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Organelle Proteomics
by Delphine Pflieger Jean RossierThis is the first book to examine organelle proteomics in depth. It begins by introducing the different analytical strategies developed and successfully utilized to study organelle proteomes, and detailing the use of multidimensional liquid chromatography coupled to tandem mass spectrometry for peptide sample analysis. Detailed protocols are provided and a section is devoted to methods enabling a global estimate of the reliability of the protein list assigned to an organelle.
Organelle and Molecular Targeting
by Lara Scheherazade Milane and Mansoor M. AmijiWe have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.
Organelle-Specific Pharmaceutical Nanotechnology
by Volkmar Weissig Gerard G. D'SouzaThis book introduces and discusses the latest in biomedical research--Pharmaceutical Nanotechnology applied at the sub-cellular level.
Organelles, Genomes and Eukaryote Phylogeny: An Evolutionary Synthesis in the Age of Genomics
by Robert P. Hirt David S. HornerThe recent revolution in molecular biology has spread through every field of biology including systematics and evolution. Researchers can now analyze the genomes of different species relatively quickly, and this is generating a great deal of data and theories about relationships between taxa as well as how they originated and diversified. Org
Organic Agriculture and Climate Change
by Klaus Lorenz Rattan LalThis book will collate, review and synthesize information on how Organic Agriculture (OA) practices affect and are affected by climate change, in comparison to the more widely used conventional agricultural practices. Pros and cons of OA practices will be discussed separately for croplands, pasture lands, mixed livestock cropping systems, vegetable fields, fruit and tree orchards, and vineyards. The book concludes with an overview on how conventional and OA practices can be prudently and discriminately combined to identify and adopt climate-resilient agro-ecosystems under site-specific conditions.
Organic Amendments and Soil Suppressiveness in Plant Disease Management
by Ajit Varma Mukesh K. MeghvansiThis book provides a timely review of concepts in plant disease management involving microbial soil suppressiveness and organic amendments. Topics discussed include the impact of suppressive soils on plant pathogens and agricultural productivity, the enhancement of soil suppressiveness through the application of compost and the development of disease suppressive soils through agronomic management. Further chapters describe diseases caused by phytopathogens, such as Pythium, Fusarium and Rhizoctonia, interaction of rhizobia with soil suppressiveness factors, biocontrol of plant parasitic nematodes by fungi and soil suppressive microorganisms.
Organic Aquaculture: Impacts and Future Developments
by Giuseppe Lembo Elena MenteThis book addresses, reviews and evaluates key themes in organic aquaculture and is set out to show how these relate to the challenges and bottlenecks for a responsible organic aquaculture production in Europe. The key themes reflect the main challenges facing the organic aquaculture industry: guarantee and certification system, nutrition, reproduction, production system design and animal welfare. In addition, it assesses the impact of new and future potential development of new knowledge to update and modify the criteria and standards for organic aquaculture. Organic aquaculture is an alternative production approach driven by the growing interest in sustainable utilization of resources. It is rightly viewed as an important contributor to the economy and to the well-being and health of communities. This work will contribute to the scientific knowledge that needs to strengthen effective organic aquaculture. The collation of information on research and data will be of applied value to researchers, university students, end users and policy authorities in the EU and worldwide.
Organic Bionics
by Michael Higgins Gordon G. Wallace Simon Moulton Robert M.I. KapsaThe first reference on this emerging interdisciplinary research area at the interface between materials science and biomedicine is writtenby pioneers in the field, who address the requirements, current status and future challenges. Focusing on inherently conducting polymers,carbon nanotubes and graphene, they adopt a systematic approach, covering all relevant aspects and concepts: synthesis and fabrication,properties, introduction of biological function, components of bionic devices and materials requirements. Established bionic devices, such asthe bionic ear are examined, as are emerging areas of application, including use of organic bionic materials as conduits for bone re-growth,spinal cord injury repair and muscle regeneration. The whole is rounded off with a look at future prospects in sustainable energy generation and storage.Invaluable reading for materials scientists, polymer chemists, electrotechnicians, chemists, biologists, and bioengineers.
Organic Cation Transporters
by Giuliano Ciarimboli Sophie Gautron Eberhard SchlatterThis innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
Organic Cation Transporters in the Central Nervous System (Handbook of Experimental Pharmacology #266)
by Lynette C. DawsRapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com
Organic Chemicals From Biomass
by Irving S. GoldsteinThe biomass emphasis in on material of terrestrial plant origin, although principles are directly transferable to aquatic plants with similar components. Products of animal origin are not included. Since animal fats and oils are not considered, it seemed logical to exclude vegetable oils as well. Biomass emphasis is on material of terrestrial plant origin, although the principles are directly transferrable to aquatic plants with similar components.
Organic Chemicals in the Aquatic Environment: Distribution, Persistence, and Toxicity
by Alasdair H. NeilsonOrganic Chemicals in the Aquatic Environment draws from the author's experience with a variety of problems dealing with the fate, distribution, and toxicity of organic compounds in the aquatic environment. It discusses the basic issues of chemical analysis, distribution, persistence, and ecotoxicology, with an emphasis on microbial reactions. The necessary input and the difficulties of achieving a rigorous synthesis of the various elements are illustrated with specific examples. The book includes a wide range of structurally diverse compounds as illustration and presents a mechanistic approach to biodegradation and biotransformation. The final chapter addresses the issue of environmental hazard assessment and constructs a strategy for carrying it out.
Organic Chemicals in the Environment: Mechanisms of Degradation and Transformation, Second Edition
by Alasdair H. Neilson Ann-Sofie AllardAddressing the persistent environmental threat of organic chemicals with a fresh approach to degradation and transformation processes, Organic Chemicals in the Environment: Mechanisms of Degradation and Transformation, Second Edition examines a wide range of compounds as well as abiotic and microbiological reactions mediated by microorganisms
Organic Chemist's Desk Reference
by Caroline Cooper Rupert PurchaseLaunched in 1995 as a companion to the Dictionary of Organic Compounds, the Organic Chemist’s Desk Reference has been essential reading for laboratory chemists who need a succinct guide to the ‘nuts and bolts’ of organic chemistry — the literature, nomenclature, stereochemistry, spectroscopy, hazard information, and laboratory data. This third edition reflects changes in the dissemination of chemical information, revisions to chemical nomenclature, and the adoption of new techniques in NMR spectroscopy, which have taken place since publication of the last edition in 2011. Organic chemistry embraces many other disciplines — from material sciences to molecular biology — whose practitioners will benefit from the comprehensive but concise information brought together in this book. Extensively revised and updated, this new edition contains the very latest data that chemists need access to for experimentation and research.
Organic Chemistry
by T. W. Graham Solomons Craig B. Fryhle Scott A. SnyderThe 12th edition of Organic Chemistry continues Solomons, Fryhle & Snyder's tradition of excellence in teaching and preparing students for success in the organic classroom and beyond. A central theme of the authors' approach to organic chemistry is to emphasize the relationship between structure and reactivity. To accomplish this, the content is organized in a way that combines the most useful features of a functional group approach with one largely based on reaction mechanisms. The authors' philosophy is to emphasize mechanisms and their common aspects as often as possible, and at the same time, use the unifying features of functional groups as the basis for most chapters. The structural aspects of the authors' approach show students what organic chemistry is. Mechanistic aspects of their approach show students how it works. And wherever an opportunity arises, the authors' show students what it does in living systems and the physical world around us.
Organic Chemistry
by David KleinThe textbook includes important concepts in Organic chemistry, complete with conceptual checkpoints that promote mastery of the concepts, and special emphasis is placed on skills development through Skill Builders to support these concepts.
Organic Chemistry
by David KleinOrganic Chemistry, 4th Edition provides a comprehensive yet accessible treatment of all the essential organic chemistry concepts covered in a two-semester course. Presenting a skills-based approach that bridges the gap between organic chemistry theory and real-world practice, Dr. David Klein makes content comprehensible to students while placing special emphasis on developing their problem-solving skills through applied exercises and activities. This edition is available with the new and improved WileyPLUS--an immersive online environment packed with interactive study tools, strategies, and resources that support different learning styles.
Organic Chemistry
by David R. KleinOrganic Chemistry, 2nd Edition is not merely a compilation of principles, but rather, it is a disciplined method of thought and analysis. Success in organic chemistry requires mastery in two core aspects: fundamental concepts and the skills needed to apply those concepts and solve problems. Readers must learn to become proficient at approaching new situations methodically, based on a repertoire of skills. These skills are vital for successful problem solving in organic chemistry. Existing textbooks provide extensive coverage of, the principles, but there is far less emphasis on the skills needed to actually solve problems.
Organic Chemistry
by Francis A. Carey Robert M. GiulianoOrganic Chemistry has been designed to meet the needs of the "mainstream," two-semester, undergraduate organic chemistry course. This best-selling text gives students a solid understanding of organic chemistry by stressing how fundamental reaction mechanisms function and reactions occur.
Organic Chemistry
by Francis A. Carey Robert M. Giuliano Neil Allison Susan BaneOrganic Chemistry has been designed to meet the needs of the two-semester, undergraduate organic chemistry course. This best-selling text gives students a solid understanding of organic chemistry by focusing on how fundamental reaction mechanisms function and reactions occur. The authors strive for students to have a deeper understanding of the physical concepts that underlie organic chemistry, and for them to have a broader knowledge of the role of organic chemistry in biological systems.
Organic Chemistry
by Marye Anne Fox James K. WhitesellOrganic Chemistry by Fox and Whitesell is the pioneer in the mechanistic approach. Now in its third volume, this classic and proven pedagogy provides a much better basis for students to retain a knowledge base and extend it to practical applications in other areas of science. The mechanistic approach groups chemical reactions according to how the sequence of changes occurs- their common mechanisms- rather than by functional groups (what category- alcohols, amines, alkenes, etc.). Where appropriate, the text subdivides information based on functional groups. The text covers ALL of basic organic chemistry in the first 14 chapters and reviews the reactions covered in these chapters in chapter 15 on multi-step synthesis. The text also contains extensive coverage of both industrial and biological polymers, and describes molecular basis for drug action.
Organic Chemistry
by Leroy Wade Jan SimekA Student-Centered Approach to Learning and Studying Organic Chemistry Wade & Simek’s Ninth edition of Organic Chemistry presents key principles of organic chemistry in the context of fundamental reasoning and problem solving. Authored to complement how students use a textbook today, new Problem Solving Strategies, Partially Solved Problems, Visual Reaction Guides and Reaction Starbursts encourage students to use the text before class as a primary introduction to organic chemistry as well as a comprehensive study tool for working problems and/or preparing for exams. With unparalleled and highly refined pedagogy, this Ninth edition gives students a contemporary overview of organic principles and the tools for organizing and understanding reaction mechanisms and synthetic organic chemistry.
Organic Chemistry
by Janice Gorzynski SmithSmith's Organic Chemistry continues to breathe new life into the organic chemistry world. This new fifth edition retains its popular delivery of organic chemistry content in a student-friendly format. Janice Smith draws on her extensive teaching background to deliver organic chemistry in a way in which students learn: with limited use of text paragraphs, and through concisely written bulleted lists and highly detailed, well-labeled “teaching” illustrations. The fifth edition features a modernized look with updated chemical structures throughout. Don’t make your text decision without seeing Organic Chemistry, 5th edition by Janice Gorzynski Smith!
Organic Chemistry
by L. G. WadeAcclaimed for its clarity and precision, Wade's Organic Chemistry maintains scientific rigor while engaging students at all levels. Wade presents a logical, systematic approach to understanding the principles of organic reactivity and the mechanisms of organic reactions. This approach helps students develop the problem-solving strategies and the scientific intuition they will apply throughout the course and in their future scientific work. The Eighth Edition provides enhanced and proven features in every chapter, including new Chapter Goals, Essential Problem-Solving Skills and Hints that encourage both majors and non-majors to think critically and avoid taking "short cuts" to solve problems. Mechanism Boxes and Key Mechanism Boxes strengthen student understanding of Organic Chemistry as a whole while contemporary applications reinforce the relevance of this science to the real world.
Organic Chemistry
by Peter Vollhardt Neil SchoreWith authors who are both accomplished researchers and educators, Vollhardt and Schore's Organic Chemistry takes a functional group approach with a heavy emphasis on understanding how the structure of a molecule determines how that molecule will function in chemical reactions. By understanding the connection between structure and function, students will be better prepared to understand mechanisms and solve practical problems in organic chemistry. The new edition brings in the latest research breakthroughs and applications, expanded problem-solving help, and new online homework options.