused read. Reviewing GCSE flash cards is the first step toward more confident GCSE preparation and ultimately, higher GCSE exam scores!
GCSE Test Prep Flash Cards: Chemistry (Exambusters GCSE Workbook #3)
by Ace Inc.<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 700 questions and answers. Essential definitions, formulas, concepts, and sample problems. <P><P>Topics: Introduction, Matter, Atoms, Formulas, Moles, Reactions, Elements, Periodic Table, Electrons, Chemical Bonds, Heat, Gases, Phase Changes, Solutions, Reaction Rates, Equilibrium, Acids and Bases, Oxidation and Reduction, Introduction to Organic Chemistry, Radioactivity <P> Exambusters GCSE Prep Workbooks provide comprehensive GCSE review--one fact at a time--to prepare students to take practice GCSE tests. Each GCSE study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the GCSE exam. Up to 600 questions and answers, each volume in the GCSE series is a quick and easy, focused read. Reviewing GCSE flash cards is the first step toward more confident GCSE preparation and ultimately, higher GCSE exam scores!
GCSE Test Prep Flash Cards: Geology (Exambusters GCSE Workbook #1)
by Ace Inc.<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 600 questions and answers. Essential definitions and concepts.<P><P> Topics: Calculations, Earth's Origin, Save Our Planet, Minerals, Rocks, Weathering, Groundwater, Running Water, Glaciers, The Changing Crust, The Oceans, Maps, The Atmosphere, Wind, Weather Patterns, Introduction to Astronomy <P> Exambusters GCSE Prep Workbooks provide comprehensive GCSE review--one fact at a time--to prepare students to take practice GCSE tests. Each GCSE study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the GCSE exam. Up to 600 questions and answers, each volume in the GCSE series is a quick and easy, focused read. Reviewing GCSE flash cards is the first step toward more confident GCSE preparation and ultimately, higher GCSE exam scores!
GCSE Test Prep Flash Cards: Physics (Exambusters GCSE Workbook #4)
by Ace Inc.<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 600 questions and answers. Essential definitions, formulas, concepts, and sample problems. <P><P>Topics: Measurement, Motion and Forces, Work and Energy, Heat and Gases, Atoms, Fluids, Sound, Light and Optics, DC Circuits, Magnetism, AC Circuits <P> Exambusters GCSE Prep Workbooks provide comprehensive GCSE review--one fact at a time--to prepare students to take practice GCSE tests. Each GCSE study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the GCSE exam. Up to 600 questions and answers, each volume in the GCSE series is a quick and easy, focused read. Reviewing GCSE flash cards is the first step toward more confident GCSE preparation and ultimately, higher GCSE exam scores!
GED Test Prep Flash Cards: Biology (Exambusters GED Workbook #2 of 13)
by Ace Inc.<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 450 questions. Topics: Cells, Biochemistry and Energy, Evolution, Kingdoms: Monera, Fungi, Protista, Plants, Animals; Human: Locomotion, Circulation, Immunology, Respiration, Excretion, Digestion, Nervous System <P><P> "EXAMBUSTERS GED Prep Workbooks" provide comprehensive, fundamental GED review--one fact at a time--to prepare students to take practice GED tests. Each GED study guide focuses on one specific subject area covered on the GED exam. From 300 to 600 questions and answers, each volume in the GED series is a quick and easy, focused read. Reviewing GED flash cards is the first step toward more confident GED preparation and ultimately, higher GED exam scores!
GED Test Prep Flash Cards: Chemistry (Exambusters GED Workbook #3 of 13)
by Ace Inc.<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 700 questions. Essential chemistry formulas and concepts. Topics: Metric System, Matter, Atoms, Formulas, Moles, Reactions, Elements, Chemical Bonds, Phase Changes, Solutions, Reaction Rates, Acids and Bases, Oxidation and Reduction, Introduction to Organic <P><P> "EXAMBUSTERS GED Prep Workbooks" provide comprehensive, fundamental GED review--one fact at a time--to prepare students to take practice GED tests. Each GED study guide focuses on one specific subject area covered on the GED exam. From 300 to 600 questions and answers, each volume in the GED series is a quick and easy, focused read. Reviewing GED flash cards is the first step toward more confident GED preparation and ultimately, higher GED exam scores!