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Regulative Schmerztherapie: Praxismanual für Ärzte, Physio-, Ergo- und Sporttherapeuten
by Wolfgang Laube Axel DaaseDie regulative Schmerztherapie ist mit ihren physiologisch begründeten aufeinanderfolgenden Interventionen spezifisch auf die Verhinderung bzw. Behandlung von chronischem Schmerz ausgerichtet. In diesem Buch wird die gesamte nicht pharmakologische Therapiekette von möglichen Interventionen vorgestellt. Es werden dabei passiv provozierte Maßnahmen zur Schmerzlinderung und Durchblutungsförderung beschrieben, mit dem Ziel die Gewebeverhältnisse als Grundlage der Schmerzinformationen zu verbessern. Zudem werden aktive Methoden vorgestellt, z. B. das Beweglichkeitstraining von Gelenkregionen und andere aktive therapeutische Belastungsinterventionen, die den Körper in eine anti-nozizeptive Reorganisation bringen können. Das Buch ist somit ein Leitfaden für die nicht-medikamentöse Schmerztherapie und die medizinische Rehabilitation aller chronisch nicht entzündlichen und entzündlichen Erkrankungen und kann auch bei onkologischen Krankheiten angewandt werden. Als Zielgruppe werden Physiotherapeuten, Sporttherapeuten und Ärzte angesprochen, die Schmerzpatienten betreuen.
Regulatory and Pharmacological Basis of Ayurvedic Formulations
by Amritpal SinghRegulatory affairs and pharmacological drug safety issues of Ayurvedic medicine has been overlooked by practitioners for many years. Research in Ayurveda is now a world-wide phenomenon, and several large pharmaceutical corporations are investing money for novel drug discovery from Ayurvedic sources. This book examines the regulatory and pharmacological aspects and includes extensive data on scientific evaluation carried out on Ayurvedic formulations. It will also serve as a reference book on standardization, pre-clinical studies, and clinical and toxicological studies on Ayurvedic formulations.
The Regulatory Approach to Air Quality Management: A Case Study of New Mexico (Routledge Revivals)
by Winston HarringtonIn the wake of the Clean Air Amendments of 1970 in the United States, sources of emissions could be held accountable for the degradation of air quality in the local environment. This case study of air quality management in New Mexico was produced to shed some light on the procedures and activities used by agencies in order to control air quality. Originally published in 1981, Winston Harrington uses New Mexico as a case study for its largely centralised control system in Santa Fe to explore the behaviour of air quality agencies and pollution sources and comments on policy implications from this study’s conclusions. This title will be of interest to students of environmental studies and policy makers.
Regulatory Aspects of Gene Therapy and Cell Therapy Products: A Global Perspective (Advances in Experimental Medicine and Biology #1430)
by Maria Cristina GalliThis book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization.This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
Regulatory Chemicals Handbook (Chemical Industries)
by Jennifer M. Spero Bella Devito Louis TheodoreThis volume provides data - from physical and chemical properties to storage and exposure guidelines - on over 185 hazardous air pollutants (HAPs), more than 125 priority water pollutants (PWPs), and some 450 chemicals listed by the Occupational, Safety, and Health Administration (OSHA). Arranged alphabetically and by CAS number, the handbook serve
Regulatory Gaps in Baltic Sea Governance: Selected Issues (Mare Publication Ser. #18)
by Henrik RingbomThe focus of this publication is the uniqueness of the Baltic Sea from a legal perspective, and the regulatory voids that result from the multiple layers of regulation this area is subjected to: up to six layers of regulation (general international law, regional conventions, EU law, national laws, local and municipal rules plus a whole range of non-binding norms and other 'soft law' arrangements) act in parallel. However, a large number of rules or regulatory layers does not in itself ensure effectiveness or consistency. When the regulatory landscape is approached from the point of view of individual substantive topics, it is apparent that the norms of different regulatory layers entail both overlaps, gaps and uncertainties, differently for each topic. This publication addresses a selection of topics that are decidedly international in nature, but for which current international and EU rules include important gaps or uncertainties.In addition to presenting a set of legal analyses of topical issues for the region, which in itself is a meritorious objective in view of the relative scarcity of legal studies with a focus on the Baltic Sea, the publication also seeks to analyze the regulatory 'anatomy' of the selected issues in more detail. Through the legal analyses the chapters explore how regulatory gaps are formed, how they are filled, how the rules of the different layers work together and interact with each other in the selected areas. Accordingly, the secondary ambition is to explore, through the chapters, whether more general conclusions can be drawn about the nature of the regulatory gaps and multi-layerism in order to produce a better understanding of how regulations on multiple levels operate in practice.
Regulatory Issues in Organic Food Safety in the Asia Pacific
by Goh Bee Chen Rohan PriceThe book seeks to address the intersection of food organics and the emergence of a new contractualism between producers, distributors and consumers, and between nation states. Additionally, it seeks to cater to the needs of a discerning public concerned about how its own country aims to meet their demands for organic food quality and safety, as well as how they will benefit from integration in the standard-setting processes increasingly occurring regionally and internationally. This edited volume brings together expert scholars and practitioners and draws on their respective insights and experiences in the field of organics, food and health safety. The book is organized in three parts. Part I outlines certain international perspectives; Part II reflects upon relevant histories and influences and finally, Part III examines the organic food regulatory regime of various jurisdictions in the Asia Pacific.
Regulatory Nascent Polypeptides
by Koreaki ItoThis book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.
Regulatory Networks in Stem Cells
by Vinagolu K. RajasekharThis book brings together current advances in embryonic, adult, neural, hematopoietic, mesenchymal and pancreatic stem cell functions. The well presented chapters are authored by top-notch scientists in specialized areas of stem cell biology.
Regulatory RNAs: Basics, Methods and Applications
by Bibekanand Mallick and Zhumur GhoshRecent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
Regulatory RNAs
by Zhumur Ghosh Bibekanand MallickRecent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on "Regulatory RNAs" offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, "Regulatory RNAs: Basics, Methods and Applications" promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
Regulatory Status Of Direct Food Additives
by Thomas E. FuriaThe primary purpose of this volume is to provide readers with quick summaries of and references to the current U.S. government and other regulations for some of the most frequently employed direct food additives. Indirect additives, such as pesticide residues, packaging adhesives, polymeric coatings, and animal feed chemicals, have not been included.
Regulatory Support for Off-Grid Renewable Electricity (Routledge Explorations in Energy Studies)
by Ngozi Chinwa Ole, Eduardo G. Pereira, Peter Kayode Oniemola, and Gustavo Kaercher LoureiroThis book investigates the role of law in enabling and addressing the barriers to the development of off-grid renewable electricity (OGRE). The limited development of OGRE is ascribed to a host of social, economic, and legal barriers, including the problem of initial capital costs, existing subsidies for conventional electricity, and lack of technological and institutional capacity. Through the analyses of selected case studies from Africa, Asia, Europe and North and South America, this book discusses the typical barriers to the development of OGRE from a global perspective and examines the role of the law in addressing them. Drawing together the lessons learnt from the case studies, this book offers robust recommendations on how the development of OGRE will support the goal of achieving universal access to low carbon, reliable, and sustainable electricity globally. This volume will be of great interest to students, scholars, policy makers, investors, and practitioners in the fields of energy law and policy, climate change, and renewable energy development.
Regulatory T Cells
by Adrian Liston George KassiotisDriven by methodological success in identifying reliable lineage markers, regulatory T cells have quickly been recognized as the most numerous subset of immune regulators in the body with critical functions in a wide array of immune responses. In Regulatory T Cells: Methods and Protocols, experts in the field to offer a collection of current techniques to advance the study of regulatory T cells, including the use of the IL-2 receptor alpha chain and other markers, as well as the more recently desirable use of the transcription factor FoxP3. Divided into three sections, the book covers, in equal measure, in vitro, in vivo, and human studies. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known methodological pitfalls. Authoritative and cutting-edge, Regulatory T Cells: Methods and Protocols distills the most vital current techniques through several years of optimization and standardization in order to allow reliable and reproducible use by both young and experienced cellular and molecular immunologists.
Regulatory T Cells and Clinical Application
by Shuiping JiangThe immune system reacts vigorously to foreign invaders such as viruses, bacteria, protozoa, and parasites, and yet shows unresponsiveness to our own proteins. In the past decade, several types of T lymphocytes in the immune system have been discovered to function as regulatory cells to suppress unwanted immune responses to self-proteins, leading to the protection of autoimmunity. Furthermore, regulatory T cells also protect us from the development of asthma allergy, and prevent organ transplantation rejection. "Regulatory T Cells and Clinical Application" provides a comprehensive view of all types of regulatory T cells described so far in the literature. By thoroughly reviewing the immunobiology of regulatory T cells and their implications in various forms of human diseases, a new perspective of therapy using regulatory T cells as individualized medicine to treat inflammatory diseases including diabetes, allergy and transplantation rejection is highlighted.
Regulatory Toxicology
by Franz-Xaver Reichl Michael SchwenkThis book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e. g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. "
Regulatory Toxicology
by Franz-Xaver Reichl Michael SchwenkThis 2nd edition of the Handbook "Regulatory Toxicology" was written and updated by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It includes a number of new chapters that cover recent developments, such as regulation of nanoparticles, illicit designer drugs or tattoos.The Handbook deals comprehensively with the safety-ensuring methods and concepts employed for acute and chronic toxicity by regulatory agencies, industry and academics.
Rehabilitating Damaged Ecosystems
by John Cairns Jr.Built on a strong foundation in restoration ecology, this unique handbook provides practitioners, academics, and managers with vital tools needed to plan for ecosystem conservation, to restore degraded ecosystems, to make cost-effective restoration decisions, and to understand important legal issues. Rehabilitation of Damaged Ecosystems, Second Edition boasts three completely new chapters and five major chapter revisions. Coastal wetlands restoration, watershed rehabilitation and management, mined land reclamation, revegetation of disturbed ecosystems, and river and stream restoration are only a few of the critical topics explored in this timely reference handbook.This Second Edition provides valuable, reliable data as well as practical methods and techniques for the ongoing fight to protect natural resources and restore damaged ecosystems.
Rehabilitation Approach in Autism
by Manu Goyal Kanu GoyalThe book introduces a pioneering approach to the comprehensive care of individuals with autism spectrum disorder (ASD), emphasizing its multidisciplinary nature, evidence-based foundation, and innovative treatments. It addresses a critical gap in current literature by highlighting the collaborative roles of diverse healthcare professionals, such as pediatricians, physiotherapists, occupational therapists, speech therapists, and nurses, in the rehabilitation and treatment of ASD. The manual intervention strategies advocated by physiotherapists aim to enhance motor skills and cognitive processes through interactive and playful methods, fostering social integration and independence among patients. The book emphasizes evidence-based practices across disciplines, ensuring that all healthcare professionals receive essential, up-to-date knowledge pertinent to their roles in Autism Spectrum Disorder care. Moreover, it explores recent advancements in treatment approaches, providing readers with insights into innovative therapies and methodologies. This multidisciplinary approach consolidates fragmented knowledge into a single resource, equipping healthcare professionals with the necessary tools to deliver effective and holistic care to individuals with ASD. The targeted audience for the book includes pediatricians, physiotherapists, occupational therapists, speech therapists, and nurses.
Rehabilitation Engineering: Principles and Practice (Rehabilitation Science in Practice Series)
by Alex Mihailidis and Roger SmithThis book will provide an overview of the rehabilitation engineering field, including key concepts that are required to provide a solid foundation about the discipline. It will present these concepts through a mix of basic and applied knowledge from rehabilitation engineering research and practice. It's written as an introductory text in order to provide access to the field by those without previous experience or background in the field.These concepts will include those related to engineering and health that are necessary to understand the application of rehabilitation engineering to support human function.
Rehabilitation Methodology and Strategies: A Study Guide for Physiotherapists
by Giuseppe VerdeThis book explores rehabilitation methodology in Evidence Based Medicine (EBM), providing a description of the main traditional strategies used by physiotherapists. It supplies both physiotherapists and students with updated information on scientific professional choices for the patient’s benefit by collecting traditional knowledge and trying to answer a fundamental question: is there an objective way of rehabilitating patients by using traditional concepts at the light of new evidences? Every physiotherapist experiences the need of updating his knowledge and professional actions. Research can help but personal experience remains fundamental for clinical reasoning. The book examines rehabilitation strategies, main rehabilitation techniques, as well as scientific practice and suggestions stemming from research. The various rehabilitation strategies and techniques converge in the daily work becoming the basis for operative choices finalized to solve the patient's needs. Methodology characterizes the work of a physiotherapist who should take care of his scientific education by means of effective teaching plans, educational rules and ethic professional code. This book will be a useful tool for physiotherapy students but also for professionals.
Rehabilitation of Neuropsychological Disorders: A Practical Guide for Rehabilitation Professionals
by Brick Johnstone Henry H. StonningtonMany contemporary neuropsychology texts focus on neuropathology, the description of specific tests, and the differential diagnosis of central nervous system disorders. However, increasingly sophisticated neuroradiological techniques, managed care factors, and the growth of rehabilitation necessitates that rehabilitation professionals provide more functionally (versus diagnostically) useful evaluations to improve the neuropsychological functioning and community integration of persons with brain injuries or diseases. This book aims to fill this gap and to provide an overview of standard neuropsychological treatment strategies for specific cognitive impairments that are identified on testing. The new edition enhances this goal with three chapters outlining important recommendations, services, and issues for rehabilitation professionals. Written by a team of experienced scientists and professionals, the volume provides a universal taxonomy of neuropsychological abilities (emphasizing relatively simple terms), with a list of basic rehabilitation strategies to improve impairments identified in general cognitive domains. Specific chapters are included on the neuropsychological remediation of memory, attention, language, visual-spatial skills, and executive function impairments. Each chapter proposes a taxonomy of relatively unitary cognitive constructs (e.g., divided attention, sustained attention, focused attention), lists tests which may be used to assess each cognitive construct, and provides specific rehabilitation strategies to improve or accommodate the identified neuropsychological impairments. The final chapters cover basic resources and issues of which the rehabilitation professional needs to be aware (vocational rehabilitation, disability determination, and guardianship issues). This new edition provides a wealth of useful information for family members, rehabilitation professionals, and others who work with persons with brain injury in improving the community functioning for those with brain dysfunction. An accompanying website facilitates access to the resources and strategies from the book, allowing the practitioner to cut and paste these recommendations into their clinical reports.
Rehabilitation of Visual Disorders After Brain Injury: 2nd Edition (Neuropsychological Rehabilitation: A Modular Handbook)
by Josef ZihlThis thoroughly updated and extended edition covers the various cerebral visual disorders acquired after brain injury, as well as the rehabilitation techniques used to treat them. These are described within a brain plasticity framework, using data from single and group case studies along with follow up observation data. This original, tailor-made approach also includes the recording of eye movements for assessing scanning performance in scene perception and reading. The book gives a brief synopsis of the historical background on the subject, alongside an outline of intervention designs and methodological difficulties in the field, and goes on to discuss the mechanisms and processes that provide the foundations for recovery of function and successful adaptation in visually impaired patients. The author concludes by analyzing the importance of the procedures and outcomes of treatments to the reduction of patients’ visual handicaps. The new edition also contains an appendix with recommendations on the case histories, diagnostics and treatments. It is ideal reading for students in clinical neuropsychology, as well as professionals in the fields of neurology, visual neuroscience and rehabilitation experts.
Rehabilitation of Visual Disorders After Brain Injury: 2nd Edition (Neuropsychological Rehabilitation: A Modular Handbook Ser.)
by Josef ZihlDespite a long research tradition in visual neuroscience, the rehabilitation of cerebral visual deficits has, until recently, been neglected. This book is the first to report systematic observations on spontaneous recovery of cerebral visual deficits after acquired brain injury, and the outcome of treating these deficits. The whole range of human visual functions and capacities is covered: visual field, visual acuity and contrast sensitivity, visual adaptation, colour vision, visual space perception, and visual cognition. Additionally, there is a special section devoted to patients with central scotoma. All treatment procedures described are empirically founded.
Rehabilitation Science in Context (Advances in Experimental Medicine and Biology #1096)
by Mieczyslaw PokorskiThe focus of this book lies on novel aspects of rehabilitation medicine used as a treatment tool in both physical and mental spheres.The articles cover a diverse spectrum, such as rehabilitation in orthopedic pathologies, the exemplary of which is knee joint degeneration, in perioperative metastatic cancer diseases, or in neural degeneration requiring a transplant of donor nerve fibers into the defunct nerve. Advanced research studies involving proprioceptive neuromuscular facilitation, photobiomodulation, or yoga meditative techniques to regain functional ability are dealt with. The topic is expanded by a comprehensive picture of chosen molecular, genetically underpinned, diagnostics in hepatitis C infections and of novel ideas in drug design holding a curative promise in central neurodegeneration, such as development of brain-blood-barrier permeable oleic derivatives of the hydrophilic dopamine compound. The emerging rehabilitative modes and applications are posed to influence future health care delivery.The state-of-the art research is addressed to scientists, clinicians, therapists, and allied health care professionals.