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Neurobiology of Cancer: Role of the Nervous System in Cancer Etiopathogenesis, Treatment, and Prevention
by Boris MravecThe focus of this book is to describe the current understanding of the interactions between the nervous system and cancer and the use of this information in the treatment and prevention of cancer. Author and noted researcher Boris Mravec presents a clearly written and well-illustrated monograph on this rapidly developing new field. The book begins with an exploration of the basic concepts supporting the neurobiology of cancer, discusses the ways in which the nervous system affects all the hallmarks of cancer, delves extensively into stress and cancer, covers the etiopathogenetic consequences of the neurobiology of cancer, the implications for cancer prevention and treatment, and looks at future directions in the field.
Neurobiology of Chemical Communication (Frontiers in Neuroscience)
by Carla Mucignat-CarettaIntraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism-ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their prese
Neurobiology of Comparative Cognition (Comparative Cognition and Neuroscience Series)
by Raymond P. Kesner David S. OltonThis book represents a unique and elaborate exposition of the neural organization of language, memory, and spatial perception in a wide variety of species including humans, bees, fish, rodents, and monkeys. The editors have united the comparative approach with its emphasis on evolutionary determinants of behavior, the neurobiological approach with its emphasis on the neural determinants of behavior, and the cognitive approach with its emphasis on understanding higher-order mental functions. The combination of these three approaches provides an unusual look at the neurobiology of comparative cognition, and should stimulate increased investigations in this field and related disciplines.
Neurobiology of Depression (Frontiers in Neuroscience)
by Cecilio Álamo Francisco López-MunozMajor depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, mol
Neurobiology of Grooming Behavior
by Allan V. Kalueff Justin L. Laporte Carisa L. BergnerGrooming is among the most evolutionary ancient and highly represented behaviours in many animal species. It represents a significant proportion of an animal's total activity and between 30-50% of their waking hours. Recent research has demonstrated that grooming is regulated by specific brain circuits and is sensitive to stress, as well as to pharmacologic compounds and genetic manipulation, making it ideal for modelling affective disorders that arise as a function of stressful environments, such as stress and post-traumatic stress disorder. Over a series of 12 chapters that introduce and explicate the field of grooming research and its significance for the human and animal brain, this book covers the breadth of grooming animal models while simultaneously providing sufficient depth in introducing the concepts and translational approaches to grooming research. Written primarily for graduates and researchers within the neuroscientific community.
Neurobiology of Huntington's Disease: Applications to Drug Discovery (Frontiers in Neuroscience)
by Donald C. Lo Robert E. HughesIn 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that see
Neurobiology of Interval Timing (Advances in Experimental Medicine and Biology #1455)
by Hugo Merchant Victor De LafuenteThe study of how the brain processes time is becoming one of the most important topics in systems, cellular, computational, and cognitive neuroscience, as well as in the physiologic bases of music and language. During the last and current decade, interval timing has been intensively studied in humans and animals using increasingly sophisticated approaches. This new edition of the Neurobiology of Interval Timing integrates the current knowledge of animal behavior and human cognition of the passage of time in different behavioral contexts, including the perception and production of time intervals, as well as rhythmic activities. The chapters are written by the leading experts in the fields of psychophysics, functional imaging, systems neurophysiology, and musicology. The new edition features a complete updating of the content with many new chapters. The main updates are the remarkable advances in our understanding of the neural basis of temporal processing in monkeys, rodents, and humans. The notion is that the neural clock depends on the dynamics of neural populations in the motor system, and that this general internal time representation interacts with the sensory and cognitive systems depending on the timing requirements and the behavioral contingencies of a specific task. Also, this edition delineates a clearer distinction between interval-based and beat-based timing in humans.
Neurobiology of Respiration
by Mieczyslaw PokorskiRespiration is an area of the medical study that undergoes fast developments. A better understanding of the neural and cellular mechanisms underlying respiratory disorders and lung function is essential for the evidence-based pharmacotherapy and for optimizing the patient care and prophylactic measures to improve the health and quality of life. This comprehensive book is a blend of basic and clinical research. The book is thought to promote the translation of science into clinical practice. The book presents an update on the areas of current research and clinical interest in the neurobiology of the respiratory system. Recent innovations in detection and management of respiratory diseases are described. The book will be a base of reference in the field of respiration for years to come and a source of future research ideas. This book is a required text for respiratory scientists, neuropathologists, and for clinicians searching for 'bench to bedside' treatments of lung diseases.
Neurobiology of Sensation and Reward
by Jay A. GottfriedSynthesizing coverage of sensation and reward into a comprehensive systems overview, Neurobiology of Sensation and Reward presents a cutting-edge and multidisciplinary approach to the interplay of sensory and reward processing in the brain. While over the past 70 years these areas have drifted apart, this book makes a case for reuniting sensation a
Neurobiology of TRP Channels (Frontiers in Neuroscience)
by Tamara Luti Rosenbaum EmirDuring the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels. Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology. Features: • Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins. • Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes. • Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance. • Features several full color illustrations to allow the reader better comprehension of TRP channels. A volume in the Frontiers in Neuroscience series
Neurobionics: The Biomedical Engineering of Neural Prostheses
by Robert K. ShepherdTechnological advances have greatly increased the potential for, and practicability of, using medical neurotechnologies to revolutionize how a wide array of neurological and nervous system diseases and dysfunctions are treated. These technologies have the potential to help reduce the impact of symptoms in neurological disorders such as Parkinson's Disease and depression as well as help regain lost function caused by spinal cord damage or nerve damage. Medical Neurobionics is a concise overview of the biological underpinnings of neurotechnologies, the development process for these technologies, and the practical application of these advances in clinical settings. Medical Neurobionics is divided into three sections. The first section focuses specifically on providing a sound foundational understanding of the biological mechanisms that support the development of neurotechnologies. The second section looks at the efforts being carried out to develop new and exciting bioengineering advances. The book then closes with chapters that discuss practical clinical application and explore the ethical questions that surround neurobionics. A timely work that provides readers with a useful introduction to the field, Medical Neurobionics will be an essential book for neuroscientists, neuroengineers, biomedical researchers, and industry personnel.
Neurochemical Systems and Signaling: From Molecules to Networks
by Ghulam AshrafThe human brain is made up of billions of neurons that communicate with each other through chemical messengers, which are referred to as neuroactive substances. These neuroactive substances include neurotransmitters, neuromodulators, and neurohormones. Some neurotransmitters also act as neuromodulators and neurohormones. It is unlikely that there would ever be a consensus about the meanings of these neuroactive substances, including neurotransmitters, since the term ‘neurotransmitter’ has traditionally been used very loosely indeed, to include neurotransmitters, neurohormones, and neuromodulators. Any alterations in the functioning of these neuroactive substances can cause diseases. The brain is the ultimate center that regulates all neurological and behavioral aspects of the body through neuronal communications mediated via various neurochemicals. Thus, neurological and psychiatric disorders are, in most cases, the result of disturbed neurochemical balance. Besides the multifaceted involvement of billions of neuronal cells, the central nervous system is a complex organization with a diverse number of neurotransmitter systems, as compared to the autonomic nervous system, in which the parasympathetic system works on the ‘rest and digest’ phenomenon, and the sympathetic system works on the ‘fight or flight’ phenomenon. There are more than 20 neurotransmitter systems and multiple receptors for each neurotransmitter. Any alterations in neurochemical balance are expressed in the form of neurological or psychiatric disorders such as epilepsy, Parkinson’s disease, Alzheimer’s disease, psychosis, depression, etc. Acetylcholine, noradrenaline, dopamine, and 5-HT are of the utmost importance among neurotransmitters for their profound role in the pathogenesis of various neurological and psychiatric disorders in humans. Yet the involvement of various proteins and peptides, such as neurotrophic factors, growth factors, and endogenous chemical compounds, cannot be ignored. Day by day, the suffering of people due to an imbalance of neurotransmitters is increasing. Various factors, for example stress, diet, genetics, and toxins such as alcohol and nicotine, contribute to this imbalance. This imbalance may lead to mental health complaints. The main purpose of this book is to give a comprehensive overview of the neurological diseases associated with neurochemical imbalances. This book will help readers gain a comprehensive understanding of neuronal signaling and related neurological disorders, as well as status and future opportunities and challenges. It will provide a brief account of neurotransmission, as either a study or high-yield revision aid.
Neurochemistry & Clinical Disorders (Routledge Revivals)
by Fuad Lechin Bertha van der DijsFirst Published in 1989, this book offers a full, comprehensive guide to neurochemistry in certain mental health conditions and psychosomatic syndromes. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of medicine, and other practitioners in their respective fields.
Neurochemistry of Abused Drugs
by Steven B. KarchExtracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.Beginning with a detailed look at individual drugs and their effects on the brain, Neurochemistry of Abused Drugs considers the changes in neurotransmitter levels and discusses the relationship of these
Neurochemistry of the Vestibular System
by Alvin J. Beitz John H. AndersonNeurochemistry of the Vestibular System covers the proliferation of information stemming from the technical advances in the areas of molecular biology and neurochemistry. It analyzes developments in areas that relate to the neurochemical organization of the hair cells in the inner ear, the vestibular nerve, the vestibular nuclear complex, and central afferent and efferent vestibular projections. The book also identifies future directions for research in the areas of neurotransmitters, second messengers, transcription factors, and molecular mechanisms involved with both normal vestibular function and compensation.
Neurociencia para (nunca) cambiar de opinión
by Pedro BekinschteinEste libro intenta recorrer algunos de los mecanismos psicológicos y cognitivos involucrados en la resistencia al cambio de visión. Las preguntas irán desde cómo nuestras expectativas y creencias afectan la manera en la que percibimos el mundo hasta si existen bases biológicas que expliquen las diferencias en ideología política. Somos capaces de discutir por las cosas más banales y las más profundas como, por ejemplo, si son mejores los perros o los gatos, si es mejor el invierno o el verano, si la marihuana debe ser legal o no, si pinot noir o cabernet, si paridad de género o meritocracia, si es más rico el helado de agua o el de crema, si el alma existe o si es una creación de las religiones, y así podría hacer un libro entero sobre las grietas. (Y sobre cuánto nos gusta tener razón.) Probablemente la mayoría tenga una opinión sobre muchos de esos temas. Estos juicios crecen como malezas sobre nuestro suelo fértil de creencias y van ocupando la capacidad de decidir según las evidencias. Las opiniones no se llevan muy bien con las evidencias cuando estas no coinciden. Este libro intenta recorrer algunos de los mecanismos psicológicos y cognitivos involucrados en la resistencia al cambio de visión. Las preguntas irán desde cómo nuestras expectativas y convicciones afectan la manera en la que percibimos el mundo y recordamos las experiencias colectivas hasta si existen bases biológicas que expliquen las diferencias en las ideologías políticas. Pedro Bekinschtein, doctor en biología, se cuestiona, por ejemplo, si nuestras decisiones a la hora de votar representantes están basadas en sus propuestas o en aspectos más misteriosos e indescifrables que ocurren fuera de nuestra conciencia. En estas páginas vibrantes que encastran a la perfección ciencia y actualidad, nos invita a descubrir qué nos pasa cuando no podemos cambiar de opinión, lo que él llama "la necedad del cerebro".
Neurocognitive Music Therapy: Intersecting Music, Medicine and Technology for Health and Well-Being
by Rafael Ramírez-MeléndezFor thousands of years, music has acted as a powerful medium for evoking emotions, facilitating communication, and nurturing overall well-being. With the advent of new sophisticated neuroimaging technology, human responses to music and music therapy are being viewed through a new lens. As a consequence, new knowledge is being obtained about how music can produce significant improvements in cognitive, social, overt and agitated behaviours. The aim of this book is to provide an overview of neurocognitive music therapy, its impact and implications in the practice of evidence-based music interventions. The book seeks to provide researchers, psychologists, music therapists, musicians and physicians interested in the therapeutic applications of music, with a source of information about current techniques and novel music interventions. It is structured into several chapters, each of them presenting peer-reviewed research and evidence-based procedures carried out in a specific clinical context. Topics covered in the book include: Musical engagement for individuals with motor disabilities Enhancing emotional processing in autism through music Stroke rehabilitation via musical interventions Musical neurofeedback for emotional disorders Emotional modulation with music therapy in palliative care AI-driven personalisation in music interventionsThe book highlights the profound capacity of music-based interventions to facilitate cognitive and emotional processing, enhance communication, and promote motor rehabilitation. At the same time, the book demonstrates how modern technologies offer new opportunities to evaluate, validate, and potentiate music-based interventions, allowing new and innovative possibilities and more personalised interventions. This book aims to contribute to the growing body of knowledge in this field and inspire further research and innovation in the practice of music therapy.
Neurocriminology: Forensic and Legal Applications, Public Policy Implications
by Diana ConcannonNeurocriminology: Forensic and Legal Applications, Public Policy Implications explores the dramatic impact of advances in neuroscience research and practice to our present understanding of criminality and crime control. Contemporary, cutting-edge research in neuroscience is cited and explained. Studies and cases are clearly and concisely outlined with potential uses for practical applications detailed. This will be framed in the context of criminological foundations, theory, and the notion of the nature of crime itself. This comprehensive and engaging book also delves into recent developments in modern neurology, and connections between neuroscience and its criminal, legal, and forensic implications and ramifications. The book poses various questions about what insight neurology can provide to human cognition, to motivation and—in particular—criminal motivation. From biological observations is there a pattern, or are there similarities, in what the brainscan of a criminal looks like? What are the treatment implications and are their valid assessments or treatments that can be used in a corrections environment to curb, or even modify, behavior definitively? And, ultimately, what are the moral, legal and social implications of all? Coverage throughout incorporates leading research that links neurological and biological factors to heightened risk for criminality. This includes coverage of suboptimal arousal (low heart rate), testosterone, neurotransmitters, and variations in MAOA—the so-called "warrior gene"—and more. Neurocriminology will offer a thought-provoking analysis of the broad-reaching implications of this science to better inform the prevention, investigation, monitoring, and control of crime. This includes the remarkable potential for neuroscience to serve as a resource and potential tool to criminology and penology researchers, psychologists, forensic psychologists, forensic scientists, legal professionals, and investigators of crime and criminal behavior.
Neurocutaneous Disorders: A Clinical, Diagnostic and Therapeutic Approach
by Christos P. Panteliadis Ramsis Benjamin Christian HagelThis book provides extensive data on the more common and many of the more rare congenital and hereditary syndromes that manifest in the nervous system and skin. Though often complex and multi-systemic, these disorders can frequently be diagnosed using a combination of simple visual inspection and sound clinical expertise. Drawing on fully referenced information from thousands of articles, the international editorial team has prepared a comprehensive overview that includes historical perspectives, clinical features, the pathogenesis, and diagnostic and therapeutic strategies. In addition, it addresses the biochemical, molecular, and genetic basis of the disorders. The book is divided into four main sections. Starting with general aspects of aetiology, diagnostics and therapy, the first part then covers the genetics, neuro-imaging, neuropathology, ocular manifestations and surgical management. The second part discusses developmental malformations, such as Sturge-Weber syndrome, Ataxia-Telangiectasia, Hypomelanosis of Ito and other rare syndromes, including haemangiomas. The focus of the third part is on tumour suppressor/DNA repair disorders, the most common of which is Neurofibromatosis 1. It also describes Neurofibromatosis 2, Schwannomatosis, Tuberous sclerosis, von Hippel-Lindau disease, Naevoid basal cell carcinoma and others. The book’s fourth and final section covers defects in enzymes and structural proteins, which manifest as Cerebrotendinous xanthromatosis, Ehlers-Danlos syndrome, Menkes syndrome, Refsum disease.
Neurocytology
by Ennio PanneseDuring the second half of the 20th century, the introduction of a variety of new techniques greatly expanded our knowledge of the structure of nerve and neuroglial cells and of the organization of the nervous system at the cellular level. This new information has, however, generally been scattered throughout the literature, making it difficult for investigators to gain an overall vision of the discipline. The author has marshalled these scattered data to provide a systematic overview of the field placed within a historical context. He has correlated the major new findings with the classical notions of light microscopy and has integrated them with elements of biochemistry and cell physiology. After the publication of the first edition, the introduction of new microscopies and especially the growth of molecular biology have greatly expanded our knowledge, in particular on the intercellular communication in the nervous system and on the roles of neuroglial cells. These achievements have made a second edition of the book necessary. The fully revised and updated text, together with unique high-quality illustrations of structures of the central and peripheral nervous system, ensure that this new edition will be invaluable for neuroscientists, particularly those involved in cellular neuropathology, neurochemistry, neurophysiology and molecular neurobiology.
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Second Edition)
by Roy O. Weller Dennis DicksonMost textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Neurodegenerative Diseases
by Celia DominguezThe Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach.- Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer's Disease.- Glutamate and Neurodegenerative Disease.- Modulation of the Kynurenine Pathway for the Potential Treatment of Neurodegenerative Diseases.- Spinal Muscular Atrophy: Current Therapeutic Strategies
Neurodegenerative Diseases
by Daniela Galimberti Elio ScarpiniThis book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
Neurodegenerative Diseases: Translational Models, Mechanisms, and Therapeutics
by Sandeep Singh Santosh Kumar Singh Sachchida Nand RaiThis reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease
Neurodevelopmental Disorders: A Definitive Guide for Educators
by Frank E. VargoFrom autism to ADHD to learning disabilities, a guide for all teachers to this constellation of disorders. Developmental deficits in learning and communication in young children are defined as neurodevelopmental disorders. This constellation, newly defined in the DSM-5, represents a range of issues that educators must address. Neurodevelopmental Disorders: A Definitive Guide for Educators provides extensive and practical information to a range of professionals, and to all others who are interested in the complex and often misunderstood disabilities that fall within the general medical and psychological diagnostic categories of neurodevelopmental disability. Noted psychologist and educator Dr. Frank E. Vargo provides a comprehensive overview of neurodevelopmental deficits and disabilities, as well as of their related learning and cognitive processes, with a strong focus on educational considerations, applications, and relevance across academic areas and with a mind to global educational models. Well researched and accessibly written, this book is an up-to-date and authoritative reference to all of the educational and clinical topics in the diagnostic categories of neurodevelopmental disorder. This informative book will provide a primary reference source for all educators, school and clinical psychologists, clinical mental health counselors and therapists, special education and medical professionals, and parents of children with special needs.