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Matrix Metalloproteinase Biology
by Jean Gaffney Irit SagiDiscussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs. The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics. The following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states. Written and edited by leaders in the field, Matrix Metalloproteinase Biology addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.
Matrix Metalloproteinase Protocols
by Ian M. Clark Andrew D. Rowan David A. YoungSince the discovery of a collagen-degrading protease in the tadpole tail in 1962, matrix metalloproteinase research has led to the discovery of more than twenty distinct vertebrate MMPs, along with a variety of homologues from diverse organisms such as the sea urchin, plants, insects, and nematode worms. Fully updating and adding to the popular first edition, Matrix Metalloproteinase Protocols, Second Edition includes a series of state-of-the-art techniques provided by eminent experts in the field. Beginning with a brief overview of the MMP arena, from how these enzymes fit into the larger degradome to what occurs when their expression and function in the mouse is modulated, the volume continues with sections on the expression and purification of MMPs and TIMPs, the detection of MMPs and TIMPs at both the protein and mRNA level, and our ability to assay MMP and TIMP activities in a wide variety of circumstances. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Matrix Metalloproteinase Protocols, Second Edition is an ideal source for many of the essential laboratory techniques for both novice and seasoned researchers alike collected in one convenient volume.
Matrix Metalloproteinase Protocols
by Ian M. ClarkLeading experts detail proven laboratory techniques for the study of MMPs. The methods include those for the expression and purification of MMPs and TIMPs, for the detection of MMPs and TIMPs at both the protein and mRNA levels, and for the assay of MMP and TIMP activities in a wide variety of circumstances. Each method includes step-by-step instructions and notes variant applications and pitfalls to avoid. A selective overview of the MMP arena spells out where the field has been, where it is, and where it is going. Comprehensive and highly practical, Matrix Metalloproteinase Protocols brings together the long and hard-earned experience of master experimentalists that will allow not only novices to get up to speed quickly, but also add to the repertoire of successful techniques in expert laboratories.
Matrix Methods in the Design Analysis of Mechanisms and Multibody Systems
by John J. Uicker Bahram Ravani Pradip N. Sheth John J. Uicker Bahram RavaniThis book is an integrated approach to kinematic and dynamic analysis. The matrix techniques presented are general and fully applicable to two- or three-dimensional systems. They lend themselves to programming and digital computation and can act as the basis of a usable tool for designers. Techniques have broad applicability to the design analysis of all multibody mechanical systems. The more powerful and more flexible the approach, and the less specialisation and reprogramming required for each application, the better. The matrix methods presented have been developed using these ideas as primary goals. Matrix methods can be applied by hand to such problems as the slider-crank mechanism, but this is not the intent of this text, and often the rigor required for such an attempt becomes quite burdensome in comparison with other techniques. The matrix methods have been extensively tested, both in the classroom and in the world of engineering industry.
Matrix Pathobiology and Angiogenesis (Biology of Extracellular Matrix #12)
by Evangelia Papadimitriou Constantinos M. MikelisIn the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Matrix Proteases in Health and Disease
by Niels BehrendtPresenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
Matrix and Finite Element Analyses of Structures
by Madhujit Mukhopadhyay Abdul Hamid SheikhThis textbook has been primarily written for undergraduate and postgraduate engineering students studying the mechanics of solids and structural systems. The content focuses on matrix, finite elements, structural analysis, and computer implementation in a unified and integrated manner. Using classical methods of structural analysis, it discusses matrix and the finite element methods in an easy-to-understand manner. It consists of a large number of diagrams and illustrations for easy understanding of the concepts. All the computer codes are presented in "FORTRAN" AND "C". This textbook is highly useful for the undergraduate and postgraduate engineering students. It also acquaints the practicing engineers about the computer-based techniques used in structural analysis.
Matrix of Creation: Sacred Geometry in the Realm of the Planets
by Richard HeathReveals the ancient mathematical principles refuting the notion of the solar system as an accidental creation• Reveals how ancient civilizations encoded their secret knowledge of the sky in mythology, music, and sacred measures• Shows how modern culture can benefit from the ancient astronomical and astrological worldview based on number• Shows the role of ratio and harmonic proportions in the creation of the material worldHumanity’s understanding of number was deeper and richer when the concept of creation was rooted in direct experience. But modern sensibility favors knowledge based exclusively on physical laws. We have forgotten what our ancestors once knew: that numbers and their properties create the forms of the world. Ancient units of measurement held within them the secrets of cosmic proportion and alignment that are hidden by the arbitrary decimal units of modern mathematical thinking.Sacred numbers arose from ancient man’s observations of the heavens. Just as base ten numbers relate to the fingers and toes in terms of counting, each celestial period divides into the others like fingers revealing the base numbers of planetary creation. This ancient system made the art of counting a sacramental art, its units being given spiritual meanings beyond just measurement. The imperial yard, for example, retains a direct relationship to the Equator, the length of a day and a year, and the angular values of Earth, Moon, and Jupiter.The ancients encoded their secret knowledge of the skies within mythology, music, monuments, and units of sacred measurement. They understood that the ripeness of the natural world is the perfection of ratio and realized that the planetary environment--and time itself--is a creation of number.
Matter (Early Bird Energy)
by Sally M. WalkerEverything around you is made of matter. Matter can be soft or hard. Matter can be any color. It can be invisible.
Matter Comes in All Shapes
by Amy S. Hansen Kristi LewThis book introduces matter in its different forms with examples that make it fun and interesting for children.
Matter and Desire: An Erotic Ecology
by Andreas WeberNautilus Award Gold Medal Winner, Ecology & Environment In Matter and Desire, internationally renowned biologist and philosopher Andreas Weber rewrites ecology as a tender practice of forging relationships, of yearning for connections, and of expressing these desires through our bodies. Being alive is an erotic process—constantly transforming the self through contact with others, desiring ever more life.In clever and surprising ways, Weber recognizes that love—the impulse to establish connections, to intermingle, to weave our existence poetically together with that of other beings—is a foundational principle of reality. The fact that we disregard this principle lies at the core of a global crisis of meaning that plays out in the avalanche of species loss and in our belief that the world is a dead mechanism controlled through economic efficiency.Although rooted in scientific observation, Matter and Desire becomes a tender philosophy for the Anthropocene, a &“poetic materialism,&” that closes the gap between mind and matter. Ultimately, Weber discovers, in order to save life on Earth—and our own meaningful existence as human beings—we must learn to love.&“If what Andreas says is anything to go by—that love permeates all things so intrusively that the world can only be conceived in terms of relationship—then holding this book in your hand is an outrageous act of lovemaking, the breadth and depth of which you will never know! This is a gasp of a book.&”—Bayo Akomolafe, author of These Wilds Beyond our Fences&“Andreas Weber offers us the best medicine I know for a culture benumbed by dead-end pursuits. Pulsing with life, his work delivers us from the centuries-long dichotomies between mind and matter that have robbed us of vitality, joy, and true purpose. It brings us home to the fertile reciprocities that link us with all forms and levels of life; in so doing, it reflects and reinforces great spiritual teachings of our planet.&”—Joanna Macy, author of Coming Back to Life
Matter and Energy
by Lawrence Hall of Science University of California at BerkeleyNIMAC-sourced textbook
Matter and Energy: Principles of Matter and Thermodynamics
by Paul FleisherHave you ever seen a magician make something seem to disappear Did it make you wonder if anything can really just vanish? To answer these and many other questions, author Paul Fleisher looks at the scientific laws that describe how matter and energy behave. Through simple experiments and concepts that are easy to understand, readers are introduced to the basic principles of matter and thermodynamics in a fun, exciting way.
Matter and Interactions
by Ruth W. Chabay Bruce A. Sherwood"Matter and Interactions" offers a modern curriculum for introductory physics (calculus-based). It presents physics the way practicing physicists view their discipline and integrates 20th Century physics and computational physics. The text emphasizes the small number of fundamental principles that underlie the behavior of matter, and models that can explain and predict a wide variety of physical phenomena. "Matter and Interactions" will be available as a single volume hardcover text and also two paperback volumes.
Matter and Interactions: Volume 1, Modern Mechanics
by Ruth Chabay Bruce SherwoodMatter and Interactions offers a modern curriculum for introductory physics (calculus-based). It presents physics the way practicing physicists view their discipline while integrating 20th Century physics and computational physics. The text emphasizes the small number of fundamental principles that underlie the behavior of matter, and models that can explain and predict a wide variety of physical phenomena. Matter and Interactions will be available as a single volume hardcover text and also two paperback volumes. Volume One includes chapters 1-12.
Matter and It's Interactions: Student Guide
by Carolina Biological Supply CompanyGrades 6–8. This hardbound Student Guide and Source Book provides the student investigations, student goals and objectives, and reading selections for the Matter and Its Interactions unit.
Matter and Its Interactions
by Carolina Biological Supply Company Smithsonian Science Education CenterNIMAC-sourced textbook