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Wir lieben Wissenschaft: Mit einer wissenschaftlichen Grundhaltung gegen Betrug, Leugnung und Pseudowissenschaft
by Lee MclntyreAngriffe auf die Wissenschaft sind alltäglich geworden: Die Erforschung des Klimawandels sei keine „anständige“ Wissenschaft, die Evolution „nur eine Theorie“, die „Wahrheit“ über Impfstoffe werde vertuscht. In diesem Buch diskutiert Lee McIntyre, was Wissenschaft von Nicht-Wissenschaft unterscheidet: der Stellenwert der Evidenz und die Bereitschaft, Theorien auf Basis neuer Evidenz zu verwerfen. Diese beiden wesentlichen Eigenschaften nennt er die „wissenschaftliche Grundhaltung“. McIntyre führt Beispiele an, die sowohl den wissenschaftlichen Erfolg (eine Verringerung des Kindbettfiebers im 19. Jahrhundert) als auch das Scheitern (die fehlerhafte „Entdeckung“ der kalten Fusion im 20. Jahrhundert) veranschaulichen. Er beschreibt den Wandel der Medizin von einer weitgehend auf Vermutungen beruhenden Praxis zu einer Wissenschaft, die sich auf Beweise stützt; er betrachtet wissenschaftlichen Betrug und untersucht die Positionen von ideologiegetriebenen Leugnern, Pseudowissenschaftlern und „Skeptikern“, die wissenschaftliche Erkenntnisse ablehnen.Das Buch macht in einer Welt der „alternativen Fakten“ klar, dass die Beachtung von Fakten ein einzigartig wirkungsvolles Instrument zur Verteidigung der Wissenschaft selbst ist.
Wire Ropes
by Klaus FeyrerThe main goal of this book is to present the methods used to calculate the most important parameters for ropes, and to explain how they are applied on the basis of numerous sample calculations. The book, based on the most important chapters of the German book DRAHTSEILE, has been updated to reflect the latest developments, with the new edition especially focusing on computational methods for wire ropes. Many new calculations and examples have also been added to facilitate the dimensioning and calculation of mechanical characteristics of wire ropes. This book offers a valuable resource for all those working with wire ropes, including construction engineers, operators and supervisors of machines and installations involving wire ropes.
Wired for Culture: Origins of the Human Social Mind
by Mark Pagel"Does an excellent job of using evolutionary biology to discuss the origins of religion, music, art, and . . . morality."--Publishers Weekly, starred review A unique trait of the human species is that our personalities, lifestyles, and worldviews are shaped by an accident of birth--namely, the culture into which we are born. It is our cultures and not our genes that determine which foods we eat, which languages we speak, which people we love and marry, and which people we kill in war. But how did our species develop a mind that is hardwired for culture--and why? Evolutionary biologist Mark Pagel tracks this intriguing question through the last 80,000 years of human evolution, revealing how an innate propensity to contribute and conform to the culture of our birth not only enabled human survival and progress in the past but also continues to influence our behavior today. Shedding light on our species' defining attributes--from art, morality, and altruism to self-interest, deception, and prejudice--Wired for Culture offers surprising new insights into what it means to be human.
Wired for Joy!: A Revolutionary Method For Creating Happiness From Within
by Laurel MellinCan you imagine a world where drug companies throw bake sales to make ends meet? A world without all the jaw clenching, nail biting, and stress-induced melt downs? Eighty percent of health problems today are due to the downstream effects of stress, so learning to break free from stress could dramatically improve your mood, your relationships, your health––and your life. In Wired for Joy , researcher and New York Times -bestselling author Laurel Mellin presents a simple yet proven way to train your brain to move through stress and back to joy. Her method has been called the missing link in health care, as it focuses on rewiring the emotional brain—the caldron of our stress—rather than the thinking brain, which has been the focus of most other stress-busting methods. Based on the cutting-edge science of neuroplasticity, Mellin outlines the five states of the emotional brain. For each state she presents a specific tool that easily and quickly switches the brain back to a state of well-being. Once you know how to make that switch, life becomes easier, and stress symptoms—depression, anxiety, overeating, high blood pressure—tend to fade. Finally, instead of focusing on the symptoms of stress, we can change the wiring that triggers it and experience new sense of freedom in our lives.
Wired For Love: A Neuroscientist’s Journey Through Romance, Loss and the Essence of Human Connection
by Stephanie CacioppoFrom the world's foremost neuroscientist of romantic love comes a personal story of connection and heartbreak that brings new understanding to an old truth: it is better to have loved and lost than never to have loved at all.At thirty-seven, Dr. Stephanie Cacioppo was content to be single. She was fulfilled by her work on the neuroscience of romantic love; how finding and growing with a partner literally reshapes our brains. That was, until she met the foremost neuroscientist of loneliness. A whirlwind romance led to marriage, to sharing an office at the University of Chicago. After seven years of being inseparable at work and home, she lost her beloved husband following a devastating battle with cancer.In Wired for Love, Dr. Stephanie Cacioppo tells not just a science story, but also a love story. She shares revelatory insights into how we fall in love, and why; what makes love last; and how we process love lost - all grounded in cutting-edge findings in brain chemistry and behavioural science. Woven through it all is her moving personal story, from astonishment, to unbreakable bond, to grief and healing. Her experience and her work enrich each other, creating a singular blend of science and lyricism that's essential reading for anyone looking for connection.
Wired For Love: A Neuroscientist’s Journey Through Romance, Loss and the Essence of Human Connection (Language Acts and Worldmaking #5)
by Stephanie CacioppoFrom the world's foremost neuroscientist of romantic love comes the untold story of what happens in our brains when we are in love.Dr Stephanie Cacioppo shares revelatory insights into how we fall in love, and why; what makes love last; and how we process love lost - all grounded in cutting-edge findings in brain chemistry and behavioural science. You will learn how to make a closer bond in your relationship, how to make sure the spark isn't lost, how to tell the difference between lust and love, and how to find a path beyond heartbreak or bereavement.Wired for Love is not just a science story, but also a love story. At thirty-seven, Dr. Stephanie Cacioppo was content to be single. She was fulfilled by her work on the neuroscience of romantic love; how finding and growing with a partner literally reshapes our brains. That was, until she met the foremost neuroscientist of loneliness. A whirlwind romance led to marriage, to sharing an office at the University of Chicago. After seven years of being inseparable at work and home, she lost her beloved husband following a devastating battle with cancer.This moving personal story is woven through the book, from astonishment, to unbreakable bond, to grief and healing. Her experience and her work enrich each other, creating a singular blend of science, lyricism and expert tips that are essential reading for anyone looking for connection.
Wired for Love: A Neuroscientist's Journey Through Romance, Loss, and the Essence of Human Connection
by Stephanie CacioppoFrom the world’s foremost neuroscientist of romantic love comes a personal story of connection and heartbreak that brings new understanding to an old truth: better to have loved and lost than never to have loved at all.At thirty-seven, Dr. Stephanie Cacioppo was content to be single. She was fulfilled by her work on the neuroscience of romantic love—how finding and growing with a partner literally reshapes our brains. That was, until she met the foremost neuroscientist of loneliness. A whirlwind romance led to marriage and to sharing an office at the University of Chicago. After seven years of being inseparable at work and at home, Stephanie lost her beloved husband, John, following his intense battle with cancer.In Wired for Love, Stephanie tells not just a science story but also a love story. She shares revelatory insights into how and why we fall in love, what makes love last, and how we process love lost—all grounded in cutting-edge findings in brain chemistry and behavioral science. Woven through it all is her moving personal story, from astonishment to unbreakable bond to grief and healing. Her experience and her work enrich each other, creating a singular blend of science and lyricism that’s essential reading for anyone looking for connection.
Wired for Story
by Lisa CronThis guide reveals how writers can utilize cognitive storytelling strategies to craft stories that ignite readers' brains and captivate them through each plot element. Imagine knowing what the brain craves from every tale it encounters, what fuels the success of any great story, and what keeps readers transfixed. Wired for Story reveals these cognitive secrets--and it's a game-changer for anyone who has ever set pen to paper. The vast majority of writing advice focuses on "writing well" as if it were the same as telling a great story. This is exactly where many aspiring writers fail--they strive for beautiful metaphors, authentic dialogue, and interesting characters, losing sight of the one thing that every engaging story must do: ignite the brain's hardwired desire to learn what happens next. When writers tap into the evolutionary purpose of story and electrify our curiosity, it triggers a delicious dopamine rush that tells us to pay attention. Without it, even the most perfect prose won't hold anyone's interest. Backed by recent breakthroughs in neuroscience as well as examples from novels, screenplays, and short stories, Wired for Story offers a revolutionary look at story as the brain experiences it. Each chapter zeroes in on an aspect of the brain, its corresponding revelation about story, and the way to apply it to your storytelling right now.
Wired for Story
by Lisa CronThis guide reveals how writers can utilize cognitive storytelling strategies to craft stories that ignite readers' brains and captivate them through each plot element. Imagine knowing what the brain craves from every tale it encounters, what fuels the success of any great story, and what keeps readers transfixed. Wired for Story reveals these cognitive secrets--and it's a game-changer for anyone who has ever set pen to paper. The vast majority of writing advice focuses on "writing well" as if it were the same as telling a great story. This is exactly where many aspiring writers fail--they strive for beautiful metaphors, authentic dialogue, and interesting characters, losing sight of the one thing that every engaging story must do: ignite the brain's hardwired desire to learn what happens next. When writers tap into the evolutionary purpose of story and electrify our curiosity, it triggers a delicious dopamine rush that tells us to pay attention. Without it, even the most perfect prose won't hold anyone's interest. Backed by recent breakthroughs in neuroscience as well as examples from novels, screenplays, and short stories, Wired for Story offers a revolutionary look at story as the brain experiences it. Each chapter zeroes in on an aspect of the brain, its corresponding revelation about story, and the way to apply it to your storytelling right now.
Wired for War
by P. W. SingerIn Wired for War, P. W. Singer explores the greatest revolution in military affairs since the atom bomb: the dawn of robotic warfare. We are on the cusp of a massive shift in military technology that threatens to make real the stuff of I, Robot and The Terminator. Blending historical evidence with interviews of an amazing cast of characters, Singer shows how technology is changing not just how wars are fought, but also the politics, economics, laws, and the ethics that surround war itself. Travelling from the battlefields of Iraq and Afghanistan to modern-day "skunk works" in the midst of suburbia, Wired for War will tantalise a wide readership, from military buffs to policy wonks to gearheads.
Wired for War: The Robotics Revolution And Conflict In The Twenty-First Century
by P. W. SingerA military expert reveals how science fiction is fast becoming reality on the battlefield, changing not just how wars are fought, but also the politics, economics, laws, and ethics that surround war itself P. W. Singer's previous two books foretold the rise of private military contractors and the advent of child soldiers- predictions that proved all too accurate. Now, he explores the greatest revolution in military affairs since the atom bomb-the advent of robotic warfare.We are just beginning to see a massive shift in military technology that threatens to make the stuff of I,Robot and the Terminator all too real. More than 7,000 robotic systems are now in Iraq. Pilots in Nevada are remotely killing terrorists in Afghanistan. Scientists are debating just how smart-and how lethal-to make their current robotic prototypes. And many of the most renowned science fiction authors are secretly consulting for the Pentagon on the next generation.Blending historic evidence with interviews from the field, Singer vividly shows that as these technologies multiply, they will have profound effects on the front lines as well as on the politics back home. Moving humans off the battlefield makes wars easier to start, but more complex to fight. Replacing men with machines may save some lives, but will lower the morale and psychological barriers to killing. The 'warrior ethos,' which has long defined soldiers' identity, will erode, as will the laws of war that have governed military conflict for generations.Paradoxically, these new technologies will also bring war to our doorstep. As other nations and even terrorist organizations start to build or buy their own robotic weapons, the robot revolution could undermine America's military preeminence.
Wired for War
by P. W. Singer"riveting and comprehensive, encompassing every aspect of the rise of military robotics." --Financial Times In Wired for War, P. W. Singer explores the greatest revolution in military affairs since the atom bomb: the dawn of robotic warfare. We are on the cusp of a massive shift in military technology that threatens to make real the stuff of I, Robot and The Terminator. Blending historical evidence with interviews of an amazing cast of characters, Singer shows how technology is changing not just how wars are fought, but also the politics, economics, laws, and the ethics that surround war itself. Traveling from the battlefields of Iraq and Afghanistan to modern-day "skunk works" in the midst of suburbia, Wired for War will tantalize a wide readership, from military buffs to policy wonks to gearheads.
Wired For Wealth: Change The Money Mindsets That Keep You Trapped and Unleash Your Wealth Potential
by Ted Klontz Rick Kahler Brad KlontzRecession-Proof Your Mind and Rewire Your Brain for Wealth As financial stress mounts and an economic crash looms, Wired for Wealth shows you that the biggest threat to your financial health is not a recession; it's your brain. Markets go up and markets go down, but one fact holds true: Your money scripts--the unconscious core beliefs you hold about money--will determine whether you win or lose in the long run. But there is hope. Drawing on the results of a landmark survey of people's money habits, as well as their decades of work improving their clients' financial lives, renowned financial psychologists Drs. Brad Klontz and Ted Klontz and financial planner Rick Kahler, CFP® show you how you can rewire your brain for wealth. Their unexpected insights show you how you can free yourself from excessive debt, financial stress, money avoidance, and a lack of savings. You'll discover: The top 10 money scripts that mess up people's financial lives--and how to change them How to identify your 'financial comfort zone'--and how to break through it How to curtail family money issues, including financial infidelity, financially dependent children, and conflicts over money. What to do if your money scripts are keeping you poor by overspending, underspending, excessive debt, lack of savings, and lack of retirement planning. What to do if your money scripts keeping you poor in spirit--how to release guilt and fear for good, and be at peace with what you have. Entertaining and enlightening, Wired for Wealth will put you in control of your finances and enable you to break through to new levels of wealth and security.
Wired Shut: Copyright and the Shape of Digital Culture (The\mit Press Ser.)
by Tarleton GillespieHow the shift toward "technical copy protection" in the battle over digital copyright depends on changing political and commercial alignments that are profoundly shaping the future of cultural expression in a digital age.While the public and the media have been distracted by the story of Napster, warnings about the evils of "piracy," and lawsuits by the recording and film industries, the enforcement of copyright law in the digital world has quietly shifted from regulating copying to regulating the design of technology. Lawmakers and commercial interests are pursuing what might be called a technical fix: instead of specifying what can and cannot be done legally with a copyrighted work, this new approach calls for the strategic use of encryption technologies to build standards of copyright directly into digital devices so that some uses are possible and others rendered impossible. In Wired Shut, Tarleton Gillespie examines this shift to "technical copy protection" and its profound political, economic, and cultural implications.Gillespie reveals that the real story is not the technological controls themselves but the political, economic, and cultural arrangements being put in place to make them work. He shows that this approach to digital copyright depends on new kinds of alliances among content and technology industries, legislators, regulators, and the courts, and is changing the relationship between law and technology in the process. The film and music industries, he claims, are deploying copyright in order to funnel digital culture into increasingly commercial patterns that threaten to undermine the democratic potential of a network society. In this broad context, Gillespie examines three recent controversies over digital copyright: the failed effort to develop copy protection for portable music players with the Strategic Digital Music Initiative (SDMI); the encryption system used in DVDs, and the film industry's legal response to the tools that challenged them; and the attempt by the FCC to mandate the "broadcast flag" copy protection system for digital television. In each, he argues that whether or not such technical constraints ever succeed, the political alignments required will profoundly shape the future of cultural expression in a digital age.
Wired Wilderness: Technologies of Tracking and the Making of Modern Wildlife (Animals, History, Culture)
by Etienne BensonAmerican wildlife biologists first began fitting animals with radio transmitters in the 1950s. By the 1980s the practice had proven so useful to scientists and nonscientists alike that it became global. Wired Wilderness is the first book-length study of the origin, evolution, use, and impact of these now-commonplace tracking technologies.Combining approaches from environmental history, the history of science and technology, animal studies, and the cultural and political history of the United States, Etienne Benson traces the radio tracking of wild animals across a wide range of institutions, regions, and species and in a variety of contexts. He explains how hunters, animal-rights activists, and other conservation-minded groups gradually turned tagging from a tool for control into a conduit for connection with wildlife. Drawing on extensive archival research, interviews with wildlife biologists and engineers, and in-depth case studies of specific conservation issues—such as the management of deer, grouse, and other game animals in the upper Midwest and the conservation of tigers and rhinoceroses in Nepal—Benson illuminates telemetry's context-dependent uses and meanings as well as commonalities among tagging practices.Wired Wilderness traces the evolution of the modern wildlife biologist’s field practices and shows how the intense interest of nonscientists at once constrained and benefited the field. Scholars of and researchers involved in wildlife management will find this history both fascinating and revealing.
Wired Wonder Woof (AstroKids #3)
by Robert ElmerWELCOME TO 2175! Meet the Astrokids --Mir, Buzz, Miko, DeeBee, and Tag --five friends learning biblical truth through out-of-this-world adventures aboard space station CLEO-7. "Nyet, my jokes aren't always a hit. Still, who knew they'd land me in so much trouble? Especially when I was trying to be serious!" "Please understand, I felt guilty about spying on my friends. It all started with a Galaxian trader--and our dog, Zero-G. Sure, Zero-G can talk, thanks to the Mind-2-Voice collar DeeBee made him. But why was the Galaxian so interested in our space mutt? This guy had to be hiding something. But would the other AstroKids believe me?"
Wireless and Mobile Networking
by Mahbub HassanThere has been phenomenal uptake of wireless and mobile networking technologies in the past decades. Significant developments have taken place during this time making the wireless technology more affordable, effective, and reliable. This book explains the fundamental principles and protocols of key existing and emerging wireless networking technologies. The book begins with a review of the fundamentals of wireless communications. It covers the basic theories and terminologies of coding and modulation, which maps digital information to the underlying signal, as well as the models to capture the dynamics of wireless signal propagation in the environment. It provides in-depth coverage of the WiFi evolution covering both the mainstream WiFi, which operates in 2.4/5GHz with new versions targeting 6GHz, as well as some of the niche WiFi standards that operate outside the mainstream bands such as 802.11af in 700MHz TV bands, 802.11ah in 900MHz to connect the Internet of Things (IoT), and 802.11ad/ay in 60GHz to support multi-gigabit applications. The book covers the fundamental concepts of cellular networks, examines the advancements brought forth by each generation, and discusses new applications and the underpinning wireless technologies promised by 5G. It also covers a recently developed long-range low-power wireless networking technology called LoRa, which is the fastest growing technology to connect millions of IoT sensors and devices throughout the world. The concluding chapters examine emerging wireless paradigms such as Artificial Intelligence for wireless networking, sensing with wireless signals, and mobile networking with flying base stations carried by drones and unmanned aerial vehicles (UAVs). With many worked-out examples, illustrative figures, and multiple choice questions, this book is an ideal for students and a valuable reference for anyone working in this rapidly evolving field.
Wireless Computing in Medicine: From Nano to Cloud with Ethical and Legal Implications
by Mary Mehrnoosh Eshaghian-WilnerProvides a comprehensive overview of wireless computing in medicine, with technological, medical, and legal advances This book brings together the latest work of leading scientists in the disciplines of Computing, Medicine, and Law, in the field of Wireless Health. The book is organized into three main sections. The first section discusses the use of distributed computing in medicine. It concentrates on methods for treating chronic diseases and cognitive disabilities like Alzheimer's, Autism, etc. It also discusses how to improve portability and accuracy of monitoring instruments and reduce the redundancy of data. It emphasizes the privacy and security of using such devices. The role of mobile sensing, wireless power and Markov decision process in distributed computing is also examined. The second section covers nanomedicine and discusses how the drug delivery strategies for chronic diseases can be efficiently improved by Nanotechnology enabled materials and devices such as MENs and Nanorobots. The authors will also explain how to use DNA computation in medicine, model brain disorders and detect bio-markers using nanotechnology. The third section will focus on the legal and privacy issues, and how to implement these technologies in a way that is a safe and ethical. Defines the technologies of distributed wireless health, from software that runs cloud computing data centers, to the technologies that allow new sensors to work Explains the applications of nanotechnologies to prevent, diagnose and cure disease Includes case studies on how the technologies covered in the book are being implemented in the medical field, through both the creation of new medical applications and their integration into current systems Discusses pervasive computing's organizational benefits to hospitals and health care organizations, and their ethical and legal challenges Wireless Computing in Medicine: From Nano to Cloud with Its Ethical and Legal Implications is written as a reference for computer engineers working in wireless computing, as well as medical and legal professionals. The book will also serve students in the fields of advanced computing, nanomedicine, health informatics, and technology law.
Wireless Information and Power Transfer: A New Paradigm for Green Communications
by Salman Durrani Symeon Chatzinotas John Thompson Dushantha Nalin K. JayakodyThis book presents breakthroughs in the design of Wireless Energy Harvesting (WEH) networks. It bridges the gap between WEH through radio waves communications and power transfer, which have largely been designed separately. The authors present an overview of the RF-EHNs including system architecture and RF energy harvesting techniques and existing applications. They also cover the idea of WEH in novel discoveries of information, the theoretical bounds in WEH, wireless sensor networks, usage of modern channel coding together with WEH, energy efficient resource allocation mechanisms, distributed self-organized energy efficient designs, delay-energy trade-off, specific protocols for energy efficient communication designs, D2D communication and energy efficiency, cooperative wireless networks, and cognitive networks.
Wireless Medical Systems and Algorithms: Design and Applications (Devices, Circuits, and Systems #56)
by Pietro Salvo Miguel Hernandez-SilveiraWireless Medical Systems and Algorithms: Design and Applications provides a state-of-the-art overview of the key steps in the development of wireless medical systems, from biochips to brain–computer interfaces and beyond. The book also examines some of the most advanced algorithms and data processing in the field. Addressing the latest challenges and solutions related to the medical needs, electronic design, advanced materials chemistry, wireless body sensor networks, and technologies suitable for wireless medical devices, the text: Investigates the technological and manufacturing issues associated with the development of wireless medical devices Introduces the techniques and strategies that can optimize the performances of algorithms for medical applications and provide robust results in terms of data reliability Includes a variety of practical examples and case studies relevant to engineers, medical doctors, chemists, and biologists Wireless Medical Systems and Algorithms: Design and Applications not only highlights new technologies for the continuous surveillance of patient health conditions, but also shows how disciplines such as chemistry, biology, engineering, and medicine are merging to produce a new class of smart devices capable of managing and monitoring a wide range of cognitive and physical disabilities.
Wiring the Nervous System: Mechanisms of Axonal and Dendritic Remodelling in Health and Disease (River Publishers Series in Biotechnology and Medical Research)
by Tracy S. Tran Avraham YaronThis book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders. The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions. Topics discussed in the book include: Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration
Wirkstoffdesign: Entwurf und Wirkung von Arzneistoffen
by Gerhard KlebeDie vorliegende 3. Auflage bringt das Thema Wirkstoffdesign wieder auf den aktuellen Stand der Forschung. Der Leser lernt neue Methoden in der Gentechnologie und die erweiterte Palette strukturbiologischer Verfahren kennen. Gerade die letzten 10 Jahre wurden durch Einsatz dieser Methoden viele komplexe Zielstrukturen wie die G-Protein gekoppelten Rezeptoren oder Ionenkanälen aufgeklärt. Der Leser erfährt wie diese lange ersehnten Komplexstrukturen mit klassischen Arzneistoffen aussehen und wie die therapeutische Wirkung erzielt wird. Im Wirkstoffdesign ist die räumliche Struktur der interagierenden Moleküle von zentraler Bedeutung. Hier liegt der Schlüssel, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Daher wurden die Farbabbildungen in der 3. Auflage neu gestaltet und mit Videos verknüpft, die direkt über QR-Codes neben den Abbildungen mit üblichen Handys oder Tablets ohne weitere App aufgerufen werden. Die bewegten Moleküldarstellungen geben dem Leser einen leichten Zugang zum räumlichen Verständnis der molekularen Strukturen und Interaktionen. Dieses Lehrbuch wurde ursprünglich von Hans-Joachim Böhm, Gerhard Klebe und Hugo Kubinyi begründet und richtet sich an Studierende der Pharmazie, Chemie und der Biowissenschaften, aber auch an Quereinsteiger und Medizinische Chemiker in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Es wurde mit dem Literaturpreis des Fonds der Chemischen Industrie ausgezeichnet. Konzeptionell hebt es sich sehr stark von klassischen Lehrbüchern der pharmazeutischen Chemie ab und rückt den Weg zum neuen Arzneistoff in den Mittelpunkt. Die Auswahl der Fallbeispiele erfolgte nach didaktischen Gesichtspunkten und versucht einen weiten Überblick über Methoden und Strategien zu geben ohne den Blick zurück auf die Anfänge dieses Arbeitsgebiet zu vergessen. So spannt sich der Bogen von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsverfahren, Modelling, Moleküldynamik und QSAR-Methoden bis zum struktur- und computergestützten Design. In der 3. Auflage kommen neue Methoden und Konzepte wie die Epigenetik, der PROTAC-Ansatz, die CRISPR-Cas9-Genschere, Strukturvorhersagen aus der Sequenz, der Einsatz von Künstlicher Intelligenz und neue Screening-Technologien aus der Biophysik zur Sprache. Erfolge beim Stören bzw. Verstärken von Protein-Protein-Wechselwirkungen als Konzept der Arzneistofftherapie werden vorgestellt und Überlegungen zur Optimierung von Arzneistoffen unter Berücksichtigung ihrer thermodynamischen wie kinetischen Bindungsprofile werden diskutiert.Videos per App: einfach die SN More Media App kostenfrei herunterladen, einen Link mit dem Play-Button scannen und sofort das video auf Smartphone oder Tablet ausspiele.
Wirtschaftliches Grundwissen: Für Naturwissenschaftler und Ingenieure
by Hergen Scheck Birgitt ScheckWenn frisch gebackene Absolventen eines natur- oder ingenieurwissenschaftlichen Studienganges in ihr erstes Wirtschaftsunternehmen kommen, landen sie auf einem fremden Planeten: dem der Kaufleute, Betriebswirte, Juristen und Manager. Um dort bestehen zu konnen, ist zumindest ein Grundwissen daruber, wie Wirtschaft funktioniert und geregelt ist, unverzichtbar. Dieser Kompaktkurs fur das moderne Wirtschaftsleben spart nichts aus: Von der doppelten Buchfuhrung bis zur Erschlie?ung globaler Markte - hier wird alles in leicht verstandlichen Begriffen erklart. - Der Crash-Kurs fur Berufsanfanger: Nimmt die Scheu vor dem Umgang mit Geld, Markten und Produkten. Alle Aspekte des Wirtschaftslebens werden dargestellt, ohne unnotigen Ballast und ohne "Fachchinesisch". - Praxisnah: Zahlreiche Fallbeispiele und Ubungsaufgaben zu aktuellen Themen aus dem Wirtschaftleben - mit Losungen im Anhang! Von der Markteinfuhrung eines 3-Liter-Autos bis zur Existenzgrundung als "Ich-AG" werden reale Szenarien erklart und analysiert. - Lesefreundliches Layout: Eine Doppelseite zu jedem Thema, mit klar gekennzeichneten Zusammenfassungen und Beispielen. - Aktuell: Alle Kapitel berucksichtigen jetzt die Anderungen in der nationalen und internationalen Gesetzgebung bis 2006 (z. B. neue Rechtsformen bei Gesellschaften, neue Regelungen beim Kundigungsschutz, Ich-AGs, etc.) - alle Anderungen in den wirtschaftlichen und politischen Rahmenbedingungen der letzten 5 Jahre sind berucksichtigt.
Wisdom: From Philosophy to Neuroscience
by Stephen S. HallA compelling investigation into one of our most coveted and cherished ideals, and the efforts of modern science to penetrate the mysterious nature of this timeless virtue. We all recognize wisdom, but defining it is more elusive. In this fascinating journey from philosophy to science, Stephen S. Hall gives us a dramatic history of wisdom, from its sudden emergence in four different locations (Greece, China, Israel, and India) in the fifth century B. C. to its modern manifestations in education, politics, and the workplace. We learn how wisdom became the provenance of philosophy and religion through its embodiment in individuals such as Buddha, Confucius, and Jesus; how it has consistently been a catalyst for social change; and how revelatory work in the last fifty years by psychologists, economists, and neuroscientists has begun to shed light on the biology of cognitive traits long associated with wisdom--and, in doing so, begun to suggest how we might cultivate it. Hall explores the neural mechanisms for wise decision making; the conflict between the emotional and cognitive parts of the brain; the development of compassion, humility, and empathy; the effect of adversity and the impact of early-life stress on the development of wisdom; and how we can learn to optimize our future choices and future selves. Hall's bracing exploration of the science of wisdom allows us to see this ancient virtue with fresh eyes, yet also makes clear that despite modern science's most powerful efforts, wisdom continues to elude easy understanding.
Wisdom for a Livable Planet
by Carl N. McdanielThe author profiles the work of eight visionaries who have dedicated their lives to various environmental issues. Each story provides a portrait of an individual's valiant and inspiring campaign to improve the conditions for life on our planet. Taken together, the work of these people points the way toward creating an ecologically centered civilization in which a brighter future for all life, including human, is possible.*Terri Swearingen takes on one of the world's largest hazardous waste incinerators burning toxic waste next door to an elementary school.*Stephen Schneider establishes the scientific basis for climate change*Herman Daly advocates a dynamic steady-state economy that respects the laws of nature and human behavior.*David Orr champions educational reform to make universities a place where students learn how to be environmentally aware citizens*Werner Fornos works toward empowering every person with the knowledge and means to decide when and how many children to have*Helena Norberg-Hodge champions local living with appropriate technologies to enhance our spiritual and ecological well-being.*Wes Jackson promotes sustainable agriculture based on local ecology and community values*Dave Foreman leads the effort to rewild almost half of North America with wolves, mountain lions, jaguars, falcons, and others to restore functional ecosystems and preserve biodiversity