- Table View
- List View
Introduces the field of bioinformatics: "the application of computational and analytical methods to biological problems.
Bioinformatics--the application of computational and analytical methods to biological problems--is a rapidly evolving scientific discipline. Genome sequencing projects are producing vast amounts of biological data for many different organisms, and, increasingly, storing these data in public databases. Such biological databases are growing exponentially, along with the biological literature. It's impossible for even the most zealous researcher to stay on top of necessary information in the field without the aid of computer-based tools. Bioinformatics is all about building these tools. Developing Bioinformatics Computer Skills is for scientists and students who are learning computational approaches to biology for the first time, as well as for experienced biology researchers who are just starting to use computers to handle their data. The book covers the Unix file system, building tools and databases for bioinformatics, computational approaches to biological problems, an introduction to Perl for bioinformatics, data mining, and data visualization. Written in a clear, engaging style, Developing Bioinformatics Computer Skills will help biologists develop a structured approach to biological data as well as the tools they'll need to analyze the data.
Spurred on by new discoveries and rapid technological advances, the capacity for life science research is expanding across the globe--and with it comes concerns about the unintended impacts of research on the physical and biological environment, human well-being, or the deliberate misuse of knowledge, tools, and techniques to cause harm. This report describes efforts to address dual use issues by developing institutes around the world that will help life sciences faculty learn to teach about the responsible conduct of science. Based on the successful National Academies Summer Institute for Undergraduate Biology Education and on previous NRC reports on effective methods for teaching about dual use issues, the report's authoring committee designed a general framework for the faculty institutes and chose the Middle East-North Africa (MENA) region to test a prototype faculty institute. In September 2012, the first Institute was held in Aqaba, Jordan, bringing together 28 participants from Algeria, Egypt, Jordan, Libya, and Yemen to engage with effective, evidence-based teaching methods, develop curricular materials for use in their own classrooms, and become community leaders on dual use and related topics. Developing Capacities for Teaching Responsible Science in the MENA Region: Refashioning Scientific Dialogue offers insights from the institute that will help in the design and implementation of future programs in the MENA region, and in other parts of the world.
This book is an authoritative, established text that engages students in the study of lifespan development from a chronological viewpoint.
"Scaffolding" is a concept that is becoming widely used across disciplines. This book investigates common threads in diverse applications of scaffolding, including theoretical biology, cognitive science, social theory, science and technology studies, and human development. Despite its widespread use, the concept of scaffolding is often given short shrift; the contributors to this volume, from a range of disciplines, offer a more fully developed analysis of scaffolding that highlights the role of temporal and temporary resources in development, broadly conceived, across concepts of culture, cognition, and evolution. The book emphasizes reproduction, repeated assembly, and entrenchment of heterogeneous relations, parts, and processes as a complement to neo-Darwinism in the developmentalist tradition of conceptualizing evolutionary change. After describing an integration of theoretical perspectives that can accommodate different levels of analysis and connect various methodologies, the book discusses multilevel organization; differences (and reciprocality) between individuals and institutions as units of analysis; and perspectives on development that span brains, careers, corporations, and cultural cycles. Contributors: Colin Allen, Linnda R. Caporael, James Evans, Elihu M. Gerson, Simona Ginsburg, James R. Griesemer, Christophe Heintz, Eva Jablonka, Sanjay Joshi, Shu-Chen Li, Pamela Lyon, Sergio F. Martinez, Christopher J. May, Johann Peter Murmann, Stuart A. Newman, Jeffrey C. Schank, Iddo Tavory, Georg Theiner, Barbara Hoeberg Wimsatt, William C. Wimsatt
Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the 'unit dose' and 'unit effect' with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.
This book provides a comprehensive view of research in lens developmental biology, emphasising technical and molecular breakthroughs. Elucidation of the mechanisms that govern lens development has enabled us to understand how the normal lens forms and how developmental processes are involved in the maintenance of its normal structure, function and growth throughout life. This knowledge is fundamental to our understanding of many lens disorders. The ocular lens has also become a model for understanding the developmental biology of more complex organ systems. In this 2004 book, leading experts in lens cell biology and development discuss lens evolution, induction, morphology, the regulation of the lens cell cycle and fiber cell differentiation, as well as lens regeneration. This book is an authoritative treatment of the subject that will serve as a reference for graduate students and research scientists in developmental biology and in the visual sciences, as well as for ophthalmologists.
Drawing on state-of-the-art cellular and molecular techniques as well as new and sophisticated imaging and information technologies, this comprehensive, three-volume collection of cutting-edge protocols provides readily reproducible methods for studying and analyzing the events of embryonic development. Volume 1 (ISBN: 089603-574-3) contains techniques for establishing and characterizing several widely used experimental model systems, for the study of developmental patterns and morphogenesis, and for the examination of embryo structure and function. There are also step-by-step methods for the analaysis of cell lineage, the production and use of chimeras, and the experimental and molecular manipulation of embryos, including the application of viral vectors. Volume 2 (ISBN: 0-89603-575-1) describes state-of-the-art methods for the study of organogenesis, the analysis of abnormal development and teratology, the screening and mapping of novel genes and mutations, and the application of transgenesis, including the production of transgenic animals and gene knockouts. No less innovative, volume 3 (ISBN: 0-89603-576-X) introduces powerful techniques for the manipulation of developmental gene expression and function, the analysis of gene expression, the characterization of tissue morphogenesis and development, the in vitro study of differentiation and development, and the genetic analysis of developmental models of diseases. Highly practical and richly annotated, the three volumes of Developmental Biology Protocols describe multiple experimental systems and details techniques adopted from the broadest array of biomedical disciplines.
The simplicity and lack of redundancy in their regulatory genes have made ascidians one of the most useful species in studying developmental genomics. In Developmental Genomics of Ascidians, Dr. Noriyuki Satoh explains the developmental genomics of ascidians, stresses the simplicity of Ciona developmental system, and emphasizes single-cell level analyses. This book actively accentuates the advantages of using ascidians as model organisms in an up-and-coming field of developmental genomics.
Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. Experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. The book brings together the work of researchers investigating inhibitory plasticity at many levels of analysis and in several different preparations. This topic is of wide relevance across a number of different areas of research in neuroscience and neurology. Medical problems such as epilepsy, mental illness, drug abuse, and movement disorders can result from malfunctioning inhibitory circuits. Further, the maturation of inhibitory circuits may trigger the onset of critical periods of neural circuit plasticity, raising the possibility that such plastici periods could be reactivated for medical benefit by manipulating inhibitory circuitry.
Synthesizing cutting-edge knowledge from multiple disciplines, this book explores the impact of acquired brain injury and developmental disabilities on children's emerging social skills. The editors present an innovative framework for understanding how brain processes interact with social development in both typically developing children and clinical populations. Key issues in assessment are addressed, including ways to measure both social function and brain function using developmentally sound tools. Balancing theoretical and clinical concerns, the book describes promising interventions for promoting children's adjustment and helping them participate more fully in the social world. Illustrations include six color plates.
The life cycle, until recently, has been neither descriptive nor conceptual but metaphorical, suggesting an underlying sequence of events that everyone experiences rather than clear external milestones of development, althought every life, of course, is acknowledged to be unique.
Martin Fleischmann was truly one of the 'fathers' of modern electrochemistry having made major contributions to diverse topics within electrochemical science and technology. These include the theory and practice of voltammetry and in situ spectroscopic techniques, instrumentation, electrochemical phase formation, corrosion, electrochemical engineering, electrosynthesis and cold fusion. While intended to honour the memory of Martin Fleischmann, Developments in Electrochemistry is neither a biography nor a history of his contributions. Rather, the book is a series of critical reviews of topics in electrochemical science associated with Martin Fleischmann but remaining important today. The authors are all scientists with outstanding international reputations who have made their own contribution to their topic; most have also worked with Martin Fleischmann and benefitted from his guidance.Each of the 19 chapters within this volume begin with an outline of Martin Fleischmann's contribution to the topic, followed by examples of research, established applications and prospects for future developments.The book is of interest to both students and experienced workers in universities and industry who are active in developing electrochemical science.
The impact of proton exchange membrane (PEM) fuel cells on energy generation will parallel the impact of the integrated circuit on information technology. The underlying processes in PEM fuel cells have strong ties to energy generation at the mitochondrial level in organic life. The potential applications range from the micron scale to large scale industrial production. Successful integrated of PEM fuel cells into the mass-market will require new materials and a deepening understanding of the balance required to maintain the various operational states. Key areas of development include electrocatalysts for the fuel and air electrodes and membranes exhibiting good proton conductivity under minimal hydration and temperatures between -20 °C to 120 °C. New materials possessing improved properties will emerge as a result of a collaborative effort between experimentalists, engineers, and theorists, the latter doing both device and materials modeling. This book presents a series of contributed articles from scientists who have made a contribution in the modeling of fuel cells from either a device or materials perspective. As fuel cell technologies are an emerging area this book will be of interest to any working in this field. This book will provide a survey (with significant depth) of virtually all the computational and modeling work done in this area.
In The Devil and Philosophy, 34 philosophers explore questions about one of the most recognizable and influential characters (villains?) of all time. From Roman Polanski's The Ninth Gate to J.R.R. Tolkien's The Silmarillion to Bram Stoker's Dracula to Darth Vader to Al Pacino's iconic performance in The Devil's Advocate, this book demonstrates that a little devil goes a long way. From humorous appearances, as in Kevin Smith's film Dogma and Chuck Palahniuk's novels Damned and its sequel Doomed, to more villanous appearances, such as Gabriel Byrne's cold outing as Satan in End of Days, The Devil in Philosophy proves that the Devil comes in many forms.Through the lenses of Jung, Kant, Kundera, Balkan, Plato, Bradwardine, Aristotle, Hume, Blackburn, Descartes, Lavey, Thoreau, and Aquinas, The Devil and Philosophy take a philosophical look at one of time's greatest characters. Are there any good arguments for the actual existence of the Devil? Does demonic evil thrive in Gotham City? Can humans really be accountable for all evil? Which truths about the Devil are actual facts? Is Milton correct, in that the Devil believes he is doing good?
The sound of breaking glass. A scream. A shot. Then ... silence. Blood, fingerprints, a bullet, a skull, fire debris, a hair, shoeprints--enter the wonderful world of forensic science. A world of searching to find clues, collecting that which others cannot see, testing to find answers to seemingly impossible questions, and testifying to juries so that justice will be served. A world where curiosity, love of a puzzle, and gathering information are basic. The books in this series will take you to this world. Each tale is followed by a guide to its vocabulary, technology, and background.
The first collection of essays from renowned scientist and best-selling author Richard Dawkins is an enthusiastic declaration, a testament to the power of rigorous scientific examination to reveal the wonders of the world. In these essays Dawkins revisits the meme, the unit of cultural information that he named and wrote about in his groundbreaking work The Selfish Gene. Here also are moving tributes to friends and colleagues, including a eulogy for novelist Douglas Adams, author of The Hitchhiker's Guide to the Galaxy; correspondence with the evolutionary biologist Stephen Jay Gould; and visits with the famed paleoanthropologists Richard and Maeve Leakey at their African wildlife preserve. The collection ends with a vivid note to Dawkins's ten-year-old daughter, reminding her to remain curious, to ask questions, and to live the examined life.
Bestselling author Dawkins offers another dazzling gift to his readers -- his first collection of essays on what matters most to him, from science, religion and mysticism to today's educational methods.
Diagnosing Autism Spectrum Disorders: A Lifespan Perspective is the first book of its kind to provide authoritative information for medical and mental health professionals on how to properly evaluate and diagnose autism spectrum disorders in individuals of all ages. The first book of its kind which demonstrates how to conduct an appropriate diagnostic interview to assess a child for an Autism Spectrum Disorder Considers the issues of Autism Spectrum Disorders in children, teenagers, and adults Aimed at both medical and mental health professionals Includes an in-depth treatment of the entire diagnostic process
From a trusted expert in the field, this authoritative work provides an accessible overview of what learning disorders are, how they develop, and how to diagnose and treat them effectively. The author presents the most current neuroscientific knowledge on a range of conditions, including dyslexia, autism spectrum disorders, attention-deficit/hyperactivity disorder, and others. Practitioners gain vital insights and tools for making sense of children's impairments and strengths, collecting and interpreting diagnostic data from a variety of sources, and linking diagnosis to evidence-based interventions. The second edition has been substantially revised and expanded to reflect significant clinical and research advances. New to This Edition Covers additional disorders intellectual disability, mathematics disorder, and developmental coordination disorder, plus a chapter on less well-validated disorders. New case illustrations and a focus on empirically based practice. Now grounded in a multiple cognitive-deficit model of learning disorders, replacing the prior edition's modular, single-deficit model. An illuminating chapter on controversial therapies separates myths from facts.
This is the first textbook entirely dedicated to the endovascular treatment of complications related to arteriovenous accesses for hemodialysis (native fistulas and prosthetic grafts). The book addresses the anatomy of upper limb arteries and veins as well as the clinical presentation of patients and the way to perform and read a fistulogram. Many details and illustrations are provided, clarifying the subtleties in catheterization and the dilation of stenoses. From a strategic point of view, it is explained for the first time that many stenoses must either be ignored or deliberately underdilated. A wealth of images helps to understand the different stages of access recovery from thrombosis. As the number of incident dialysis patients is increasing by 5% every year, this is a field of growing interest. In testament to this there are several annual or bi-annual meetings held by numerous national and international societies (vascularaccesssociety.com, sfav.org, vasamd.org, dialysiscontroversies.org, asdin.org).
Diagnostic Bacteriology Protocols presents a broad range of currently used techniques for detecting, identifying, and differentiating bacterial cell components, including structured proteins, nucleic acids, enzyme activities, lipopolysaccharides, and metabolites. It describes each technique in simple easy-to-follow steps that guarantee reproducible results for novices and senior researchers alike. Troubleshooting tips, alternative ways of performing procedures, and informative explanations about why certain steps are necessary-aids not usually found in standard journal recipes help even highly skilled researchers to obtain the results they want.
This fully updated edition includes the novel identification, detection, and typing technologies that are transforming the field of diagnostic testing. The authors, working at the forefront of diagnostic test development, highlight these new technologies and describe current and future molecular diagnostic tests and related nucleic acid extraction methods. The protocols range from advanced molecular detection, quantification, and typing systems, to protocols for diagnostic protein identification, serological testing, and cell culture-based assays. The emphasis is on nucleic acid-based diagnostics and alternative biochemically- and immunologically-based formats that can provide significant potential for multiparameter testing and automation.
This handbook is designed to help jobbing histopathologists jog their memory and get through more workload in any working day. Rapid access is facilitated by a bullet-point, tabular and diagrammatic style, as well as by handy anatomical diagrams, guidance on the 'Cut-Up' with emphasis on core 'datasets' and by a special index for frozen section advice, grading systems and scoring systems. The book provides, where useful, differential diagnosis lists and presents diagnostically helpful molecular and immunohistochemical findings. Information is kept up-to-date on a dedicated website www.pathbook.com. The Diagnostic Criteria Handbook in Histopathology is not designed to be an "exam cram" and neither will it serve as a basic text for beginners. Trainees, however, will still benefit from the sheer breadth of topics covered in this one small volume: from lab management and lab methods, to autopsy practice, cytology and all sub-specialties in surgical pathology. A chapter on exam technique and mnemonics makes the book also an essential companion for those revising for professional exams. So why clutter your precious desk space with multiple sets of heavy two-volume reference works?Give this handy Vade Mecum a place next to your microscope and see how much time you could save!
Diagnostic Electron Microscopy: A Practical Guide to Interpretation and Technique summarises the current interpretational applications of TEM in diagnostic pathology. This concise and accessible volume provides a working guide to the main, or most useful, applications of the technique including practical topics of concern to laboratory scientists, brief guides to traditional tissue and microbiological preparation techniques, microwave processing, digital imaging and measurement uncertainty.The text features both a screening and interpretational guide for TEM diagnostic applications and current TEM diagnostic tissue preparation methods pertinent to all clinical electron microscope units worldwide. Containing high-quality representative images, this up-to-date text includes detailed information on the most important diagnostic applications of transmission electron microscopy as well as instructions for specific tissues and current basic preparative techniques.The book is relevant to trainee pathologists and practising pathologists who are expected to understand and evaluate/screen tissues by TEM. In addition, technical and scientific staff involved in tissue preparation and diagnostic tissue evaluation/screening by TEM will find this text useful.
Select your format based upon: 1) how you want to read your book, and 2) compatibility with your reading tool. To learn more about using Bookshare with your device, visit the "Using Bookshare" page in the Help Center.
Here is an overview of the specialized formats that Bookshare offers its members with links that go to the Help Center for more information.
- Bookshare Web Reader - a customized reading tool for Bookshare members offering all the features of DAISY with a single click of the "Read Now" link.
- DAISY (Digital Accessible Information System) - a digital book file format. DAISY books from Bookshare are DAISY 3.0 text files that work with just about every type of access technology that reads text. Books that contain images will have the download option of ‘DAISY Text with Images’.
- BRF (Braille Refreshable Format) - digital Braille for use with refreshable Braille devices and Braille embossers.
- MP3 (Mpeg audio layer 3) - Provides audio only with no text. These books are created with a text-to-speech engine and spoken by Kendra, a high quality synthetic voice from Ivona. Any device that supports MP3 playback is compatible.
- DAISY Audio - Similar to the Daisy 3.0 option above; however, this option uses MP3 files created with our text-to-speech engine that utilizes Ivona's Kendra voice. This format will work with Daisy Audio compatible players such as Victor Reader Stream and Read2Go.