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Statistical Methods for Global Health and Epidemiology: Principles, Methods and Applications (ICSA Book Series in Statistics)
by Xinguang Chen Din Ding-Geng ChenThis book examines statistical methods and models used in the fields of global health and epidemiology. It includes methods such as innovative probability sampling, data harmonization and encryption, and advanced descriptive, analytical and monitory methods. Program codes using R are included as well as real data examples. Contemporary global health and epidemiology involves a myriad of medical and health challenges, including inequality of treatment, the HIV/AIDS epidemic and its subsequent control, the flu, cancer, tobacco control, drug use, and environmental pollution. In addition to its vast scales and telescopic perspective; addressing global health concerns often involves examining resource-limited populations with large geographic, socioeconomic diversities. Therefore, advancing global health requires new epidemiological design, new data, and new methods for sampling, data processing, and statistical analysis. This book provides global health researchers with methods that will enable access to and utilization of existing data. Featuring contributions from both epidemiological and biostatistical scholars, this book is a practical resource for researchers, practitioners, and students in solving global health problems in research, education, training, and consultation.
Statistical Methods for Imbalanced Data in Ecological and Biological Studies (SpringerBriefs in Statistics)
by Osamu Komori Shinto EguchiThis book presents a fresh, new approach in that it provides a comprehensive recent review of challenging problems caused by imbalanced data in prediction and classification, and also in that it introduces several of the latest statistical methods of dealing with these problems. The book discusses the property of the imbalance of data from two points of view. The first is quantitative imbalance, meaning that the sample size in one population highly outnumbers that in another population. It includes presence-only data as an extreme case, where the presence of a species is confirmed, whereas the information on its absence is uncertain, which is especially common in ecology in predicting habitat distribution. The second is qualitative imbalance, meaning that the data distribution of one population can be well specified whereas that of the other one shows a highly heterogeneous property. A typical case is the existence of outliers commonly observed in gene expression data, and another is heterogeneous characteristics often observed in a case group in case-control studies. The extension of the logistic regression model, maxent, and AdaBoost for imbalanced data is discussed, providing a new framework for improvement of prediction, classification, and performance of variable selection. Weights functions introduced in the methods play an important role in alleviating the imbalance of data. This book also furnishes a new perspective on these problem and shows some applications of the recently developed statistical methods to real data sets.
Statistical Methods for Materials Science: The Data Science of Microstructure Characterization
by Marc De Graef Jeffrey P. Simmons Lawrence F. Drummy Charles A. BoumanData analytics has become an integral part of materials science. This book provides the practical tools and fundamentals needed for researchers in materials science to understand how to analyze large datasets using statistical methods, especially inverse methods applied to microstructure characterization. It contains valuable guidance on essential topics such as denoising and data modeling. Additionally, the analysis and applications section addresses compressed sensing methods, stochastic models, extreme estimation, and approaches to pattern detection.
Statistical Methods for QTL Mapping (Chapman & Hall/CRC Computational Biology Series #53)
by Zehua ChenWhile numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping. After introducing basic genetics topics an
Statistical Methods for Spoken Dialogue Management
by Blaise ThomsonSpeech is the most natural mode of communication and yet attempts to build systems which support robust habitable conversations between a human and a machine have so far had only limited success. A key reason is that current systems treat speech input as equivalent to a keyboard or mouse, and behaviour is controlled by predefined scripts that try to anticipate what the user will say and act accordingly. But speech recognisers make many errors and humans are not predictable; the result is systems which are difficult to design and fragile in use. Statistical methods for spoken dialogue management takes a radically different view. It treats dialogue as the problem of inferring a user's intentions based on what is said. The dialogue is modelled as a probabilistic network and the input speech acts are observations that provide evidence for performing Bayesian inference. The result is a system which is much more robust to speech recognition errors and for which a dialogue strategy can be learned automatically using reinforcement learning. The thesis describes both the architecture, the algorithms needed for fast real-time inference over very large networks, model parameter estimation and policy optimisation. This ground-breaking work will be of interest both to practitioners in spoken dialogue systems and to cognitive scientists interested in models of human behaviour.
Statistical Methods in Biomarker and Early Clinical Development
by Liang Fang Cheng SuThis contributed volume offers a much-needed overview of the statistical methods in early clinical drug and biomarker development. Chapters are written by expert statisticians with extensive experience in the pharmaceutical industry and regulatory agencies. Because of this, the data presented is often accompanied by real world case studies, which will help make examples more tangible for readers. The many applications of statistics in drug development are covered in detail, making this volume a must-have reference.Biomarker development and early clinical development are the two critical areas on which the book focuses. By having the two sections of the book dedicated to each of these topics, readers will have a more complete understanding of how applying statistical methods to early drug development can help identify the right drug for the right patient at the right dose. Also presented are exciting applications of machine learning and statistical modeling, along with innovative methods and state-of-the-art advances, making this a timely and practical resource.This volume is ideal for statisticians, researchers, and professionals interested in pharmaceutical research and development. Readers should be familiar with the fundamentals of statistics and clinical trials.
Statistical Methods in Human Genetics (Indian Statistical Institute Series)
by Indranil Mukhopadhyay Partha Pratim MajumderThis book provides an overview of statistical concepts and basic methodology for the study of genetics of human traits and diseases. It attempts to provide a step-by-step description of problem identification, study design, methodology of data collection, data exploration, data summarization and visualization, and more advanced analytical methods for inferring genetic underpinnings of human phenotypes. The book provides codes in R programming language for implementation of most of the statistical methods described, which will enable practitioners to perform analysis of data on their own, without having to mold the data to fit the requirements of commercial statistical packages. Useful to anyone engaged in studies to understand and manage good health, the book is a useful guide for sustainable development of humankind. Primarily intended for practicing biologists especially those who carry out quantitative biological research, in particular, human geneticists, the book is also helpful in classroom teaching.
Statistical Methods in Medical Research
by Charan Singh RayatThis book covers all aspects of statistical methods in detail with applications. It presents solutions to the needs of post-graduate medical students, doctors and basic medical scientists for statistical evaluation of data. In present era, dependency on softwares for statistical analysis is eroding the basic understanding of the statistical methods and their applications. As a result, there are very few basic medical scientists capable of analyzing their research data due to lack of knowledge and ability. This book has been written in systematic way supported by figures and tables for basic understanding of various terms, definitions, formulae and applications of statistical methods with solved examples and graphic presentation of data to create interest in this mathematical science.
Statistical Methods in Molecular Biology
by Madhu Mazumdar Heather L. Epps Xi Kathy Zhou Heejung BangWhile there is a wide selection of 'by experts, for experts' books in statistics and molecular biology, there is a distinct need for a book that presents the basic principles of proper statistical analyses and progresses to more advanced statistical methods in response to rapidly developing technologies and methodologies in the field of molecular biology. Statistical Methods in Molecular Biology strives to fill that gap by covering basic and intermediate statistics that are useful for classical molecular biology settings and advanced statistical techniques that can be used to help solve problems commonly encountered in modern molecular biology studies, such as supervised and unsupervised learning, hidden Markov models, methods for manipulation and analysis of high-throughput microarray and proteomic data, and methods for the synthesis of the available evidences. This detailed volume offers molecular biologists a book in a progressive style where basic statistical methods are introduced and gradually elevated to an intermediate level, while providing statisticians knowledge of various biological data generated from the field of molecular biology, the types of questions of interest to molecular biologists, and the state-of-the-art statistical approaches to analyzing the data. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides the kind of meticulous descriptions and implementation advice for diverse topics that are crucial for getting optimal results. Comprehensive but convenient, Statistical Methods in Molecular Biology will aid students, scientists, and researchers along the pathway from beginning strategies to a deeper understanding of these vital systems of data analysis and interpretation within one concise volume.
Statistical Methods in Neuropsychology
by David Aaron MaroofThis book describes appropriate statistical models that are commonly utilized in neuropsychology. The book discusses such issues as developing normative data for neuropsychological measures, assessing the validity of neuropsychological tests, and quantifying change "over time" through longitudinal analyses. The rationale for and allure of the volume is the fact that there are no publications that dovetail the two subdisciplines of applied statistics and neuropsychology. The overall objective of this book is to provide a pragmatic and concrete source for applying methodological and statistical techniques in research studies whose emphasis includes neuropsychology. Since there are a plethora of technique to arrive at similar answers, each method with its strengths and weaknesses will be delineated. The beauty of the book will be that it will hopefully demystify commonly encountered issues faced with researchers. More specifically, it will provide a "how to do it" approach.
Statistical Methods in Radiation Physics
by James E. Turner Darryl J. Downing James S. BogardThis statistics textbook, with particular emphasis on radiation protection and dosimetry, deals with statistical solutions to problems inherent in health physics measurements and decision making. The authors begin with a description of our current understanding of the statistical nature of physical processes at the atomic level, including radioactive decay and interactions of radiation with matter. Examples are taken from problems encountered in health physics, and the material is presented such that health physicists and most other nuclear professionals will more readily understand the application of statistical principles in the familiar context of the examples. Problems are presented at the end of each chapter, with solutions to selected problems provided online. In addition, numerous worked examples are included throughout the text.
Statistical Modeling Using Bayesian Latent Gaussian Models: With Applications in Geophysics and Environmental Sciences
by Birgir HrafnkelssonThis book focuses on the statistical modeling of geophysical and environmental data using Bayesian latent Gaussian models. The structure of these models is described in a thorough introductory chapter, which explains how to construct prior densities for the model parameters, how to infer the parameters using Bayesian computation, and how to use the models to make predictions. The remaining six chapters focus on the application of Bayesian latent Gaussian models to real examples in glaciology, hydrology, engineering seismology, seismology, meteorology and climatology. These examples include: spatial predictions of surface mass balance; the estimation of Antarctica’s contribution to sea-level rise; the estimation of rating curves for the projection of water level to discharge; ground motion models for strong motion; spatial modeling of earthquake magnitudes; weather forecasting based on numerical model forecasts; and extreme value analysis of precipitation on a high-dimensional grid. The book is aimed at graduate students and experts in statistics, geophysics, environmental sciences, engineering, and related fields.
Statistical Modeling and Machine Learning for Molecular Biology (Chapman & Hall/CRC Computational Biology Series)
by Alan MosesMolecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs, ortholog identification, motif finding, inference of population structure, protein fold prediction and many more. The book takes a pragmatic approach, focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics.
Statistical Modeling for Biological Systems: In Memory of Andrei Yakovlev
by David Oakes Anthony Almudevar Jack HallThis book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev’s many research interests including stochastic modeling and the analysis of micro-array data, and throughout the book it emphasizes applications of the theory in biology, medicine and public health. The contributions to this volume are divided into two parts. Part A consists of original research articles, which can be roughly grouped into four thematic areas: (i) branching processes, especially as models for cell kinetics, (ii) multiple testing issues as they arise in the analysis of biologic data, (iii) applications of mathematical models and of new inferential techniques in epidemiology, and (iv) contributions to statistical methodology, with an emphasis on the modeling and analysis of survival time data. Part B consists of methodological research reported as a short communication, ending with some personal reflections on research fields associated with Andrei and on his approach to science. The Appendix contains an abbreviated vitae and a list of Andrei’s publications, complete as far as we know. The contributions in this book are written by Dr. Yakovlev’s collaborators and notable statisticians including former presidents of the Institute of Mathematical Statistics and of the Statistics Section of the AAAS. Dr. Yakovlev’s research appeared in four books and almost 200 scientific papers, in mathematics, statistics, biomathematics and biology journals. Ultimately this book offers a tribute to Dr. Yakovlev’s work and recognizes the legacy of his contributions in the biostatistics community.
Statistical Modeling in Biomedical Research: Contemporary Topics and Voices in the Field (Emerging Topics in Statistics and Biostatistics)
by Ding-Geng Din Chen Yichuan ZhaoThis edited collection discusses the emerging topics in statistical modeling for biomedical research. Leading experts in the frontiers of biostatistics and biomedical research discuss the statistical procedures, useful methods, and their novel applications in biostatistics research. Interdisciplinary in scope, the volume as a whole reflects the latest advances in statistical modeling in biomedical research, identifies impactful new directions, and seeks to drive the field forward. It also fosters the interaction of scholars in the arena, offering great opportunities to stimulate further collaborations. This book will appeal to industry data scientists and statisticians, researchers, and graduate students in biostatistics and biomedical science. It covers topics in:Next generation sequence data analysisDeep learning, precision medicine, and their applicationsLarge scale data analysis and its applicationsBiomedical research and modelingSurvival analysis with complex data structure and its applications.
Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications (Algorithms for Intelligent Systems)
by K. G. Srinivasa G. M. Siddesh S. R. ManisekharThis book discusses topics related to bioinformatics, statistics, and machine learning, presenting the latest research in various areas of bioinformatics. It also highlights the role of computing and machine learning in knowledge extraction from biological data, and how this knowledge can be applied in fields such as drug design, health supplements, gene therapy, proteomics and agriculture.
Statistical Modelling and Risk Analysis: Selected contributions from ICRA9, Perugia, Italy, May 25-27, 2022 (Springer Proceedings in Mathematics & Statistics #430)
by Christos P. Kitsos Teresa A. Oliveira Francesca Pierri Marialuisa RestainoThis volume covers the latest results on novel methods in Risk Analysis and assessment, with applications in Biostatistics (which is providing food for thought since the first ICRAs, covering traditional areas of RA, until now), Engineering Reliability, the Environmental Sciences and Economics. The contributions, based on lectures given at the 9th International Conference on Risk Analysis (ICRA 9), at Perugia, Italy, May 2022, detail a wide variety of daily risks, building on ideas presented at previous ICRA conferences. Working within a strong theoretical framework, supporting applications, the material describes a modern extension of the traditional research of the 1980s. This book is intended for graduate students in Mathematics, Statistics, Biology, Toxicology, Medicine, Management, and Economics, as well as quantitative researchers in Risk Analysis.
Statistical Modelling in Biostatistics and Bioinformatics
by Gilbert Mackenzie Defen PengThis book presents selected papers on statistical model development related mainly to the fields of Biostatistics and Bioinformatics. The coverage of the material falls squarely into the following categories: (a) Survival analysis and multivariate survival analysis, (b) Time series and longitudinal data analysis, (c) Statistical model development and (d) Applied statistical modelling. Innovations in statistical modelling are presented throughout each of the four areas, with some intriguing new ideas on hierarchical generalized non-linear models and on frailty models with structural dispersion, just to mention two examples. The contributors include distinguished international statisticians such as Philip Hougaard, John Hinde, Il Do Ha, Roger Payne and Alessandra Durio, among others, as well as promising newcomers. Some of the contributions have come from researchers working in the BIO-SI research programme on Biostatistics and Bioinformatics, centred on the Universities of Limerick and Galway in Ireland and funded by the Science Foundation Ireland under its Mathematics Initiative.
Statistical Modelling of Occupant Behaviour
by Henrik Madsen Marcel Schweiker Jan Kloppenborg Møller Rune Korsholm Andersen Burak Gunay Selin Yilmaz Verena Marie BarthelmesDo you have data on occupant behaviour, indoor environment or energy use in buildings? Are you interested in statistical analysis and modelling? Do you have a specific (research) question and dataset and would like to know how to answer the question with the data available? Statistical Modelling of Occupant Behaviour covers a range of statistical methods and models used for modelling energy- and comfort-related occupant behaviour in buildings. It is a classical textbook on statistics, including many practical examples related to occupant behaviour that are either taken from real research problems or adapted from such. The main focus is traditional statistical techniques based on the likelihood principle that can be applied to occupant behaviour modelling, including: General, generalised linear and survival models Mixed effect and hierarchical models Linear time series and Markov models Linear state space and hidden Markov models Illustration of all methods using occupant behaviour examples implemented in R The built environment affects occupants who live and work in it, and occupants affect the built environment by adapting it to their needs – for example, by adapting their indoor environments by interacting with building components and systems. These adaptive behaviours account for great uncertainty in the prediction of building energy use and indoor environmental conditions. Occupant behaviour is complex and multi-disciplinary but can be successfully modelled using statistical approaches. Statistical Modelling of Occupant Behaviour is written for researchers and advanced practitioners who work with real-world applications and modelling of occupant data. It describes the kinds of statistical models that may be used in various occupant behaviour modelling research. It gives a theoretical overview of these methods and then applies them to the study of occupant behaviour using readily replaceable examples in the R environment that are based on actual and experimental data.
Statistical Models for Nuclear Decay: From Evaporation to Vaporization (Series in Fundamental and Applied Nuclear Physics)
by A.J ColeStatistical Models for Nuclear Decay: From Evaporation to Vaporization describes statistical models that are applied to the decay of atomic nuclei, emphasizing highly excited nuclei usually produced using heavy ion collisions. The first two chapters present essential introductions to statistical mechanics and nuclear physics, followed by a descript
Statistical Optics (Wiley Series in Pure and Applied Optics)
by Joseph W. GoodmanThis book discusses statistical methods that are useful for treating problems in modern optics, and the application of these methods to solving a variety of such problems This book covers a variety of statistical problems in optics, including both theory and applications. The text covers the necessary background in statistics, statistical properties of light waves of various types, the theory of partial coherence and its applications, imaging with partially coherent light, atmospheric degradations of images, and noise limitations in the detection of light. New topics have been introduced in the second edition, including: Analysis of the Vander Pol oscillator model of laser light Coverage on coherence tomography and coherence multiplexing of fiber sensors An expansion of the chapter on imaging with partially coherent light, including several new examples An expanded section on speckle and its properties New sections on the cross-spectrum and bispectrum techniques for obtaining images free from atmospheric distortions A new section on imaging through atmospheric turbulence using coherent light The addition of the effects of "read noise" to the discussions of limitations encountered in detecting very weak optical signals A number of new problems and many new references have been added Statistical Optics, Second Edition is written for researchers and engineering students interested in optics, physicists and chemists, as well as graduate level courses in a University Engineering or Physics Department.
Statistical Outliers and Related Topics
by Mir Masoom Ali Irfan Ali Haitham M. Yousof Rahmatullah ImonThe book is a collection of different aspects of outliers and related topics written by experts. Topics covered include definition of outliers, their sources, consequences, identification, computational and robustness issues, handling of outliers in diversified areas of statistics such as univariate and multivariate data, linear and generalized linear models, time series, linear functional and structural models, circular data, spatial data, big data, high dimensional data, multi-view data. The book emphasizes the importance of outliers, and will appeal to workers in Data Mining; which is one of the fastest-growing business applications of statistics. The book makes outlier detection methods widely usable by practitioners. Examples are drawn from various fields.
Statistical Physics
by Franz MandlThe Manchester Physics Series General Editors: D. J. Sandiford; F. Mandl; A. C. Phillips Department of Physics and Astronomy, University of Manchester Properties of Matter B. H. Flowers and E. Mendoza Optics Second Edition F. G. Smith and J. H. Thomson Statistical Physics Second Edition E. Mandl Electromagnetism Second Edition I. S. Grant and W. R. Phillips Statistics R. J. Barlow Solid State Physics Second Edition J. R. Hook and H. E. Hall Quantum Mechanics F. Mandl Particle Physics Second Edition B. R. Martin and G. Shaw The Physics of Stars Second Edition A. C. Phillips Computing for Scientists R. J. Barlow and A. R. Barnett Statistical Physics, Second Edition develops a unified treatment of statistical mechanics and thermodynamics, which emphasises the statistical nature of the laws of thermodynamics and the atomic nature of matter. Prominence is given to the Gibbs distribution, leading to a simple treatment of quantum statistics and of chemical reactions. Undergraduate students of physics and related sciences will find this a stimulating account of the basic physics and its applications. Only an elementary knowledge of kinetic theory and atomic physics, as well as the rudiments of quantum theory, are presupposed for an understanding of this book. Statistical Physics, Second Edition features:A fully integrated treatment of thermodynamics and statistical mechanics.A flow diagram allowing topics to be studied in different orders or omitted altogether.Optional "starred" and highlighted sections containing more advanced and specialised material for the more ambitious reader.Sets of problems at the end of each chapter to help student understanding. Hints for solving the problems are given in an Appendix.
Statistical Physics
by Ian FordThis undergraduate textbook provides a statistical mechanical foundation to the classical laws of thermodynamics via a comprehensive treatment of the basics of classical thermodynamics, equilibrium statistical mechanics, irreversible thermodynamics, and the statistical mechanics of non-equilibrium phenomena.This timely book has a unique focus on the concept of entropy, which is studied starting from the well-known ideal gas law, employing various thermodynamic processes, example systems and interpretations to expose its role in the second law of thermodynamics. This modern treatment of statistical physics includes studies of neutron stars, superconductivity and the recently developed fluctuation theorems. It also presents figures and problems in a clear and concise way, aiding the student's understanding.
Statistical Physics
by Y KlimontovichA look at Statistical Physics by renowned Russia-Soviet physicist Yuri Klimontovich of the Moscow State University, MSU Faculty of Physics.