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Metals in Cells
by Valeria CulottaOver the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the "metallome"] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Metals in Groundwater
by David S. Brown Herbert E. Allen E. Michael PerdueMetal contamination of groundwater results from many human activities, including agriculture, mining, and the disposal of municipal waste and fly ash. Metals in Groundwater describes the transport of metals to groundwater from these and other sources. It also covers risk assessment of metals in groundwater, coupling of chemicals and hydrological models, and sorption of metals onto soils and clays. The speciation of metals is examined in detail. The book will interest researchers in environmental quality, mining, and agriculture; consultants; industry professionals; and personnel within regulatory agencies.
Metals in Medicine
by James C. DabrowiakMetals in Medicine is a textbook directed a senior undergraduates and beginning graduate students, which describes metal-based agents for treating and diagnosing disease. Opening chapters present basic bonding concepts that are applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background.The remaining chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Throughout the book, "Feature Boxes" expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine.
Metals in Medicine
by James C. DabrowiakWorking from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.
Metalwork: Technology and Practice (8th edition)
by Victor E. Repp Willard J. MccarthyMetalwork Technology and Practice provides a comprehensive introduction to metal fabrication technology, It is intended as a textbook for entry level courses that provide laboratory experiences in metal fabrication. It also may be used as a reference book in metal product manufacturing courses or exercises. For the Eighth Edition, each unit has been revised as needed to reflect current practice, The application of mathematics and science to metal processing has been emphasized, and a new Section on Metal Product Manufacturing has been added, The product section has also been revised and expanded, and now includes several new products designed for production on numerically controlled machine tools. The traditional features of the book have been retained. The reading level is as low as practicable for a metalworking technical book of this level. Tech¬nical terms are in boldface type, and a list of them is provided at the end of each unit. A glossary of technical terms is also provided at the end of the text to aid student development of technical vocabulary. The review questions at the end of each unit also provides students with a convenient way to check their knowledge of each topic.
Metal–Molecular Assembly for Functional Materials
by Takafumi Ueno Michito Yoshizawa Masayoshi Higuchi Soichiro Yoshimoto Yuichi Negishi Yutaka Matsuo Takashi Uemura Hikaru Takaya Masayuki TakeuchiThis book focuses on modern coordination chemistry, covering porous coordination polymers, metalloproteins, metallopeptides, nanoclusters, nanocapsules, aligned polymers, and fullerenes. As well, it deals with applications to electronic devices and surface characterization. These wide-ranging topics are integrally described from the perspectives of dimensionality (one-, two-, and three-dimension), new materials design, synthesis, molecular assembly, function and application. The nine chapters making up this book have been authored by scientists who are at the cutting edge of research in this particular field. The level is appropriate for graduate students, post-doc researchers, and new faculty members whose aim is to become familiar with modern coordination chemistry from its basics to applications.
Metamaterial for Microwave Applications
by Mohammad Tariqul IslamMetamaterials are geometrically patterned new materials that are arranged in periodic way on top of dielectric substrates to exhibit properties unobtainable naturally. This book discusses artificially engineered structures for the development of metamaterials and meta surfaces in the advancement of microwave sensors in sensing technology, non-invasive microwave-based imaging system, antenna performance improvement with miniaturization, flexible materials for microwave applications and finally metamaterials in antennas for its use in nanosatellites.The book serves as a reference for designing industrial applications of metamaterials in 5G wireless communication system and healthcare technology using metamaterials and meta surfaces. This well illustrated book will be a useful resource for students, engineers, physicists, and other researchers for various microwave applications. It provides newcomers with fundamental knowledge of metamaterials and their prospective applications. The researchers will benefit from thought-provoking perspectives that will enhance their knowledge and steer them to modern day innovation.
Metamaterial-Based Optical and Radio Frequency Sensing (Advances in Optics and Optoelectronics)
by Jun Luo Dong Wei Xinyu ZhangThis book highlights the fundamentals and practical methods of metamaterials-based optical and radio frequency sensing. Combined with engineering practices, the book illustrates in detail wide frequency electromagnetic signal cloaking and the detection behavior of metasurfaces, including the structure of metasurfaces, electric-controlled behaviors, layout design and fabrication methods, and related experiment results. This book is expected to inspire the research and development of new optical and radio frequency detectors. It is suitable for researchers and engineers working on semiconductor devices, applied optics, and wide frequency signal detection. It is also a good reference for students in these areas.
Metamaterials and Wave Control
by Eric LheuretteSince the concept was first proposed at the end of the 20th Century, metamaterials have been the subject of much research and discussion throughout the wave community. More than 10 years later, the number of related published articles is increasing significantly. On the one hand, this success can be attributed to dreams of new physical objects which are the consequences of the singular properties of metamaterials. Among them, we can consider the examples of perfect lensing and invisibility cloaking. On other hand, metamaterials also provide new tools for the design of well-known wave functions such as antennas for electromagnetic waves. The goal of this book is to propose an overview of the concept of metamaterials as a perspective on a new practical tool for wave study and engineering. This includes both the electromagnetic spectrum, from microwave to optics, and the field of acoustic waves. Contents 1. Overview of Microwave and Optical Metamaterial Technologies, Didier Lippens. 2. MetaLines: Transmission Line Approach for the Design of Metamaterial Devices, Bruno Sauviac. 3. Metamaterials for Non-Radiative Microwave Functions and Antennas, Divitha Seetharamdoo and Bruno Sauviac. 4. Toward New Prospects for Electromagnetic Compatibility, Divitha Seetharamdoo. 5. Dissipative Loss in Resonant Metamaterials, Philippe Tassin, Thomas Koschny, and Costas M. Soukoulis. 6. Transformation Optics and Antennas, André de Lustrac, Shah Nawaz Burokur and Paul-Henri Tichit. 7. Metamaterials for Control of Surface Electromagnetic and Liquid Waves, Sébastien Guenneau, Mohamed Farhat, Muamer Kadic, Stefan Enoch and Romain Quidant. 8. Classical Analog of Electromagnetically Induced Transparency, Philippe Tassin, Thomas Koschny and Costas M. Soukoulis.
Metamaterials for Manipulation of Thermal Radiation and Photoluminescence in Near and Far Fields (Springer Theses)
by Yinhui KanThis book provides a series of methods for flexibly and actively manipulating thermal emission and photoluminance by advanced nanostructures—metamaterials. Nanostructures in subwavelength scales can be designed to precisely modulate light-matter interactions and thereby tailoring both thermal radiations and photon emissions. This book explores approaches for designing different kinds of nanostructures, including multilayers, gratings, nanoridges, and waveguides, to improve the flexibility and functionality of micro/nanodevices. With the help of these subwavelength nanostructures, thermal radiation and photoluminescence have been fully manipulated in near and far fields regarding to the intensity, spectrum, polarization, and direction. The proposed methods together with designed metamaterials open new avenues for designing novel micro-/nanodevices or systems for promising applications like thermal energy harvesting, detecting, sensing, and on-chip quantum-optical networks.
Metamaterials in Topological Acoustics
by Sourav BanerjeeAs an equivalent counterpart of topological research on photonics and condensed matter physics, acoustic metamaterials create an opportunity to explore the topological behaviors in phononics and physics of programmable acoustics. This book introduces the topological behavior of acoustics through the novel design of metamaterials. It provides valuable insight into acoustic metamaterials, from multidisciplinary fundamentals to cutting-edge research. Serves as a single resource on acoustic metamaterials Covers the fundamentals of classical mechanics, quantum mechanics, and state-of-the-art condensed matter physics principles so that topological acoustics can be easily understood by engineers Introduces topological behaviors with acoustics and elastic waves through quantum analogue Hall effects, quantum spin Hall effects, and quantum valley Hall effects and their applications Explains the pros and cons of different design methods and gives guidelines for selecting specific designs of acoustic metamaterials with specific topological behaviors Includes MATLAB® code for numerical analysis of band structures This book is written for graduate students, researchers, scientists, and professionals across materials, mechanical, civil, and aerospace engineering, and those who want to enhance their understanding and commence research in metamaterials.
Metamaterials: Beyond Crystals, Noncrystals, and Quasicrystals
by Tie Jun Cui Wen Xuan Tang Xin Mi Yang Zhong Lei Mei Wei Xiang JiangMetamaterials: Beyond Crystals, Noncrystals, and Quasicrystals is a comprehensive and updated research monograph that focuses on recent advances in metamaterials based on the effective medium theory in microwave frequencies. Most of these procedures were conducted in the State Key Laboratory of Millimeter Waves, Southeast University, China. The book conveys the essential concept of metamaterials from the microcosmic structure to the macroscopic electromagnetic properties and helps readers quickly obtain needed skills in creating new devices at microwave frequencies using metamaterials. The authors present the latest progress on metamaterials and transformation optics and provide abundant examples of metamaterial-based devices accompanied with detailed procedures to simulate, fabricate, and measure them. Comprised of ten chapters, the book comprehensively covers both the fundamentals and the applications of metamaterials. Along with an introduction to the subject, the first three chapters discuss effective medium theory and artificial particles. The next three chapters cover homogeneous metamaterials (super crystals), random metamaterials (super noncrystals), and inhomogeneous metamaterials (super quasicrystals). The final four chapters examine gradient-index inhomogeneous metamaterials, nearly isotropic inhomogeneous metamaterials, and anisotropic inhomogeneous metamaterials, after which the authors provide their conclusions and closing remarks. The book is completely self-contained, making it easy to follow.
Metametaphysics and the Sciences: Historical and Philosophical Perspectives (Routledge Studies in Metaphysics)
by Frode Kjosavik Camilla Serck-HanssenThis collection addresses metaphysical issues at the intersection between philosophy and science. A unique feature is the way in which it is guided both by history of philosophy, by interaction between philosophy and science, and by methodological awareness. In asking how metaphysics is possible in an age of science, the contributors draw on philosophical tools provided by three great thinkers who were fully conversant with and actively engaged with the sciences of their day: Kant, Husserl, and Frege. Part I sets out frameworks for scientifically informed metaphysics in accordance with the meta-metaphysics outlined by these three self-reflective philosophers. Part II explores the domain for co-existent metaphysics and science. Constraints on ambitious critical metaphysics are laid down in close consideration of logic, meta-theory, and specific conditions for science. Part III exemplifies the role of language and science in contemporary metaphysics. Quine’s pursuit of truth is analysed; Cantor’s absolute infinitude is reconstrued in modal terms; and sense is made of Weyl’s take on the relationship between mathematics and empirical aspects of physics. With chapters by leading scholars, Metametaphysics and the Sciences is an in-depth resource for researchers and advanced students working within metaphysics, philosophy of science, and the history of philosophy.
Metamorphosis: Nature's Magical Transformations (Dover Children's Science Bks.)
by Alvin Silverstein Virginia SilversteinWith this easy-to-read book, children will discover the facts behind the seemingly magical conversions that transform a wooly caterpillar into a graceful butterfly and a swimming tadpole into a leaping frog. This book presents a well-illustrated look at how some baby animals develop from a larval stage into a completely different creature.
Metamorphosis: Unmasking the Mystery of How Life Transforms (Sciencewriters Ser.)
by Frank RyanIn this enchanting work of scientific exploration, acclaimed science author Frank Ryan explains how metamorphosis - the intricate trick of nature by which caterpillars transform into butterflies - reveals secrets that are shaking the scientific world. Ryan brings to life the work of pioneering naturalists who have traced metamorphosis in myriad species, from amphibians to marine creatures, even human puberty, to rewrite some of our longest-held beliefs about evolution. Lyrical and provocative, The Mystery of Metamorphosis offers a new understanding of some of the most ancient miracles of the nature.
Metapatterns: Across Space, Time, and Mind
by Tyler VolkIn the interdisciplinary tradition of Buckminster Fuller’s work, Gregory Bateson’s Mind and Nature, and Fritjof Capra’s Tao of Physics, Metapatterns embraces both nature and culture, seeking out the grand-scale patterns that help explain the functioning of our universe.
Metaphors We Live By
by George Lakoff Mark JohnsonThe now-classic Metaphors We Live By changed our understanding of metaphor and its role in language and the mind. Metaphor, the authors explain, is a fundamental mechanism of mind, one that allows us to use what we know about our physical and social experience to provide understanding of countless other subjects. Because such metaphors structure our most basic understandings of our experience, they are "metaphors we live by"—metaphors that can shape our perceptions and actions without our ever noticing them. In this updated edition of Lakoff and Johnson's influential book, the authors supply an afterword surveying how their theory of metaphor has developed within the cognitive sciences to become central to the contemporary understanding of how we think and how we express our thoughts in language.
Metaphors and Analogies in Sciences and Humanities: Words and Worlds (Synthese Library #453)
by A. C. Grayling Shyam WuppuluriIn this highly-interdisciplinary volume, we systematically study the role of metaphors and analogies in (mis)shaping our understanding of the world. Metaphors and Analogies occupy a prominent place in scientific discourses, as they do in literature, humanities and at the very level of our thinking itself. But when misused they can lead us astray, blinding our understanding inexorably. How can metaphors aid us in our understanding of the world? What role do they play in our scientific discourses and in humanities? How do they help us understand and skillfully deal with our complex socio-political scenarios? Where is the dividing line between their use and abuse? Join us as we explore some of these questions in this volume.
Metaphors for Change: Partnerships, Tools and Civic Action for Sustainability
by David Gee Penny Allen Christophe BonazziHow can we get from where we are to where we want to be? Metaphors for Change attempts to answer this question and provide a roadmap for sustainability by bringing together the thoughts of a unique collection of leading change agents from business, government and academia. Environmental questions have previously been dealt with metaphorically, by catastrophism or manicheism (zero growth; Malthusianism, Deep Ecology; "man is the enemy"; less is more). These metaphors have had limited impact because they have failed to connect with the mainstream of cultural, political, and business ideas. This book examines a number of new metaphors – and related partnerships, tools and action – which appear to have greater possibilities for the world in which we now live. The editors argue that Metaphors for Change can deliver to the public and to decision-makers new perceptions ("structured knowledge") that can help interpret the past and the present, and help us forge the future. The wider the gap between the "now" and the "necessary", the stronger the bridging perceptions have to be in order to break through barriers of fear and conservatism. Some of the concepts considered are: sustainable development; the polluter pays principle; the precautionary principle; eco-efficiency; eco-effectiveness; life-cycle assessment; design for the environment; eco-services; dematerialization; industrial symbiosis; industrial ecology; and zero emissions. There are of course other useful metaphors on the horizon, some of them included in this book. Including key contributions from the ground-breaking conferences ECO 97 and ECO 99, along with other specially commissioned and reprinted pieces, Metaphors for Change provides a treasure chest of new ideas, innovations and action. Accessible and forward-thinking, it will prove indispensable both as a student learning tool and as a panoramic overview of the sustainability metaphors key thinkers believe we should be putting into practice.
Metaphors for Environmental Sustainability: Redefining Our Relationship with Nature
by Brendon LarsonScientists turn to metaphors to formulate and explain scientific concepts, but an ill-considered metaphor can lead to social misunderstandings and counterproductive policies, Brendon Larson observes in this stimulating book. He explores how metaphors can entangle scientific facts with social values and warns that, particularly in the environmental realm, incautious metaphors can reinforce prevailing values that are inconsistent with desirable sustainability outcomes. Metaphors for Environmental Sustainabilitydraws on four case studies--two from nineteenth-century evolutionary science, and two from contemporary biodiversity science--to reveal how metaphors may shape the possibility of sustainability. Arguing that scientists must assume greater responsibility for their metaphors, and that the rest of us must become more critically aware of them, the author urges more critical reflection on the social dimensions and implications of metaphors while offering practical suggestions for choosing among alternative scientific metaphors.
Metaphors of Ed Tech (Issues in Distance Education)
by Martin WellerThe criticisms leveled at online education during the Covid-19 pandemic revealed not only a lack of understanding about how educational technology can be deployed effectively, but a lack of imagination. In this refreshing and insightful volume, Martin Weller provides new ways of thinking about educational technology through a wide range of metaphors. By using metaphors as a mental model, Weller enables educators to move beyond pragmatic concerns into more imaginative and playful uses of technology and to critically examine the appropriate implementation and adoption of ed tech.
Metaphysical Experiments: Physics and the Invention of the Universe (Posthumanities #49)
by Bjørn EkebergAn engaging critique of the science and metaphysics behind our understanding of the universe The James Webb Space Telescope, when launched in 2021, will be the premier orbital observatory, capable of studying every phase of the history of the universe, from the afterglow of the Big Bang to the formation of our solar system. Examining the theoretical basis for key experiments that have made this latest venture in astrophysics possible, Bjørn Ekeberg reveals that scientific cosmology actually operates in a twilight zone between the physical and metaphysical. Metaphysical Experiments explains how our current framework for understanding the universe, the Big Bang theory, is more determined by a deep faith in mathematical universality than empirical observation. Ekeberg draws on philosophical insights by Spinoza, Bergson, Heidegger, and Arendt; on the critical perspectives of Latour, Stengers, and Serres; and on cutting-edge physics research at the Large Hadron Collider, to show how the universe of modern physics was invented to reconcile a Christian metaphysical premise with a claim to the theoretical unification of nature.By focusing on the nonmathematical assumptions underlying some of the most significant events in modern science, Metaphysical Experiments offers a critical history of contemporary physics that demystifies such concepts as the universe, particles, singularity, gravity, blackbody radiation, the speed of light, wave/particle duality, natural constants, black holes, dark matter, and dark energy. Ekeberg&’s incisive reading of the metaphysical underpinnings of scientific cosmology offers an innovative account of how we understand our place in the universe.
Metapopulations and Wildlife Conservation
by Dale Richard Mccullough Jonathan Ballou Glen Woolfenden Bradley Stith F. Lance Craighead Bill PrantyDevelopment of rural landscapes is converting once-vast expanses of open space into pockets of habitat where wildlife populations exist in isolation from other members of their species. The central concept of metapopulation dynamics -- that a constellation of partially isolated patches can yield overall stability to a system that is chaotic at the level of the individual patch -- offers an important new way of thinking about the conservation and management of populations dispersed among small habitat fragments. This approach is proving to be a rich resource for biologists hoping to arrest the current catastrophic loss of biodiversity.This volume provides a comprehensive overview of the subject, addressing the needs of an applied professional audience for comprehensible information to integrate into their practices. Leading conservation biologists, ecologists, wildlife managers, and other experts consider the emergence and development of metapopulation theory and explore its applicability and usefulness to real-world conservation programs. Conservation is essential reading for anyone working in the field of wildlife conservation and management.
Metaproteomics: Methods and Protocols (Methods in Molecular Biology #2820)
by Carlo SalernoThis volume provides references for methods about the proteomics of microbial communities, also called metaproteomics. Chapters guide readers first through specific protein extractions from different environments and/or ecological niches crowded by heterogeneous microbial communities, then deepening the possible complete metaproteomic workflows in several situations or conditions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metaproteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Metastable States in Amorphous Chalcogenide Semiconductors
by Victor V. Mikla Victor I. MiklaThis book addresses an interesting and technologically important class of materials, the amorphous chalcogenide semiconductors. Experimental results on the structural and electronic metastable states in Se-rich chalcogenides are presented. Special attention is paid to the states in the mobility gap and their sensitivity to various factors such as irradiation, annealing and composition. Photoinduced changes of structure and physical properties are also considered and structural transformation at photocrystallization is studied in detail. Finally, the authors discuss potential applications of the observed effects in xerography, digital radiography and for optical data storage.