- Table View
- List View
Stephen Hawking: A Life in Science
by Michael White John GribbinAn updated edition of the definitive biography on Stephen Hawking that marries biography and science to tell the story of one of the most remarkable men in history Stephen Hawking is no ordinary scientist. He has broadened our basic understanding of the universe and his theoretical work on black holes and the origins of the cosmos have been groundbreaking, if not downright revolutionary. He has also spent much of his adult life confined to a wheelchair, a victim of ALS. But his physical limitations have done nothing to confine him intellectually. Hawking would already be remarkable for his cutting-edge work in theoretical physics alone. However, he has also managed to popularize science unlike anyone else. He achieved almost cult-like fame with his A Brief History of Time and has since become a household name by making the complexities of cosmology accessible to millions of people. In Stephen Hawking, science writers White and Gribbin have painted a compelling portrait of a scientific mind that seemingly knows no bounds. Weaving together clear explanations of Hawking’s science with a detailed, balanced, and sensitive personal history, readers will come to know and appreciate both sides of this incredible man. Includes new updates in Hawking’s biography and the recent discovery of the Higgs-Boson (or “God”) particle.
Stephen Hawking: A Life in Science, Updated New Edition
by Michael White John GribbinOriginally published in 1992 to great acclaim, this updated edition traces the course of Hawking’s life and science, successfully marrying biography and physics to tell the story of a remarkable man.<P> Stephen Hawking is no ordinary scientist. With a career that began over thirty years ago at Cambridge University, he has managed to do more than perhaps any other scientist to broaden our basic understanding of the universe. His theoretical work on black holes and his progress in advancing our knowledge of the origin and nature of the cosmos have been groundbreaking—if not downright revolutionary.<P> Stephen Hawking has also spent much of his adult life confined to a wheelchair, a victim of ALS, a degenerative motor neuron disease. Clearly his physical limitations have done nothing to confine him intellectually. He simply never allowed his illness to hinder his scientific development. In fact, many would argue that his liberation from the routine chores of life has allowed him to focus his efforts more keenly on his science.<P> Hawking certainly would have been remarkable for his cutting edge work in theoretical physics alone. However, he has also managed to popularize science in a way unparalleled by other scientists of his stature. He became a household name, achieving almost cult-like fame, with the release of his best-selling book, A Brief History of Time. Although steeped in the potentially overwhelming complexities of cosmology, he succeeded in selling millions of copies to audiences eager to learn even some of what he has to offer.<P> Science writers White and Gribbin have skillfully painted a portrait of an indefatigable genius and a scientific mind that seemingly knows no bounds. Knitting together clear explanations of Hawking’s science with a detailed personal history that is both balanced as well as sensitive, we come to know—and appreciate—both.<P> As Stephen Hawking’s new book, The Universe in a Nutshell, hits the best-seller lists, it is the ideal time for readers to learn more about this remarkable man and his vast body of accomplishments.
Stephen Hawking Genius at Work
by Roger HighfieldA behind-the-scenes tour of the inner sanctum of one of the world's most prominent scientific thinkers.In 2021, The Science Museum made a once-in-a-lifetime acquisition of the contents of Stephen Hawking's office. This book delves into that remarkable collection, using the seminal papers, items, and curiosities in his office to explain his theories and reveal more about one of the greatest minds in modern science. It's an unprecedented glimpse into the life of the best-known scientist of modern times. - Artifacts include:- A Simpsons bomber jacket gifted to him following his appearance on the show- A copy of Hawking's PhD thesis: Properties of an Expanding Universe- Singularities and the Geometry of Space, written at the beginning of his vital collaboration with Roger Penrose- His blackboard, where he debated ideas and doodled with his contemporaries- Scientific bets made with colleagues to prove (and sometimes disprove) his theories- His Permobil F3 wheelchair and communications systems- Hawking's Franklin medal and his CBE
Stephen Hawking's Universe: An Introduction to the Most Remarkable Scientist of Our Time
by John BosloughSince the publication of "A Brief History of Time" - an introduction to some of the most important theories on the cosmos - Stephen Hawking is known widely as a man who has changed the way we look at the universe. He became a member of the Royal Society at the unusually early age of 32 and became in 1980 Lucasian Professor of Mathematics at Cambridge University. Written with Hawking's assistance, this is a readable account for the non-specialist of his contribution to theoretical physics. It encompasses his theories on the Big Bang and the nature of black holes, and contains the transcript of one of his most important essays.
Stephen J. Gould: The Scientific Legacy
by Alessandro Minelli Telmo Pievani Gian Antonio DanieliStephen J. Gould's greatest contribution to science is a revised version of the theory of evolution which offers today a useful framework for understanding progress in many evolutionary fields. His intuitions about the conjunction of evolution and development, the role of ecological factors in speciation, the multi-level interpretation of the units of selection, and the interplay between functional pressures and constraints all represent fruitful lines of experimental research. His opposition to the progressive representations of evolution, the gene-centered view of natural history, or the adaptationist "just-so stories" has also left its mark on current biology. In May 2012, at the Istituto Veneto di Scienze, Lettere ed Arti in Venice, an international panel of scientists and philosophers discussed Stephen J. Gould's legacy, ten years after his death. This book presents a selection of those contributions, chosen for their interest and importance. A broad range of themes are covered: Gould's contribution to evolutionary theory, including the concept of punctuated equilibria and the importance of his pluralism; the Gouldian view of genome and development; Gould's legacy in anthropology; and, finally, the significance of his thought for the human sciences. This book provides a fascinating appraisal of the cultural legacy of one of the world's greatest popular writers in the life sciences. This is the first time that scientists including some of Gould's personal friends and co-authors of papers of momentous importance such as Niles Eldredge have come together to strike a balanced view of Gould's intellectual heritage.
Stephen of Pisa and Antioch: An Introduction to Ptolemaic Cosmology and Astronomy from the Early Crusader States (Sources and Studies in the History of Mathematics and Physical Sciences)
by Dirk GrupeThis volume aims to make Stephen of Pisa and Antioch’s work on the celestial sciences accessible to a wider readership, providing not just the text but a translation and introduction as well. The edition is based on the only known manuscript of the Liber Mamonis, MS Cambrai, Médiathèque d’Agglomération, A 930. It is split into two parts: the first provides an extensive introduction to Stephen and his work, while the second features the edition and translation. A comprehensive glossary and collection of photographs of plates are also included.
Stepped Care 2.0: A Paradigm Shift in Mental Health
by Peter CornishThis book is a primer on Stepped Care 2.0. It is the first book in a series of three. This primer addresses the increased demand for mental health care by supporting stakeholders (help-seekers, providers, and policy-makers) to collaborate in enhancing care outcomes through work that is both more meaningful and sustainable. Our current mental health system is organized to offer highly intensive psychiatric and psychological care. While undoubtedly effective, demand far exceeds the supply for such specialized programming. Many people seeking to improve their mental health do not need psychiatric medication or sophisticated psychotherapy. A typical help seeker needs basic support. For knee pain, a nurse or physician might first recommend icing and resting the knee, working to achieve a healthy weight, and introducing low impact exercise before considering specialist care. Unfortunately, there is no parallel continuum of care for mental health and wellness. As a result, a person seeking the most basic support must line up and wait for the specialist along with those who may have very severe and/or complex needs. Why are there no lower intensity options? One reason is fear and stigma. A thorough assessment by a specialist is considered best practice. After all, what if we miss signs of suicide or potential harm to others? A reasonable question on the surface; however, the premise is flawed. First, the risk of suicide, or threat to others, for those already seeking care, is low. Second, our technical capacity to predict on these threats is virtually nil. Finally, assessment in our current culture of fear tends to focus more on the identification of deficits (as opposed to functional capacities), leading to over-prescription of expensive remedies and lost opportunities for autonomy and self-management. Despite little evidence linking assessment to treatment outcomes, and no evidence supporting our capacity to detect risk for harm, we persist with lengthy intake assessments and automatic specialist referrals that delay care. Before providers and policy makers can feel comfortable letting go of risk assessment, however, they need to understand the forces underlying the risk paradigm that dominates our society and restricts creative solutions for supporting those in need.
Stepped Care 2.0: The Power of Conundrums
by Peter Cornish Gillian BerryStepped Care 2.0: A Paradigm Shift in Mental Health, by Dr Peter Cornish, made a compelling argument for why the existing mental health care system has consistently struggled to meet the needs of clients from all walks of life, and laid out key principles and guidelines for how the system could be changed. But what challenges are involved in putting these ideas into practice? Stepped Care 2.0: The Power of Conundrums features essays, interviews, and arguments from a wide range of contributors who have tried to do just that. The Power of Conundrums dives deep into the practical application of the Stepped Care 2.0 model (SC2.0), looking at the ways SC2.0 has succeeded, the difficulties administrators face when implementing it, and how it could be improved. Chapters touch on topics including: the evidence for stepped care, the way SC2.0 can be stymied by the Western cultural values that dominate mental healthcare, implementation science and SC2.0, the risk paradigm and SC2.0, the model’s one-at-a-time approach to therapy, what co-design means in an SC2.0 context, a case study on how implementing SC2.0 can go wrong, the understanding of recovery put forward by the model, and how SC2.0 can work for clients experiencing complex, persistent, or chronic mental health issues. Each chapter is followed by a reflection from Cornish, and the book concludes with a roundtable discussion about how SC2.0 can evolve to meet the challenges it faces. This text brings theory and practice together by including an updated version of Stepped Care 2.0: A Paradigm Shift in Mental Health, as well as the full text of Stepped Care 2.0: The Power of Conundrums.
Stepping in the Same River Twice: Replication in Biological Research
by Aaron M. Ellison Ayelet Shavit W. John KressAn international team of biologists, philosophers, and historians of science explores the critically important process of replication in biological and biomedical research Without replication, the trustworthiness of scientific research remains in doubt. Although replication is increasingly recognized as a central problem in many scientific disciplines, repeating the same scientific observations of experiments or reproducing the same set of analyses from existing data is remarkably difficult. In this important volume, an international team of biologists, philosophers, and historians of science addresses challenges and solutions for valid replication of research in medicine, ecology, natural history, agriculture, physiology, and computer science. After the introduction to important concepts and historical background, the book offers paired chapters that provide theoretical overviews followed by detailed case studies. These studies range widely in topics, from infectious-diseases and environmental monitoring to museum collections, meta-analysis, bioinformatics, and more. The closing chapters explicate and quantify problems in the case studies, and the volume concludes with important recommendations for best practices.
Stepping Stones to Synthetic Biology (The Frontiers Collection)
by Sergio CarràThis book explores fascinating topics at the edge of life, guiding the reader all the way from the relation of life processes to the second law of thermodynamics and the abundance of complex organic compounds in the universe through to the latest advances in synthetic biology and metabolic engineering. The background to the book is the extraordinary scientific adventures that are being undertaken as progress is made toward the creation of an artificial cell and the control of life processes. This journey involves input from research areas as diverse as genetic engineering, physical chemistry, and information theory. Life is to be thought of not only as a chemical event but also as an information process, with the genome a repository of information gathered over time through evolution. Knowledge of the mechanisms affecting the increase in complexity associated with evolutionary paths is improving, and there appear to be analogies with the evolution of the technologies promoting the development of our society. The book will be of wide interest to students at all levels and to others with an interest in the subject.
Stepping-Stones to the Future of Space Exploration: A Workshop Report
by Aeronautics Space Engineering BoardNASA’s Human Exploration and Development of Space (HEDS) program within the Office of Space Flight has proposed a new framework for space technology and systems development—Advanced Systems, Technology, Research, and Analysis (ASTRA) for future space flight capabilities. To assist in the development of this framework, NASA asked the National Research Council to convene a series of workshops on technology policy issues concerning the relationship of the various stakeholders in advancing human and robotic exploration and development of space. The first workshop, which is the topic of this report, focused on policy issues about the development and demonstration of space technologies. Four policy topics—selected by the project steering committee as the foci of this first workshop—are discussed in the report: the rationale for human and robotic space exploration; technology as a driver for capability transformation; risk mitigation and perception; and international cooperation and competition.
Stepping Stones to the Stars: The Story of Manned Spaceflight
by Terry C Treadwell Henry HartsfieldStepping Stones to the Stars is the story of manned spaceflight from its inception to the era of the Space Shuttle. It begins with a short history of the evolution of the rocket, before describing the first manned rocket flights by both the Americans and the Russians. There is also the little-known story of what is thought to be the earliest manned rocket flight, said to have taken place in 1933 on the island of Rgen in the Baltic under the control of the German War Ministry. The story continues through Yuri Gagarin becoming the first person in space and Neil Armstrong's giant leap for mankind; to the first space stations, Skylab, Salyut and Mir.With the development of the Shuttle, the USA moved ahead in the space race, but the Americans and Russians soon realised that it was easier to co-operate than compete, and the two nations began to work together for the first time. Terry C. Treadwell's book is a non-technical history of human spaceflight, that tells the exciting and dramatic story of how we took our early steps towards the stars.
The Steps of the Sun: From the author of The Queen's Gambit – now a major Netflix drama (Gateway Essentials #510)
by Walter TevisA science fiction thriller from the author of THE MAN WHO FELL TO EARTH.'A fine engrossing novel by a master!' Philadelphia EnquirerIn a time when America's power has been eroded by energy depletion, and world control has been virtually given over to the Chinese, only one man has the courage to seek new mineral resources among the stars. He is Ben Belson, one of the richest men in the world, a man haunted by the memory of a loveless childhood and driven by needs and desires he can barely understand or control. His dream is to find the means to help America break the stranglehold of the corrupt interests who are keeping it a second class power.
The Steps of the Sun: From the author of The Queen's Gambit – now a major Netflix drama (Gateway Essentials #510)
by Walter TevisA science fiction thriller from the author of THE MAN WHO FELL TO EARTH.'A fine engrossing novel by a master!' Philadelphia EnquirerIn a time when America's power has been eroded by energy depletion, and world control has been virtually given over to the Chinese, only one man has the courage to seek new mineral resources among the stars. He is Ben Belson, one of the richest men in the world, a man haunted by the memory of a loveless childhood and driven by needs and desires he can barely understand or control. His dream is to find the means to help America break the stranglehold of the corrupt interests who are keeping it a second class power.
Steps to an Ecology of Mind
by Gregory BatesonGregory Bateson was a philosopher, anthropologist, photographer, naturalist, and poet, as well as the husband and collaborator of Margaret Mead. With a new foreword by his daughter Mary Katherine Bateson, this classic anthology of his major work will continue to delight and inform generations of readers. "This collection amounts to a retrospective exhibition of a working life. . . . Bateson has come to this position during a career that carried him not only into anthropology, for which he was first trained, but into psychiatry, genetics, and communication theory. . . . He . . . examines the nature of the mind, seeing it not as a nebulous something, somehow lodged somewhere in the body of each man, but as a network of interactions relating the individual with his society and his species and with the universe at large. "—D. W. Harding, New York Review of Books "[Bateson's] view of the world, of science, of culture, and of man is vast and challenging. His efforts at synthesis are tantalizingly and cryptically suggestive. . . . This is a book we should all read and ponder. "—Roger Keesing, American Anthropologist Gregory Bateson (1904-1980) was the author of Naven and Mind and Nature.
Stepwise Culture of Human Adult Stem Cells (River Publishers Series in Biotechnology and Medical Research)
by Pranela RameshwarThis volume on stepwise techniques to culture adult human stem cells begins with the basic methods to culture adult stem cells followed by related methods to supplement stem cell culture. This and future volumes of techniques will allow laboratories across scientific entities – academic and commercial – to adapt the described methods for similar methods with cells from other species. The standardized techniques will allow across the board interpretation of other technologies such as Omics studies. These methods can be a starting platform for culturing stem cells even in laboratories that might not be familiar with the techniques. Scientific and early clinical trials strongly favor the development of translational studies with adult stem cells. A major impediment to progress in the field of regenerative medicine is a lack of standardized methods to culture specific stem cells. Such documented methods would allow for scientific rigor and reproducibility to enhance efficient and safe translation of stem cells to patients. This book fills that gap.
Stereochemistry and Stereoselective Synthesis: An Introduction
by László Poppe Zoltán Boros József Nagy Mihály Nógrádi Gábor HornyánszkyWritten by a well-respected and experienced author, this textbook fills the gap for a concise introduction to the key concepts of organic stereochemistry and the most important classical and modern methods in stereoselective synthesis. The concepts are extensively illustrated in color, with practical examples and question-answer sets to help consolidate the reader's knowledge. In addition, animations are available from the Wiley website. A must-have for students in chemistry, biochemistry, and life sciences, as well as researchers in pharmaceutical and agrochemical companies in need of a quick introduction to the field.
Stereochemistry of Organic Compounds
by V.K. AhluwaliaThis textbook provides a simple approach to understand the various complex aspects of stereochemistry. It deals with basic static stereochemistry and gives an overview of the different isomeric forms and nomenclatures. With simple writing style and many examples, this book covers the topics such as stereochemistry of hydrocarbons, alkenes, cycloalkenes, optically active compounds, trivalent carbon, fused, bridged and caged rings and related compounds. This textbook also covers the additional topics such as optical rotatory dispersion and circular dichroism, steroechemistry of elimination reactions, substitution reactions, rearrangement reactions and pericyclic reactions. The book includes pedagogical features like end-of-chapter problems and key concepts to help students in self-learning. The textbook is extremely useful for the senior undergraduate and postgraduate students pursuing course in chemistry, especially organic chemistry. Besides, this book will also be a useful reference book for professionals working in various chemical industries, biotechnology, bioscience and pharmacy.
Stereoelectronic Effects: A Bridge Between Structure and Reactivity
by Igor V. AlabuginStereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules. This advanced textbook provides an up-to-date overview of the field, starting from the fundamental principles and presenting a large selection of modern examples of stereoelectronic effects in organic reactivity. Modern theoretical concepts are described in an accessible manner for students and experimentalists working in organic synthesis, medicinal chemistry and materials science; the background/concept part of the book is based on a wealth of computational and theoretical work but the mathematics behind the concepts is distilled in a general non-technical discussion of the role of stereoelectronic effects in chemistry. Topics covered include: * Effects of orbital overlap on reactivity * Experimental and theoretical approaches for studies of stereoelectronic effects * The fundamentals of stereoelectronic effects * Hyperconjugative stereoelectronic effects * Transition state stabilization * Remote stereoelectronic effects * Practical applciations of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science. The aim of this book is to make life easier for students of organic chemistry and practicing organic chemists by providing them with a concise set of rules which govern interactions between molecules and between functional groups in molecules. These rules will offer a unifying framework for the understanding of molecular structure and reactivity.
Stereophonica: Sound and Space in Science, Technology, and the Arts
by Gascia OuzounianEpisodes in the transformation of our understanding of sound and space, from binaural listening in the nineteenth century to contemporary sound art.The relationship between sound and space has become central to both creative practices in music and sound art and contemporary scholarship on sound. Entire subfields have emerged in connection to the spatial aspects of sound, from spatial audio and sound installation to acoustic ecology and soundscape studies. But how did our understanding of sound become spatial? In Stereophonica, Gascia Ouzounian examines a series of historical episodes that transformed ideas of sound and space, from the advent of stereo technologies in the nineteenth century to visual representations of sonic environments today.Developing a uniquely interdisciplinary perspective, Ouzounian draws on both the history of science and technology and the history of music and sound art. She investigates the binaural apparatus that allowed nineteenth-century listeners to observe sound in three dimensions; examines the development of military technologies for sound location during World War I; revisits experiments in stereo sound at Bell Telephone Laboratories in the 1930s; and considers the creation of "optimized acoustical environments" for theaters and factories. She explores the development of multichannel "spatial music" in the 1950s and sound installation art in the 1960s; analyzes the mapping of soundscapes; and investigates contemporary approaches to sonic urbanism, sonic practices that reimagine urban environments through sound.Rich in detail but accessible and engaging, and generously illustrated with photographs, drawings, maps, and diagrams of devices and artworks, Stereophonica brings an acute, imaginative, and much-needed historical sensibility to the growing literature around sound and space.
Stereoselective Alkene Synthesis
by Jianbo WangStereoselective Synthesis of Tetrasubstituted Alkenes via Torquoselectivity-Controlled Olefination of Carbonyl Compounds with Ynolates, by Mitsuru Shindo and Kenji Matsumoto.- Stereoselective Synthesis of Z-Alkenes, by Woon-Yew Siau, Yao Zhang and Yu Zhao.- Stereoselective Synthesis of Mono-fluoroalkenes, by Shoji Hara.- Recent Advances in Stereoselective Synthesis of 1,3-Dienes, by Michael De Paolis, Isabelle Chataigner and Jacques Maddaluno.- Selective Olefination of Carbonyl Compounds via Metal-Catalyzed Carbene Transfer from Diazo Reagents, by Yang Hu and X. Peter Zhang.- Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product, by Xiaoguang Lei and Houhua Li.- Olefination Reactions of Phosphorus-Stabilized Carbon Nucleophiles, by Yonghong Gu and Shi-Kai Tian.- Alkene Synthesis Through Transition Metal-Catalyzed Cross-Coupling of N-Tosylhydrazones, by Yan Zhang and Jianbo Wang.
Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules
by Robert. J SharpeThis thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials - the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
Stereoselective Formation of Amines
by Wei Li Xumu ZhangEach review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Stereoselective Heterocycle Synthesis via Alkene Difunctionalization
by David A. PetroneThis book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon–carbon (C‒C) and carbon–halogen (C‒X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.
Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis
by Dieter Enders Jean Rodriguez Damien BonneCombining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. * Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development * Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists * Organizes chapters by molecular structure of final products, making for a handbook-style resource * Discusses applications of the synthesis of natural products and of drug intermediates * Brings together otherwise-scattered information about a number of key, efficient chemical reactions