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Stem Cells, Craniofacial Development and Regeneration
by Irma Thesleff George T.J. HuangStem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle. Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue.The authoritative resource for dentistry students as well as craniofacial researchers at the graduate and post-graduate level, Stem Cells, Craniofacial Development and Regeneration explores the rapidly expanding field of stem cells and regeneration from the perspective of the dentistry and craniofacial community, and points the way forward in areas of tissue bioengineering and craniofacial stem cell therapies.
Stem Cells: Biology and Application
by Mary Clarke Jonathan FramptonStem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.
Stem Cells: Biology and Engineering (Advances in Experimental Medicine and Biology #1083)
by Phuc Van PhamThis new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Stem Cells: Biology and Engineering is a proceedings volume which reflects papers presented at the Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Tissue Engineering and Regenerative Medicine it provides a complete overview of the papers from that meeting of international experts.
Stem Cells: Biology and Therapeutics
by Shyamasree Ghosh Suchandra ChowdhuryStem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.
Stem Cells: Latest Advances
by Khawaja H. HaiderIn this volume, the contributing authors from top labs involved in stem cell theranostics share the latest advances in the field of stem cell research. The book covers many aspects of stem cell-based therapy and the progress made toward stem cell therapy for liver, ocular, and cardiovascular diseases as well as cancer. This volume serves as a continuation of Prof. Khawaja Husnain Haider’s previously edited books pertaining to stem cells-based therapnostics. This is an ideal book for researchers involved in drug development as well as regenerative medicine and stem cell-based therapy. The secondary audience includes graduate and postgraduate medical students, doctors, cellular pharmacology, drug industry, and researchers involved in using stem cells as ex-vivo disease models for drug development.
Stem Cells: Therapeutic Applications (Advances in Experimental Medicine and Biology #1201)
by Mariusz Z. RatajczakSince different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.
Stem Lesson Essentials, Grades 3-8: Integrating Science, Technology, Engineering, And Mathematics
by Jo Anne Vasquez Michael Comer Cary SneiderIntegrating Science, Technology, Engineering, and Mathematics STEM Lesson Essentials moves beyond the rhetoric and provides knowledge, tools, models, and examples that make STEM a reality of teaching and learning in classrooms. -Rodger Bybee, Executive Director (Retired), Biological Sciences Curriculum Study Want to know how to implement authentic STEM teaching and learning into your classroom? STEM Lesson Essentials provides all the tools and strategies you'll need to design integrated, interdisciplinary STEM lessons and units that are relevant and exciting to your students. With clear definitions of both STEM and STEM literacy, the authors argue that STEM in itself is not a curriculum, but rather a way of organizing and delivering instruction by weaving the four disciplines together in intentional ways. Rather than adding two new subjects to the curriculum, the engineering and technology practices can instead be blended into existing math and science lessons in ways that engage students and help them master 21st century skills. STEM Lesson Essentials shows teachers how to begin the STEM integration journey with: five guiding principles for effective STEM instruction classroom examples of what these principles look like in action sample activities that put all four STEM fields into practice lesson planning templates for STEM units. Explicit connections are made among the STEM practices, including the Common Core Standards for Mathematical Practice and the Framework for K-12 Science Education, helping you easily recognize ways in which STEM lessons can engage students in multiple standards at the same time. With ideas that are practical and achievable in any classroom, STEM Lesson Essentials will give you the confidence and knowledge to weave engineering and technology concepts into your math and science curriculum. STEM teaching doesn't have to be hard. You just have to get started. Try it out with STEM Lesson Essentials, and watch student understanding, achievement, and motivation soar.
Stem cell and Non-stem Cell Components of Breast Milk
by Indumathi Somasundaram Pankaj Kaingade Ramesh BhondeThis book reviews the cellular and non-cellular components of human breast milk and their contribution to infant growth and development. It also discusses various cellular growth factors in breast milk, including stem cells and their significance in promoting optimal growth, immunity and regeneration in neonates and in mitigating several neonatal diseases. Further, the book examines variations in the macronutrient concentrations of human milk in different lactation stages and maternal factors. It also describes the potential of antimicrobial proteins/peptides in human milk to provide innate immunity to infants. Lastly, it explores the regenerative therapeutic applications of breast milk cells in feeding infants.
Stem cells: From Potential to Promise
by Khawaja Husnain HaiderThe book highlights the therapeutic applications of various stem cells, and introduces readers to thymus stem cells and their applications in the reconstitution of thymic structure and function. It also discusses the significant role of mesenchymal stem cells (MSCs) in the treatment of autoimmune diseases and the use of MSC-derived exosomes in cell-free therapy. Moreover, it explores the application of hematopoietic stem cells in the vasculoprotection of the ischemially injured heart. Further topics include the regenerative potential of ovarian germline stem cells and the significance of endometrial stem cells in the pathogenesis of female reproductive tract diseases. Lastly, the book addresses stem cells from perinatal tissues and their immunoregulatory and differentiation potentials, and summarizes new strategies for targeting cancer stem cells to treat tumors.
Stemming the Tide: Controlling Introductions of Nonindigenous Species by Ships' Ballast Water
by Committee on Ships' Ballast OperationsThe European zebra mussel in the Great Lakes, a toxic Japanese dinoflagellate transferred to Australia--such biologically and economically harmful stowaways have made it imperative to achieve better management of ballast water in ocean-going vessels.Stemming the Tide examines the introduction of nonindigenous species through ballast water discharge. Ballast is any solid or liquid that is taken aboard ship to achieve more controlled and safer operation. This expert volume Assesses current national and international approaches to the problem and makes recommendations for U.S. government agencies, the U.S. maritime industry, and the member states of the International Maritime Organization. Appraises technologies for controlling the transfer of organisms--biocides, filtration, heat treatment, and others --with a view toward developing the most promising methods for shipboard demonstration. Evaluates methods for monitoring the effectiveness of ballast water management in removing unwanted organisms. The book addresses the constraints inherent in ballast water management, notably shipboard ballast treatment and monitoring. Also, the committee outlines efforts to set an acceptable level of risk for species introduction using the techniques of risk analysis. Stemming the Tide will be important to all stakeholders in the issue of unwanted species introduction through ballast discharge: policymakers, port authorities, shippers, ship operators, suppliers to the maritime industry, marine biologists, marine engineers, and environmentalists.
Step Into Reading® 3: Henry Ford’s First Race
by Monica KullingIt’s 1901 and Henry Ford wants to build a car that everyone can own. But first he needs the money to produce it. How will he get it? He enters a car race, of course! Readers will love this fast-paced, fact-based story!
Step Into STEAM, Grades PreK-5: Your Standards-Based Action Plan for Deepening Mathematics and Science Learning
by Sarah B. Bush Kristin L. CookCreate innovative and equitable experiences that prepare your learners for the future! STEAM education is crucial for preparing learners to meet the demands of a rapidly evolving world. Not every learner is going to pursue a STEAM-related career, but each and every learner needs to be challenged with opportunities to transfer what they are learning in mathematics and science instruction to seek solutions to the complex problems of today—and to meet our future world head on! In this Second Edition of Step Into STEAM, authors Sarah Bush and Kristin Cook guide and inspire PreK–5 educators through a seamless process of designing and implementing STEAM inquiries that align precisely to key mathematics and science content and practices—all while meeting the demands of guiding assessments. Going far beyond a collection of STEAM activities, this book shows educators, as well as school and district leaders, how to build a STEAM ecosystem that can measurably improve every learner’s mathematics and science achievement, as well as engagement, belonging, and interest. What truly sets this book apart is its masterful integration of problem-based inquiry as the foundation for STEAM instruction. This updated edition: Expands on the latest research in STEAM education across PreK-5 in various educational settings Incorporates strategies grounded in Universal Design for Learning to engage all learners Provides updated STEAM resources aligned to the Integrated STEM Practices Embeds actionable tips throughout each chapter that educators can implement immediately in addition to suggestions for ongoing learning and growth for all Offers an updated companion website with additional templates for brainstorming sessions or book studies, action plans, and checklists to help educators put their ideas into practice This is an essential guide for educators looking to implement STEAM education in their classrooms and beyond. Step Into STEAM provides a comprehensive roadmap for cultivating the creativity, problem-solving abilities, resilience, and empathy that will empower the next generation of innovators, entrepreneurs, and global citizens. Make the most of your limited instructional time and become part of the Step Into STEAM journey!
Step Into STEAM, Grades PreK-5: Your Standards-Based Action Plan for Deepening Mathematics and Science Learning
by Sarah B. Bush Kristin L. CookCreate innovative and equitable experiences that prepare your learners for the future! STEAM education is crucial for preparing learners to meet the demands of a rapidly evolving world. Not every learner is going to pursue a STEAM-related career, but each and every learner needs to be challenged with opportunities to transfer what they are learning in mathematics and science instruction to seek solutions to the complex problems of today—and to meet our future world head on! In this Second Edition of Step Into STEAM, authors Sarah Bush and Kristin Cook guide and inspire PreK–5 educators through a seamless process of designing and implementing STEAM inquiries that align precisely to key mathematics and science content and practices—all while meeting the demands of guiding assessments. Going far beyond a collection of STEAM activities, this book shows educators, as well as school and district leaders, how to build a STEAM ecosystem that can measurably improve every learner’s mathematics and science achievement, as well as engagement, belonging, and interest. What truly sets this book apart is its masterful integration of problem-based inquiry as the foundation for STEAM instruction. This updated edition: Expands on the latest research in STEAM education across PreK-5 in various educational settings Incorporates strategies grounded in Universal Design for Learning to engage all learners Provides updated STEAM resources aligned to the Integrated STEM Practices Embeds actionable tips throughout each chapter that educators can implement immediately in addition to suggestions for ongoing learning and growth for all Offers an updated companion website with additional templates for brainstorming sessions or book studies, action plans, and checklists to help educators put their ideas into practice This is an essential guide for educators looking to implement STEAM education in their classrooms and beyond. Step Into STEAM provides a comprehensive roadmap for cultivating the creativity, problem-solving abilities, resilience, and empathy that will empower the next generation of innovators, entrepreneurs, and global citizens. Make the most of your limited instructional time and become part of the Step Into STEAM journey!
Step Wise Protocols for Somatic Embryogenesis of Important Woody Plants: Volume I (Forestry Sciences #84)
by Shri Mohan Jain Pramod GuptaWorld population is increasing at an alarming rate and this has resulted in increasing tremendously the demand for tree products such as wood for construction materials, fuel and paper, fruits, oils and medicines etc. This has put immense pressure on the world’s supplies of trees and raw material to industry and will continue to do so as long as human population continues to grow. Also, the quality of human diet, especially nutritional components, is adversely affected due to limited genetic improvement of most of fruit trees. Thus there is an immediate need to increase productivity of trees. Improvement has been made through conventional breeding methods, however, conventional breeding is very slow due to long life cycle of trees. A basic strategy in tree improvement is to capture genetic gain through clonal propagation. Clonal propagation via organogenesis is being used for the production of selected elite individual trees. However, the methods are labour intensive, costly, and produce low volumes. Genetic gain can now be captured through somatic embryogenesis. Formation of embryos from somatic cells by a process resembling zygotic embryogenesis is one of the most important features of plants. In 1958, Reinert in Germany and Steward in USA independently reported somatic embryogenesis in carrot cultures. Since then, tremendous progress in somatic embryogenesis of woody and non-woody plants has taken place. It offers a potentially large-scale propagation system for superior clones.
Step Wise Protocols for Somatic Embryogenesis of Important Woody Plants: Volume I (Forestry Sciences Ser. #84)
by Shri Mohan Jain Pramod GuptaWorld population is increasing at an alarming rate and this has resulted in increasing tremendously the demand for tree products such as wood for construction materials, fuel and paper, fruits, oils and medicines etc. This has put immense pressure on the world’s supplies of trees and raw material to industry and will continue to do so as long as human population continues to grow. Also, the quality of human diet, especially nutritional components, is adversely affected due to limited genetic improvement of most of fruit trees. Thus there is an immediate need to increase productivity of trees. Improvement has been made through conventional breeding methods, however, conventional breeding is very slow due to long life cycle of trees. A basic strategy in tree improvement is to capture genetic gain through clonal propagation. Clonal propagation via organogenesis is being used for the production of selected elite individual trees. However, the methods are labour intensive, costly, and produce low volumes. Genetic gain can now be captured through somatic embryogenesis. Formation of embryos from somatic cells by a process resembling zygotic embryogenesis is one of the most important features of plants. In 1958, Reinert in Germany and Steward in USA independently reported somatic embryogenesis in carrot cultures. Since then, tremendous progress in somatic embryogenesis of woody and non-woody plants has taken place. It offers a potentially large-scale propagation system for superior clones.
Step by Step
by Loreen LeedyAn adorable guessing-game introduction to baby animals and their footprints!Who walks in the snow? A penguin chick! Who crawls to the ocean? A sea turtle hatchling! In this adorable introduction to animal tracks and habitats, young readers must guess which baby animals have made which footprints. Thirteen different species appear, including--in a final surprise--our own.Published simultaneously in hardcover.
Step into the World of Mathematics: Math Is Beautiful and Belongs to All of Us
by Samuli SiltanenModern life is increasingly relying on digital technology, which in turn runs on mathematics. However, this underlying math is hidden from us. That is mostly a good thing since we do not want to be solving equations and calculating fractions just to get things done in our everyday business. But the mathematical details do matter for anyone who wants to understand how stuff works, or wishes to create something new in the jungle of apps and algorithms. This book takes a look at the mathematical models behind weather forecasting, climate change prediction, artificial intelligence, medical imaging and computer graphics. The reader is expected to have only a curious mind; technical math skills are not needed for enjoying this text.
Step-by-Step Design of Large-Scale Photovoltaic Power Plants
by Houshang Karimi Davood Naghaviha Hassan NikkhajoeiHow to design a solar power plant, from start to finish In Step-by-Step Design of Large-Scale Photovoltaic Power Plants, a team of distinguished engineers delivers a comprehensive reference on PV power plants—and their design—for specialists, experts, and academics. Written in three parts, the book covers the detailed theoretical knowledge required to properly design a PV power plant. It goes on to explore the step-by-step requirements for creating a real-world PV power plant, including parts and components design, mathematical formulations and calculations, analyses, evaluations, and planning. The book concludes with a discussion of a sample solar plant design, as well as tips on how to avoid common design mistakes, and how to handle the operation and maintenance of PV power plants. Step-by-Step Design of Large-Scale Photovoltaic Power Plants also includes: Thorough introductions to the basic requirements of design, economic analyses, and investment revenue Comprehensive explorations of the requirements for feasibility study and grid connection study Introducing solar resource, and determining optimum tilt angle and module inter-row spacing Presenting methodology for design of large-scale PV plant, requirements of engineering document, and optimal design algorithm In-depth examinations for selecting PV module, inverter, string, and DC side equipment Practical discussions of system losses, as well as estimation of yearly electrical energy production, capacity factor, and performance ratio of large-scale PV plant Perfect for professionals in the solar power industry, Step-by-Step Design of Large-Scale Photovoltaic Power Plants will also earn a place in the libraries of equipment manufacturers and university professors seeking a one-stop resource for the design of PV power plants.
Stephen Biesty's Incredible Body Cross-Sections (DK Stephen Biesty Cross-Sections)
by Richard PlattHow does the body protect itself from infections? What makes your tummy rumble? Are you taller at the beginning or end of the day?This extraordinary book actually takes you inside - and around - the human body to see how it works, with the help of some truly unique illustrations and some very small people! Explore your brain, your bones, and everything in between in incredible cross-section drawings of all the body systems. Inside each one are teams of tiny characters busy at work, and explaining what's going on.Every page is packed with jaw-dropping facts. Did you know that the skin is your largest organ - in an adult, it's 2 sq m (22 sq ft). Have you ever thought about how heavy the brain is? Well, it's about 1.4 kg (3 lb) and is crammed with 100 billion nerve cells that help you think and move. And by the time you turn 75, your heart will have pumped blood around your body 4,000 million times! With the challenge of finding two tiny explorers making their way through the body, learning about anatomy has never been so much fun!
Stephen Hawking Genius at Work
by Roger HighfieldA behind-the-scenes tour of the inner sanctum of one of the world's most prominent scientific thinkers.In 2021, The Science Museum made a once-in-a-lifetime acquisition of the contents of Stephen Hawking's office. This book delves into that remarkable collection, using the seminal papers, items, and curiosities in his office to explain his theories and reveal more about one of the greatest minds in modern science. It's an unprecedented glimpse into the life of the best-known scientist of modern times. - Artifacts include:- A Simpsons bomber jacket gifted to him following his appearance on the show- A copy of Hawking's PhD thesis: Properties of an Expanding Universe- Singularities and the Geometry of Space, written at the beginning of his vital collaboration with Roger Penrose- His blackboard, where he debated ideas and doodled with his contemporaries- Scientific bets made with colleagues to prove (and sometimes disprove) his theories- His Permobil F3 wheelchair and communications systems- Hawking's Franklin medal and his CBE
Stephen Hawking's Universe: An Introduction to the Most Remarkable Scientist of Our Time
by John BosloughSince the publication of "A Brief History of Time" - an introduction to some of the most important theories on the cosmos - Stephen Hawking is known widely as a man who has changed the way we look at the universe. He became a member of the Royal Society at the unusually early age of 32 and became in 1980 Lucasian Professor of Mathematics at Cambridge University. Written with Hawking's assistance, this is a readable account for the non-specialist of his contribution to theoretical physics. It encompasses his theories on the Big Bang and the nature of black holes, and contains the transcript of one of his most important essays.
Stephen Hawking: A Life In Science
by Michael White John GribbinOriginally published in 1992 to great acclaim, this updated edition traces the course of Hawking’s life and science, successfully marrying biography and physics to tell the story of a remarkable man. Stephen Hawking is no ordinary scientist. With a career that began over thirty years ago at Cambridge University, he has managed to do more than perhaps any other scientist to broaden our basic understanding of the universe. His theoretical work on black holes and his progress in advancing our knowledge of the origin and nature of the cosmos have been groundbreaking—if not downright revolutionary. Stephen Hawking has also spent much of his adult life confined to a wheelchair, a victim of ALS, a degenerative motor neuron disease. Clearly his physical limitations have done nothing to confine him intellectually. He simply never allowed his illness to hinder his scientific development. In fact, many would argue that his liberation from the routine chores of life has allowed him to focus his efforts more keenly on his science. Hawking certainly would have been remarkable for his cutting edge work in theoretical physics alone. However, he has also managed to popularize science in a way unparalleled by other scientists of his stature. He became a household name, achieving almost cult-like fame, with the release of his best-selling book, A Brief History of Time. Although steeped in the potentially overwhelming complexities of cosmology, he succeeded in selling millions of copies to audiences eager to learn even some of what he has to offer. Science writers White and Gribbin have skillfully painted a portrait of an indefatigable genius and a scientific mind that seemingly knows no bounds. Knitting together clear explanations of Hawking’s science with a detailed personal history that is both balanced as well as sensitive, we come to know—and appreciate—both. As Stephen Hawking’s new book, The Universe in a Nutshell, hits the best-seller lists, it is the ideal time for readers to learn more about this remarkable man and his vast body of accomplishments.
Stephen Hawking: A Life Well Lived
by Kitty FergusonIn 1963 Stephen Hawking was given two years to live. Defying all the odds, he died in March 2018 at age seventy-six as the most celebrated scientist in the world. This carefully researched and updated biography and tribute gives a rich picture of Hawking's remarkable life - his childhood, the heart-rending beginning of his struggle with motor neurone disease, his ever-increasing international fame, and his long personal battle for survival in pursuit of a scientific understanding of the universe. From more recent years, Kitty Ferguson describes his inspiring leadership at the London Paralympic Games, the release of the film The Theory of Everything, his continuing work on black holes and the origin of the universe, the discovery of 'supertranslations', and the astounding 'Starshot' program. Here also are his intense concern for the future of the Earth and his use of his celebrity to fight for environmental and humanitarian causes, and, finally, a ground-breaking paper he was working on at the time of his death, in which he took issue with some of his own earlier theories. Throughout, Ferguson summarizes and explains the cutting-edge science in which Hawking was engaged and offers vivid first-hand descriptions of his funeral in Cambridge and the interment of his ashes in Westminster Abbey. This is an amazing and revealing tribute, assessing Hawking's legacy in and out of science.
Stephen Hawking: A Life in Science
by Michael White John GribbinAn updated edition of the definitive biography on Stephen Hawking that marries biography and science to tell the story of one of the most remarkable men in history Stephen Hawking is no ordinary scientist. He has broadened our basic understanding of the universe and his theoretical work on black holes and the origins of the cosmos have been groundbreaking, if not downright revolutionary. He has also spent much of his adult life confined to a wheelchair, a victim of ALS. But his physical limitations have done nothing to confine him intellectually. Hawking would already be remarkable for his cutting-edge work in theoretical physics alone. However, he has also managed to popularize science unlike anyone else. He achieved almost cult-like fame with his A Brief History of Time and has since become a household name by making the complexities of cosmology accessible to millions of people. In Stephen Hawking, science writers White and Gribbin have painted a compelling portrait of a scientific mind that seemingly knows no bounds. Weaving together clear explanations of Hawking’s science with a detailed, balanced, and sensitive personal history, readers will come to know and appreciate both sides of this incredible man. Includes new updates in Hawking’s biography and the recent discovery of the Higgs-Boson (or “God”) particle.