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Genesis: The Ultimate Origin Story
by Guido TonelliWhat if the ancient Greeks were right, and the universe really did spring into being out of chaos and the void? How could we know? And what must its first moments have been like?To answer these questions, scientists are delving into all the hidden crevices of creation. Armed with giant telescopes and powerful particle accelerators, they probe the subtle mechanisms by which our familiar world came to be, and try to foretell the manner in which it will end.The result of all this collective effort is a complex story, stranger at times than even our most ancient creation myths. But its building blocks give us the power to work marvels our predecessors could scarcely comprehend. In Genesis, the CERN physicist and bestselling author Guido Tonelli sets out to do justice to that great story.
Genetic Algorithms and Machine Learning for Programmers
by Frances BuontempoSelf-driving cars, natural language recognition, and online recommendation engines are all possible thanks to Machine Learning. Now you can create your own genetic algorithms, nature-inspired swarms, Monte Carlo simulations, cellular automata, and clusters. Learn how to test your ML code and dive into even more advanced topics. If you are a beginner-to-intermediate programmer keen to understand machine learning, this book is for you. Discover machine learning algorithms using a handful of self-contained recipes. Build a repertoire of algorithms, discovering terms and approaches that apply generally. Bake intelligence into your algorithms, guiding them to discover good solutions to problems. In this book, you will: Use heuristics and design fitness functions.Build genetic algorithms.Make nature-inspired swarms with ants, bees and particles.Create Monte Carlo simulations.Investigate cellular automata.Find minima and maxima, using hill climbing and simulated annealing.Try selection methods, including tournament and roulette wheels.Learn about heuristics, fitness functions, metrics, and clusters. Test your code and get inspired to try new problems. Work through scenarios to code your way out of a paper bag; an important skill for any competent programmer. See how the algorithms explore and learn by creating visualizations of each problem. Get inspired to design your own machine learning projects and become familiar with the jargon. What You Need: Code in C++ (>= C++11), Python (2.x or 3.x) and JavaScript (using the HTML5 canvas). Also uses matplotlib and some open source libraries, including SFML, Catch and Cosmic-Ray. These plotting and testing libraries are not required but their use will give you a fuller experience. Armed with just a text editor and compiler/interpreter for your language of choice you can still code along from the general algorithm descriptions.
Genetic Analyses of Wheat and Molecular Marker-Assisted Breeding, Volume 1
by Chun Li Jichun Tian Zhiying Deng Kunpu Zhang Haixia Yu Xiaoling JiangThe book mainly describes the QTL mappings and efficacy analyses that are associated with wheat productivity, quality, physiology and various stress resistances and provides summaries of results from studies conducted both at home and abroad. It presents comparable data and analyses, helping readers to arrive at a more comprehensive understanding of the latest development in this field. The book provides a wealth of novel information, broad range of applications and in-depth findings on crop genetics and molecular breeding, making it valuable not only for plant breeders but also for academic faculties, senior researchers and advanced graduate students who are involved in plant breeding and genetics. Dr. Jichun Tian is a professor at the Department of Agronomy, Shandong Agricultural University, Tai'an, China.
Genetic Analyses of Wheat and Molecular Marker-Assisted Breeding, Volume 2
by Yong Zhao Peng Wu Jichun Tian Jiansheng Chen Guangfeng Chen Han ZhangWhile focusing on various interactions between trait genes/QTL and dynamic expressions of conditional QTL genes, this book also discusses aspects of molecular marker-assisted breeding, and applications of molecular markers associated with yield, quality, physiology and disease resistance in wheat. It covers QTL studies in wheat breeding and presents the available information on wheat MAS breeding. This volume provides a wealth of novel information, a wide range of applications and deep insights into crop genetics and molecular breeding, which is valuable not only for plant breeders but also for academic faculties, senior researchers and advanced graduate students who are involved in plant breeding and genetics. Dr. Jichun Tian is a professor at the Department of Agronomy, Shandong Agricultural University, Tai'an, China.
Genetic Analyses of Wheat and Molecular Marker-Assisted Breeding, Volume 2: Conditional QTL Analysis and MAS
by Yong Zhao Peng Wu Jichun Tian Jiansheng Chen Guangfeng Chen Han ZhangWhile focusing on various interactions between trait genes/QTL and dynamic expressions of conditional QTL genes, this book also discusses aspects of molecular marker-assisted breeding, and applications of molecular markers associated with yield, quality, physiology and disease resistance in wheat. It covers QTL studies in wheat breeding and presents the available information on wheat MAS breeding. This volume provides a wealth of novel information, a wide range of applications and deep insights into crop genetics and molecular breeding, which is valuable not only for plant breeders but also for academic faculties, senior researchers and advanced graduate students who are involved in plant breeding and genetics. Dr. Jichun Tian is a professor at the Department of Agronomy, Shandong Agricultural University, Tai’an, China.
Genetic Analysis of Complex Disease
by William K. Scott Marylyn D. RitchieGenetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
Genetic Association Studies: Background, Conduct, Analysis, Interpretation
by Mehmet Tevfik DorakGenetic Association Studies is designed for students of public health, epidemiology, and the health sciecnes, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.
Genetic Causes of Cardiac Disease (Cardiac and Vascular Biology #7)
by Jeanette Erdmann Alessandra MorettiThis book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives. The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists.
Genetic Counseling Practice
by Bonnie S. Leroy Patricia M. Veach Dianne M. BartelsThe first advanced-level genetics counseling skills resourceAs genetic medicine and testing continue to expand, so the role of the genetic counselor is transforming and evolving. Genetic Counseling Practice: Advanced Concepts and Skills is the first text to address ways that genetic counselors can deepen their skills to meet expanding practice demands. This timely resource not only helps readers further develop their abilities to gather relevant data and interpret it for patients, it also aids them in surpassing their usual role by truly understanding patient situations, incorporating patient values into clinical practice, providing in-depth support, and facilitating thoroughly informed, autonomous decisions.Edited by an expert cross-disciplinary team consisting of a genetic counseling program director, a licensed psychologist, and a nurse/bioethicist/family social scientist, this authoritative reference provides specific and detailed instruction in addressing psychosocial aspects of genetic counseling practice and professional development and training issues of genetic counselors.Provides a process view of genetic counselor service provision; i.e., skills that promote desired genetic counseling outcomes are emphasized (such as relationship skills, patient characteristics, client behaviors, and extra-clinical skills)Includes experiential activities in every chapter to help readers apply concepts and skillsDraws on the experience of widely recognized experts in genetic counseling theory, practice, and research, who serve as chapter authorsFeatures numerous specific, real-life examples from clinical practiceGenetic Counseling Practice addresses issues relevant to practicing genetic counselors as well as students of genetic counseling programs. In addition, oncology nurses, social workers, and psychologists working with genetic counseling patients and families; medical geneticists and physicians training in the field; and physician assistants will also benefit from this resource.
Genetic Crossroads: The Middle East and the Science of Human Heredity
by Elise K. BurtonThe Middle East plays a major role in the history of genetic science. Early in the twentieth century, technological breakthroughs in human genetics coincided with the birth of modern Middle Eastern nation-states, who proclaimed that the region's ancient history—as a cradle of civilizations and crossroads of humankind—was preserved in the bones and blood of their citizens. Using letters and publications from the 1920s to the present, Elise K. Burton follows the field expeditions and hospital surveys that scrutinized the bodies of tribal nomads and religious minorities. These studies, geneticists claim, not only detect the living descendants of biblical civilizations but also reveal the deeper past of human evolution. Genetic Crossroads is an unprecedented history of human genetics in the Middle East, from its roots in colonial anthropology and medicine to recent genome sequencing projects. It illuminates how scientists from Turkey to Yemen, Egypt to Iran, transformed genetic data into territorial claims and national origin myths. Burton shows why such nationalist appropriations of genetics are not local or temporary aberrations, but rather the enduring foundations of international scientific interest in Middle Eastern populations to this day.
Genetic Data Analysis for Plant and Animal Breeding
by James Holland Fikret Isik Christian MalteccaThis book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this book is composed of two sections. The first section (Chapters 1 to 8) covers topics of classical phenotypic data analysis for prediction of breeding values in animal and plant breeding programs. In the second section (Chapters 9 to 13) we provide the concept and overall review of available tools for using DNA markers for predictions of genetic merits in breeding populations. With advances in DNA sequencing technologies, genomic data, especially single nucleotide polymorphism (SNP) markers, have become available for animal and plant breeding programs in recent years. Analysis of DNA markers for prediction of genetic merit is a relatively new and active research area. The algorithms and software to implement these algorithms are changing rapidly. This section represents state-of-the-art knowledge on the tools and technologies available for genetic analysis of plants and animals. However, readers should be aware that the methods or statistical packages covered here may not be available or they might be out of date in a few years. Ultimately the book is intended for professional breeders interested in utilizing these tools and approaches in their breeding programs. Lastly, we anticipate the usage of this volume for advanced level graduate courses in agricultural and breeding courses.
Genetic Design Automation: A Practical Approach for the Analysis, Verification and Synthesis of Genetic Logic Circuits
by Jan Madsen Hasan BaigThis textbook introduces readers to the recent advances in the emerging field of genetic design automation (GDA). Starting with an introduction and the basic concepts of molecular biology, the authors provide an overview of various genetic design automation tools. The authors then present the DVASim tool (Dynamic Virtual Analyzer and Simulator) which is used for the analysis and verification of genetic logic circuits. This includes methods and algorithms for the timing and threshold value analyses of genetic logic circuits. Next, the book presents the GeneTech tool (A technology mapping tool for genetic circuits) and the methods developed for optimization, synthesis, and technology mapping of genetic circuits. Chapters are followed by exercises which give readers hands-on practice with the tools presented. The concepts and algorithms are thoroughly described, enabling readers to improve the tools or use them as a starting point to develop new tools. Both DVASim and GeneTech are available from the developer’s website, free of charge. This book is intended for a multidisciplinary audience of computer scientists, engineers and biologists. It provides enough background knowledge for computer scientists and engineers, who usually do not have any background in biology but are interested to get involved in this domain. This book not only presents an accessible basic introduction to molecular biology, it also includes software tools which allow users to perform laboratory experiments in a virtual in-silico environment. This helps newbies to get a quick start in understanding and developing genetic design automation tools. The third part of this book is particular useful for biologists who usually find it difficult to grasp programming and are reluctant to developing computer software. They are introduced to the graphical programming language, LabVIEW, from which they can start developing computer programs rapidly. Readers are further provided with small projects which will help them to start developing GDA tools.
Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment
by Aubrey MilunskyGenetic Disorders and the Fetus: Diagnosis, Prevention and Treatment, Eighth Edition is the eagerly awaited new edition of the discipline-leading work that has been at the forefront of diagnosis, prevention, and treatment of fetal genetic disorders for over 36 years. This timely update builds on the foundations of preconception and prenatal genetic counseling and the original pillars of prenatal diagnosis while also providing authoritative coverage of exciting developments in non-invasive genetic testing and rapidly developing molecular techniques. Chapters are once again authored by internationally recognized authorities in the field of prenatal diagnosis. The editors have brought together an invaluable collection of evidence-based facts bolstered by knowledge and decades of experience in the field.
Genetic Diversity and Erosion in Plants
by M. R. Ahuja S. Mohan JainGenetic erosion is the loss of genetic diversity within a species. It can happen very quickly, due to catastrophic events, or changes in land use leading to habitat loss. But it can also occur more gradually and remain unnoticed for a long time. One of the main causes of genetic erosion is the replacement of local varieties by modern varieties. Other causes include environmental degradation, urbanization, and land clearing through deforestation and brush fires. In order to conserve biodiversity in plants, it is important to targets three independent levels that include ecosystems, species and genes. Genetic diversity is important to a species' fitness, long-term viability, and ability to adapt to changing environmental conditions. Chapters in this book are written by leading geneticists, molecular biologists and other specialists on relevant topics on genetic erosion and conservation genetic diversity in plants. This divisible set of two volumes deals with a broad spectrum of topics on genetic erosion, and approaches to biodiversity conservation in crop plants and trees. Volume 1 deals with indicators and prevention of genetic erosion, while volume 2 covers genetic diversity and erosion in a number of plants species. These two volumes will also be useful to botanists, biotechnologists, environmentalists, policy makers, conservationists, and NGOs working to manage genetic erosion and biodiversity.
Genetic Diversity and Erosion in Plants
by M. R. Ahuja S. Mohan JainGenetic erosion is the loss of genetic diversity within a species. It can happen very quickly, due to catastrophic events, or changes in land use leading to habitat loss. But it can also occur more gradually and remain unnoticed for a long time. One of the main causes of genetic erosion is the replacement of local varieties by modern varieties. Other causes include environmental degradation, urbanization, and land clearing through deforestation and brush fires. In order to conserve biodiversity in plants, it is important to targets three independent levels that include ecosystems, species and genes. Genetic diversity is important to a species' fitness, long-term viability, and ability to adapt to changing environmental conditions. Chapters in this book are written by leading geneticists, molecular biologists and other specialists on relevant topics on genetic erosion and conservation genetic diversity in plants. This divisible set of two volumes deals with a broad spectrum of topics on genetic erosion, and approaches to biodiversity conservation in crop plants and trees. Volume 1 deals with indicators and prevention of genetic erosion, while volume 2 covers genetic diversity and erosion in a number of plants species. These two volumes will also be useful to botanists, biotechnologists, environmentalists, policy makers, conservationists, and NGOs working to manage genetic erosion and biodiversity.
Genetic Diversity and Human Behavior
by J.N. SpuhlerGenetic differences in humans, like those between individuals of any animal or plant species and those between species, are all products of the evolutionary development of the living world. These differences, with their behavioral consequences, can only be understood in the light of evolution. Our understanding of evolution, however, has itself evolved. The Darwin- Wallace theory of evolution appeared in the nineteenth century. Since then, development of evolutionary thought has gone through several stages. The contributions in this volume describe those stages.
Genetic Diversity in Horticultural Plants (Sustainable Development and Biodiversity #22)
by Dilip NandwaniThis book in the series “Sustainable Development and Biodiversity” contains peer-reviewed chapters from leading academicians and researchers around the world in the field of horticulture, plant taxonomy, plant biotechnology, genetics and related areas of biodiversity science centered on genetic diversity. This book includes original research reviews (national, regional and global) and case studies in genetic diversity in fruits and vegetables, horticulture, and ecology from sub-tropical and tropical regions.It is unique as it covers a wide array of topics covering global interests and will constitute valuable reference material for students, researchers, extension specialists, farmers and certification agencies who are concerned with biodiversity, ecology and sustainable development.
Genetic Diversity of Fruits and Nuts: Sustainable Utilization
by Hosakatte Niranjana MurthyGenetic Diversity of Fruits and Nuts: Sustainable Utilization presents an account of the diversity and possible exploitation of such variability in the improvement of varied fruits and nuts of the world. Expert authors in the field have addressed the significance of fruit and nut crops’ genetic variability for their sustainable exploitation to develop new cultivars that can cater to growers' needs, adapt to climate change, and address the rising need for food.
Genetic Engineering (Let's Relate to Genetics #4)
by Marina CohenDiscusses current and potential uses of genetic engineering in fields such as medicine, criminal investigation, and agriculture and examines some of the ethical questions involved. <P><P>Lexile Measure: 840L
Genetic Engineering Fundamentals: An Introduction to Principles and Applications
by John KammermeyerThis important reference/text provides technologists with the basic informationnecessary to interact scientifically with molecular biologists and get involved in scalinguplaboratory procedures and designing and constructing commercial plants.Requiring no previous training or experience in biology, Genetic EngineeringFundamentals explains the biological and chemical principles of recombinant DNAtechnology ... emphasizes techniques used to isolate and clone specific genes frombacteria, plants, and animals, and methods of scaling-up the formation of the geneproduct for commercial applications ... analyzes problems encountered in scaling-upthe microprocessing of biochemical procedures . .. includes an extensive glossary andnumerous illustrations ... identifies other resource materials in the field ... and more.Presenting the fundamentals of biochemistry and molecular biology to workers andstudents in other fields, this state-of-the-art reference/text is essentiai reading fortechnologists in chemistry and engineering; biomedical, chemical, electrical andelectronics, industrial, mechanical, manufacturing, design, plant, control, civil, genetic,and environmental engineers; chemists, botanists, and zoologists; and advancedundergraduate and graduate courses in engineering, biotechnology, and industrialmicrobiology.
Genetic Engineering and Biotechnology: Concepts, Methods and Agronomic Applications
by Yves TourteIntroductory text for students of genetics is general and the students of agronomy as the book gives numerous agronomic applications.
Genetic Engineering of Crop Plants for Food and Health Security: Volume 1
by Siddharth Tiwari Bhupendra KoulThis edited book support Sustainable Development Goal 2 (SDG 2): Zero Hunger. This book summarizes the contribution of genetic engineering for sustainable crop improvement toward global food and health security, climate resilience and economic growth. The book acts as a compendium of research reports on recent developments in the arena of cisgenics or transgenics or genome editing of crop plants for tolerance to biotic or abiotic stresses, introgression of value-added traits, molecular pharming etc. Sustainable crop productivity, yield and nutrition are the major constrain for food and nutritional security for the human population especially, in developing countries where arable land per capita is shrinking while the human population is steadily increasing. Zero hunger and achieving food security is the top priority of the United Nations development goals. This book explains various methods of genetic transformation such as transgenic, cisgenic, and genome editing for crop improvement. It also encompasses the advantages of genetic engineering in plants and their scope for sustainable crop improvement. The importance, limitations, challenges, GM biosafety regulations, recent advancements and future prospects of GM crops are covered in various chapters. This book is of interest to teachers, researchers, plant tissue culturists, GM crop experts, research scholars, academicians, plant breeders, policymakers etc. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists and policymakers will also find this to be a useful read.
Genetic Engineering of Crop Plants for Food and Health Security: Volume 2
by Siddharth Tiwari Bhupendra KoulThis edited volume presents recent advancements in genetic transformation and genome editing, offering a comprehensive understanding of their applications for creating more sustainable crops. These innovations are revolutionizing crop development, enhancing yields, and mitigating environmental challenges.The demand for sustainable crop production, driven by a growing global population and mounting environmental challenges, has never been more pressing. Genetic transformation and genome editing techniques offer precise and targeted ways to enhance crop traits, increase yields, and reduce the need for chemical inputs. The book traces the evolution of these technologies, from the early days of genetic modification to the current era of CRISPR-based genome editing. It covers cutting-edge technologies, from CRISPR-Cas9 to advanced gene editing techniques, while discussing the current scenario and future prospects of GM crops developed either by transgenic or genome editing approaches. The book explores the ethical and regulatory aspects surrounding genetic transformation, providing a complete perspective on this evolving domain.It is an essential read for researchers, students, and professionals in the fields of agriculture, plant sciences, biotechnology, agronomy, as well as policymakers.
Genetic Engineering of Plants for Crop Improvement
by Rup LalGenetic Engineering of Plants for Crop Improvement discusses current genetic engineering methods for plants and addresses the commercial opportunities for transgenic plants. Topics covered include Agrobacterium-mediated transformations, the use of electroporation, PEG-mediated transformation, microinjection, the microprojectile bombardment method, and the electrical discharge particle acceleration method. A concise account of the resistance of transgenic plants to insect attack, viral infection, and herbicides has also been provided. Possibilities for genetic manipulation for proteins that have superior nutritional properties are discussed, and a brief account of tests confirming the safety and commercial validity of transgenic plants is included. A valuable source of information for researchers and students in plant biotechnology, plant gene manipulation, molecular biology, and all areas of the life sciences.
Genetic Engineering of Vegetable Crops (CABI Biotechnology Series)
by Pritam KaliaConventional plant breeding alone can no longer sustain the rising global demand for food. Genetic engineering technology makes it possible to develop new crop varieties with improved yield performance, specific quality attributes (external and internal in vegetable crops), resistance to diseases and insect pests, and environmental stresses. Genetic engineering technology for developing GM crops is complementary to genome editing and other breeding technologies. In addition to food requirements, transgenic crops have the possibility to carry edible vaccines and therapeutic proteins, to help combat human disease and malnutrition. This book reviews the importance and safety of transgenic vegetable crops and covers a wide variety of crops and different technologies. It includes: Genetic engineering in tomato, eggplant, peppers, amaranth, cauliflower, carrot, cucurbits, potato, tropical tubers and melons. Transgenic resistance to viral diseases. Embryogenic cell suspension culture. Genome editing and CRISPR/Cas9. Molecular techniques for biofortification. RNAi strategies for vegetable crop improvement. Designing futuristic vegetable crop varieties. This book is suitable for researchers in horticulture, plant science, and agricultural biotechnology as well as practitioners in vegetable breeding and seed production.