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Mitochondrial Regulation: Methods and Protocols (Methods in Molecular Biology #2310)
by Carlos M. Palmeira Anabela P. RoloThis fully updated edition explores the different pathways that converge into the regulation of mitochondrial function. The book integrates mitochondria with other cellular components, discussing the dynamic properties of mitochondria with an emphasis on how these processes respond to signaling events and how they affect cellular metabolism. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mitochondrial Regulation: Methods and Protocols, Second Edition is an ideal guide for advanced undergraduates, graduates, postgraduates, and beginning researchers in the areas of molecular and cellular biology, biochemistry, and bioenergetics.
Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations
by Engineering Medicine National Academies of SciencesMitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration’s consideration of investigational new drug applications.
Mitochondrial Signaling in Health and Disease (Oxidative Stress and Disease)
by Enrique Cadenas Lester Packer Sten OrreniusMitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic
Mitophagy: Methods and Protocols (Methods in Molecular Biology #1759)
by Nobutaka Hattori Shinji SaikiThis volume focuses on mitophagy providing methods and protocols on the methodologies and the background information on monitoring mitophagy. Chapters detail the analysis of mitophagy in connection with Parkinson’s disease, especially young onset Parkinson’s disease impaired by PINK/parkin pathway, Drosophila, yeast, and Caenorhabditis elegans models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mitophagy: Methods and Protocols aims to stimulate and encourage researchers to carry out ongoing and new investigations into mitophagy.
Mitosis
by Andrew D. McainshWith the advent of modern methodology, the phenomenal complexity of the protein components and regulatory steps involved in mitosis has become approachable. In Mitosis: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate the mechanism of mitosis at the molecular level. Ideal for both experienced and novice scientists, the volume includes step-by-step methods covering inactivation of genes of interest, depletion of proteins of interest, biochemical and microscope-based techniques, and procedures to monitor and measure key mitotic processes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to the respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Mitosis: Methods and Protocols combines imaging, biochemical, and genetic methodologies in order to best guide researchers in their attempts to better understand the crucial processes of mitotic regulation.
Mitosis
by David J. SharpMitosis: Methods and Protocols provides state-of-the-art overviews on the most important approaches currently used in mitosis research spanning from the analysis of single molecules in isolation to their utilization within the complex environment of the cell. The volume is divided into four parts, each focused on methods pertaining to distinct aspects of mitosis research. Part I presents approaches for visualizing and analyzing the dynamic behaviors of the spindle apparatus, the microtubule based machine that drives chromosome segregation. Part II focuses more generally on methods for studying and manipulating the microtubule cytoskeleton in cells and complex cell free extracts. Part III provides state of the art biophysical and high resolution microscopy approaches for assessing complex interactions between microtubules and microtubule-associated proteins in isolation as well as microtubule structure in cells. Part IV provides methods for studying the effects of cell shape on cell division and methods for quantifying aneuploidy (aberrant chromosome number) which frequently results from mitotic defects and has been linked to human maladies ranging from birth defects to cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mitosis: Methods and Protocols seeks to provide diverse methods and new techniques to address new or old questions related to the mechanisms of mitosis. "
Mitosis: Methods and Protocols (Methods in Molecular Biology #2415)
by Edward H. HinchcliffeThis detailed volume collects a selection of key techniques for studying cell division, representing multiple model systems and varied scales of approach. Over the past 20 years, a series of revolutions in experimental molecular biology, including chimeric fluorescent protein expression, multiple advanced modes of quantitative microscopy, and array of small molecule inhibitors, proteomic profiling, and gene silencing/manipulation/analysis, has advanced the mitosis field to a point where single cell biology not only allows for imaging/localization studies, but also for quantitative analysis and sequencing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mitosis: Methods and Protocols provides a repository of techniques and approaches for those working in the field as well as a working resource for those venturing into the study of mitosis for the first time.
Mitotic Exit: Methods and Protocols (Methods in Molecular Biology #2874)
by Victor M. Bolanos-GarciaThis volume explores the latest approaches and techniques used to study mitotic exit in diverse model organisms. The chapters in this book cover topics such as transgenic methods generation of RNAi-sensitive cell lines; gene overexpression in heterologue gene expression systems; quantitative live cell imaging and FRET-FLIM; biochemical protocols for analyzing post-translational modifications responsible for mitotic exit regulation; and ways to promote mitosis arrest in disease-associated conditions such as cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Mitotic Exit: Methods and Protocols is a valuable resource for all researchers interested in learning more about this important and advancing field.
Mitral Valve Surgery
by Robert S. Bonser Domenico Pagano Axel HaverichPart of the Monographs in Cardiac Surgery Series - Introducing 'basic science into the cardiac operating room'. Fast systematic review of small areas of cardiac surgery including up-to-date information. This will allow more rapid publication than the alternative cardiac surgery 'tomes'. This entry into the series will provide readers with a complete review of the current understanding in mitral valve surgery and include extensive details on the diagnosis and surgical management of patients with mitral valve disease.
Mitzi and the Big Bad Nosy Wolf: A Digital Citizenship Story
by Teresa BatemanA clever lamb outsmarts a nosy wolf in this humorous fable about online safety for young children.When a furry stranger named Rolf starts asking Mitzi questions about her name, where she lives, where her mom and dad work, and more, Mitzi quickly devises a strategy to dispatch the nosy wolf using her dance skills!A refrain of &“That&’s Private!&” teaches kids the importance of privacy when it comes to sharing personal information while hilarious visual gags keep the reading experience light. Author Teresa Bateman created Mitzi when she was a school librarian as a way to talk with her students about the dos and don'ts of online safety. Perfect for teaching children how to use the internet in a safe, respectful manner, Mitzi and the Big Bad Nosy Wolf is just the book for today's young digital citizens.Back matter includes Mitzi&’s Rules for Digital Citizenship, which outlines best practices when using the internet, from safety to cyberbullying; a glossary that include such terms as public, private, and digital footprint; and a memory game activity for at home or classroom use.
Mixed Convection in Fluid Superposed Porous Layers
by Francis A. Kulacki John M. DixonThis Brief describes and analyzes flow and heat transport over a liquid-saturated porous bed. The porous bed is saturated by a liquid layer and heating takes place from a section of the bottom. The effect on flow patterns of heating from the bottom is shown by calculation, and when the heating is sufficiently strong, the flow is affected through the porous and upper liquid layers. Measurements of the heat transfer rate from the heated section confirm calculations. General heat transfer laws are developed for varying porous bed depths for applications to process industry needs, environmental sciences, and materials processing. Addressing a topic of considerable interest to the research community, the brief features an up-to-date literature review of mixed convection energy transport in fluid superposed porous layers.
Mixed Cultures in Industrial Bioprocesses (Advances in Biochemical Engineering/Biotechnology #189)
by Elias HakalehtoThis book reviews the potential of mixed microbial cultures in industrial bioprocesses, offering groundbreaking insights and practical applications. It addresses different applications and challenges and discusses potential solutions for utilizing mixed cultures. Through this book, readers will learn about the latest advancements in microbial bioprocessing, from innovative fermentation techniques to sustainable waste management solutions. Divided into 10 chapters, the book covers topics such as mixed strain fermentation and metabolomics, and the dynamic nature of the human gut microbiota. Expert contributors also explore critical issues like selenium removal from wastewater, simultaneous CO2 absorption and wastewater treatment, and the production of novel energy gases using undefined mixed cultures. This book highlights the power and benefits of microbial communities and their metabolic networks by describing how they can be harnessed for food and forest industry waste reuse and the upgrading of products from bio-refinery pilots. The combinations of economically feasible and sustainable processes in ecosystem engineering are also discussed. Finally, the future of biorefinery industries as a part of circulation economies and healthier environments is discussed. Given its breadth, the book is a valuable resource for researchers in biochemical engineering and biotechnology fields, as well as anyone dealing with industrial R&D, construction projects or sustainable food and feed production. The empirical research and its outcomes presented here address pressing environmental challenges, making this volume a must-read for anyone committed to advancing sustainable biotechnological solutions.
Mixed Effects Models and Extensions in Ecology with R
by Neil Walker Elena N. Ieno Graham M. Smith Anatoly A. Saveliev Alain ZuurThis book discusses advanced statistical methods that can be used to analyse ecological data. Most environmental collected data are measured repeatedly over time, or space and this requires the use of GLMM or GAMM methods. The book starts by revising regression, additive modelling, GAM and GLM, and then discusses dealing with spatial or temporal dependencies and nested data.
Mixed Messages: Cultural and Genetic Inheritance in the Constitution of Human Society
by Robert A. PaulAs social and symbolic animals--animals with language and systems of signs--humans are informed by two different kinds of heritage, one biological, the other cultural. Scholars have tended to study our genetic and symbolic lineages separately, but in recent years some have begun to explore them together, offering a "dual inheritance theory. ” In this book, Robert A. Paul offers an entirely new and original consideration of our dual inheritance to date, going deep inside an extensive ethnographic record to outline a fascinating relationship between our genetic codes and symbolic systems. Examining a wide array of cultures, Paul reveals how the inherent tensions between these two modes of transmission generate many of the features of human society, such as marriage rules, initiation rituals, gender asymmetry, and sexual symbolism. Exploring differences in the requirements, range, and agendas of genetic and symbolic reproduction, he shows that a properly conceived dual inheritance model does a better job of accounting for the distinctive character of actual human societies than either evolutionary or socio-cultural construction theories can do alone. Ultimately this book offers a powerful call for a synthesis of the traditions inspired by Darwin, Durkheim, and Freud--one that is critically necessary if we are to advance our understanding of human social life.
Mixed Methods in den Digital Humanities: Topic-informierte Diskursanalyse am Beispiel der Volkszählungs- und Zensusdebatte (Digitalitätsforschung / Digitality Research)
by Anne DeremetzDie Topic-informierte Diskursanalyse ist ein Mixed-Methods-Verfahren, das Methoden des Text-Mining mit der Wissenssoziologischen Diskursanalyse verbindet, um Diskurstransformationen im Zeitverlauf zu analysieren. Im ersten Teil wird das Verfahren entwickelt und der epistemologische, theoretische, methodologische und methodische Aufbau erläutert. Im zweiten Teil wird das Verfahren am Beispiel der Volkszählungs- und Zensusdebatte in Deutschland in den Jahren 1982-2020 angewendet und veranschaulicht. Das Buch richtet sich an Diskursforscher:innen und Forscher:innen der Digital Humanities, die Methoden aus beiden Fachbereichen kombiniert einsetzen und anwenden wollen.
Mixed Mode Oscillations: Fundamentals and Applications (Studies in Systems, Decision and Control #374)
by Zdzislaw TrzaskaThis book aims to present a survey of a large class of nonlinear dynamical systems exhibiting mixed-mode oscillations (MMOs). It is a sort of a guide to systems related to MMOs that features material from original research papers, including the author’s own studies. The material is presented in seven chapters divided into sections. Usually, the first sections are of an introductory nature, explain phenomena, and exhibit numerical results. More advanced investigations are presented in the subsequent sections. Coverage includes* Dynamic behavior of nonlinear systems, * Fundamentals of processes exhibiting MMOs,* Mechanism and function of an structure of MMOs patterns, * Analysis of MMOs in electric circuits and systems, * MMOs in chemistry, biology, and medicine, * MMOs in mechanics and transport vehicles, * MMOs in fractional order systems.This is the first extensive description of these topics and the interpretation of analytical results and those obtained from computer simulations with the MATLAB environment. The book provides the readers with better understanding of the nature of MMOs, richness of their behaviors, and interesting applications.
Mixed Plantations of Eucalyptus and Leguminous Trees: Soil, Microbiology and Ecosystem Services
by Elke Jurandy Bran Nogueira Cardoso José Leonardo de Moraes Gonçalves Fabiano de Carvalho Balieiro Avílio Antônio FrancoThe aim of this book is to present, in depth, updated information on soil and microbial processes involved in mixed plantations of Eucalyptus and N2-fixing species, especially Acacia mangium, focusing on Forestry, Soils, Biology, Ecosystem Services and Sustainability. The potential of substituting chemical N fertilizer by a consortium of leguminous species that fix atmospheric nitrogen is an interesting solution for a more sustainable, economically and environmentally sound forest system. Among the main topics, we present reference topics on soil microbiology, as biological nitrogen fixation, the role of mycorrhiza in mixed plantations, bio-indicators of soil quality, and plantgrowth promoting bacteria with biotechnological potential. Here we discuss Ecosystem services and ecological benefits of these systems, the invasive potential of A.mangium, as well as the regulations and perspectives of land use policies for mixed forests and their role in the sustainability of the system.
Mixed Signals: Alien Communication Across the Iron Curtain
by Rebecca CharbonneauIn the shadow of the Cold War, whispers from the cosmos fueled an unlikely alliance between the US and USSR. The search for extraterrestrial intelligence (or SETI) emerged as a foundational field of radio astronomy characterized by an unusual level of international collaboration—but SETI’s use of signals intelligence technology also served military and governmental purposes. In this captivating new history of the collaboration between American and Soviet radio astronomers as they sought to detect evidence of extraterrestrial civilizations, historian Rebecca Charbonneau reveals the triumphs and challenges they faced amidst a hostile political atmosphere. Shedding light on the untold stories from the Soviet side for the first time, she expertly unravels the complex web of military and political interests entangling radio astronomy and the search for alien intelligence, offering a thought-provoking perspective on the evolving relationship between science and power. This is not just a story of radio waves and telescopes; it's a revelation of how scientists on both sides of the Iron Curtain navigated the complexities of the Cold War, blurring the lines between espionage and the quest for cosmic community. Filled with tension, contradiction, and the enduring human desire for connection, this is a history that transcends national boundaries and reaches out to the cosmic unknown, ultimately asking: how can we communicate with extraterrestrials when we struggle to communicate amongst ourselves?
Mixed Surfactant Systems (Surfactant Science)
by Masahiko Abe John F. ScamehornCompletely revised and expanded throughout, Mixed Surfactant Systems, Second Edition surveys the latest results, newest experimental perspectives, and theoretical investigations of properties, behavior, and techniques applicable to mixed surfactant systems. This important book elucidates core theoretical notions while summarizing results of
Mixed and Augmented Reality in Medicine (Series in Medical Physics and Biomedical Engineering)
by Ziv Yaniv Jacqueline Williams Terry M. Peters Cristian A. LinteAugmented reality (AR) is transforming how we work, learn, play and connect with the world, and is now being introduced to the field of medicine, where it is revolutionising healthcare as pioneering virtual elements are being added to real images to provide a more compelling and intuitive view during procedures. This book, which had its beginnings at the AE-CAI: Augmented Environments for Computer-Assisted Interventions MICCAI Workshop in Munich in 2015, is the first to review the area of mixed and augmented reality in medicine. Covering a range of examples of the use of AR in medicine, it explores its relevance to minimally-invasive interventions, how it can improve the accuracy of a procedure and reduce procedure time, and how it may be employed to reduce radiation risks. It also discusses how AR can be an effective tool in the education of physicians, medical students, nurses and other health professionals. Features: An ideal practical guide for medical professionals and students looking to understand the implementation, applications, and future of AR Contains the latest developments and technologies in this innovative field Edited by highly respected pioneers in the field, who have been immersed in AR as well as virtual reality and image-guided surgery since their inception, with chapter contributions from subject area specialists working with AR
Mixed-Integer Representations in Control Design
by Florin Stoican Sorin Olaru Silviu-Iulian Niculescu Ionela ProdanIn this book, the authors propose efficient characterizations of the non-convex regions that appear in many control problems, such as those involving collision/obstacle avoidance and, in a broader sense, in the description of feasible sets for optimization-based control design involving contradictory objectives. The text deals with a large class of systems that require the solution of appropriate optimization problems over a feasible region, which is neither convex nor compact. The proposed approach uses the combinatorial notion of hyperplane arrangement, partitioning the space by a finite collection of hyperplanes, to describe non-convex regions efficiently. Mixed-integer programming techniques are then applied to propose acceptable formulations of the overall problem. Multiple constructions may arise from the same initial problem, and their complexity under various parameters - space dimension, number of binary variables, etc. - is also discussed. This book is a useful tool for academic researchers and graduate students interested in non-convex systems working in control engineering area, mobile robotics and/or optimal planning and decision-making.
Mixed-Mode Chromatography: Principles, Methods, and Applications
by Qian-Hong WanThe book is about the technology and application of Mixed-mode chromatography (MMC). Unlike conventional single-mode HPLC, which resolves the analytes primarily based on their ionic or hydrophobic properties, MMC employs multifunctional stationary phases to exploit at least two modes of interactions (i.e., ionic and hydrophobic) with the analytes and as such often provides resolution that far exceeds that observed with a single-mode process. Over the past two decades, MMC has developed into an important analytical and purification tool in a number of applications in pharmaceutical and biotechnology industries. The technique has been used widely for the analyses of nucleic acids, amino acids, peptides, proteins, glycoproteins, carbohydrates, antibiotics, vaccines, and other products. The purpose of this book is to present a comprehensive survey of mixed-mode chromatography and is intended as a reference guide for graduate students and experienced scientists in pharmaceutical and biotechnology disciplines wishing to gain a deep understanding of this continuously evolving technology.
Mixed-Valence Systems: Fundamentals, Synthesis, Electron Transfer, and Applications
by Jeffrey R. Reimers Yu‐Wu Zhong Chun Y. LiuMixed-Valence Systems Comprehensive overview on the advanced development of mixed-valence chemistry Mixed-Valence Systems: Fundamentals, Synthesis, Electron Transfer, and Applications covers all topics related to the theory and experimental results of mixed-valence systems, including the design, synthesis, and applications of mixed-valence compounds containing inorganic, organometallic and organic redox-active centers. The text also covers the recent advances in mixed-valence chemistry, including the development of new mixed-valence systems, transition of mixed valency, better understanding of the spectral characteristics of intervalence charge transfer, and controllable electron transfer related to molecular electronics. In Mixed-Valence Systems, readers can expect to find detailed information on sample topics such as: Characterization and evaluation of mixed-valence systems, electron paramagnetic resonance spectroscopy, and electrochemical methods Optical analysis, important issues in mixed-valence chemistry, transition of mixed valency from localized to delocalized, and solvent control of electron transfer Theoretical background, potential energy surfaces from classical two-state model, and quantum description of the potential energy surfaces Reorganization energies, electronic coupling matrix element and the transition moments, generalized Mulliken–Hush theory, and analysis of the band shape of intervalence charge transfer Strengthening the relationship of mixed-valence electron transfer and molecular electronics, Mixed-Valence Systems is of immense value to researchers and professionals working in the field of electron transfer, molecular electronics, and optoelectronics.
Mixed-flow Pumps: Modeling, Simulation, and Measurements (Wiley-ASME Press Series)
by Wei Li Ramesh Agarwal Ling Zhou Leilei Ji Weidong ShiMixed-flow Pumps Modeling, Simulation, and Measurements Learn to improve and optimize the design and operation of mixed-flow pumps Mixed-flow pumps have a huge range of applications in agriculture, hydroelectric power, and other industries that incorporate fluid transport. They are centrifugal pumps incorporating the characteristics of both axial and radial pumps to increase the flow rate and discharge pressure. Though essential in a variety of industries, they pose serious challenges to numerical simulation methods, challenges which are starting to be met by the application of computational fluid dynamics using high-performance computing. Mixed-flow Pumps introduces engineers and researchers to this subject and its important applications. Incorporating all major varieties of mixed-flow pumps used in industrial applications, it employs methods from advanced computational fluid dynamics and high-precision flow field experimentation to characterize and analyze these crucial technologies. Moving from the fundamentals of the technology to its most advanced applications, it’s an essential resource for engineers and industry practitioners looking to develop their understanding of fluid transport. Mixed-flow Pumps readers will also find: Detailed information on how to design and optimize mixed-flow pumps to meet the increasingly stringent industry demands Detailed information on energy performance tests and experiments, methods for data analysis, entropy production theory, CFD solutions using Reynolds-Averaged Navier-Stokes (RANS) equations, and more An authoritative team with immense global experience in flow pumps and broader industrial experience Mixed-flow Pumps is a useful reference for mixed-flow pump design by academic researchers, including graduate students, industry practitioners, and test engineers.
Mixing Races: From Scientific Racism to Modern Evolutionary Ideas (Johns Hopkins Introductory Studies in the History of Science)
by Paul Lawrence FarberThis book explores changing American views of race mixing in the twentieth century, showing how new scientific ideas transformed accepted notions of race and how those ideas played out on college campuses in the 1960s.In the 1930s it was not unusual for medical experts to caution against miscegenation, or race mixing, espousing the common opinion that it would produce biologically dysfunctional offspring. By the 1960s the scientific community roundly refuted this theory. Paul Lawrence Farber traces this revolutionary shift in scientific thought, explaining how developments in modern population biology, genetics, and anthropology proved that opposition to race mixing was a social prejudice with no justification in scientific knowledge.In the 1960s, this new knowledge helped to change attitudes toward race and discrimination, especially among college students. Their embrace of social integration caused tension on campuses across the country. Students rebelled against administrative interference in their private lives, and university regulations against interracial dating became a flashpoint in the campus revolts that revolutionized American educational institutions. Farber’s provocative study is a personal one, featuring interviews with mixed-race couples and stories from the author’s student years at the University of Pittsburgh. As such, Mixing Races offers a unique perspective on how contentious debates taking place on college campuses reflected radical shifts in race relations in the larger society.