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Peripheral Visions: Learning Along the Way
by Mary C. BatesonMary Catherine Bateson, author of Composing a Life, is our guide on a fascinating intellectual exploration of lifetime learning from experience and encountering the unfamiliar. Peripheral Visions begins with a sacrifice in a Persian garden, moving on to a Philippine village and then to the Sinai desert, and concludes with a description of a tour bus full of Tibetan monks. Bateson's reflections bring theses narratives homes, proposing surprising new vision of our own diverse and changing society and offering us the courage to participate even as we are still learning.
Periphery: How Your Nervous System Predicts and Protects against Disease
by Moses V. ChaoA leading neuroscientist argues that the peripheral nervous system, long understood to play a key role in regulating basic bodily functions, also signals the onset of illness.The central nervous system, consisting of the brain and the spinal cord, has long been considered the command center of the body. Yet outside the central nervous system, an elaborate network of nerve cells and fibers extends throughout our bodies, transmitting messages between the brain and other organs. The peripheral nervous system, as it’s known, regulates such vital functions as heart rate, digestion, and perspiration and enables us to experience the barrage of sounds, tastes, smells, and other sensory information that surrounds us. But beyond these crucial roles, the peripheral nervous system might do even more: it might warn us of diseases in our future.As Moses Chao argues in Periphery, from Parkinson’s disease to autism to dementia, many neurological conditions emerge not in the brain but rather within the peripheral nervous system, in the dense network of nerves that wrap around the gastrointestinal tract. What’s more, dysfunctions of the peripheral nervous system can signal the onset of disease decades before symptoms like tremor or memory loss occur. Fortunately, unlike nerves in the brain and spinal cord, peripheral nerves can heal and regenerate in response to injury and aging. The therapeutic implications are remarkable. Chao shows how, with a better understanding of the peripheral nervous system, we could not only predict and treat neurological diseases long before their onset, but possibly prevent them altogether.Full of new ideas and bold interpretations of the latest data, Periphery opens exciting avenues for medical research while deepening our understanding of a crucial yet underappreciated biological system.
Perl for System Administration
by David N. Blank-EdelmanPerl for System Administrationis for anyone who needs to use Perl for administrative tasks and needs to hit the ground running.
Permafrost Ecosystems
by Akira Osawa Olga A. Zyryanova Takuya Kajimoto Yojiro Matsuura Ross W. WeinDrawing from a decade-long collaboration between Japan and Russia, this important volume presents the first major synthesis of current knowledge on the ecophysiology of the coniferous forests growing on permafrost at high latitudes. It presents ecological data for a region long inaccessible to most scientists, and raises important questions about the global carbon balance as these systems are affected by the changing climate. Making up around 20% of the entire boreal forests of the northern hemisphere, these 'permafrost forest ecosystems' are subject to particular constraints in terms of temperature, nutrient availability, and root space, creating exceptional ecosystem characteristics not known elsewhere. This authoritative text explores their diversity, structure, dynamics and physiology. It provides a comparison of these forests in relation to boreal forests elsewhere, and concludes with an assessment of the potential responses of this unique biome to climate change. The book will be invaluable to advanced students and researchers interested in boreal vegetation, forest ecology, silviculture and forest soils, as well as to researchers into climate change and the global carbon balance.
Permafrost Hydrology
by Ming-Ko WooPermafrost Hydrology systematically elucidates the roles of seasonally and perennially frozen ground on the distribution, storage and flow of water. Cold regions of the World are subject to mounting development which significantly affects the physical environment. Climate change, natural or human-induced, reinforces the impacts. Knowledge of surface and ground water processes operating in permafrost terrain is fundamental to planning, management and conservation. This book is an indispensable reference for libraries and researchers, an information source for practitioners, and a valuable text for training the next generations of cold region scientists and engineers.
Permanent Magnetism
by J.M.D CoeyOne of the first books to approach magnetism from a metal physics perspective, Permanent Magnetism presents research ideas that are being translated into commercial reality for ferrite and Nd-Fe-B magnets, and follows the discovery of interstitial, intermetallic materials. Written by well-known authors, the book contains a comprehensive yet concise treatment of the fundamental theory underlying permanent magnetism and illustrates applications with modern, permanent magnetic materials, including ceramics and intermetallic compounds. Each chapter contains worked examples to reinforce applications and the appendices include detailed mathematics and tabular data on material properties.
Permeability and Stability of Lipid Bilayers
by E. Anibal Disalvo Sidney A. SimonThis book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.
Permeability Barrier: Methods and Protocols (Methods in Molecular Biology #2367)
by Kursad TurksenThis detailed edition reflects the significant new findings in the components of permeability barriers and how they work in different tissues with a collection of cutting-edge techniques. Chapters explore the formation, maintenance, regulation, and dynamics of permeability barriers in an effort to push the boundaries of the field. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Permeability Barrier: Methods and Protocols, Second Edition serves as an invaluable guide for both experts but novices in the stem cell field and other related areas of research.
Permeability Barrier
by Kursad TurksenThe significant biological subject, the permeability barrier, is incredibly diverse and vital for a vast assortment of crucial functions in the body. In Permeability Barrier: Methods and Protocols, a variety of experienced researchers contribute techniques to study this complex system in its many forms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, detailed lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Permeability Barrier: Methods and Protocols serves as an ideal guide for all scientists seeking to further our understanding of this vital area of research.
Permeability of Biological Membranes
by Gaspar BanfalviThis book dealswith biological membranes, focuses on permeabilization and pays particularattention to reversible permeabilization to maintain the viability andphysiological conditions of the cells. Selectivepermeability of biological membranes also known as semipermeability, partialpermeability or differential permeability allows molecules to diffuse, pass bypassive and active or by other types of transport processes mediated byproteins. The firstchapter of the book deals with the composition of biological membranes,characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes ofcellular organelles and the function of biological membranes. The second chapter provides an overview of bilayerpermeability, selectivity of permeabilization and cellular transportprocesses. Chapter3 overviews different cell manipulations that aim to make cells permeable whilemaintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly withreversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose)biosynthetic processes, replication, gene expression, visualization ofreplicons, intermediates of chromosome condensation, genotoxic chromatinchanges, upon treatment with heavy metals and different types of irradiation. The interdisciplinaryaspects of the book contribute to the understanding of the structure of nucleicacids, replicative intermediates, Okazaki fragments, RNA primer mechanism,subphases of replication and repair synthesis, replicons, gene expression,chromosome condensation generated a wealth of information that will attract awide readership. The natural audience engaged in DNA research, includinggenetics, cell and molecular biology, chemistry, biochemistry, medicine,pharmacy will find essential material in the book.
Permeable Reactive Barrier: Sustainable Groundwater Remediation (Advances in Trace Elements in the Environment #1)
by Ravi NaiduRemediation of groundwater is complex and often challenging. But the cost of pump and treat technology, coupled with the dismal results achieved, has paved the way for newer, better technologies to be developed. Among these techniques is permeable reactive barrier (PRB) technology, which allows groundwater to pass through a buried porous barrier that either captures the contaminants or breaks them down. And although this approach is gaining popularity, there are few references available on the subject. Until now. Permeable Reactive Barrier: Sustainable Groundwater Remediation brings together the information required to plan, design/model, and apply a successful, cost-effective, and sustainable PRB technology. With contributions from pioneers in this area, the book covers state-of-the-art information on PRB technology. It details design criteria, predictive modeling, and application to contaminants beyond petroleum hydrocarbons, including inorganics and radionuclides. The text also examines implementation stages such as the initial feasibility assessment, laboratory treatability studies (including column studies), estimation of PRB design parameters, and development of a long-term monitoring network for the performance evaluation of the barrier. It also outlines the predictive tools required for life cycle analysis and cost/performance assessment. A review of current PRB technology and its applications, this book includes case studies that exemplify the concepts discussed. It helps you determine when to recommend PRB, what information is needed from the site investigation to design it, and what regulatory validation is required.
Permutation Testing for Isotonic Inference on Association Studies in Genetics
by Rosa Arboretti Livio Corain Luigi Salmaso Dario MazzaroThe purpose of this book is to illustrate a new statistical approach to test allelic association and genotype-specific effects in the genetic study of diseases. There are some parametric and non-parametric methods available for this purpose. We deal with population-based association studies, but comparisons with other methods will also be drawn, analysing the advantages and disadvantages of each one, particularly with regard to power properties with small sample sizes. In this framework we will work out some nonparametric statistical permutation tests and likelihood-based tests to perform case-control analyses to study allelic association between marker, disease-gene and environmental factors. Permutation tests, in particular, will be extended to multivariate and more complex studies, where we deal with several genes and several alleles together. Furthermore, we show simulations under different assumptions on the genetic model and analyse real data sets by simply studying one locus with the permutation test.
Perovskite Light Emitting Diodes: Materials and Devices
by Hong MengPerovskite Light Emitting Diodes An introduction to revolutionary display technology Perovskite Light Emitting Diodes, commonly referred to as Pe-LEDs, leverage a perovskite nanocrystal core to engender a luminous and efficient diode, holding the potential to bring about a paradigm shift in the realm of display technology. In recent times, Pe-LEDs have garnered substantial industrial interest due to their intrinsic capability to exhibit a diverse array of colors with exceptional fidelity, their operation at low voltage thresholds, and their straightforward structural composition. The prospective implications for enabling cost-effective, heightened-performance flat-panel displays as well as flexible display solutions remain notably profound. Perovskite Light Emitting Diodes: Materials and Devices presents a comprehensive and insightful overview of these diodes and their multifaceted applications. Commencing with an incisive exploration of the historical trajectory of this technology, alongside a delineation of its foundational materials and intricate device architectures, this compendium provides a gateway into both contemporaneous state-of-the-art deployments and the vanguard of ongoing research endeavors directed towards charting future advancements. Perovskite Light Emitting Diodes readers will also find: Stability analysis for different Pe-LED devices, a key aspect of creating physical displays Authorship by an established expert in organic electronics Detailed discussion of perovskite preparation methods including ultrasonic, solvent heat, thermal injection, and many more Perovskite Light Emitting Diodes is ideal for materials scientists, electrical engineers, solid state chemists, solid state physicists, inorganic chemists, and any researchers or engineers working with display technology.
Perovskite Oxide for Solid Oxide Fuel Cells
by Tatsumi IshiharaThe continuing development of fuel cells offers promising technologies for the conversion of chemical energy from hydrocarbon fuels into electricity without forming air pollutants. Perovskite Oxides for Solid Oxide Fuel Cells provides insight into the materials aspects of one of the most promising fuel cell types available. Solid Oxide Fuel Cells (SOFCs) have significant advantages over other fuel cell types, such as high efficiency, flexibility in fuel, high reliability, simple balance of plant (BOP) and a long history. Because of these advantages, SOFC technology is attracting a great deal of attention for use in power generation and for its potential in heat generation. Perovskite oxides are widely used for different SOFC components. Detailed description of various aspects of perovskite oxides are presented in this book. Each chapter in the book is written by leading international researchers and covers topics including: General Introduction of SOFC; Perovskite fast oxide ion conductors; High temperature perovskite proton conductors; Perovskite electrode catalyst and catalysis; SOFC stack development using perovskite oxide; The effects of decreasing SOFC operating temperatures to increase reliability, durability and stability. Perovskite Oxides for Solid Oxide Fuel Cells provides comprehensive and up-to-date information on the materials, properties, and performance for SOFCs and is appropriate for researchers and engineers in the field.
Perovskite Quantum Dots: Synthesis, Properties and Applications (Springer Series in Materials Science #303)
by Ye Zhou Yan WangThis book addresses perovskite quantum dots, discussing their unique properties, synthesis, and applications in nanoscale optoelectronic and photonic devices, as well as the challenges and possible solutions in the context of device design and the prospects for commercial applications. It particularly focuses on the luminescent properties, which differ from those of the corresponding quantum dots materials, such as multicolor emission, fluorescence narrowing, and tunable and switchable emissions from doped nanostructures. The book first describes the characterization and fabrication of perovskite quantum dots. It also provides detailed methods for analyzing the electrical and optical properties, and demonstrates promising applications of perovskite quantum dots. Furthermore, it presents a series of optoelectronic and photonic devices based on functional perovskite quantum dots, and explains the incorporation of perovskite quantum dots in semiconductor devices and their effect of the performance. It also explores the challenges related to optoelectronic devices, as well as possible strategies to promote their commercialization. As such, this book is a valuable resource for graduate students and researchers in the field of solid-state materials and electronics wanting to gain a better understanding of the characteristics of quantum dots, and the fundamental optoelectronic properties and operation mechanisms of the latest perovskite quantum dot-based devices.
Peroxiporins: Redox Signal Mediators In and Between Cells (Oxidative Stress and Disease #50)
by Iria Medraño-Fernandez Gerd Patrick Bienert Roberto SitiaTo produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emitters to receptors. Thus, these channels are strategically situated in the thin line between life and death, guaranteeing adequate but safe signaling. Key Features: - Provides a brief history of the discovery and characterization of peroxiporins- Reviews key findings on hydrogen peroxide transport across biological membranes- Discusses the cartography of redox signaling in crowded cells- Includes lavish illustrations and comprehensive images to facilitate teaching- Highlights recent findings, outstanding controversies and open questions
Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases (Advances in Experimental Medicine and Biology #1299)
by Gérard LizardThis book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases.It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances
by Mostafa Z. Badr Jihan A. YoussefAll three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described.<P><P> As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.
Peroxisome Proliferator-Activated Receptors (PPARs): Methods and Protocols
by Jihan A. Youssef Mostafa Z. BadrAll three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology but differ in function, tissue distribution and ligand specificity. PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, and efforts are currently underway to fully characterize their functioning and to develop safer and more effective PPAR modulators to treat a myriad of diseases and conditions. In Peroxisome proliferator-Activated Receptors: Methods and Protocols, renowned experts in the PPAR arena provide detailed protocols for investigating these receptors. Chapters contain methods ranging from the cloning of receptors to their knockdown, to protocols exploring posttranslational modifications of PPARs and coactivators, as well as receptor subcellular localization. Also assembled are methods to evaluate the involvement of these receptors in behavior functions, an emerging facet in PPAR research. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.<P><P> With its well-honed methodologies, Peroxisome proliferator-Activated Receptors: Methods and Protocols, will be a useful resource for all seeking to advance their knowledge of this field.
Peroxisomes
by Michael SchraderThis volume provides easily accessible and comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Chapters detail valuable instructions, guidelines and protocols for molecular cell biologists, biochemists and biomedical researchers with an interest in peroxisome biology. Chapters in Peroxisomes: Methods and Protocols illustrate the isolation of peroxisomes, investigation of properties of membrane proteins, protocols to investigate and manipulate peroxisomes in cellular systems, detection of peroxisomes, including immunofluorescence, cytochemistry, cryo-immuno electron microscopy, and live cell imaging approaches. Authoritative and practical, Peroxisomes: Methods and Protocols aims to be useful for those already working on peroxisomes as well as for those who would like to start working on this fascinating organelle.
Peroxisomes: Methods and Protocols (Methods in Molecular Biology #2643)
by Michael SchraderThis fully updated volume assembles a comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Peroxisome research is on the rise, as novel functions and proteins of this dynamic organelle are still being discovered through studies in model systems including humans, mice, flies, plants, fungi, and yeast, and this progress is reflected in the chapters included in this collection. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Peroxisomes: Methods and Protocols, Second Edition serves as an ideal guide for researchers working on peroxisome- and organelle-based research questions.
Peroxisomes and their Key Role in Cellular Signaling and Metabolism
by Luis A. del RíoPeroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases. In plants, peroxisomes carry out the fatty acid beta-oxidation, photorespiration, metabolism of ROS, RNS and RSS, photomorphogenesis, biosynthesis of phytohormones, senescence, and defence against pathogens and herbivores. In recent years it has been postulated a possible contribution of peroxisomes to cellular signaling. In this volume an updated view of the capacity and function of peroxisomes from human, animal, fungal and plant origin as cell generators of different signal molecules involved in distinct processes of high physiological importance is presented.
Peroxisomes: Biogenesis, Function, and Role in Human Disease
by Tsuneo Imanaka Nobuyuki ShimozawaThis book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.
The Perpetual Now: A Story of Amnesia, Memory, and Love
by Michael D. LemonickIn the aftermath of a shattering illness, Lonni Sue Johnson lives in a "perpetual now," where she has almost no memories of the past and a nearly complete inability to form new ones. The Perpetual Now is the moving story of this exceptional woman, and the groundbreaking revelations about memory, learning, and consciousness her unique case has uncovered. Lonni Sue Johnson was a renowned artist who regularly produced covers for The New Yorker, a gifted musician, a skilled amateur pilot, and a joyful presence to all who knew her. But in late 2007, she contracted encephalitis. The disease burned through her hippocampus like wildfire, leaving her severely amnesic, living in a present that rarely progresses beyond ten to fifteen minutes. Remarkably, she still retains much of the intellect and artistic skills from her previous life, but it's not at all clear how closely her consciousness resembles yours or mine. As such, Lonni Sue's story has become part of a much larger scientific narrative—one that is currently challenging traditional wisdom about how human memory and awareness are stored in the brain. In this probing, compassionate, and illuminating book, award-winning science journalist Michael D. Lemonick uses the unique drama of Lonni Sue Johnson's day-to-day life to give us a nuanced and intimate understanding of the science that lies at the very heart of human nature.
The Perpetuation of Living Beings
by Thomas Henry HuxleyEarly scientific work on heredity variance and genetic transmission.