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The Cell Game: Sam Waksal's Fast Money and False Promises—and the Fate of ImClone's Cancer Drug
by Alex Prud'hommeThe “chilling tale” of ImClone Systems, its promising cancer drug, Erbitux, and the insider trading scandal that ensnared Martha Stewart (U.S. News & World Report).The Cell Game is the quintessential business saga of the late 1990s. It's the story of big money and cutting-edge science, celebrity, greed, and slipshod business practices; the story of biotech hype and hope and every kind of excess.At the center of it all stands a single, enigmatic figure named Sam Waksal. A brilliant, mercurial, and desperate-to-be-liked entrepreneur, Waksal was addicted to the trappings of wealth and fame that accrued to a darling of the stock market and the overheated atmosphere of biotech IPOs. At the height of his stardom, Waksal hobnobbed with Martha Stewart in New York and Carl Icahn in the Hamptons, hosted parties at his fabulous art-filled loft, and was a fixture in the gossip columns. He promised that Erbitux would "change oncology," and would soon be making $1 billion a year.But as Waksal partied late into the night, desperate cancer patients languished, waiting for his drug to come to market. When the FDA withheld approval of Erbitux, the charming scientist who had always stayed just one step ahead of bankruptcy panicked and desperately tried to cash in his stock before the bad news hit Wall Street.Waksal served time in prison, the first of the Enron-era white-collar criminals to be sentenced. Yet his cancer drug has proved more durable than his evanescent profits.“A fast-paced, absorbing, and dramatic account . . . An important, excellent book that makes for fascinating reading.” —Library Journal
The Cell Manufacturing Playbook: A Step-by-Step Guideline for the Lean Practitioner (The\lean Playbook Ser.)
by Chris A. OrtizThis book describes how to effectively implement cell manufacturing. It covers the eight Wastes of Lean and the six Lean metrics that are recommended in each implementation and a description of what cell manufacturing is and its application to improving operational processes.
The Cell as a Machine (Cambridge Texts in Biomedical Engineering)
by Michael Sheetz Hanry YuThis unique introductory text explains cell functions using the engineering principles of robust devices. Adopting a process-based approach to understanding cell and tissue biology, it describes the molecular and mechanical features that enable the cell to be robust in operating its various components, and explores the ways in which molecular modules respond to environmental signals to execute complex functions. The design and operation of a variety of complex functions are covered, including engineering lipid bilayers to provide fluid boundaries and mechanical controls, adjusting cell shape and forces with dynamic filament networks, and DNA packaging for information retrieval and propagation. Numerous problems, case studies and application examples help readers connect theory with practice, and solutions for instructors and videos of lectures accompany the book online. Assuming only basic mathematical knowledge, this is an invaluable resource for graduate and senior undergraduate students taking single-semester courses in cell mechanics, biophysics and cell biology.
The Cell: A Molecular Approach
by Geoffrey M. Cooper Robert E. HausmanTeaching cell biology can be a daunting task because the field is so vast and rapidly moving, characterized by a continual explosion of new information. The challenge is how to teach students the fundamental concepts without becoming bogged down in details. Students need to understand the principles of cell biology and be able to appreciate new advances, rather than just memorizing "the facts" as we see them today. At the same time, the material must be presented in sufficient depth to thoughtfully engage students and provide a sound basis for further studies. The Cell, Seventh Edition, provides a balance of concepts and details that meets the needs of today's students and their teachers. Written by an active scientist and experienced educator, this textbook combines readability and cohesiveness with comprehensive and up to date science. In keeping with prior editions, the new seventh edition: Is ideally suited in length and complexity for sophomore and junior level courses at the undergraduate level. Can be covered in a single semester. Students can master the material in its entirety, rather than sampling a small fraction from a much larger text. Is written in an efficient and compact style, covering a broad range of material in a direct and pedagogically approachable manner. Focuses on the molecular biology of cells as a unifying theme, with topics such as developmental biology, the nervous system, the immune system, and plant biology being discussed as examples of more general principles. Features "Key Experiment" and "Molecular Medicine" boxes that highlight the experimental nature of molecular and cellular biology and convey the excitement and medical relevance of research in this area.
The Cell: A Visual Tour of the Building Block of Life
by Jack Challoner“Handsome and elegantly designed, this tour through the cell’s history and diversity in form and function is a delight to peruse . . . stunning.” —American ScientistWith The Cell, Jack Challoner treats readers to a visually striking tour of these remarkable molecular machines. Most of the living things we’re familiar with—the plants in our gardens, the animals we eat—are composed of billions or trillions of cells. Most multicellular organisms consist of many different types of cells, each highly specialized to play a particular role—from building bones or producing the pigment in flower petals to fighting disease or sensing environmental cues. But the great majority of living things on our planet exist as single cell. These cellular singletons are every bit as successful and diverse as multicellular organisms, and our very existence relies on them.The book is an authoritative yet accessible account of what goes on inside every living cell—from building proteins and producing energy to making identical copies of themselves—and the importance of these chemical reactions both on the familiar everyday scale and on the global scale. Along the way, Challoner sheds light on many of the most intriguing questions guiding current scientific research: What special properties make stem cells so promising in the treatment of injury and disease? How and when did single-celled organisms first come together to form multicellular ones? And how might scientists soon be prepared to build on the basic principles of cell biology to build similar living cells from scratch?“Small really is beautiful: Psychedelic images show the inner workings of cells in stunning detail.” —Daily Mail
The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future
by Joshua Z. RappoportYour body has trillions of cells, and each one has the complexity and dynamism of a city. Your life, your thoughts, your diseases, and your health are all the function of cells. But what do you really know about what goes on inside you? The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant. The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world. Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover: * A deeper understanding of how cells work and the basic nature of life on earth. * Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research. * The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells. * The ability to make better decisions about health and to debunk the misinformation that comes in daily via media. Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.
The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future
by Joshua Z. RappoportYour body has trillions of cells, and each one has the complexity and dynamism of a city. Your life, your thoughts, your diseases, and your health are all the function of cells. But what do you really know about what goes on inside you? The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant. The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world. Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover: A deeper understanding of how cells work and the basic nature of life on earth. Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research. The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells. The ability to make better decisions about health and to debunk the misinformation that comes in daily via media. Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.
The Cellular Automaton Interpretation of Quantum Mechanics
by Gerard 'T HooftThis book presents the deterministic view of quantum mechanics developed by Nobel Laureate Gerard 't Hooft. Dissatisfied with the uncomfortable gaps in the way conventional quantum mechanics meshes with the classical world, 't Hooft has revived the old hidden variable ideas, but now in a much more systematic way than usual. In this, quantum mechanics is viewed as a tool rather than a theory. The author gives examples of models that are classical in essence, but can be analysed by the use of quantum techniques, and argues that even the Standard Model, together with gravitational interactions, might be viewed as a quantum mechanical approach to analysing a system that could be classical at its core. He shows how this approach, even though it is based on hidden variables, can be plausibly reconciled with Bell's theorem, and how the usual objections voiced against the idea of 'superdeterminism' can be overcome, at least in principle. This framework elegantly explains - and automatically cures - the problems of the wave function collapse and the measurement problem. Even the existence of an "arrow of time" can perhaps be explained in a more elegant way than usual. As well as reviewing the author's earlier work in the field, the book also contains many new observations and calculations. It provides stimulating reading for all physicists working on the foundations of quantum theory.
The Celluloid Specimen: Moving Image Research into Animal Life
by Benjamin Schultz-FigueroaA free ebook version of this title is available through Luminos, University of California Press’s Open Access publishing program. Visit www.luminosoa.org to learn more. In The Celluloid Specimen, Benjamín Schultz‑Figueroa examines rarely seen behaviorist films of animal experiments from the 1930s and 1940s. These laboratory recordings—including Robert Yerkes's work with North American primate colonies, Yale University's rat‑based simulations of human society, and B. F. Skinner's promotions for pigeon‑guided missiles—have long been considered passive records of scientific research. In Schultz‑Figueroa's incisive analysis, however, they are revealed to be rich historical, political, and aesthetic texts that played a crucial role in American scientific and cultural history—and remain foundational to contemporary conceptions of species, race, identity, and society.
The Central Appalachians: Mountains of the Chesapeake
by Mark Hendricks--The book will be the first to specialize on the Appalachians of the Chesapeake Bay Watershed. --Interspersed amongst seasonal portfolios of images will be stories of characters- scientists, conservationists and a thru hiker on the Appalachian Trail. No other project on these ancient mountains has used traditional photography as well as camera trapping, underwater photography, and drones to attempt to tell a complete story. --Tourism is booming in the mountains and this could be an important compilation for the four states that it documents
The Centrosome
by Heide SchattenThe Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease includes chapters on classic and modern aspects of centrosome research to cover topics of current interest that have not been covered in depth in most books on the market so far. It extends on previous topics and includes new exciting aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases. Each chapter will be written by experts in their fields who will contribute their unique expertise in specific research fields and include cell and molecular details that are important for the specific subtopics. The book will be comprehensive, concise and will include reviews of key topics in the field. Cutting edge new information will be balanced with background information that will be readily understandable for the newcomer and the experienced centrosome researcher alike.
The Centrosome and its Functions and Dysfunctions (Advances in Anatomy, Embryology and Cell Biology #235)
by Heide SchattenThe book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
The Century of the Gene
by Evelyn Fox KellerThe Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain.
The Cerrados of Brazil: Ecology and Natural History of a Neotropical Savanna
by Paulo Oliveira Robert MarquisWhile the imperiled Brazilian rainforest has been the focus of considerable international media attention and conservation efforts, the massive grasslands of Brazil—known as the cerrados—which cover roughly a quarter of its land surface and are among the most threatened regions in South America, have received little notice. This book brings together leading researchers on the area to produce the first detailed account in English of the natural history and ecology of the cerrado/savanna ecosystem. Given their extent and threatened status, the richness of their flora and fauna, and the lack of familiarity with their unique ecology at the international level, the cerrados are badly in need of this important and timely work.
The Certification of Insanity: Local Origins and Imperial Consequences (Mental Health in Historical Perspective)
by Filippo Maria SposiniThis book represents the first systematic study of the certification of lunacy in the British Empire. Considering a variety of legal, archival, and published sources, it traces the origins and dissemination of a peculiar method for determining mental unsoundness defined as the ‘Victorian system’. Shaped by the dynamics surrounding the clandestine committal of wealthy Londoners in private madhouses, this system featured three distinctive tenets: standardized forms, independent medical examinations, and written facts of insanity. Despite their complexity, Victorian certificates achieved a remarkable success. Not only did they survive in the UK for more than a century, but they also served as a model for the development of mental health laws around the world. By the start of the Second World War, more than seventy colonial and non-colonial jurisdictions adopted the Victorian formula for making lunacy official with some countries still relying on it to this very day. Using case studies from Europe, the Americas, and the Pacific, this book charts the temporal and geographical trajectory of an imperial technology used to determine a person’s destiny. Shifting the focus from metropolitan policies to colonial dynamics, and from macro developments to micro histories, it explores the perspectives of families, doctors, and public officials as they began to deal with the delicate business of certification. This book will be of interest to scholars working on mental health policy, the history of medicine, disability studies, and the British Empire.
The Certified Criminal Investigator Body of Knowledge (Center For National Threat Assessment Ser. #3)
by 0 American College of Forensic Examiners InstituteCriminal investigators have a long list of duties. They must identify and secure a crime scene, conduct interviews of witnesses and victims, interrogate suspects, identify and properly collect evidence, and establish and maintain a chain of custody. Once an investigation is underway, the criminal investigator must demonstrate thorough knowledge of
The Chagos Archipelago: A Biological Biography
by Charles SheppardThis book is the story of the natural history of Chagos Archipelago, and of the efforts of many to get it recognized as an important and protected wildlife reserve. Exploring its immense natural riches and biodiversity, both on islands and in the marine environment, this book addresses competing claims to its resources, its politics, and the desire of some commercial and political parties to exploit the area. It is about the fight to conserve a wonderland of biodiversity and obtain its protection from exploitation, especially of its reefs and other marine life. This book shows the importance of the Chagos Archipelago and why so much research was done there. Rather than being a typical research book, this work presents research in a narrative form and describes the now substantial Government, UN, and legal interest in the archipelago since the UK was told to ‘decolonise’ it. It is also the story of our planet in miniature: the archipelago encapsulates much of the world’s conservation tribulations in a way we can much more easily understand. This narrative will explore the difficulties faced by the Chagos Archipelago, including displaced people, old and derelict industries (coconut in this case), the military, politics, rich and untouched ecosystems that some want to exploit, ruined habitats on land, climate change, and territorial claims. It will examine how all of these factors have affected the natural history, biodiversity, and conservation of the archipelago. With beautiful photography of the Chagos Archipelago coral reefs and islands, as well as graphs indicating their findings, this book offers professionals, researchers, academics, and students in conservation and biodiversity an insight into one of the world’s most diverse ecosystems. It is also accessible for non‑academic readers with an interest in climate change, biodiversity, and the importance of conservation.
The Challenge of CMC Regulatory Compliance for Biopharmaceuticals
by John GeigertEach year for the past three years, there have been about 50 new molecular medicines approved by the United States Food & Drug Administration (FDA), of which approximately 25% were new biopharmaceuticals. Over 200 recombinant proteins, monoclonal antibodies, antibody drug conjugates, fusion proteins, and Fab fragments are now in the marketplace in both the United States of America (USA) and European Union (EU). There are also now over 60 biosimilars available for all major classes of recombinant proteins and monoclonal antibodies. In addition, gene therapies using genetically engineered viruses and genetically engineered cells are now in the marketplace, and continually growing. This degree of change is reflected in the over 400 CMC regulatory compliance references listed in this book that were either issued or updated since the release of the third edition. Deficiencies in biopharmaceutical CMC regulatory compliance rarely result in termination of a product, but in can readily cause months if not years of delay in initiating clinical trials, or advancing clinical development stages, or even market approval. In summary, this book:Updates real-world CMC deficiency examples with current examples;Addresses current FDA and EMA requirements and expectations for CMC regulatory compliance;Now includes CMC regulatory compliance for the new gene-based biopharmaceuticals.
The Challenge of Chance: A Multidisciplinary Approach from Science and the Humanities (The Frontiers Collection)
by Klaas Landsman Ellen WoldeThis book presents a multidisciplinary perspective on chance, with contributions from distinguished researchers in the areas of biology, cognitive neuroscience, economics, genetics, general history, law, linguistics, logic, mathematical physics, statistics, theology and philosophy. The individual chapters are bound together by a general introduction followed by an opening chapter that surveys 2500 years of linguistic, philosophical, and scientific reflections on chance, coincidence, fortune, randomness, luck and related concepts. A main conclusion that can be drawn is that, even after all this time, we still cannot be sure whether chance is a truly fundamental and irreducible phenomenon, in that certain events are simply uncaused and could have been otherwise, or whether it is always simply a reflection of our ignorance. Other challenges that emerge from this book include a better understanding of the contextuality and perspectival character of chance (including its scale-dependence), and the curious fact that, throughout history (including contemporary science), chance has been used both as an explanation and as a hallmark of the absence of explanation. As such, this book challenges the reader to think about chance in a new way and to come to grips with this endlessly fascinating phenomenon.
The Challenge of Evolution to Religion (Elements in the Philosophy of Biology)
by Johan De Smedt Helen De CruzThis Element focuses on three challenges of evolution to religion: teleology, human origins, and the evolution of religion itself. First, religious worldviews tend to presuppose a teleological understanding of the origins of living things, but scientists mostly understand evolution as non-teleological. Second, religious and scientific accounts of human origins do not align in a straightforward sense. Third, evolutionary explanations of religion, including religious beliefs and practices, may cast doubt on their justification. We show how these tensions arise and offer potential responses for religion. Individual religions can meet these challenges, if some of their metaphysical assumptions are adapted or abandoned.
The Challenge of Highly Pathogenic Microorganisms
by Arie Ordentlich Baruch Velan Avigdor ShaffermanThis book addresses the unique features of four microorganisms that constitute the top bioterror threat agents: Bacillus anthracis; Yersinia pestis, Francisella tularensis and Orthopoxviruses. Side-by-side updated information about their pathogenisis, virulence and epidemiology is provided in a single volume, allowing for evaluation of common features as well as common strategies for defense. Classical microbiological as well as genomic, proteomic & transcriptomic approaches towards development of strategies of novel prophylactic and post-exposure treatment and related aspects of diagnostics and bioforensics are covered. Written by top scientists, this book will be of major interest to all researchers interested in the intricate biology of highly pathogenic microorganisms, to scientists and clinicians interested in microbial pathogenesis and prevention, and to a wide range of professionals dealing with the various aspects of bio-defense.
The Challenge of Sustainability in Agricultural Systems: Volume 1 (Lecture Notes in Networks and Systems #205)
by Aleksei V. BogovizThis book presents a multidisciplinary collection of original contributions made by the leading scholars and practitioners on researching, building, and maintaining sustainable agricultural systems. Being the first of its kind, the book is divided into two volumes. This book presents a comprehensive and informed review of the current state of multidisciplinary knowledge on sustainability in agriculture. The gaps in the scholarly literature are identified and rigorously analyzed, presenting a clear picture of the promising research directions. The authors critically analyze the very concept of sustainable agricultural systems, primarily focusing on the interactions existing between their integral components and with external environments. Relying on the provisions of complex systems science, the scholars then discuss the best approaches and methodologies used to build a comprehensive understanding of agricultural systems, with relation to achieving and maintaining their sustainability. More than that, this book holds two rich sections on (1) agricultural economics and (2) rural sustainability. Understanding sustainable development as a movement toward clearly defined and measurable goals, a set of chapters explore those policies, practices, technologies, and management systems that have an impact on the sustainability of agricultural systems. Agricultural sustainability is an urgent issue to be addressed, and this book makes a unique contribution. Due to its practical focus, the book appeals to practitioners and policymakers working in agricultural economics, governance, and sustainability, not just academics. This is also a valuable resource for graduate students interested in agricultural systems, sustainability, as well as complex systems theory and practice.
The Challenge of Sustainability in Agricultural Systems: Volume 2 (Lecture Notes in Networks and Systems #206)
by Aleksei V. BogovizThis book brings together segmental knowledge and creates new insights on the sustainability of agricultural systems, critically analyzing not only individual system components, but also focusing on interactions between them and external environments. This book is primarily devoted to (1) agricultural agribusiness, (2) policies and institutions, and (3) farming systems. The compelling collection of chapters presents critical, comparative, and balanced perspectives on what changes are needed to achieve and maintain sustainability in agricultural systems, actively leading to new ways of thinking about these complex issues. The research presented relies on an array of methods developed within complex systems science, addresses the existing gaps in the scholarship, and uses original data collected on the development of agricultural systems. Finally, the authors provide robust conclusions and recommendations for both scholars and practitioners in the field of studying, constructing, and maintaining sustainable agricultural systems. The special focus of the book is on technologies, policies, and management systems enabling sustainable agricultural development. A rich collection of practical cases could be used to move from theories to reality. The book appeals to both academics and professionals working in the field.
The Challenge of the Sea
by Arthur C. ClarkeWhile tremendous strides toward the conquest of space occupy most of today's headlines, scientists are also exploring the vast secret recesses of the sea. Clarke takes us beneath the sea...
The Challenger Disaster (Cornerstones of Freedom, 2nd Series)
by Tim McneeseRecounts events surrounding the explosion of the space shuttle Challenger in 1986, the first shuttle to carry a civilian passenger, and discusses the impact of this disaster on the U.S. space program. Includes bibliographical references and index.