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The Clockwork Universe is the story of a band of men who lived in a world of dirt and disease but pictured a universe that ran like a perfect machine. A meld of history and science, this book is a group portrait of some of the greatest minds who ever lived as they wrestled with nature's most sweeping mysteries. The answers they uncovered still hold the key to how we understand the world. At the end of the seventeenth century--an age of religious wars, plague, and the Great Fire of London--when most people saw the world as falling apart, these earliest scientists saw a world of perfect order. They declared that, chaotic as it looked, the universe was in fact as intricate and perfectly regulated as a clock. This was the tail end of Shakespeare's century, when the natural and the supernatural still twined around each other. Disease was a punishment ordained by God, astronomy had not yet broken free from astrology, and the sky was filled with omens. It was a time when little was known and everything was new. These brilliant, ambitious, curious men believed in angels, alchemy, and the devil, and they also believed that the universe followed precise, mathematical laws-a contradiction that tormented them and changed the course of history. The Clockwork Universe is the fascinating and compelling story of the bewildered geniuses of the Royal Society, the men who made the modern world.
The birth of Dolly -- the world's first clone -- placed in our hands the secret of creation. Few discoveries have so altered our notion of what it means to be human, or presented such a Gordian knot of ethical, spiritual, and scientific questions. Noted science journalist Gina Kolata broke the news nationally in The New York Times and was the first reporter to speak with Dr. Ian Wilmut, the embryologist who cloned Dolly. Now Kolata reveals the story behind Dolly, interweaving the social and cultural tales of our fear and fascination with cloning, reaching back nearly a century, with the riveting scientific accountof how a clone came to be and the mind-boggling questions Dolly presents for our future.Clone is a compelling blend of scientific suspense, dreams dashed, and frauds exposed, with provocative philosophical questions and an astute assessment of why Dolly's birth was only possible now. Like The Making of the Atomic Bomb, Lucy, and Chaos, this book gives us a window on history in the making, and an understanding of its profound effect on our lives.
The Cyborg Wars are over and Earth has peacefully prospered for more than one hundred years. Yet sometimes history must repeat itself until humanity learns from its mistakes. In the year 2170, cyborgs and clones are treated no better than slaves, and an underground abolitionist movement is fighting for freedom. Thirteen-year-old Leanna's entire life is thrown into chaos when the World Federation discovers her mom is part of the radical Liberty Bell Movement. As startling family secrets are revealed, Leanna must face truths about self-identity and freedom. Through time travel, advanced technologies, and artificial intelligence, this exhilarating adventure asks what it means to be human and explores the sacrifices an entire society will make to find out.
Corgan now lives on the tropical Isle of Hiva, his reward for winning the Virtual War with his genetically altered teammates Sharla and Brig. Sharla visits him and tells him Brig died--but she has created clone-twins with Brig's DNA. Sharla and Corgan discover that while the clones look identical and are growing at a terrifying rate, they couldn't be more different in temperament.
Aliens join in the fun in this fourth book of The Clone Chronicles, a series that "strikes just the right balance between over-the-top adventure and real-life middle school drama," mixing Alex Rider, Diary of a Wimpy Kid, and Michael Buckley's NERD series to create an "action-packed success." Fisher, Two, Amanda, and Veronica are happy to spend their holiday break at Fisher's parents' new amusement park. But when aliens crash-land on Fisher's favorite roller coaster, mistaking it for their home planet, it spells the end of R&R for our heroes. Meet the Gemini: not only are all the aliens identical twins, they're also all beautiful girls. If Fisher and Two already thought girls were hard to understand, wait until they meet alien girls. Now Fisher, Two, Amanda, and Veronica must convince the aliens that Earth is the worst place ever and help them fix their ship. The crew decides the best way to encourage the Gemini girls to vacate the stratosphere is to give them a taste of middle school. And Wompalog Middle School tastes pretty disgusting. But Fisher and his crew learn quickly that the Geminis are not to be messed with, not when they might literally explode at any moment. That's right, the Geminis are like puberty times one million. They can seem sweet as pie, but when they turn on you, they're deadly.
Fisher Bas and Two were able to thwart the evil Dr. X, but after somehow surviving the explosion at TechX Enterprises, Two is in Hollywood looking for his "mother." Fisher must bring him back to Palo Alto before his cloning secret is discovered. When a class field trip to see the Dr. Devilish science show arises, it becomes the perfect opportunity for Fisher to find his clone. But all kinds of complications will get in the way--including Amanda Cantrell, who knows more than Fisher would like about Two's identity. As Fisher, FP, and Amanda team up to find Two, they find trouble, high jinx, and the return of an evil mastermind--all set in the glitz of Hollywood.
Should we clone extinct or endangered species? Are we justified in using stem cells to develop cures? When will we clone the first human? Ever since Dolly the sheep, questions like these have rarely been far from the public consciousness, and cloning is now poised to revolutionize medicine, healthcare, and even the food we eat. Aaron Levine offers a masterful and accessible introduction to the science and development of cloning, right up to the present-day scandals surrounding attempts to clone humans. Guiding readers around the thorny political and ethical issues raised by such progress, Levine dispels the myths perpetuated by the media and sheds new light on the pros and cons of this fascinating and controversial topic. Aaron Levine is currently conducting research on the impact of public policy on biomedical research at the Woodrow Wilson School of Public and International Affairs, Princeton University.
Would you drink milk from a cloned cow? Should we clone extinct or endangered species? Are we justified in using stem cells to develop cures? When will we clone the first human? Ever since Dolly the sheep, such questions have rarely been far from the public consciousness. Aaron Levine explains the science of cloning and guides readers around the thorny political and ethical issues that have developed.
When the members of the Crime Scene Club visit Los Angeles, they become involved in an investigation into what appears to be the accidental death of a surfer. Includes bibliographical references and index.
Closed-form Solutions for Drug Transport through Controlled-Release Devices in Two and Three Dimensionsby Laurent Simon Juan Ospina
Provides solutions for two- and three-dimensional linear models of controlled-release systems Real-world applications are taken from used to help illustrate the methods in Cartesian, cylindrical and spherical coordinate systems Covers the modeling of drug-delivery systems and provides mathematical tools to evaluate and build controlled-release devices Includes classical and analytical techniques to solve boundary-value problems involving two- and three-dimensional partial differential equations Provides detailed examples, case studies and step-by-step analytical solutions to relevant problems using popular computational software
This volume analyses the evolution of humankind by combining approaches from science and the arts. It offers a novel perspective on the evolution of life on Earth, based on a recent reformulation of the second law of thermodynamics in terms of the "maximum entropy production principle. " In essence, the Earth is but one of many "white holes" in the universe, where life functions as a specific arrangement for the rapid dissipation of energy gradients by generating self-organized structures. Evolution of life in the universe is a creative process of increasing complexity as a Bayesian ratchet of knowledge accumulation, advancing in an evolutionary maze characterized by myriad blind alleys. On Earth, the human species has progressed more than any other by creating artefacts that have become both agents and products of in our cumulative cultural evolution. Culture has dramatically enhanced the rate of dissipation of energy gradients. Extrapolating from the acceleration of cultural evolution suggests that humanity will reach the Civilization Singularity in the middle of the 21st century, a point in time at which the rate of changes, and hence their unpredictability and uncontrollability, will converge to infinity. Humankind has now entered the ultimate age, in which the exuberance and splendour of human feats may be metaphorically likened to fireworks. The author highlights a new role of scientists as intellectuals who can create "music for the fireworks" by analysing the consequences of the astounding dynamics in order to make the closing phase of human evolution a sublime one marked by minimal political and social tensions.
Energy efficiency plays and will continue to play an important role in the world to save energy and mitigate greenhouse gas (GHG) emissions. However, little is known on how much additional capital should be invested to ensure using energy efficiently as it should be, and very little is known which sub-areas, technologies, and countries shall achieve maximum greenhouse gas emissions mitigation per dollar of investment in energy efficiency worldwide. Analyzing completed and slowly moving energy efficiency projects by the Global Environment Facility during 1991-2010, Closing the Gap: GEF Experiences in Global Energy Efficiency evaluates impacts of multi-billion-dollar investments in the world energy efficiency. It covers the following areas: 1. Reviewing the world energy efficiency investment and disclosing the global energy efficiency gap and market barriers that cause the gap; 2. Leveraging private funds with public funds and other resources in energy efficiency investments; using these funds in tangible and intangible asset investments; 3. Investment effectiveness in dollars per metric ton of CO2 emissions mitigation in 10 energy efficiency sub-areas; 4. Major barriers causing failure and abandonments in energy efficiency investments; 5. Quantification of direct and indirect CO2 emissions mitigations inside and outside a project boundary; and 6. Classification and estimation of CO2 emissions mitigations from tangible and intangible asset investments. Closing the Gap: GEF Experiences in Global Energy Efficiency can serve as a handbook for policymakers, project investors and managers, and project implementation practitioners in need of benchmarks in energy efficiency project investments for decision-making. It can also be used by students, researchers and other professionals in universities and research institutions in methodology development for evaluating energy efficiency projects and programs.
Clostridium difficile, a major nosocomial pathogen shown to be a primary cause of antibiotic-associated disease, has emerged as a highly transmissible and frequently antibiotic-resistant organism, causing a considerable burden on health care systems worldwide. In Clostridium difficile: Methods and Protocols, expert researchers bring together the most recently developed methods for studying the organism, including techniques involving isolation, molecular typing, genomics, genetic manipulation, and the use of animal models. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Clostridium difficile: Methods and Protocols serves as an ideal guide for scientists now in a position to gain an in-depth understanding of how this organism is transmitted and how it causes disease.
This book focuses specifically on bin and bulk parameterizations for the prediction of cloud and precipitation at various scales - the cloud scale, mesoscale, synoptic scale, and the global climate scale. It provides a background to the fundamental principles of parameterization physics, including processes involved in the production of clouds, ice particles, liquid water, snow aggregate, graupel and hail. It presents full derivations of the parameterizations, allowing readers to build parameterization packages, with varying levels of complexity based on information in the book. Architectures for a range of dynamical models are given, in which parameterizations form a significant tool for investigating large non-linear numerical systems. Model codes are available online at www.cambridge.org/9780521883382. Written for researchers and advanced students of cloud and precipitation microphysics, this book is also a valuable reference for all atmospheric scientists involved in models of numerical weather prediction.
Catherine Keller is professor of constructive theology at Drew University. Her work interweaves process relationalism and poststructuralist philosophy with an evolving feminist cosmopolitics. At once constructive and deconstructive in approach, it engages questions of ecological, social, and spiritual practice amidst an irreducible indeterminacy. Among her many books are Apocalypse Now & Then; God and Power; and The Face of the Deep: A Theology of Becoming.
Ever wonder why steam rises from a bowl of hot soup or why a greenhouse retains heat? And have you ever puzzled over the real meaning of "once in a blue moon" or why sand is darker when it's wet than when it's dry? And just why, exactly, do bubbles appear in a glass of beer when you add salt to it?These and many other baffling questions are answered in this engaging book by a physics professor at Pennsylvania State University. Ranging from playful to serious, Professor Bohren's lively and entertaining discussions employ a liberal mixture of humor and anecdote to debunk a host of scientific myths and render science lessons thoroughly understandable. Chapters include "On a Clear Day You Can't See Forever," "A Murder in Ceylon." "The Green Flash," "Physics on a Manure Heap," " Indoor Rainbows," and "Multiple Scattering at the Breakfast Table.""The book rings with a unifying tone: the science of the everyday physical world is fun. And so is the book," writes Jearl Walker, a member of the Physics Department at Cleveland State University. Beginning physics and general readers will be fascinated by the scientific knowledge gained from this work; and science teachers will find it a treasure trove of ideas for simple, vivid classroom demonstrations.
Cluster analysis is a multivariate classification technique that allows for identification of homogenous subgroups within diverse samples based on shared characteristics. In recent years, cluster analysis has been increasingly applied to psychological and neuropsychological variables to address a number of empirical questions. This book provides an overview of cluster analysis, including statistical and methodological considerations in its application to neurobehavioral variables. First, an introduction to cluster analysis is presented that emphasizes issues of relevance to neuropsychological research, including controversies surrounding it use. Cluster analysis is then applied to clinical disorders that do not have an associated prototypical neuropsychological profile, including traumatic brain injury, schizophrenia, and health problems associated with homelessness. In a second application, cluster analysis is used to investigate the course of normal memory development. Finally, cluster analysis is applied to classification of brain injury severity in children and adolescents who sustained traumatic brain injury.
Explores the impact of the latest breakthroughs in cluster SIMS technology Cluster secondary ion mass spectrometry (SIMS) is a high spatial resolution imaging mass spectrometry technique, which can be used to characterize the three-dimensional chemical structure in complex organic and molecular systems. It works by using a cluster ion source to sputter desorb material from a solid sample surface. Prior to the advent of the cluster source, SIMS was severely limited in its ability to characterize soft samples as a result of damage from the atomic source. Molecular samples were essentially destroyed during analysis, limiting the method's sensitivity and precluding compositional depth profiling. The use of new and emerging cluster ion beam technologies has all but eliminated these limitations, enabling researchers to enter into new fields once considered unattainable by the SIMS method. With contributions from leading mass spectrometry researchers around the world, Cluster Secondary Ion Mass Spectrometry: Principles and Applications describes the latest breakthroughs in instrumentation, and addresses best practices in cluster SIMS analysis. It serves as a compendium of knowledge on organic and polymeric surface and in-depth characterization using cluster ion beams. It covers topics ranging from the fundamentals and theory of cluster SIMS, to the important chemistries behind the success of the technique, as well as the wide-ranging applications of the technology. Examples of subjects covered include: Cluster SIMS theory and modeling Cluster ion source types and performance expectations Cluster ion beams for surface analysis experiments Molecular depth profiling and 3-D analysis with cluster ion beams Specialty applications ranging from biological samples analysis to semiconductors/metals analysis Future challenges and prospects for cluster SIMS This book is intended to benefit any scientist, ranging from beginning to advanced in level, with plenty of figures to help better understand complex concepts and processes. In addition, each chapter ends with a detailed reference set to the primary literature, facilitating further research into individual topics where desired. Cluster Secondary Ion Mass Spectrometry: Principles and Applications is a must-have read for any researcher in the surface analysis and/or imaging mass spectrometry fields.
This book provides in-depth information on clusterbean, its cultivation, genetic improvement, plant protection measures, management of abiotic stresses, molecular aspects etc. It is divided into seven chapters including an introduction to the crop, prospects, constraints, genetic improvement, variability, application of clusterbean gum and its byproducts, cultivation, plant protection, physiological and abiotic stress aspects, along with related genetic markers and biotechnological advances. Clusterbean (Cyamopsis tetragonoloba (L. ) Taub. ), commonly known as 'guar,' is an important leguminous crop grown for seed, green fodder, vegetable and green manuring in arid and semi-arid regions and has a special commercial role due to the gum content in its seeds. India's arid environment provides ideal agro-climatic conditions for the successful cultivation of clusterbean, as the plant needs little surface water, long-duration sunshine and low relative humidity during the cropping season. India accounts for nearly 82 percent of global clusterbean seed production, making it an important export product. Based on essential industry and market data, the book offers a comprehensive overview of this unique crop, and will be of interest to researchers active in the field of clusterbean breeding.
Comparing bipolar technology briefly but otherwise not considering it, Schneider and Galup-Montoro (both electrical engineering, Federal U. of Santa Catarina, Brazil) focus on analog MOS (metal-oxide-semiconductor) circuits at the transistor level. They use an accurate but simple MOS transistor model for design, in order to reduce the distance between hand design and simulation results. Instead of the usual separate analytical formulas for the strong-inversion and weak-inversion operation regions of a building block, they provide simple formulas that are valid in all operation regions, including moderate inversion. The unified design is particularly suitable for analog design in advanced complementary MOS (CMOS) technologies. Among their topics are temporal and spatial fluctuations in MOSFETs (MOS field-effect-transistors), current mirrors, basic gain stages, operational amplifiers, and fundamentals of sampled-data circuits. The text is suitable for analog CMOS design courses. Annotation ©2010 Book News, Inc. , Portland, OR (booknews. com)
The Third Edition of CMOS Circuit Design, Layout, and Simulation continues to cover the practical design of both analog and digital integrated circuits, offering a vital, contemporary view of a wide range of analog/digital circuit blocks including: phase-locked-loops, delta-sigma sensing circuits, voltage/current references, op-amps, the design of data converters, and much more. Regardless of one's integrated circuit (IC) design skill level, this book allows readers to experience both the theory behind, and the hands-on implementation of, complementary metal oxide semiconductor (CMOS) IC design via detailed derivations, discussions, and hundreds of design, layout, and simulation examples.
If you wish to gain as full an appreciation as possible of the ideas, thoughts and images set forth here, as well as experience the benefits that come with this appreciation, we recommend you find a quiet place for your reading where there is the least possible interference from artificial noises (motor traffic, radio, TV, household appliances etc.). Natural sounds, on the other hand -- the singing of birds, for example, or the patter of rain, or the rustle of leaves on nearby trees -- maybe a welcome accompaniment to the reading process.
Coal will continue to provide a major portion of energy requirements in the United States for at least the next several decades. It is imperative that accurate information describing the amount, location, and quality of the coal resources and reserves be available to fulfill energy needs. It is also important that the United States extract its coal resources efficiently, safely, and in an environmentally responsible manner. A renewed focus on federal support for coal-related research, coordinated across agencies and with the active participation of the states and industrial sector, is a critical element for each of these requirements. Coal focuses on the research and development needs and priorities in the areas of coal resource and reserve assessments, coal mining and processing, transportation of coal and coal products, and coal utilization.
Small-scale turbulent flow dynamics is traditionally viewed as universal and as enslaved to that of larger scales. In coarse grained simulation (CGS), large energy-containing structures are resolved, smaller structures are spatially filtered out, and unresolved subgrid scale (SGS) effects are modeled. Coarse Grained Simulation and Turbulent Mixing reviews our understanding of CGS. Beginning with an introduction to the fundamental theory the discussion then moves to the crucial challenges of predictability. Next, it addresses verification and validation, the primary means of assessing accuracy and reliability of numerical simulation. The final part reports on the progress made in addressing difficult non-equilibrium applications of timely current interest involving variable density turbulent mixing. The book will be of fundamental interest to graduate students, research scientists, and professionals involved in the design and analysis of complex turbulent flows.
This international collection of papers represents a selected and up-to-date overview of some of the main areas of research into the application of the geospatial technologies, including geographical information systems (GIS), remote sensing, digital mapping, global positioning systems (GPS), databases, Internet technology, and mobile field-data collection and mapping, to coastal and marine environments around the World. Aimed at the researcher, editor, practitioner and student, this volume seeks to expand the available literature in a rapidly expanding and evolving area, namely the coastal and marine environment. The book comes at a time when there is growing concern about global warming, climate change, and sea level rise, all of which will have an impact upon coastal areas. These geospatial technologies offer the possibility to gather unique environmental data to study the coast, to process the data into information, to visualise data and landscapes, to gather data in the field, and to involve stakeholders in coastal management amongst other things. Considerable potential now exists to raise awareness, to educate and to embrace these technologies as one way to promote greater knowledge and understanding of our marine and coastal environments.
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