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Microengineering in Biotechnology
by Michael P. Hughes Kai F. HoettgesMicroelectronic engineering has revolutionized electronics, providing new, faster and cheaper ways of doing things - and now the same technology is being applied to biotechnology and molecular biology. As sample volume is reduced, reaction speed and detector sensitivity are increased whilst sample and reagent requirements and device cost are reduced. Microelectronic engineering provides the potential for bench-top versions of large and expensive equipment such as flow cytometry, or novel ones that exploit physical phenomena on the micron scale, such as dielectrophoresis for cell analysis. In Microengineering in Biotechnology, experts in the field contribute chapters aimed at instilling in the reader a working understanding of the methods underlying microengineering and the means by which such methods can be used for a range of analytical techniques. It describes the methods by which microengineered devices can be built to perform a number of applications and considers how the field may progress by examining some more complex lab on a chip devices which have great potential in the advancement of the way in which molecular biology is performed. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Cutting-edge yet easy-to-use, Microengineering in Biotechnology serves as a reference guide for practical microengineering techniques and as a route into the development of new devices for biological applications in order to strengthen the promising union of molecular and cellular biology with microelectronics.
Microextraction Techniques in Analytical Toxicology
by Rajeev JainMicroextraction Techniques in Analytical Toxicology provides the information readers need to include about cutting-edge sample preparation techniques into their everyday analytical practice, including comprehensive information about principles and state-of-the-art microextraction sample preparation techniques for the analysis of drugs and poisons in biological specimens, especially in forensic and clinical settings. This book also focuses on theoretical discussions of solid-based and liquid-based microextraction techniques, their method development, validation, and applications. A detailed compilation of analytical protocols based on published microextraction procedures to aid in method development, synthesis, and the application of green solvents (ionic liquids and deep eutectic solvents) and new sorbents, such as molecularly imprinted polymers, and their application in microextraction techniques are also covered. Features: Provides a systematic review of microextraction techniques applied in analytical toxicology A comprehensive guide for the practical implementation of microextraction techniques in forensic, clinical, and analytical laboratories Contains figures and tables for easy understanding and quick adaptation of the parameters of microextraction techniques Fundamentals, development, and applications of microextraction techniques as a sample preparation procedure are discussed in detail Extremely useful for the researchers and academicians engaged in analytical method development using microextraction techniques This book appeals to a wide readership of forensic, clinical, and analytical toxicologists, as well as academicians and researchers. Written by eminent scientists and leading experts on sample preparation techniques, this book serves as a desk reference for routine laboratory analysis and as an indispensable teaching tool in the classroom for graduate and Ph.D. students.
Microextraction Techniques: Fundamentals, Applications and Recent Developments (Integrated Analytical Systems)
by Miguel Ángel Rodríguez-Delgado Bárbara Socas-Rodríguez Antonio V. Herrera-HerreraThis book presents detailed descriptions of the most relevant sorbent based and solvent-based microextraction techniques. The development of such miniaturised techniques is an important focus area in Green Analytical Chemistry as it allows for the reduction of toxic solvents and hazardous substances and decreases the complexity, cost, and time of analytical procedures. Numerous advances have been made in this field, and currently, there are a great number of microextraction techniques thanks to the development of novel materials such as nanomaterials and green solvents. This book provides an overview of the two main groups of microextractions, sorbent-based, and solvent-based. Each chapter focuses on the description of the technique fundamentals, the main applications, and the novel developments carried out in recent years written by a renowned expert or group of experts in the field. The main audience will be graduates, postgraduates, and researchers. It is also a useful resource for Master and Ph.D. students that are working in the development of sustainable extraction techniques
Microfiber Pollution (Sustainable Textiles: Production, Processing, Manufacturing & Chemistry)
by R. Rathinamoorthy S. Raja BalasaraswathiThis book provides insights into microfiber pollution in textile industries that would help researchers and professionals to work from the textile point of view to mitigate the problem, and create a green sustainable future. Microplastic pollution has received great importance due to its adverse environmental and health impact. Microplastic particles are found to contaminate the ecosystem. Research has reported microplastics on seashores, in deep seas, freshwater systems including rivers and lakes, and most importantly in the air. Various land-based and water-based organisms are also contaminated with microplastics. The most serious issue is when these particles are found in the food chain and air which can reach the human system. It has been estimated that human beings can intake up to 1,21,000 microplastic particles in a year through food and inhalation. Being one of the most polluting industries, the contribution of Textile industries in microplastic pollution is extremely higher (around 35%). This book addresses the issue of microfiber/microplastic pollution cause by various techniques including home laundry and the ways to alleviate it.
Microfibre Pollution from Textiles: Research Advances and Mitigation Strategies (ISSN)
by R. Rathinamoorthy S. Raja BalasaraswathiTextile materials shed microfibres during different phases of their life cycle. While much attention has been paid to the impact of microplastics on the environment, there has been less focus on the impact of microfibre pollution, which also poses a serious environmental threat. Microfibre Pollution from Textiles: Research Advances and Mitigation Strategies shines a light on the hidden effects of textile microfibre pollution and examines its generation in manufacturing, use including laundering, and disposal. It details advancements and gaps in the quantification and characterization techniques that are emerging in the growing field of study of microfibre pollution in textile technology.The book• Examines the contributions of the textile and fashion industries to microfibre pollution, from production to disposal.• Reviews recently developed methods and technological advancements in the identification and quantification of microfibres from textiles.• Addresses emerging sustainable mitigation strategies and sustainable textile production methods that can potentially reduce or eliminate microfibre shedding.• Details the state-of-the-art on existing regulations and standards and provides scope for future research in the area of standard development. By bridging the gap between environmental and textile studies, this book is aimed at researchers and advanced students in textile and environmental science and engineering.
Microfiltration and Ultrafiltration: Principles and Applications
by ZemanIntegrates knowledge on microfiltration and ultrification, membrane chemistry, and characterization methods with the engineering and economic aspects of device performance, device and module design, processes, and applications. The text provides a discussion of membrane fundamentals and an analytical framework for designing and developing new filtrations systems for a broad range of technologically important functions. It offers information on membrane liquid precursors, fractal and stochastic pore space analysis, novel and advanced module designs, and original process design calculations.
Microfluidic Chip-Capillary Electrophoresis Devices
by Ying Sing FungCapillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Ch
Microfluidic Diagnostics
by Colin D. Mansfield Gareth JenkinsMicrofluidic techniques are becoming widely incorporated into medical diagnostic systems due to the inherent advantages of miniaturization. In Microfluidic Diagnostics: Methods in Molecular Biology, researchers in the field detail methods and protocols covering subjects such as microfluidic device fabrication, on-chip sample preparation, diagnostic applications and detection methodologies. The protocols described range from cutting-edge developments to established techniques and basic demonstrations suitable for education and training; from basic fabrication methods to commercializing research. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microfluidic Diagnostics: Methods in Molecular Biology seeks to aid scientists in the further development and commercialization of microfluidic diagnostic technologies
Microfluidic Electrophoresis: Methods and Protocols (Methods in Molecular Biology #1906)
by Debashis DuttaThis detailed book provides a set of protocols necessary for the development of a variety of microchip-based electrophoretic assays. It compiles a range of such electrophoretic methods by leading researchers in the field, covering subjects such as microfluidic device fabrication, on-chip sample preparation, theoretical/simulation protocols for assessing these separation methods, as well as common practices followed when applying them to important real world applications. The contents of the book range from protocols for classical assays to those involving pioneering separation techniques recently developed by the scientific community for advancing our analytical capabilities. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Microfluidic Electrophoresis: Methods and Protocols serves as an convenient text for academic researchers as well as practicing engineers, biochemists, and analytical laboratory professionals.
Microfluidic Fuel Cells and Batteries
by Erik KjeangMicrofluidic fuel cells and batteries represent a special type of electrochemical power generators that can be miniaturized and integrated in a microfluidic chip. Summarizing the initial ten years of research and development in this emerging field, this SpringerBrief is the first book dedicated to microfluidic fuel cell and battery technology for electrochemical energy conversion and storage. Written at a critical juncture, where strategically applied research is urgently required to seize impending technology opportunities for commercial, analytical, and educational utility, the intention is for this book to be a 'one-stop shop' for current and prospective researchers in the general area of membraneless, microfluidic electrochemical energy conversion. As the overall goal of the book is to provide a comprehensive resource for both research and technology development, it features extensive descriptions of the underlying fundamental theory, fabrication methods, and cell design principles, as well as a thorough review of previous contributions in this field and a future outlook with recommendations for further work. It is hoped that the content will entice and enable new research groups and engineers to rapidly gain traction in their own laboratories towards the development of next generation microfluidic electrochemical cells.
Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery (Chromatographic Science Series)
by Paul C.H. LiThe microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated. This microscale advantage translates into greater sensitivity, more accurate results, and better information. Microfluidic
Microfluidic Methods for Molecular Biology
by Chang Lu Scott S. VerbridgeThis book covers the state-of-the-art research on molecular biology assays and molecular techniques enabled or enhanced by microfluidic platforms. Topics covered include microfluidic methods for cellular separations and single cell studies, droplet-based approaches to study protein expression and forensics, and microfluidic in situ hybridization for RNA analysis. Key molecular biology studies using model organisms are reviewed in detail. This is an ideal book for students and researchers in the microfluidics and molecular biology fields as well as engineers working in the biotechnology industry. This book also: Reviews exhaustively the latest techniques for single cell genetic, epigenetic, metabolomic, and proteomic analysis Illustrates microfluidic approaches for inverse metabolic engineering, as well as analysis of circulating exosomes Broadens readers' understanding of microfluidics convection-based PCR technology, microfluidic RNA-seq, and microfluidics for robust mobile diagnostics.
Microfluidic Reactors for Polymer Particles
by Piotr Garstecki Eugenia KumachevaThe manipulation of fluids in channels with dimensions in the range from tens to hundreds of micrometers - microfluidics - has recently emerged as a new field of science and technology. Microfluidics has applications spanning analytical chemistry, organic and inorganic synthesis, cell biology, optics and information technology. One particularly promising application is the microfluidic synthesis of polymer particles with precisely controlled dimensions, and a variety of shapes, morphologies and compositions.Written as a comprehensive introduction for scientists and engineers working in microfabrication and microfluidics, Microfluidic Reactors for Polymer Particles covers topics such as:Applications and methods of generation of polymer particlesPhysics of microfluidic emulsificationFormation of droplets in microfluidic systemsHigh-throughput microfluidic systems for formation of dropletsMicrofluidic production of polymer particles and hydrogel particlesPolymer capsulesSynthesis of polymer particles with non-conventional shapesThis book is intended for a broad audience, including students, researchers and engineers in industry, with interests in physics, chemistry, materials science, engineering or biotechnology.
Microfluidic Systems for Cancer Diagnosis (Methods in Molecular Biology #2679)
by Jose L. Garcia-Cordero Alexander RevzinThis detailed volume explores recent developments in microfluidics technologies for cancer diagnosis and monitoring. The book is divided into two sections that delve into techniques for liquid biopsy for cancer diagnosis and platforms for precision oncology or personalized medicine in order to create effective patient avatars for testing anti-cancer drugs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microfluidic Systems for Cancer Diagnosis serves as an ideal guide that will be helpful to either replicate the construction of microfluidic devices specifically developed for cancer diagnosis or to catalyze development of new and better cancer diagnostic devices.
Microfluidic Techniques
by Shelley D. MinteerHands-on researchers review the principles behind successful miniaturization and describe the key techniques for miniaturizing large-scale biochemical and bioanalytical methods for microchip analysis. The authors cover not only the most popular methods for the fabrication of microchips (photolithography, laser ablation, and soft lithography), but also microfluidic techniques for such bioanalytical assays and bioprocesses as DNA analysis, PCR, immunoassays, and cell reactors. Highlights include PCR on a microchip, microscale cell culturing, and the study of cellular processes on a microchip. The protocols offer step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Microfluidics
by Bingcheng LinFlow Control Methods and Devices in Micrometer Scale Channels, by Shuichi Shoji and Kentaro Kawai. Micromixing Within Microfluidic Devices, by Lorenzo Capretto, Wei Cheng, Martyn Hill and Xunli Zhang. Basic Technologies for Droplet Microfluidics, by Shaojiang Zeng, Xin Liu, Hua Xie and Bingcheng Lin. Electrorheological Fluid and Its Applications in Microfluidics, by Limu Wang, Xiuqing Gong and Weijia Wen. Biosensors in Microfluidic Chips, by Jongmin Noh, Hee Chan Kim and Taek Dong Chung. A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics, by Satyajyoti Senapati, Sagnik Basuray, Zdenek Slouka, Li-Jing Cheng and Hsueh-Chia Chang. Optical Detection Systems on Microfluidic Chips, by Hongwei Gai, Yongjun Li and Edward S. Yeung. Integrated Microfluidic Systems for DNA Analysis, by Samuel K. Njoroge, Hui-Wen Chen, Małgorzata A. Witek and Steven A. Soper. Integrated Multifunctional Microfluidics for Automated Proteome Analyses, by John K. Osiri, Hamed Shadpour, Małgorzata A. Witek and Steven A. Soper. Cells in Microfluidics, by Chi Zhang and Danny van Noort. Microfluidic Platform for the Study of Caenorhabditis elegans,by Weiwei Shi, Hui Wen, Bingcheng Lin and Jianhua Qin.
Microfluidics Based Microsystems
by A. Pramuanjaroenkij B. Kosoy D. Li S. KakaçThis volume provides a comprehensive state-of-the art review of the fundamentals and applications of the microfluidics based microsystems. As the world becomes increasingly concerned with terrorism, early on-spot detection of terrorist's weapons, particularly bio-weapons agents such as bacteria and viruses are extremely important. Microfluidics are great tools for security and anti-terrorism with many applications. New and better diagnostic technology must be developed in order to be prepared for an act of bio-terrorism. Basics of Electrokinetic Microfluidics, Lab-on-a-Chip Devices for Biomedical Applications, Microfluidic Biological Application Specific Integrated Circuits, Integrated Optofluidics and Nanofluidic, Cell Culture Revolution via Dynamical Microfluidic Controls, Fundamentals of droplet flow in microfluidics, Implementation of fluidic functions in digital microfluidics, Chip architecture and applications for digital microfluidics, Mixing in microfluidic systems are presented and discussed in detail. In addition more presentations such as Optofluidics - Fusing Nanofluidics and Nanophotonics, Programmable Matter - Micro and milliscale fluid dynamics of reconfigurable assembly for control of living systems, An Overview on Microfluidic Platforms for Lab-on-a-Chip Applications, Centrifugal Microfluidics for Lab-on-a-Chip Applications are also given. Transport of droplets and bubbles in microfluidic systems - from flow through a simple pipe to logic gates and automated chips for chemical processing, Analytical, Synthesis and Bio-Medical Applications of Microchip Technology, Hydroporetic separation method for blood sample analysis, Magnetophoretic multiplexed immunoassays in a microchannel, programmable particle manipulation using lab-on-a-display, etc. are discussed in details with fundamentals and applications.
Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (Advances in Experimental Medicine and Biology #1379)
by Rui L. Reis David Caballero Subhas C. KunduThis book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics.Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research.The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
Microfluidics and Microfabrication
by Suman ChakrabortyMicrofluidics and Microfabrication discusses the interconnect between microfluidics, microfabrication and the life sciences. Specifically, this includes fundamental aspects of fluid mechanics in micro-scale and nano-scale confinements and microfabrication. Material is also presented discussing micro-textured engineered surfaces, high-performance AFM probe-based, micro-grooving processes, fabrication with metals and polymers in bio-micromanipulation and microfluidic applications. Editor Suman Chakraborty brings together leading minds in both fields who also: Cover the fundamentals of microfluidics in a manner accessible to multi-disciplinary researchers, with a balance of mathematical details and physical principles Discuss the explicit interconnection between microfluiodics and microfabrication from an application perspective Detail the amalgamation of microfluidics with logic circuits and applications in micro-electronics Microfluidics and Microfabrication is an ideal book for researchers, engineers and senior-level graduate students interested in learning more about the two fields.
Microfluidics and Microscale Transport Processes (IIT Kharagpur Research Monograph Series)
by Suman ChakrabortyThe advancements in micro- and nano-fabrication techniques, especially in the last couple of decades, have led research communities, over the world, to invest unprecedented levels of attention on the science and technology of micro- and nano-scale devices and the concerned applications. With an intense focus on micro- and nanotechnology from a flui
Microfluidics and Multi Organs on Chip
by P. V. MohananThis book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
Microfluidics and Nanofluidics
by Clement KleinstreuerFluidics originated as the description of pneumatic and hydraulic control systems, where fluids were employed (instead of electric currents) for signal transfer and processing. Microfluidics and Nanofluidics: Theory and Selected Applications offers an accessible, broad-based coverage of the basics through advanced applications of microfluidics and nanofluidics. It is essential reading for upper-level undergraduates and graduate students in engineering and professionals in industry.
Microfluidics and Nanofluidics Handbook: Chemistry, Physics, and Life Science Principles
by Suman Chakraborty Sushanta K. MitraThe Microfluidics and Nanofluidics Handbook: Two-Volume Set comprehensively captures the cross-disciplinary breadth of the fields of micro- and nanofluidics, which encompass the biological sciences, chemistry, physics and engineering applications. To fill the knowledge gap between engineering and the basic sciences, the editors pulled together key
Microfluidics and Nanofluidics Handbook: Fabrication, Implementation, and Applications
by Sushanta K. Mitra and Suman ChakrabortyThis comprehensive handbook presents fundamental aspects, fabrication techniques, introductory materials on microbiology and chemistry, measurement techniques, and applications of microfluidics and nanofluidics. The second volume focuses on topics related to experimental and numerical methods. It also covers fabrication and applications in a variety of areas, from aerospace to biological systems. Reflecting the inherent nature of microfluidics and nanofluidics, the book includes as much interdisciplinary knowledge as possible. It provides the fundamental science background for newcomers and advanced techniques and concepts for experienced researchers and professionals.
Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit (Devices, Circuits, and Systems #27)
by Krzysztof Iniewski Eric LagallyAn increasing number of technologies are being used to detect minute quantities of biomolecules and cells. However, it can be difficult to determine which technologies show the most promise for high-sensitivity and low-limit detection in different applications. Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit details proven approaches for the detection of single cells and even single molecules—approaches employed by the world’s foremost microfluidics and nanotechnology laboratories. While similar books concentrate only on microfluidics or nanotechnology, this book focuses on the combination of soft materials (elastomers and other polymers) with hard materials (semiconductors, metals, and glass) to form integrated detection systems for biological and chemical targets. It explores physical and chemical—as well as contact and noncontact—detection methods, using case studies to demonstrate system capabilities. Presenting a snapshot of the current state of the art, the text: Explains the theory behind different detection techniques, from mechanical resonators for detecting cell density to fiber-optic methods for detecting DNA hybridization, and beyond Examines microfluidic advances, including droplet microfluidics, digital microfluidics for manipulating droplets on the microscale, and more Highlights an array of technologies to allow for a comparison of the fundamental advantages and challenges of each, as well as an appreciation of the power of leveraging scalability and integration to achieve sensitivity at low cost Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit not only serves as a quick reference for the latest achievements in biochemical detection at the single-cell and single-molecule levels, but also provides researchers with inspiration for further innovation and expansion of the field.