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The Catalogue of Computational Material Models: Basic Geometrically Linear Models in 1D
by Paul Steinmann Kenneth RunessonThis book gives a comprehensive account of the formulation and computational treatment of basic geometrically linear models in 1D. To set the stage, it assembles some preliminaries regarding necessary modelling, computational and mathematical tools. Thereafter, the remaining parts are concerned with the actual catalogue of computational material models. To this end, after starting out with elasticity as a reference, further 15 different basic variants of material models (5 x each of {visco-elasticity, plasticity, visco-plasticity}, respectively) are systematically explored. The presentation for each of these basic material models is a stand-alone account and follows in each case the same structure. On the one hand, this allows, in the true sense of a catalogue, to consult each of the basic material models separately without the need to refer to other basic material models. On the other hand, even though this somewhat repetitious concept may seem tedious, it allows to compare the formulation and resulting algorithmic setting of the various basic material models and thereby to uncover, in detail, similarities and differences. In particular, the response of each basic material model is analysed for the identical histories (Zig-Zag, Sine, Ramp) of prescribed strain and stress so as to clearly showcase and to contrast to each other the characteristics of the various modelling options.
The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
by Thomas R. CechOne of Literary Hub's Most Anticipated Books of 2024 Exploring the most transformative breakthroughs in biology since the discovery of the double helix, a Nobel Prize–winning scientist unveils the RNA age. For over half a century, DNA has dominated science and the popular imagination as the “secret of life.” But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA—long overlooked as the passive servant of DNA—sits at the center of biology’s greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century. A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA’s spectacular powers, to Cech’s own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA—once thought merely to transmit DNA’s genetic instructions to the cell’s protein-making machinery—may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies—from CRISPR, the revolutionary tool that uses RNA to rewrite the code of life, to the groundbreaking mRNA vaccines that have saved millions during the pandemic, and more—may enable us to improve and even extend life beyond nature’s current limits. Written by one of our foremost scientists, The Catalyst is a must-read guide to the present and future of biology and medicine.
The Catharanthus Genome (Compendium of Plant Genomes)
by Chittaranjan KoleThis book is the first comprehensive compilation of deliberations on botany, medicinal importance, genetic diversity, classical genetics and breeding, in vitro biosynthesis, somatic embryogenesis, genetic transformation, molecular mapping, genome sequence, and functional genomics of Catharanthus roseus. Catharanthus is the most important medicinal plant in the world that contains about 130 therapeutic alkaloids out of which vinblastine and vincristine are the two highly used anticancer drugs sold by the pharmaceutically industries. Altogether, the book contains about 10 chapters authored by globally reputed experts on the relevant field of this plant. This book is useful to the students, teachers and scientists in the academia and relevant private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful to pharmaceutical industries.
The Cation–π Interaction
by Shinji YamadaThis book introduces the role of cation–π interactions in chemistry, biology, and polymer materials science. Since the cation–π interaction was defined in 1990, its importance has been recognized in a variety of fields due to its relatively significant interaction energy. A number of examples are introduced in which the contribution of cation-π interactions was evidenced by X-ray structures, spectroscopies, computations, and other means. The latest developments in these areas are remarkable; therefore, many recent examples are included.As this book covers the basic aspects of the applications of cation–π interactions it is useful for students and researchers in a wide variety of scientific fields. In addition, the book will not only facilitate understanding of the phenomena occurring in various systems but also provides insights into the design of new catalysts, reactions, and materials.
The Causal Set Approach to Quantum Gravity: An Introduction (Lecture Notes in Physics #1036)
by Sumati SuryaThis book introduces advanced graduate students and researchers to causal set theory, offering a comprehensive discussion of its core tools. It begins with a broad, largely non-technical overview of causal set theory, situating it within the broader context of the quantum gravity problem. Discreteness and causality serve as the cornerstones of this approach, as articulated by Bombelli, Lee, Meyer, and Sorkin. The technical introduction to causal set theory starts with results on the order-theoretic foundations of Lorentzian geometry, providing a strong theoretical basis. Subsequent chapters address kinematics, including geometrical reconstruction from the discrete substructure, quantum field theory on causal sets, non-perturbative formulations, and results in the quantum dynamics of causal sets. The book concludes with a brief discussion of causal set phenomenology and some open questions. Written with a clear and pedagogical approach, this book highlights the mathematical challenges inherent in causal set theory. Readers are expected to have prior knowledge of general relativity and quantum field theory. To support understanding, exercises are included throughout the text, enabling readers to test their knowledge.
The Causal Structure of Natural Selection (Elements in the Philosophy of Biology)
by Charles H. PenceRecent arguments concerning the nature of causation in evolutionary theory, now often known as the debate between the 'causalist' and 'statisticalist' positions, have involved answers to a variety of independent questions – definitions of key evolutionary concepts like natural selection, fitness, and genetic drift; causation in multi-level systems; or the nature of evolutionary explanations, among others. This Element offers a way to disentangle one set of these questions surrounding the causal structure of natural selection. Doing so allows us to clearly reconstruct the approach that some of these major competing interpretations of evolutionary theory have to this causal structure, highlighting particular features of philosophical interest within each. Further, those features concern problems not exclusive to the philosophy of biology. Connections between them and, in two case studies, contemporary metaphysics and philosophy of physics demonstrate the potential value of broader collaboration in the understanding of evolution.
The Causes of Epilepsy
by Renzo Guerrini Simon D. Shorvon Frederick AndermannCausation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in each etiology, including its epidemiology, clinical features and prognosis, and any specific aspects of treatment. The book is a comprehensive reference work, a catalogue of all important causes of epilepsy, and a clinical tool for all clinicians dealing with patients who have epilepsy. It is aimed at epileptologists and neurologists and provides a distillation of knowledge in a form that is helpful in the clinical setting.
The Cautious Canine: How to Help Dogs Conquer Their Fears (Second Edition)
by Patricia B. McconnellIn a calm and patient manner, Dr. McConnell lays out a step-by-step program for helping dogs overcome their fears. Although this is a detailed training manual, it is both easy to read and easy to use. McConnell is a wel-known, highly-credentialed behaviorist who has specialized in helping family pets to become well-adjusted and happy canines. Gentle and sensible methods are presented here. Also available from Bookshare: "The Other End of the Leash."
The Caves Beyond: The Story of the Floyd Collins' Crystal Cave Exploration
by Roger W. Brucker Joe Lawrence Jr.THE CAVES BEYOND by Joe Lawrence, Jr. and Roger W. Brucker The Caves Beyond is the classic American caving adventure story. There is no other caving book like it. First published in 1955 in an edition of 10,000 copies, the book was out of print soon afterwards. It is now known among caving enthusiasts as the most stolen book there ever was. You will see it listed in most library catalogs, but will be lucky to find a copy on a library shelf. In February, 1954, under the direction of Joe Lawrence, the National Speleological Society sent the largest, most highly organized, and best-equipped expedition in the history of American cave exploration into Floyd Collins' Crystal Cave, Kentucky. The Caves Beyond is the official NSS account of that expedition. In the short view, the C-3 (Collins' Crystal Cave) expedition was not much of a success, but in the long view it was a major turning point in American speleology. Three cavers- Phil Smith, Roger Brucker, and Roger McClure, emerged from the C-3 expedition to organize the Central Ohio Grotto Flint Ridge Reconnaissance, and then the Cave Research Foundation, to carry on the exploration. Guided by Jim Dyer, Dr. Pohl, and Bill Austin, they molded the most concentrated speleological effort ever undertaken by a large group. Planning for the C-3 expedition had begun in 1952; 20 years later, with no letup in intensity, the big connection between the Flint Ridge Cave System and Mammoth Cave was made. The story told in The Caves Beyond culminated in the integration of the longest cave in the world-the Flint Mammoth Cave System. Roger Brucker's new introduction to the long-awaited reprint edition reveal a number of old secrets, including stories of the politics behind the C-3 expedition and of how the book came to be written in an attic in Brooklyn in two weeks' time. There is also a detailed index, which the first edition lacked.
The Cell Game: Sam Waksal's Fast Money and False Promises—and the Fate of ImClone's Cancer Drug
by Alex Prud'hommeThe “chilling tale” of ImClone Systems, its promising cancer drug, Erbitux, and the insider trading scandal that ensnared Martha Stewart (U.S. News & World Report).The Cell Game is the quintessential business saga of the late 1990s. It's the story of big money and cutting-edge science, celebrity, greed, and slipshod business practices; the story of biotech hype and hope and every kind of excess.At the center of it all stands a single, enigmatic figure named Sam Waksal. A brilliant, mercurial, and desperate-to-be-liked entrepreneur, Waksal was addicted to the trappings of wealth and fame that accrued to a darling of the stock market and the overheated atmosphere of biotech IPOs. At the height of his stardom, Waksal hobnobbed with Martha Stewart in New York and Carl Icahn in the Hamptons, hosted parties at his fabulous art-filled loft, and was a fixture in the gossip columns. He promised that Erbitux would "change oncology," and would soon be making $1 billion a year.But as Waksal partied late into the night, desperate cancer patients languished, waiting for his drug to come to market. When the FDA withheld approval of Erbitux, the charming scientist who had always stayed just one step ahead of bankruptcy panicked and desperately tried to cash in his stock before the bad news hit Wall Street.Waksal served time in prison, the first of the Enron-era white-collar criminals to be sentenced. Yet his cancer drug has proved more durable than his evanescent profits.“A fast-paced, absorbing, and dramatic account . . . An important, excellent book that makes for fascinating reading.” —Library Journal
The Cell Manufacturing Playbook: A Step-by-Step Guideline for the Lean Practitioner (The\lean Playbook Ser.)
by Chris A. OrtizThis book describes how to effectively implement cell manufacturing. It covers the eight Wastes of Lean and the six Lean metrics that are recommended in each implementation and a description of what cell manufacturing is and its application to improving operational processes.
The Cell as a Machine (Cambridge Texts in Biomedical Engineering)
by Michael Sheetz Hanry YuThis unique introductory text explains cell functions using the engineering principles of robust devices. Adopting a process-based approach to understanding cell and tissue biology, it describes the molecular and mechanical features that enable the cell to be robust in operating its various components, and explores the ways in which molecular modules respond to environmental signals to execute complex functions. The design and operation of a variety of complex functions are covered, including engineering lipid bilayers to provide fluid boundaries and mechanical controls, adjusting cell shape and forces with dynamic filament networks, and DNA packaging for information retrieval and propagation. Numerous problems, case studies and application examples help readers connect theory with practice, and solutions for instructors and videos of lectures accompany the book online. Assuming only basic mathematical knowledge, this is an invaluable resource for graduate and senior undergraduate students taking single-semester courses in cell mechanics, biophysics and cell biology.
The Cell: A Molecular Approach
by Geoffrey M. Cooper Robert E. HausmanTeaching cell biology can be a daunting task because the field is so vast and rapidly moving, characterized by a continual explosion of new information. The challenge is how to teach students the fundamental concepts without becoming bogged down in details. Students need to understand the principles of cell biology and be able to appreciate new advances, rather than just memorizing "the facts" as we see them today. At the same time, the material must be presented in sufficient depth to thoughtfully engage students and provide a sound basis for further studies. The Cell, Seventh Edition, provides a balance of concepts and details that meets the needs of today's students and their teachers. Written by an active scientist and experienced educator, this textbook combines readability and cohesiveness with comprehensive and up to date science. In keeping with prior editions, the new seventh edition: Is ideally suited in length and complexity for sophomore and junior level courses at the undergraduate level. Can be covered in a single semester. Students can master the material in its entirety, rather than sampling a small fraction from a much larger text. Is written in an efficient and compact style, covering a broad range of material in a direct and pedagogically approachable manner. Focuses on the molecular biology of cells as a unifying theme, with topics such as developmental biology, the nervous system, the immune system, and plant biology being discussed as examples of more general principles. Features "Key Experiment" and "Molecular Medicine" boxes that highlight the experimental nature of molecular and cellular biology and convey the excitement and medical relevance of research in this area.
The Cell: A Visual Tour of the Building Block of Life
by Jack Challoner“Handsome and elegantly designed, this tour through the cell’s history and diversity in form and function is a delight to peruse . . . stunning.” —American ScientistWith The Cell, Jack Challoner treats readers to a visually striking tour of these remarkable molecular machines. Most of the living things we’re familiar with—the plants in our gardens, the animals we eat—are composed of billions or trillions of cells. Most multicellular organisms consist of many different types of cells, each highly specialized to play a particular role—from building bones or producing the pigment in flower petals to fighting disease or sensing environmental cues. But the great majority of living things on our planet exist as single cell. These cellular singletons are every bit as successful and diverse as multicellular organisms, and our very existence relies on them.The book is an authoritative yet accessible account of what goes on inside every living cell—from building proteins and producing energy to making identical copies of themselves—and the importance of these chemical reactions both on the familiar everyday scale and on the global scale. Along the way, Challoner sheds light on many of the most intriguing questions guiding current scientific research: What special properties make stem cells so promising in the treatment of injury and disease? How and when did single-celled organisms first come together to form multicellular ones? And how might scientists soon be prepared to build on the basic principles of cell biology to build similar living cells from scratch?“Small really is beautiful: Psychedelic images show the inner workings of cells in stunning detail.” —Daily Mail
The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future
by Joshua Z. RappoportYour body has trillions of cells, and each one has the complexity and dynamism of a city. Your life, your thoughts, your diseases, and your health are all the function of cells. But what do you really know about what goes on inside you? The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant. The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world. Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover: * A deeper understanding of how cells work and the basic nature of life on earth. * Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research. * The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells. * The ability to make better decisions about health and to debunk the misinformation that comes in daily via media. Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.
The Cell: Discovering the Microscopic World that Determines Our Health, Our Consciousness, and Our Future
by Joshua Z. RappoportYour body has trillions of cells, and each one has the complexity and dynamism of a city. Your life, your thoughts, your diseases, and your health are all the function of cells. But what do you really know about what goes on inside you? The last time most people thought about cells in any detail was probably in high school or a college general biology class. But the field of cell biology has advanced incredibly rapidly in recent decades, and a great deal of what we may have learned in high school and college is no longer accurate or particularly relevant. The Cell: Inside the Microscopic World that Determines Our Health, Our Consciousness, and Our Future is a fascinating story of the incredible complexity and dynamism inside the cell and of the fantastic advancements in our understanding of this microscopic world. Dr. Joshua Z. Rappoport is at the forefront of this field, and he will take you on a journey to discover: A deeper understanding of how cells work and the basic nature of life on earth. Fascinating histories of some of the key discoveries from the seventeenth century to the last decade and provocative thoughts on the current state of academic research. The knowledge required to better understand the new developments that are announced almost weekly in science and health care, such as cancer, cellular therapies, and the potential promise of stem cells. The ability to make better decisions about health and to debunk the misinformation that comes in daily via media. Using the latest scientific research, The Cell illustrates the diversity of cell biology and what it all means for your everyday life.
The Cellular Automaton Interpretation of Quantum Mechanics
by Gerard 'T HooftThis book presents the deterministic view of quantum mechanics developed by Nobel Laureate Gerard 't Hooft. Dissatisfied with the uncomfortable gaps in the way conventional quantum mechanics meshes with the classical world, 't Hooft has revived the old hidden variable ideas, but now in a much more systematic way than usual. In this, quantum mechanics is viewed as a tool rather than a theory. The author gives examples of models that are classical in essence, but can be analysed by the use of quantum techniques, and argues that even the Standard Model, together with gravitational interactions, might be viewed as a quantum mechanical approach to analysing a system that could be classical at its core. He shows how this approach, even though it is based on hidden variables, can be plausibly reconciled with Bell's theorem, and how the usual objections voiced against the idea of 'superdeterminism' can be overcome, at least in principle. This framework elegantly explains - and automatically cures - the problems of the wave function collapse and the measurement problem. Even the existence of an "arrow of time" can perhaps be explained in a more elegant way than usual. As well as reviewing the author's earlier work in the field, the book also contains many new observations and calculations. It provides stimulating reading for all physicists working on the foundations of quantum theory.
The Celluloid Specimen: Moving Image Research into Animal Life
by Benjamin Schultz-FigueroaA free ebook version of this title is available through Luminos, University of California Press’s Open Access publishing program. Visit www.luminosoa.org to learn more. In The Celluloid Specimen, Benjamín Schultz‑Figueroa examines rarely seen behaviorist films of animal experiments from the 1930s and 1940s. These laboratory recordings—including Robert Yerkes's work with North American primate colonies, Yale University's rat‑based simulations of human society, and B. F. Skinner's promotions for pigeon‑guided missiles—have long been considered passive records of scientific research. In Schultz‑Figueroa's incisive analysis, however, they are revealed to be rich historical, political, and aesthetic texts that played a crucial role in American scientific and cultural history—and remain foundational to contemporary conceptions of species, race, identity, and society.
The Central Appalachians: Mountains of the Chesapeake
by Mark Hendricks--The book will be the first to specialize on the Appalachians of the Chesapeake Bay Watershed. --Interspersed amongst seasonal portfolios of images will be stories of characters- scientists, conservationists and a thru hiker on the Appalachian Trail. No other project on these ancient mountains has used traditional photography as well as camera trapping, underwater photography, and drones to attempt to tell a complete story. --Tourism is booming in the mountains and this could be an important compilation for the four states that it documents
The Centrosome
by Heide SchattenThe Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease includes chapters on classic and modern aspects of centrosome research to cover topics of current interest that have not been covered in depth in most books on the market so far. It extends on previous topics and includes new exciting aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases. Each chapter will be written by experts in their fields who will contribute their unique expertise in specific research fields and include cell and molecular details that are important for the specific subtopics. The book will be comprehensive, concise and will include reviews of key topics in the field. Cutting edge new information will be balanced with background information that will be readily understandable for the newcomer and the experienced centrosome researcher alike.
The Centrosome and its Functions and Dysfunctions (Advances in Anatomy, Embryology and Cell Biology #235)
by Heide SchattenThe book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
The Century of the Gene
by Evelyn Fox KellerThe Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain.
The Cerrados of Brazil: Ecology and Natural History of a Neotropical Savanna
by Paulo Oliveira Robert MarquisWhile the imperiled Brazilian rainforest has been the focus of considerable international media attention and conservation efforts, the massive grasslands of Brazil—known as the cerrados—which cover roughly a quarter of its land surface and are among the most threatened regions in South America, have received little notice. This book brings together leading researchers on the area to produce the first detailed account in English of the natural history and ecology of the cerrado/savanna ecosystem. Given their extent and threatened status, the richness of their flora and fauna, and the lack of familiarity with their unique ecology at the international level, the cerrados are badly in need of this important and timely work.
The Certification of Insanity: Local Origins and Imperial Consequences (Mental Health in Historical Perspective)
by Filippo Maria SposiniThis book represents the first systematic study of the certification of lunacy in the British Empire. Considering a variety of legal, archival, and published sources, it traces the origins and dissemination of a peculiar method for determining mental unsoundness defined as the ‘Victorian system’. Shaped by the dynamics surrounding the clandestine committal of wealthy Londoners in private madhouses, this system featured three distinctive tenets: standardized forms, independent medical examinations, and written facts of insanity. Despite their complexity, Victorian certificates achieved a remarkable success. Not only did they survive in the UK for more than a century, but they also served as a model for the development of mental health laws around the world. By the start of the Second World War, more than seventy colonial and non-colonial jurisdictions adopted the Victorian formula for making lunacy official with some countries still relying on it to this very day. Using case studies from Europe, the Americas, and the Pacific, this book charts the temporal and geographical trajectory of an imperial technology used to determine a person’s destiny. Shifting the focus from metropolitan policies to colonial dynamics, and from macro developments to micro histories, it explores the perspectives of families, doctors, and public officials as they began to deal with the delicate business of certification. This book will be of interest to scholars working on mental health policy, the history of medicine, disability studies, and the British Empire.
The Certified Criminal Investigator Body of Knowledge (Center For National Threat Assessment Ser. #3)
by 0 American College of Forensic Examiners InstituteCriminal investigators have a long list of duties. They must identify and secure a crime scene, conduct interviews of witnesses and victims, interrogate suspects, identify and properly collect evidence, and establish and maintain a chain of custody. Once an investigation is underway, the criminal investigator must demonstrate thorough knowledge of