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Myocardial Tissue Engineering
by Aldo R. Boccaccini Sian HardingMyocardial tissue engineering (MTE), a concept that intends to prolong patients' life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered 'vehicle', which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
Myofibroblasts: Methods and Protocols (Methods in Molecular Biology #2299)
by Boris Hinz David LagaresThis detailed book explores the fundamentals of myofibroblast biology in tissue repair, fibrosis, and tumors as well as providing cutting-edge laboratory methods used to investigate myofibroblast functions in physiological and pathological settings in vitro and in vivo, as written by leading academic scientists. Section I of this volume focuses on fundamental methods to study myofibroblast biology and covers topics such as methods for detecting myofibroblasts and senescent myofibroblasts in cell culture and histology, single cell RNA sequencing to identify myofibroblast subsets in fibrotic tissues, and functional assays to assess TGF-β activation, myofibroblast apoptosis, or matrix deposition and crosslinking. Section II discusses methods to investigate the mechanobiology of myofibroblasts in vitro, including the fabrication of functional hydrogels with tunable stiffness, the use of atomic force microscopy to characterize matrix and cellular stiffness, as well as molecular assays to assess fibroblast mechanotransduction pathways and durotaxis. Section III describes multiple animal models to investigate myofibroblast functions across organs in vivo as well as human organoid systems, precision tissue slices and decellularized 3D tissue scaffolds to assess myofibroblast functions in relevant human ex vivo models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and extensive, Myofibroblasts: Methods and Protocols is an essential collection for researchers delving into the processes and effects of these important cells.
Myogenesis
by Joseph X. DimarioOur understanding of the molecular and cellular mechanisms that control skeletal muscle development, regeneration, and adaptive responses to activity has increased dramatically in recent years, fostered by innovative techniques and approaches that are either specifically designed or adapted for research in skeletal muscle biology. Myogenesis: Methods and Protocols presents detailed, step-by-step methods in the study of the molecular and cellular biology of skeletal muscle cells. Protocols from different model systems including mammalian, avian, zebrafish, and invertebrate skeletal muscle are included in this volume. Highlighted topics cover a wide range of interests and expertise including myogenic and stem cell isolation, investigation of models of exercise and disuse, viral vector delivery systems, calcium imaging, cell profiling, as well as protein-DNA and protein-protein interactions. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Myogenesis: Methods and Protocols serves as an invaluable, state-of-the-art resource for experienced and emerging scientists in basic research as well as clinical and regenerative medicine.
Myogenesis
by Sissel Beate RønningThis detailed volume collects many of the common experimental approaches used to study myogenesis. It covers subjects ranging from isolation and purification protocols, manipulation of muscle cells, transcriptomics and proteomics, metabolism and exercise, and tissue engineering. Presented methods involve different species, including human, bovine, Atlantic salmon, rats, mice, larval zebrafish, and Drosophila melanogaster. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Myogenesis: Methods and Protocols aims to serve as an essential part of many laboratory libraries and to assist researchers throughout the world in revealing the unknowns of myogenesis.
Myosins: A Superfamily of Molecular Motors (Advances in Experimental Medicine and Biology #1239)
by Lynne M. ColuccioThis highly authoritative volume highlights the remarkable superfamily of molecular motors called myosins, which are involved in such diverse cellular functions as muscle contraction, intracellular transport, cell migration and cell division. In a timely compilation of chapters written by leading research groups that have made key discoveries in the field, the current understanding of the molecular mechanisms and biological functions of these intriguing proteins is explored.
Myself and Other Animals: A posthumous work from the beloved conservationist to celebrate the centenary of his birth
by Gerald DurrellA posthumous work from the beloved conservationist and naturalist Gerald Durrell, to celebrate the centenary of his birth, with a new foreword by HRH Princess Anne.‘Gerald Durrell was magic’ SIR DAVID ATTENBOROUGH ‘A wise, genial and world-encompassing book’ SUNDAY TIMES ‘Fills important gaps in the biographical narrative . . . Truly, there is magic here’ GUARDIAN Myself and Other Animals is a new book mosaicked from unpublished autobiographies, uncollected pieces and previously published extracts from Durrell’s work and archives. The result is an extraordinary journey through Durrell’s life in his own words, edited and introduced by his widow Lee Durrell.Drawing on a memoir that Durrell started writing before he became too ill to continue it, and an unfinished book from a trip to Australia in 1969 to the Great Barrier Reef, Northern Territory and Queensland, here is the unvarnished story of Durrell’s life, from touching family tributes to golden bats and pink pigeons.Moving from India to England and then to the always sun-lit Corfu, told with dry wit and insight into our fellow animals, here is the vivid finale of one of Britain’s most beloved conservationists and prose stylists.'Funny and readable and hugely charming' i ‘One of the finest and most lyrical nature writers in English’ OBSERVER'A moving tribute to Gerald's endeavours and achievements as a conservationist' SPECTATOR
Mysteries and Secrets of Time
by Lionel And FanthorpeThis fascinating work begins with a scientific appraisal of time and its relationship with 3D space. It explains in clear, understandable language, the complex theories of such famous men as Newton, Einstein, and Stephen Hawking. Is time infinite, or does it have a beginning and an end? Do Black Holes and White Vortices distort time, or penetrate it? The authors also analyse and evaluate puzzling, well documented reports of time travel and reincarnation, and strange cases of deja vu. Can time travel account for such anachronistic discoveries as a 20th century sparkplug found encased among fossils half a million years old? Finally, the authors bring all the unsolved time-related mysteries together in a unified field theory that suggests an awesome answer to the mysteries of time-travel and reincarnation.
Mysteries of Black Holes and Dark Matter (Solving Space's Mysteries)
by Ellen LabrecqueWhat is a black hole? What is dark matter and what is it made of? How do scientists discover black holes and dark matter if they can’t be seen? What do scientists know about these mysterious parts of the universe and what do they still hope to find out? Budding astronomers will learn the answers to these questions and more!
Mysteries of Mars (Springer Praxis Books)
by Fabio Vittorio De BlasioThis book introduces the reader to the wonders of Mars, covering all aspects from our past perceptions of the planet through to the latest knowledge on its history, its surface processes such as impact cratering, volcano formation, and glaciation, and its atmosphere and climate. In addition, a series of ten intriguing open issues are considered in a more advanced way. These include such thought-provoking questions as What turned off the planet’s magnetic field?, Why are the northern and southern hemispheres so different?, What was the fate of the once abundant water?, and Is there, or was there, life on Mars? Numerous original figures, unavailable elsewhere, reproduce details of images from Viking, CTX, MOC, HiRISE, THEMIS, and HRSC. The book will appeal especially to general readers interested in planetary sciences, astronomy, astrogeology, and space exploration and to students of Earth Sciences and Natural and Environmental Sciences. The higher-level material on the remaining mysteries of Mars will also be of interest to astrogeologists and other researchers.
Mysteries of Meteors, Asteroids, and Comets (Solving Space's Mysteries)
by Ellen LabrecqueWhat are asteroids, comets, and meteors made of? What can scientists do if an asteroid is headed toward Earth? Learn how astronomers prepare for space objects hitting Earth, from tracking them to building asteroid-hunting telescopes. Budding astronomers will learn all about meteors, asteroids, and comets, including the history of asteroids hitting Earth and the differences between space rocks.
Mysteries of Moons and Moon Phases (Solving Space's Mysteries)
by Ellen LabrecqueFull moons in folklore and legends are said to have magic power. Does a full moon really affect our planet and people living on it? Get a closer look at the moons in our solar system, from the known moons to the ones that haven’t been discovered. Budding astronomers will learn all about moons, from Jupiter’s 63 moons to the features of Earth’s moon.
Mysteries of Planets, Stars, and Galaxies (Solving Space's Mysteries)
by Lela NargiDoes life exist somewhere other than Earth? How many planets are outside our galaxy? What happens when stars crash into each other? For a long time, people believed Earth was the only planet in the galaxy. Now we know the universe is much bigger. Budding astronomers will learn all about planets, stars, and galaxies, from what’s already known to what scientists are still hoping to find out.
Mysteries of the Constellations (Solving Space's Mysteries)
by Lela NargiWhat are constellations? Who named them? Where can they be found? Ancient peoples believed constellations held clues to the future. These groupings of stars helped farmers plant crops and sailors find their way home. Budding astronomers will learn all about constellations, including the history of studying the stars, how today’s constellations were named, and how constellations help today’s astronomers.
Mysteries of the Human Body: Weird and Wonderful Anatomy Explained
by Neon Squid Dr. Azmain ChowdhuryA human body book with a twist—discover the science behind the weird and unusual stuff our bodies can do from Dr. Azmain Chowdhury, with illustrations from Daniel Nelson.You know your heart is always beating, your intestines digest your food, and even that your brain is still awake when you’re asleep—that’s no mystery. But why do we get "brain freeze" if we eat ice cream too quickly? And why on earth do we get butterflies in our stomach when we’re nervous? And is it true we can squirt milk from our eyes?!This book focuses on the bizarre things all of our bodies do—including things we don’t understand (looking at you, appendix). Dr. Azmain also asks the burning medical questions we’ve all been wondering about:Why does cilantro taste like soap to some people?How long can we stay awake for?Can our hearts actually break after a romantic break-up? (Asking for a friend).Filled with gross, surprising, and downright terrifying facts, it’s bloated with cool science to impress your friends.
Mysteries of the Social Brain: Understanding Human Behavior Through Science
by Bruce L. Miller Virginia SturmMysteries of the Social Brain describes the scientific underpinnings of human behavior and values. Through the retelling of fascinating clinical stories of people with neurological conditions, this book explores the parts of the brain that allow humans to thrive as social and creative beings. The authors reveal the relevance of our brain circuits to our well‑being—and the well‑being of our societies—and show what happens when changes in our brain circuitry drive changes in empathy, altruism, moral beliefs, and creativity.By integrating perspectives from neurology, psychology, psychiatry, and neuroscience, the stories in this book offer novel insights into the inner workings of the social brain and reveal groundbreaking findings from work in frontotemporal dementia, emotion, and the science of human values. This book showcases the novel discovery that creativity can emerge when there is decline in the brain’s language systems, a finding that highlights the robust, yet underappreciated connections between science and art. Readers will learn about the biological basis of social behavior as well as simple steps that they can take to improve the functioning of their own social brains.Miller and Sturm take us on an engaging dive into the field of behavioral neurology and neuroscience, exploring what we can learn from people with neurological conditions, and revealing the ways that neuroscience can change societies for the better. It will captivate general readers as well as clinicians and scientists who are interested in human social behavior, cognition, and emotion.
Mysteries of the Universe (Solving Space's Mysteries)
by Lela NargiHas the universe always existed? Scientists have looked further into space and discovered the galaxies moving. Were they once closer together? If scientists look far enough, can they discover where our universe started? Budding astronomers will learn all about the universe in this in-depth look at space science.
Mysterious Creatures: A Guide To Cryptozoology, Volume 1
by George M. EberhartIn the hi-tech, industrialised world of the 21st Century, monsters still loom large. Far from being relegated to the realm of myth and legend, mysterious creatures seem to be alive and well today. <p><p>In this, the first of two volumes, acclaimed researcher George M. Eberhart provides a comprehensive list of the creatures that roam our monster-haunted planet. Covering 'A-M', Volume One tackles some well-known beasts as well as more esoteric creatures few will have heard of.
Mysterious Creatures: A Guide To Cryptozoology, Volume 2
by George M. EberhartIn the hi-tech, industrialised world of the 21st Century, monsters still loom large. Far from being relegated to the realm of myth and legend, mysterious creatures seem to be alive and well today. <p><p>In this, the second of two volumes, acclaimed researcher George M. Eberhart provides a comprehensive list of the creatures that roam our monster-haunted planet. Covering 'N-Z', Volume Two tackles some well-known beasts as well as more esoteric creatures few will have heard of.
Mysterious Migrations (Fountas & Pinnell LLI Purple #Level Q)
by Terry Miller ShannonText Elements <p><p> Genre: Expository/Biography <p> Text Structures <p> Main: Chronological Sequence <p> Embedded: Description, Problem/Solution, Cause/Effect <p> Text Features: table of contents, headings, photos, captions, map, sidebars
Mysterious Ocean: Physical Processes and Geological Evolution (Springer Oceanography Ser.)
by Peter Townsend HarrisThis book provides an introduction to ocean sciences that is engaging, evocative and accessible to non-experts interested in marine geoscience, while sparking readers' interest in important unsolved mysteries in marine science. The scope of the book is quite broad, but focuses on the physical ocean and its geological evolution, including the author's experiences working as an oceanographer over the last thirty years. Across ten chapters, the book traces the origins of the ocean from its formation 4 billion years ago, reviews the discoveries of the theory of plate tectonics, the ice ages and the great ocean conveyor, and discusses seafloor features (canyons, seamounts, trenches, abyssal plains, etc.), how they formed and their current environmental issues. The book concludes with a prognosis for the future ocean we might expect with global climate change and other human impacts.
Mysterious Patterns: Finding Fractals in Nature
by Sarah C. CampbellNature's repeating patterns, better known as fractals, are beautiful, universal, and explain much about how things grow. Fractals can also be quantified mathematically. Here is an elegant introduction to fractals through examples that can be seen in parks, rivers, and our very own backyards. Young readers will be fascinated to learn that broccoli florets are fractals—just like mountain ranges, river systems, and trees—and will share in the wonder of math as it is reflected in the world around us. Perfect for any elementary school classroom or library, Mysterious Patterns is an exciting interdisciplinary introduction to repeating patterns.
Mystery Disease: Problem-Based Learning (Grades 5-8)
by Mark A. BohlandA serious illness is sweeping through town. Why are people getting sick? What is the source of this disease? With this problem-based learning unit, students become public health workers as they track down the source of a mysterious illness. Working in teams to solve the real-world problem and present their findings, they experience genuine, higher order learning. Decisions they make affect the outcome of the simulation.The activities combine science, social studies, math, research, thinking, cooperation, and speech skills in one great unit. This guide includes everything you need—teacher's directions and student information in the form of memos and medical reports.This open-ended scenario will draw students into a real-life drama.Allow your students to solve more real-life problems in Crime Scene Detective, Detective Club, Mystery Science, and The Great Chocolate Caper.Grades 5-8
Mystery Teachings from the Living Earth: An Introduction to Spiritual Ecology
by John Michael GreerThe authentic mystery teachings are not about quick fixes or easy answers. They offer something far deeper and more meaningfulùa path of personal transformation in harmony with the cosmos on all its levels, from the ultimate heights of spirit to the fragile and beautiful planet on which we live. In Mystery Teachings from the Living Earth, ecologist and Druid initiate John Michael Greer offers an introduction to the core teachings of the mysteries through the mirror of the natural world.
Mystery of the Ashen Light of Venus: Investigating a 400-Year-Old Phenomenon (Astronomers' Universe)
by John C. BarentineThe “Ashen Light” of Venus—a ghostly emission of light from the night side of our nearest planetary neighbor—is among the last unsolved mysteries of astronomical history. In the four centuries since the phenomenon was first reported, highly reputable visual observers of Venus have recorded seeing the Ashen Light, while others have spent a lifetime searching for it without once being convinced that they ever saw it. Is the Ashen Light a trick of the eye? The result of a defective lens? A real scientific event? Occasional references to the Ashen Light are scattered across the literature, yet no work to date has synthesized these records. This book therefore digs deep into the history of the mystery and our latest attempts to understand it, sifting through the clues that might explain whether it is caused by physics, is conjured up by the eye or brain, or a combination of both. This baffling story will appeal to amateur astronomers, hobbyists, and lay readers interested in joining the debate about one of the most elusive observable phenomena ever recorded in the night sky.