- Table View
- List View
The Changing Wildlife of Great Britain and Ireland (Systematics Association Special Volumes Ser.)
by David L. HawksworthPeriodic comprehensive overviews of the status of the diverse organisms that make up wildlife are essential to determining trends, threats and future prospects. Just over 25 years ago, leading authorities on different kinds of wildlife came together to prepare an assessment of their status of a wide range of organisms in Great Britain and Ireland i
The Changing World and Africa
by Xinfeng Li Chunying AnThis book brings contemporary Chinese scholarship into Africa, the relations between African states, and the relations between China and Africa into focus. As China becomes the biggest partner for many African states, constructing infrastructure across the continent, Western scrutiny has increased. This book offers a comprehensive look at what Chinese scholars have encountered on the ground, as well as comparative studies of how different nations have engaged with Africa.
The Chang’E-1 Topographic Atlas of the Moon
by Chunlai Li Jianjun Liu Lingli Mu Xin Ren Wei ZuoThis atlas is based on the lunar global Digital Elevation Models (DEM) of Chang'E-1 (CE-1), and presents CCD stereo image data with digital photogrammetry. The spatial resolution of the DEM in this atlas is 500m, with horizontal accuracy of 192m and vertical accuracy of 120m. Color-shaded relief maps with contour lines are used to show the lunar topographical characteristics. The topographical data gathered by CE-1 can provide fundamental information for the study of lunar topographical, morphological and geological structures, as well as for lunar evolution research.
The Chaotic Solar Cycle (Atmosphere, Earth, Ocean & Space)
by Arnold HanslmeierThis book offers an overview of solar physics with a focus on solar activity, particularly the activity cycle. It is known that solar activity varies periodically, but there are also phases of intermittency, such as the Maunder minimum, during which solar activity is very low or high over several decades. The book provides a brief introduction to chaos theory and investigates solar activity in terms of its chaotic behavior. It also discusses how intermittent phases of solar activity have affected and can affect Earth’s climate and long-term space weather, and reviews the underlying theories relating to the solar dynamo mechanism. Furthermore, each chapter includes references to scientific literature (review articles and papers) so that readers can delve deeper into the subjects covered. This richly illustrated book will appeal to a wide readership, and is also useful as a textbook for courses in solar physics and astrophysics.
The Chaperonopathies
by Francesco Cappello Everly Conway de Macario Alberto J.L. MacarioThis Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
The Character of Cats
by Stephen BudianskyUnlike every other domestic animal, the cat evolved as a solitary animal, not a group-dweller. A cat in a household is almost literally a fish out of water. That cats can nonetheless get along with people and (sometimes) other cats when forced to, is testimony to a remarkable adaptability. But it also makes for an extraordinary range of behaviours. Cats have for years been the subjects of intensive research in the fields of developmental psychology, learning, emotions, brain chemistry, and perception. THE CHARACTER OF CATS is the first popular book to bring this knowledge to bear on the behaviour and nature of cats. Budiansky enables us to see that many of the things that puzzle and at times baffle or even infuriate cat owners have a rational - though often very surprising - explanation in science.
The Character of Consent: The History of Cookies and the Future of Technology Policy (Information Policy)
by Meg Leta JonesThe rich, untold origin story of the ubiquitous web cookie—what&’s wrong with it, why it&’s being retired, and how we can do better.Consent pop-ups continually ask us to download cookies to our computers, but is this all-too-familiar form of privacy protection effective? No, Meg Leta Jones explains in The Character of Consent, rather than promote functionality, privacy, and decentralization, cookie technology has instead made the internet invasive, limited, and clunky. Good thing, then, that the cookie is set for retirement in 2024. In this eye-opening book, Jones tells the little-known story of this broken consent arrangement, tracing it back to the major transnational conflicts around digital consent over the last twenty-five years. What she finds is that the policy controversy is not, in fact, an information crisis—it&’s an identity crisis.Instead of asking how people consent, Jones asks who exactly is consenting and to what. Packed into those cookie pop-ups, she explains, are three distinct areas of law with three different characters who can consent. Within (mainly European) data protection law, the data subject consents. Within communication privacy law, the user consents. And within consumer protection law, the privacy consumer consents. These areas of law have very different histories, motivations, institutional structures, expertise, and strategies, so consent—and the characters who can consent—plays a unique role in those areas of law. The Character of Consent gives each computer character its due, taking us back to their origin stories within the legal history of computing. By doing so, Jones provides alternative ways of understanding the core issues within the consent dilemma. More importantly, she offers bold new approaches to creating and adopting better tech policies in the future.
The Characteristics Of Aphasia (Brain, Behaviour and Cognition)
by Chris CodeA survey of the main behavioural characteristics or symptoms of aphasia, which presents a series of essays on the history and current developments in this field of neuropsychological research. Contributors discuss recovery, rehabilitation and other contemporary issues.
The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics
by Sushil SharmaDiversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.
The Chatterbugs Manual: A 12-Week Speech, Language and Communication Programme for Early Years
by Andrea RichardsThe Chatterbugs Manual is a practical resource for all those supporting the development of the foundation communication skills of attention and listening, turn-taking and early vocabulary in children. The Chatterbugs programme has been designed to bridge the gap between education and specialist speech, language and communication provision, specifically with Early Years mainstream settings in mind. It enables school staff to prepare children—including those with delayed communication skills, EAL learners, or children with suspected special education needs—for learning in school by developing their communication skills through the use of robust communication strategies. The Chatterbugs Manual contains: An overview of the programme, including step-by-step instructions on how to plan and deliver a Chatterbugs session Guidance on identifying children likely to benefit from the programme Progress Tracking documents, along with information on measuring outcomes Child-friendly, illustrated session resources Frequently Asked Questions A parent-friendly information leaflet Information on models of implementation Information on accessing training and support Developed by an experienced speech and language therapist, Chatterbugs has consistently recorded successful outcomes for over 80% of participants since the programme’s inception in 2012, and for over 90% of participants since 2016. With its hands-on approach, the programme is an essential resource for educators, support staff, and speech and language therapists working with Early Years children.
The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer
by Athena AktipisA fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments.Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane.Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
The Cheeses of Italy: Science And Technology
by Marco Gobbetti Erasmo Neviani Patrick FoxThe book will contain a detailed description on the historical aspects of cheese manufacture, a culmination of historical information on the most traditional and worldwide popular Italian cheese varieties. An overview on cheese production is also included, covering the main general aspects. An overall classification of Italian cheeses will follow, aiming to categorize all the cheese varieties that have a tradition and/or an economic importance. Based on a large literature review, the core of the book will include descriptions cheese making traits which are unique to Italian cheese biotechnology. In particular, the milk chemical composition, the use whey or milk natural starters, some technology options (e.g., curd cooking), the microbiota composition and metabolism during curd ripening, especially for cheese made with raw milk, and the main relevant biochemical events, which occur during the very long-time ripening, will be described. The last part of the book will consider a detailed description of the biotechnology for the manufacture of the most traditional and popular cheeses worldwide.
The Chemical Age: How Chemists Fought Famine and Disease, Killed Millions, and Changed Our Relationship with the Earth
by Frank A. von HippelFor thousands of years, we’ve found ways to scorch, scour, and sterilize our surroundings to make them safer. Sometimes these methods are wonderfully effective. Often, however, they come with catastrophic consequences—consequences that aren’t typically understood for generations. The Chemical Age tells the captivating story of the scientists who waged war on famine and disease with chemistry. With depth and verve, Frank A. von Hippel explores humanity’s uneasy coexistence with pests, and how their existence, and the battles to exterminate them, have shaped our modern world. Beginning with the potato blight tragedy of the 1840s, which led scientists on an urgent mission to prevent famine using pesticides, von Hippel traces the history of pesticide use to the 1960s, when Rachel Carson’s Silent Spring revealed that those same chemicals were insidiously damaging our health and driving species toward extinction. Telling the story of these pesticides in vivid detail, von Hippel showcases the thrills and complex consequences of scientific discovery. He describes the invention of substances that could protect crops, the emergence of our understanding of the way diseases spread, the creation of chemicals used to kill pests and people, and, finally, how scientists turned those wartime chemicals on the landscape at a massive scale, prompting the vital environmental movement that continues today. The Chemical Age is a dynamic, sweeping history that exposes how humankind’s affinity for pesticides made the modern world possible—while also threatening its essential fabric.
The Chemical Biology of DNA Damage
by Nicholas E. Geacintov Suse BroydeBringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.
The Chemical Biology of Long Noncoding RNAs (RNA Technologies #11)
by Jan Barciszewski Stefan JurgaThis book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
The Chemical Biology of Nucleic Acids
by Günter MayerWith extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNAexpansion of the genetic alphabet in nucleic acids by creating new base pairschemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotidesnucleic-acid-templated chemistrychemical biology of peptide nucleic acids (PNA)the interactions of small molecules with DNA and RNAthe architectural modules of folded RNAsgenesis and biological applications of locked nucleic acid (LNA)small non-coding RNA in bacteriamicroRNA-guided gene silencingnucleic acids based therapiesinnate immune recognition of nucleic acidlight-responsive nucleic acids for the spatiotemporal control of biological processesDNA methylationframeworks for programming RNA devicesRNA as a catalyst: The Diels-Alderase-Ribozymeevolving an understanding of RNA function by in vitro approachesthe chemical biology of aptamers: synthesis and applicationsnucleic acids as detection toolsbacterial riboswitch discovery and analysisThe Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.
The Chemical Biology of Plant Biostimulants (Wiley Series in Renewable Resource)
by Christian V. StevensIntroduces readers to the chemical biology of plant biostimulants This book brings together different aspects of biostimulants, providing an overview of the variety of materials exploited as biostimulants, their biological activity, and agricultural applications. As different groups of biostimulants display different bioactivity and specificity, advances in biostimulant research is illustrated by different examples of biostimulants, such as humic substance, seaweed extracts, and substances with hormone-like activities. The book also reports on methods used to screen for new biostimulant compounds by exploring natural sources. Combining the expertise of internationally-renowned scientists and entrepreneurs in the area of biostimulants and biofertilisers, The Chemical Biology of Plant Biostimulants offers in-depth chapters that look at: agricultural functions and action mechanisms of plant biostimulants (PBs); plant biostimulants from seaweed; seaweed carbohydrates; and the possible role for electron shuttling capacity in elicitation of PB activity of humic substances on plant growth enhancement. The subject of auxins is covered next, followed closely by a chapter on plant biostimulants in vermicomposts. Other topics include: exploring natural resources for biostimulants; the impact of biostimulants on whole plant and cellular levels; the impact of PBs on molecular level; and the use of use of plant metabolites to mitigate stress effects in crops. Provides an insightful introduction to the subject of biostimulants Discusses biostimulant modes of actions Covers microbial biostimulatory activities and biostimulant application strategies Offers unique and varied perspectives on the subject by a team of international contributors Features summaries of publications on biostimulants and biostimulant activity The Chemical Biology of Plant Biostimulants will appeal to a wide range of readers, including scientists and agricultural practitioners looking for more knowledge about the development and application of biostimulants.
The Chemical Biology of Thrombin
by Roger L. LundbladThis book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin
The Chemical Bond - Fundamental Aspects of Chemical Bonding
by Sason Shaik Gernot FrenkingThis is the perfect complement to "Chemical Bonding - Across the Periodic Table" by the same editors, who are two of the top scientists working on this topic, each with extensive experience and important connections within the community.The resulting book is a unique overview of the different approaches used for describing a chemical bond, including molecular-orbital based, valence-bond based, ELF, AIM and density-functional based methods. It takes into account the many developments that have taken place in the field over the past few decades due to the rapid advances in quantum chemical models and faster computers.
The Chemical Bond I
by D. Michael P. MingosThe series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors
The Chemical Bond II
by D. Michael P. MingosThe series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors
The Chemical Bond III
by D. Michael P. MingosThe series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors
The Chemical Bond: Chemical Bonding Across the Periodic Table
by Sason Shaik Gernot FrenkingA unique overview of the different kinds of chemical bonds that can be found in the periodic table, from the main-group elements to transition elements, lanthanides and actinides. It takes into account the many developments that have taken place in the field over the past few decades due to the rapid advances in quantum chemical models and faster computers. This is the perfect complement to "Chemical Bonding - Fundamentals and Models" by the same editors, who are two of the top scientists working on this topic, each with extensive experience and important connections within the community.
The Chemical Components of Tobacco and Tobacco Smoke
by Alan Rodgman Thomas A. PerfettiAuthored by two longtime researchers in tobacco science, The Chemical Components of Tobacco and Tobacco Smoke, Second Edition chronicles the progress made from late 2008 through 2011 by scientists in the field of tobacco science. The book examines the isolation and characterization of each component. It explores developments in pertinent analytical
The Chemical Cosmos
by Steve MillerIf you have ever wondered how we get from the awesome impersonality of the Big Bang universe to the point where living creatures can start to form, and evolve into beings like you, your friends and your family, wonder no more. Steve Miller provides us with a tour through the chemical evolution of the universe, from the formation of the first molecules all the way to the chemicals required for life to evolve. Using a simple Hydrogen molecule - known as H-three-plus - as a guide, he takes us on a journey that starts with the birth of the first stars, and how, in dying, they pour their hearts out into enriching the universe in which we live. Our molecular guide makes its first appearance at the source of the Chemical Cosmos, at a time when only three elements and a total of 11 molecules existed. From those simple beginnings, H-three-plus guides us down river on the violent currents of exploding stars, through the streams of the Interstellar Medium, and into the delta where new stars and planets form. We are finally left on the shores of the sea of life. Along the way, we meet the key characters who have shaped our understanding of the chemistry of the universe, such as Cambridge physicist J.J. Thomson and the Chicago chemist Takeshi Oka. And we are given an insider's view of just how astronomers, making use of telescopes and Earth-orbiting satellites, have put together our modern view of the Chemical Cosmos.